TY  - CHAP
A1  - Raman, Aravind Hariharan
A1  - Jung, Alexander
A1  - Horváth, András
A1  - Becker, Nadine
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - https://doi.org/10.17185/duepublico/48750
SP  - 10
EP  - 11
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Schieren, Mark
A1  - Kleinschmidt, Joris
A1  - Schmutz, Axel
A1  - Loop, Torsten
A1  - Gatzweiler, Karl-Heinz
A1  - Staat, Manfred
A1  - Wappler, Frank
A1  - Defosse, Jerome
T1  - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study
JF  - Anaesthesia
Y1  - 2019
SN  - 1365-2044
U6  - https://doi.org/10.1111/anae.14815
N1  - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und 
"Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit.
VL  - 74
IS  - 12
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - BOOK
A1  - Staat, Manfred
A1  - Erni, Daniel
T1  - Symposium Proceedings; 3rd YRA MedTech Symposium 2019: May 24 / 2019 / FH Aachen
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - https://doi.org/10.17185/duepublico/48750
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  -