TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayatekin, Muammer B. A1 - Uysal, N. A1 - Resmi, H. T1 - Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats? Kayatekin, Muammer B.; Uysal N.; Resmi, H.; Bediz, Seref C.; Temiz Artmann, A.; Genç, S.; Tugyan, K. JF - International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4 Y1 - 2005 SN - 0300-9831 SP - 243 EP - 250 ER - TY - JOUR A1 - Kuerten, David A1 - Kotliar, Konstantin A1 - Fuest, Matthias A1 - Walter, Peter A1 - Hollstein, Muriel A1 - Plange, Niklas ED - Neri, Piergiorgio T1 - Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study JF - International Ophthalmology N2 - Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect. KW - Glaucoma KW - Visual field asymmetry KW - Ocular blood flow KW - RVA KW - Vascular response Y1 - 2021 SN - 1573-2630 U6 - http://dx.doi.org/10.1007/s10792-021-01876-0 VL - 41 IS - 41 SP - 3109 EP - 3119 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. A1 - Hanssen, Henner A1 - Eberhardt, Karla A1 - Vilser, Walthard A1 - Halle, Martin A1 - Heemann, Uwe A1 - Schmidt-Trucksäss, Arno A1 - Baumann, Marcus T1 - Does increased blood pressure rather than aging influence retinal pulse wave velocity? JF - Investigative Ophthalmology & Visual Science, IOVS N2 - Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0–28.8) [median(1st quartile–3rd quartile)] and 12 senior 68.5-year-old (63.8–71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8–65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5–35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280–500] RU/s) and in validated healthy seniors (400 [320–510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV. Y1 - 2012 U6 - http://dx.doi.org/10.1167/iovs.11-8815 SN - 0146-0404 VL - 53 IS - 4 SP - 2119 EP - 2126 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Kharoubi, A. A1 - Schmidt-Trucksäß, A. A1 - Halle, M. A1 - Lanzl, I. T1 - Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons? JF - Acta Ophthalmologica Y1 - 2009 SN - 1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print) VL - Vol. 87 IS - Suppl. S244 SP - 0 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Wegmann, Kilian A1 - Hackl, Michael A1 - Staat, Manfred A1 - Mayer, Katharina A1 - Müller, Lars-Peter T1 - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results JF - Knee surgery, sports traumatology, arthroscopy N2 - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00167-016-4079-0 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 58 EP - 59 PB - Springer CY - Berlin ER - TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Maier, Mathias A1 - Schmidt-Trucksäss, Arno A1 - Halle, Martin A1 - Kotliar, Konstantin T1 - Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection JF - Acta Ophthalmologica Y1 - 2011 SN - 1755-3768 VL - 89 IS - 5 SP - 472 EP - 479 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. A1 - Schmidt-Trucksäss, A. A1 - Sitnikova, Diana A1 - Ali, Mohammad A1 - Blume, Katharina A1 - Halle, Martin A1 - Hansser, Henner T1 - Dynamic retinal vessel response to flicker in obesity: A methodological approach JF - Microvascular Research Y1 - 2011 SN - 0026-2862 VL - 81 IS - 1 SP - 123 EP - 128 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions JF - Regenerative medicine. 2 (2007), H. 5 Y1 - 2007 SN - 1746-0751 N1 - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany SP - 573 EP - 573 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in red blood cells JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 724 EP - 724 ER - TY - JOUR A1 - Aimenova, Zh. E. A1 - Digel, Ilya A1 - Eshibaev, А. А. T1 - Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem JF - KazNU Bulletin. Biology series N2 - L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen – lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 % higher than in the wild-growing species. Y1 - 2016 SN - 1563-0218 N1 - Original in russischer Sprache VL - 69 IS - 4 SP - 4 EP - 11 PB - Al-Farabi Kazakh National University CY - Almaty ER - TY - JOUR A1 - Hauser, C. A1 - Kotliar, Konstantin A1 - Tholen, S. A1 - Hasenau, A. A1 - Suttmann, Y. A1 - Renders, L. A1 - Heemann, U. A1 - Baumann, M. A1 - Schmaderer, C. T1 - Dynamische retinale Gefäßreaktion bei Hämodialysepatienten JF - Nieren- und Hochdruckkrankheiten Y1 - 2015 U6 - http://dx.doi.org/10.5414/NHX01743a SN - 0300-5224 VL - 44 IS - 11 SP - 480 EP - 480 PB - Dustri-Verlag CY - Oberhaching ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Mücke, Bruno A1 - Vilser, Walthard A1 - Schilling, Rudolf T1 - Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; Mücke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M. JF - Investigative Ophthalmology & Visual Science, IOVS. 49 (2008), H. 5 Y1 - 2008 SN - 0146-0404 SP - 2094 EP - 2102 PB - - ER - TY - JOUR A1 - Pogorelova, Natalia A1 - Rogachev, Evgeniy A1 - Akimbekov, Nuraly A1 - Digel, Ilya T1 - Effect of dehydration method on the micro- and nanomorphological properties of bacterial cellulose produced by Medusomyces gisevii on different substrates JF - Journal of materials science N2 - Many important properties of bacterial cellulose (BC), such as moisture absorption capacity, elasticity and tensile strength, largely depend on its structure. This paper presents a study on the effect of the drying method on BC films produced by Medusomyces gisevii using two different procedures: room temperature drying (RT, (24 ± 2 °C, humidity 65 ± 1%, dried until a constant weight was reached) and freeze-drying (FD, treated at − 75 °C for 48 h). BC was synthesized using one of two different carbon sources—either glucose or sucrose. Structural differences in the obtained BC films were evaluated using atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray diffraction. Macroscopically, the RT samples appeared semi-transparent and smooth, whereas the FD group exhibited an opaque white color and sponge-like structure. SEM examination showed denser packing of fibrils in FD samples while RT-samples displayed smaller average fiber diameter, lower surface roughness and less porosity. AFM confirmed the SEM observations and showed that the FD material exhibited a more branched structure and a higher surface roughness. The samples cultivated in a glucose-containing nutrient medium, generally displayed a straight and ordered shape of fibrils compared to the sucrose-derived BC, characterized by a rougher and wavier structure. The BC films dried under different conditions showed distinctly different crystallinity degrees, whereas the carbon source in the culture medium was found to have a relatively small effect on the BC crystallinity. Y1 - 2024 U6 - http://dx.doi.org/10.1007/s10853-024-09596-3 SN - 1573-4803 (Online) SN - 0022-2461 (Print) N1 - Corresponding author: Ilya Digel VL - 2024 PB - Springer Science + Business Media CY - Dordrecht ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Baskurt, O. K. A1 - Edremitlioglu, M. T1 - Effect of erythrocyte deformability on myocardial hematocrit gradient. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A. JF - American Journal of Physiology: Heart and Circulatory Physiology. 268 (1995), H. 1 Y1 - 1995 SN - 0363-6135 SP - 260 EP - 264 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Maier, Mathias A1 - Bauer, Svetlana A1 - Feucht, Nikolaus T1 - Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines JF - Acta Ophthalmologica Scandinavica. 85 (2007), H. 7 Y1 - 2007 SN - 1755-3768 SP - 777 EP - 781 PB - - ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Baskurt, O. K. A1 - Meiselman, H. J. T1 - Effect of superoxide anions on red blood cell rheologic properties. Baskurt, O. K.; Temiz, A.; Meiselman, H. J. JF - Free Radical Biology and Medicine. 24 (1998), H. 1 Y1 - 1998 SN - 0891-5849 SP - 102 EP - 110 ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Albracht, Kirsten A1 - Cronin, Neil J A1 - Paulsen, Gøran A1 - Bojsen-Møller, Jens A1 - Seynnes, Olivier R T1 - Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing JF - Frontiers in physiology N2 - During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation. KW - achilles tendon KW - energy absorption KW - energy dissipation KW - mechanical buffer KW - stiffness Y1 - 2018 U6 - http://dx.doi.org/10.3389/fphys.2018.00794 SN - 1664-042X IS - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Cehreli, Ruksan A1 - Akpinar, Hale A1 - Temiz Artmann, Aysegül A1 - Sagol, Ozgul T1 - Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis JF - Gastroenterology Research Y1 - 2015 U6 - http://dx.doi.org/10.14740/gr683w SN - 1918-2813 VL - 8 IS - 5 SP - 265 EP - 273 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Li, Anlan A1 - Seipelt, H. A1 - Müller, C. [u.a.] T1 - Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; Müller, C.;Shi, Yong de; Artmann, Gerhard Michael JF - Pharmacology and Toxicology. 85 (1999) Y1 - 1999 SN - 0902-9938 SP - 206 EP - 211 ER - TY - JOUR A1 - Erbayraktar, Zubeyde A1 - Yilmaz, Osman A1 - Temiz Artmann, Aysegül A1 - Cehreli, Ruksan A1 - Coker, Canan T1 - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus JF - Biological Trace Element Research Y1 - 2007 SN - 1559-0720 VL - 118 IS - 3 SP - 217 EP - 226 ER - TY - JOUR A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences JF - BMC Biophysics Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?10.1186/2046-1682-6-1 SN - 2046-1682 SP - 1 EP - 14 PB - BioMed Central CY - London ER - TY - JOUR A1 - Bassam, Rasha A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Digel, Ilya T1 - Effects of spermine NONOate and ATP on the thermal stability of hemoglobin JF - BMC Biophysics N2 - Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell. KW - Nitric Oxide Donor KW - NONOate KW - Circular Dichroism KW - Nitric Oxide Y1 - 2012 U6 - http://dx.doi.org/10.1186/2046-1682-5-16 SN - 2046-1682 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Thiebes, Anja Lena A1 - Klein, Sarah A1 - Zingsheim, Jonas A1 - Möller, Georg H. A1 - Gürzing, Stefanie A1 - Reddemann, Manuel A. A1 - Behbahani, Mehdi A1 - Cornelissen, Christian G. T1 - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio JF - pharmaceutics N2 - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing. KW - tri-lineage differentiation KW - survival KW - twin-fluid atomizer KW - adipose-derived stromal cells (ASCs) KW - cell atomization KW - cell aerosolization Y1 - 2022 U6 - http://dx.doi.org/10.3390/pharmaceutics14112421 N1 - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells" VL - 14 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Sponagel, Stefan A1 - Lutz, Th. T1 - Ein Beitrag zur Bestimmung der Haertewerte von Elastomeren JF - Kautschuk Gummi Kunststoffe. 43 (1990), H. 10 Y1 - 1990 SN - 0022-9520 SP - 861 EP - 865 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Groling, G. T1 - Eine Bemerkung zum Beweis des π Theorems. G. Groling, S. Sponagel JF - Zeitschrift für angewandte Mathematik und Mechanik: ZAMM. 63 (1983) Y1 - 1983 SN - 0044-2267 N1 - weitere ISSN: 0946-8463 SP - T258 EP - T259 ER - TY - JOUR A1 - Linden, A. A1 - Fischöder, M. A1 - Laack, Walter van A1 - Staat, Manfred T1 - Einschränkung von Taluskippung und -vorschub durch Sprunggelenkorthesen nach fibularer Bandruptur JF - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis N2 - Die fibulare Bandruptur zählt zu einer der am häufigsten auftretenden Verletzungen des Bewegungsapparats. In den meisten Fällen wird heute die konservativ frühfunktionelle Therapie mit Sprunggelenkorthesen allgemein bevorzugt. Im Rahmen der vorliegenden Studie wurden 14 verschiedene Sprunggelenkorthesen im Hinblick auf ihre Einschränkung von Taluskippung und Talusvorschub untersucht. Zur Simulation einer fibularen Bandruptur wurde ein Unterschenkelmodell aus Holz mit Fußteil, mit angelegten Orthesen in einen Scheuba-Halteapparat eingespannt und mit 150 N seitlich sowie anterior-posterior belastet. Anhand der erstellten "gehaltenen" Röntgenaufnahmen konnten Taluskippung und Talusvorschub jeder einzelnen Orthese eindeutig bestimmt werden. Die meisten Orthesen erreichten zufriedenstellende Ergebnisse. Es stellte sich heraus, dass vor allem eine eng anliegende, im Gelenkbereich anatomisch angepasste Form vorteilhaft zu sein scheint. N2 - The ankle sprain is actually one of the most common injuries. Nowadays the conservative pre-functional therapy with ankle braces is generally preferred. In the present study 14 different ankle braces were tested with regard to their ability to constrict the talar tilt and anterior drawer displacement. As part of the tests a wooden model of a foot was used in order to simulate an ankle sprain. This model was clamped in a Scheuba-device with different ankle braces and a force of 150 N was applied to it. The stress radiographs showed different talar tilts and anterior drawers of each brace. Most ankle braces achieved a satisfying result. It has become obvious that a tight fitting and an anatomically designed shape seem to be favourable. T2 - Constraint of talar tilt and anterior drawer by different ankle braces after the rupture of fibular ligaments KW - Sprunggelenkorthesen KW - fibulare Bandruptur KW - Distorsion des oberen Sprunggelenks KW - ankle sprain KW - rupture of the fibular ligament KW - ankle braces Y1 - 2013 SN - 2193-5785 U6 - http://dx.doi.org/10.3238/oup.2013.0306-0309 VL - 2 IS - 6 SP - 306 EP - 309 PB - Deutscher Ärzte-Verl. CY - Köln ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Zinoviewa, N. V. A1 - Krylova, I. S. T1 - Elaboration of the conception of the biomechanical model of the aqueous intraocular outflow / Svetlova, O. V. ; Zinoviewa, N. V. ; Krylova, I. S. ; Koshitz, I. N. ; Smolnikov, B. A. ; Fedorova, E. M. ; Kotliar, K. E. JF - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 5 (2001), H. 3 Y1 - 2001 SN - 1812-5123 SP - 23 EP - 27 PB - - ER - TY - JOUR A1 - Albanna, Walid A1 - Lueke, Jan Niklas A1 - Sjapic, Volha A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Sjapic, Sergej A1 - Alpdogan, Serdan A1 - Schneider, Toni A1 - Schubert, Gerrit Alexander A1 - Neumaier, Felix T1 - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina JF - Current Eye Research Y1 - 2017 U6 - http://dx.doi.org/10.1080/02713683.2017.1339807 SN - 1460-2202 IS - Article in press SP - 1 EP - 9 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Eschweiler, J. A1 - Laack, Walter van A1 - Staat, Manfred T1 - Elektromyographische Untersuchungen zur Kräftigung der Oberschenkelmuskulatur mit einem myoelektrischen Stimulator nach arthroskopischen Eingriffen am Kniegelenk JF - Orthopädische Praxis. 43 (2007), H. 10 Y1 - 2007 SN - 0030-588x SP - 539 EP - 542 ER - TY - JOUR A1 - Preiß, C. A1 - Linder, Peter A1 - Wendt, K. A1 - Krystek, M. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Bassam, Rasha A1 - Artmann, Gerhard T1 - Engineering technology for plant physiology and plant stress research N2 - Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology. KW - Pflanzenphysiologie KW - Pflanzenstress KW - Pflanzenscanner KW - plant stress KW - plant scanner Y1 - 2011 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Hovav, T. A1 - Goldfarb, A. A1 - Yedgar, S. [u.a.] T1 - Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G. JF - British Journal of Haematology. 106 (1999), H. 1 Y1 - 1999 SN - 1365-2141 SP - 178 EP - 181 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Vogel, A. A1 - Zink, S. A1 - Stache, O. T1 - Entwicklung eines automatisierten, computergesteuerten Permeabilitätsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; Königsfeld, J. ; Artmann, G. JF - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 Y1 - 2000 SN - 1862-278X SP - 479 EP - 480 ER - TY - JOUR A1 - Dachwald, Bernd T1 - Entwicklung sicherer und wartbarer Software für den Eurofighter JF - Soldat und Technik : Strategie und Technik, Sicherheit (1996) Y1 - 1996 SN - 0038-0989 SP - 663 EP - 668 ER - TY - JOUR A1 - Alexyuk, Madina A1 - Bogoyavlenskiy, Andrey A1 - Alexyuk, Pavel A1 - Moldakhanov, Yergali A1 - Berezin, Vladimir A1 - Digel, Ilya T1 - Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity JF - MicrobiologyOpen N2 - Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40% and 37% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before. KW - ecological structure KW - metagenomics KW - microbial diversity KW - shotgun sequencing KW - Small Aral Sea Y1 - 2021 U6 - http://dx.doi.org/10.1002/mbo3.1142 SN - 2045-8827 VL - 10 IS - 1 SP - 1 EP - 10 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred T1 - Erratum to "Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue" [GAMM-Mitteilungen, (2019), 42, 4, 10.1002/gamm.201900002] JF - GAMM-Mitteilungen Y1 - 2020 U6 - http://dx.doi.org/10.1002/gamm.202000011 SN - 1522-2608 N1 - Refers to: Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue. Alexander Jung, Manfred Staat. Volume 42, Issue 4. GAMM-Mitteilungen, 2019. https://doi.org/10.1002/gamm.201900002 VL - 43 IS - 4 PB - Wiley-VCH GmbH CY - Weinheim ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Ates, H. A1 - Üretmen, Ö. A1 - Andac, K. T1 - Erythrocyte deformability in high-tension and normal tension glaucoma. Ates, H.; Üretmen, Ö.; Temiz, A.; Andac, K. JF - International Ophthalmology. 22 (1998), H. 1 Y1 - 1998 SN - 0165-5701 SP - 7 EP - 12 ER - TY - JOUR A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Abel, Dirk A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training JF - Computer methods and programs in biomedicine N2 - Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training. KW - External knee adduction moments KW - Manipulated variables KW - Inverse dynamic problem KW - Inverse kinematic problem KW - Musculoskeletal model Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.cmpb.2016.09.005 SN - 0169-2607 N1 - Part of special issue: "SI: Personalised Models and System Identification" VL - 171 SP - 81 EP - 86 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Trzewik, Jürgen A1 - Temiz Artmann, Aysegül A1 - Linder, Peter A1 - Demirci, T. A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Evaluation of lateral mechanical tension in thin-film tissue constructs JF - Annals of Biomedical Engineering. 32 (2004), H. 9 Y1 - 2004 SN - 1573-9686 SP - 1243 EP - 1251 ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results. Y1 - 2018 U6 - http://dx.doi.org/10.3233/IES-184111 SN - 1878-5913 VL - 26 IS - 4 SP - 265 EP - 274 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Artmann, Gerhard A1 - Trzewik, Jürgen A1 - Mallipattu, S. K. A1 - Delano, F. A. [u.a.] T1 - Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, Jürgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W JF - The FASEB Journal. 15 (2001) Y1 - 2001 SN - 1530-6860 SP - 1711 EP - 1717 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Carnelli, I. A1 - Vasile, M. T1 - Evolutionary Neurocontrol as a Novel Method for Low-Thrust Gravity Assist Trajectory Optimization / I. Carnelli ; B. Dachwald ; M. Vasile JF - Proceedings of the Twenty-Fifth International Symposium on Space Technology and Science (Selected papers) : Kanazawa, [June 4 through June 11, 2006, at Kanazawa-shi Kanko Kaikan in Kanazawa city] / [Japan Society for Aeronautical and Space Sciences. Kohtaro Matsumoto [ed.-in-chief] Y1 - 2006 SN - 4-99005-002-9 N1 - International Symposium on Space Technology and Science <25, 2006, Kanazawa> ; ISTS 2006-d-46 SP - 569 EP - 574 PB - JSASS CY - Tokyo ER - TY - JOUR A1 - Dachwald, Bernd A1 - Carnelli, Ian A1 - Vasile, Massimiliano T1 - Evolutionary Neurocontrol: A Novel Method for Low-Thrust Gravity-Assist Trajectory Optimization / Carnelli, Ian ; Dachwald, Bernd ; Vasile, Massimiliano JF - Journal of guidance control and dynamics. 32 (2009), H. 2 Y1 - 2009 SN - 0731-5090 SP - 616 EP - 625 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Dachwald, Bernd T1 - Evolutionary Neurocontrol: A Smart Method for Global Optimization of Low-Thrust Trajectories JF - 22nd AIAA Applied Aerodynamics Conference and Exhibit - AIAA/AAS Astrodynamics Specialist Conference and Exhibit - AIAA Guidance, Navigation, and Control Conference and Exhibit - AIAA Modeling and Simulation Technologies Conference and Exhibit - AIAA Atmospheric Flight Mechanics Conference and Exhibit : 16 - 19 August 2004, Providence, Rhode Island / American Institute of Aeronautics and Astronautics. - (AIAA meeting papers on disc ; 2004,14-15) Y1 - 2004 N1 - American Institute of Aeronautics and Astronautics ; AIAA/AAS Astrodynamics Specialist Conference and Exhibit <2004, Providence, RI> ; AIAA paper number: AIAA-2004-5405 PB - American Inst. of Aeronautics and Astronautics CY - Reston, Va. ER - TY - JOUR A1 - Sponagel, Stefan A1 - Müller, H. T1 - Exakte instationäre Lösungen der Navier-Stokes-Gleichung. H. Müller, S. Sponagel JF - Zeitschrift für angewandte Mathematik und Mechanik: ZAMM. 63 (1983) Y1 - 1983 SN - 0044-2267 N1 - weitere ISSN: 0946-8463 SP - T273 EP - T275 ER - TY - JOUR A1 - Hanssen, H. A1 - Nickel, T. A1 - Drexel, V. A1 - Hertel, G. A1 - Emslander, I. A1 - Sisic, Z. A1 - Lorang, D. A1 - Schuster, T. A1 - Kotliar, Konstantin A1 - Pressler, A. A1 - Schmidt-Trucksäss, A. A1 - Weis, M. A1 - Halle, M. T1 - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity JF - Atherosclerosis Y1 - 2011 SN - 0021-9150 VL - 216 IS - 2 SP - 433 EP - 439 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Staat, Manfred A1 - Sponagel, Stefan A1 - Nguyen, Nhu Huynh T1 - Experiment and material model for soft tissue materials JF - Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ... Y1 - 2010 SN - 978-0-415-56327-7 SP - 465 EP - 470 PB - CRC Press CY - Boca Raton [u.a.] ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 189 EP - 196 ER - TY - JOUR A1 - Gorissen, P. A1 - Staat, Manfred A1 - Laack, Walter van T1 - Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport T1 - Experimental measurement of forces as a contribution to evaluate the effectiveness of shin guards in soccer JF - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis N2 - Diese Studie beschäftigte sich mit der Dämpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgeführt, der verschiedene Aufschlagkräfte auf die Schoner ermöglichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkräften unterhalb von 5kN erreichen können, dass bei größerer Belastung allerdings Verbesserungsbedarf besteht. Hierfür konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „adäquaten Zusammenspiel von Schale und Polsterung“ der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der Dämpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte. N2 - This study was conducted to test the damping effects of commercially available soccer shin guards on their damping effects. Therefore a pendulum impact apparatus with varying impact forces was used. It became clear that shin guards show the best effect at maximum forces of less than 5kN. There is however a need for improvement at greater impact forces. A good starting point was found in an „appropriate interaction of shell and padding” of the shin guard. It was further clarified that a significant improvement on the damping effect could be achieved at least partially over the last years. KW - Fußball KW - Schienbeinschoner KW - Aufschlagversuch Y1 - 2012 U6 - http://dx.doi.org/10.3238/oup.2012.0010-0015 SN - 2193-5785 VL - 1 IS - 1 SP - 10 EP - 15 PB - Deutscher Ärzte-Verlag CY - Köln ER - TY - JOUR A1 - Artmann, Gerhard A1 - Witte, Ch. T1 - Expertensystem für Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael JF - Biomedizinische Technik = Biomedical engineering. 36 (1991) Y1 - 1991 SN - 0013-5585 SP - 228 EP - 230 ER - TY - JOUR A1 - Staat, Manfred T1 - Failure probabilities of the primary circuit pressure boundary of an HTR-Module for process heat generation under accident conditions for different failure modes JF - Nuclear Engineering and Design. 144 (1993), H. 1 Y1 - 1993 SN - 0029-5493 SP - 53 EP - 67 ER - TY - JOUR A1 - Lapitan, Denis G. A1 - Rogatkin, Dmitrii A. A1 - Persheyev, Sydulla K. A1 - Kotliar, Konstantin T1 - False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter JF - Biomedizinische Technik N2 - Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise. Y1 - 2018 U6 - http://dx.doi.org/10.1515/bmt-2017-0060 SN - 0013-5585 VL - 63 IS - 4 SP - 439 EP - 444 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Leimena, W. A1 - Artmann, Gerhard A1 - Dachwald, Bernd A1 - Temiz Artmann, Aysegül A1 - Gossmann, Matthias A1 - Digel, Ilya T1 - Feasibility of an in-situ microbial decontamination of an ice-melting probe JF - Eurasian Chemico-Technological Journal. 12 (2010), H. 2 Y1 - 2010 SN - 1562-3920 SP - 145 EP - 150 ER - TY - JOUR A1 - Tran, Ngoc Trinh A1 - Trinh, Tu Luc A1 - Dao, Ngoc Tien A1 - Giap, Van Tan A1 - Truong, Manh Khuyen A1 - Dinh, Thuy Ha A1 - Staat, Manfred T1 - FEM shakedown analysis of structures under random strength with chance constrained programming JF - Vietnam Journal of Mechanics N2 - Direct methods, comprising limit and shakedown analysis, are a branch of computational mechanics. They play a significant role in mechanical and civil engineering design. The concept of direct methods aims to determine the ultimate load carrying capacity of structures beyond the elastic range. In practical problems, the direct methods lead to nonlinear convex optimization problems with a large number of variables and constraints. If strength and loading are random quantities, the shakedown analysis can be formulated as stochastic programming problem. In this paper, a method called chance constrained programming is presented, which is an effective method of stochastic programming to solve shakedown analysis problems under random conditions of strength. In this study, the loading is deterministic, and the strength is a normally or lognormally distributed variable. KW - limit analysis KW - shakedown analysis KW - chance constrained programming KW - stochastic programming KW - reliability of structures Y1 - 2022 U6 - http://dx.doi.org/10.15625/0866-7136/17943 SN - 0866-7136 SN - 2815-5882 VL - 44 IS - 4 SP - 459 EP - 473 PB - Vietnam Academy of Science and Technology (VAST) ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - FEM-based shakedown analysis of hardening structures JF - Asia Pacific journal on computational engineering N2 - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature. Y1 - 2014 U6 - http://dx.doi.org/10.1186/2196-1166-1-4 SN - 2196-1166 (E-Journal) IS - 1 SP - Article No. 4 PB - SpringerOpen CY - Berlin ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. T1 - FEM-computation of load carrying capacity of highly loaded passive components by direct methods. Heitzer, M. ; Staat, M. JF - Nuclear Engineering and Design. 193 (1999), H. 3 Y1 - 1999 SN - 0029-5493 SP - 349 EP - 358 ER - TY - JOUR A1 - Baader, Fabian A1 - Boxberg, Marc S. A1 - Chen, Qian A1 - Förstner, Roger A1 - Kowalski, Julia A1 - Dachwald, Bernd T1 - Field-test performance of an ice-melting probe in a terrestrial analogue environment JF - Icarus N2 - Melting probes are a proven tool for the exploration of thick ice layers and clean sampling of subglacial water on Earth. Their compact size and ease of operation also make them a key technology for the future exploration of icy moons in our Solar System, most prominently Europa and Enceladus. For both mission planning and hardware engineering, metrics such as efficiency and expected performance in terms of achievable speed, power requirements, and necessary heating power have to be known. Theoretical studies aim at describing thermal losses on the one hand, while laboratory experiments and field tests allow an empirical investigation of the true performance on the other hand. To investigate the practical value of a performance model for the operational performance in extraterrestrial environments, we first contrast measured data from terrestrial field tests on temperate and polythermal glaciers with results from basic heat loss models and a melt trajectory model. For this purpose, we propose conventions for the determination of two different efficiencies that can be applied to both measured data and models. One definition of efficiency is related to the melting head only, while the other definition considers the melting probe as a whole. We also present methods to combine several sources of heat loss for probes with a circular cross-section, and to translate the geometry of probes with a non-circular cross-section to analyse them in the same way. The models were selected in a way that minimizes the need to make assumptions about unknown parameters of the probe or the ice environment. The results indicate that currently used models do not yet reliably reproduce the performance of a probe under realistic conditions. Melting velocities and efficiencies are constantly overestimated by 15 to 50 % in the models, but qualitatively agree with the field test data. Hence, losses are observed, that are not yet covered and quantified by the available loss models. We find that the deviation increases with decreasing ice temperature. We suspect that this mismatch is mainly due to the too restrictive idealization of the probe model and the fact that the probe was not operated in an efficiency-optimized manner during the field tests. With respect to space mission engineering, we find that performance and efficiency models must be used with caution in unknown ice environments, as various ice parameters have a significant effect on the melting process. Some of these are difficult to estimate from afar. Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.icarus.2023.115852 N1 - Forschungsdaten hierzu: "Performance data of an ice-melting probe from field tests in two different ice environments" (https://opus.bibliothek.fh-aachen.de/opus4/frontdoor/index/index/docId/10890) IS - 409 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Novacek, V. A1 - Tran, Thanh Ngoc A1 - Klinge, U. A1 - Tolba, R. H. A1 - Staat, Manfred A1 - Bronson, D. G. A1 - Miesse, A. M. A1 - Whiffen, J. A1 - Turquier, F. T1 - Finite element modelling of stapled colorectal end-to-end anastomosis : Advantages of variable height stapler design JF - Journal of Biomechanics N2 - The impact of surgical staplers on tissues has been studied mostly in an empirical manner. In this paper, finite element method was used to clarify the mechanics of tissue stapling and associated phenomena. Various stapling modalities and several designs of circular staplers were investigated to evaluate the impact of the device on tissues and mechanical performance of the end-to-end colorectal anastomosis. Numerical simulations demonstrated that a single row of staples is not adequate to resist leakage due to non-linear buckling and opening of the tissue layers between two adjacent staples. Compared to the single staple row configuration, significant increase in stress experienced by the tissue at the inner staple rows was observed in two and three rows designs. On the other hand, adding second and/or third staple row had no effect on strain in the tissue inside the staples. Variable height design with higher staples in outer rows significantly reduced the stresses and strains in outer rows when compared to the same configuration with flat cartridge. KW - Variable height stapler design KW - Anastomotic leakage KW - Finite element modelling KW - End-to-end colorectal anastomosis KW - Surgical staplers Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jbiomech.2012.07.021 SN - 1873-2380 VL - 45 IS - 115 SP - 2693 EP - 2697 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dachwald, Bernd A1 - Schmidt, Tanja D. A1 - Seboldt, Wolfgang A1 - Auweter-Kurtz, T1 - Flight Opportunities from Mars to Earth for Piloted Missions Using Continuous Thrust Propulsion / Schmidt, Tanja D. ; Dachwald, Bernd ; Seboldt, Wolfgang ; Auweter-Kurtz, Monika Y1 - 2003 N1 - 39th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit 20-23 July 2003, Huntsville, Alabama ; AIAA 2003-4573 SP - 1 EP - 9 PB - - ER - TY - JOUR A1 - Scholz, A. A1 - Ley, Wilfried A1 - Dachwald, Bernd A1 - Miau, J. J. A1 - Juang, J. C. T1 - Flight results of the COMPASS-1 picosatellite mission JF - Acta Astronautica. 67 (2010), H. 9-10 Y1 - 2010 SN - 0094-5765 SP - 1289 EP - 1298 ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Flight style optimization in ski jumping on normal, large, and ski flying hills JF - Journal of biomechanics Y1 - 2013 SN - 1873-2380 (E-Journal); 0021-9290 (Print) N1 - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716-722] Journal of Biomechanics, 2018;71:313. VL - Vol. 47 IS - Iss. 3 SP - 716 EP - 722 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Artmann, Gerhard A1 - Hueck, Isgard S. A1 - Rossiter, Katharine A1 - Schmid-Schönbein, Geert W. T1 - Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Schönbein, Geert W. JF - Microcirculation. 15 (2008), H. 6 Y1 - 2008 SN - 1549-8719 SP - 531 EP - 542 ER - TY - JOUR A1 - Digel, Ilya A1 - Demirci, Taylan A1 - Temiz Artmann, Aysegül A1 - Nishikawa, K. T1 - Free Radical Nature of the Bactericidal Effect of Plasma-Generated Cluster Ions (PCIs) JF - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 982 EP - 983 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Digel, Ilya A1 - Embs, Jan P. A1 - Unruh, Tobias A1 - Tehei, M. A1 - Zaccai, G. A1 - Büldt, G. A1 - Artmann, Gerhard T1 - From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature JF - Biophysical Journal. 96 (2009), H. 12 Y1 - 2009 SN - 0006-3495 SP - 5073 EP - 5081 PB - Cell Press CY - Cambridge, Mass. ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zang, Werner T1 - Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen JF - Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3 Y1 - 1990 SN - 0013-5585 SP - 94 EP - 96 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M. JF - Acta Ophthalmologica. 86 (2008), H. 4 Y1 - 2008 SN - 1755-3768 SP - 424 EP - 433 PB - - ER - TY - JOUR A1 - Seidova, Seid-Fatima A1 - Kotliar, Konstantin A1 - Foerger, Frauke A1 - Klopfer, Matthias A1 - Lanzl, Ines T1 - Functional retinal changes in Gaucher disease JF - Documenta Ophthalmologica Y1 - 2009 SN - 1573-2622 VL - 118 IS - 2 SP - 151 EP - 154 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dachwald, Bernd A1 - Turyshev, Slava G. A1 - Dittus, H. A1 - Shao, M. [u.a.] T1 - Fundamental Physics with the Laser Astrometric Test Of Relativity / S.G. Turyshev ; H. Dittus ; M. Shao ... B.Dachwald ... JF - Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588) Y1 - 2005 SN - 9290928999 N1 - ISBN der CD-ROM-Ausg.: 9290928999 ; Symposium Trends in Space Science and Cosmic Vision 2020 <2005, Noordwijk> ; ESLAB symposium <39, 2005, Noordwijk> ; European Space Laboratory SP - 8 EP - 11 PB - ESA Publ. Div. CY - Noordwijk ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Björn A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Süss, Alexander A1 - Weber, Tobias A1 - Mileva, Katya N. A1 - Rittweger, Jörn A1 - Green, David A. A1 - Albracht, Kirsten T1 - Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities JF - Scientific reports N2 - The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity. KW - Bone quality and biomechanics KW - Environmental impact KW - Skeletal muscle KW - Tendons KW - Ultrasound Y1 - 2021 U6 - http://dx.doi.org/10.1038/s41598-021-00527-9 SN - 2045-2322 N1 - Corresponding author: Charlotte Richter VL - 11 IS - Article number: 22555 PB - Springer Nature CY - London ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Suess, Alexander A1 - Weber, Tobias A1 - Mileva, Katja N. A1 - Rittweger, Joern A1 - Green, David A. A1 - Albracht, Kirsten T1 - Gastrocnemius medialis contractile behavior is preserved during 30% body weight supported gait training JF - Frontiers in Sports and Active Living N2 - Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75% of the speed at which they typically transition to running, with 0% and 30% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle–tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle–tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle–series elastic element behavior. Walking with 30% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle–tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle–series elastic element behavior was observed during walking with 30% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking. KW - AlterG KW - rehabilitation KW - gait KW - walking KW - ultrasound imaging KW - series elastic element behavior KW - muscle fascicle behavior KW - unloading Y1 - 2021 U6 - http://dx.doi.org/10.3389/fspor.2020.614559 SN - 2624-9367 VL - 2021 IS - 2 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Demirci, Taylan A1 - Kurulgan Demirci, Eylem A1 - Trzewik, Jürgen A1 - Linder, Peter A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Sakizli, Meral A1 - Temiz Artmann, Aysegül T1 - Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress JF - IUBMB Life. 61 (2009), H. 3 Y1 - 2009 SN - 1521-6543 N1 - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey SP - 311 EP - 312 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kurulgan Demirci, Eylem A1 - Demirci, T. A1 - Trzewik, Jürgen A1 - Linder, Peter A1 - Karakulah, G. A1 - Artmann, Gerhard A1 - Sakizli, M. A1 - Temiz Artmann, Aysegül T1 - Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation JF - Cellular and molecular bioengineering. 4 (2011), H. 1 Y1 - 2011 SN - 1865-5025 SP - 46 EP - 55 PB - Springer CY - Berlin ER - TY - JOUR A1 - Artmann, Gerhard A1 - Schikarsky, C. T1 - Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C. JF - Clinical Hemorheology. 13 (1993), H. 4 Y1 - 1993 SN - 0271-5198 SP - 529 EP - 539 ER - TY - JOUR A1 - Laack, Walter van A1 - Levers, A. A1 - Staat, Manfred T1 - Gonarthrosetherapie auf Kernspinresonanzbasis mit MBST-Vierjahresbeobachtungen JF - Orthopädische Nachrichten : Zeitung für Orthopädie und Unfallchirurgie. 2013, H. 7/8 Y1 - 2013 SN - 1437-2193 SP - 13 PB - Biermann CY - Köln ER - TY - JOUR A1 - Dachwald, Bernd A1 - MacDonald, Malcolm A1 - McInnes, Colin R. T1 - Heliocentric Solar Sail Orbit Transfers with Locally Optimal Control Laws / Malcolm Macdonald ; Colin McInnes ; Bernd Dachwald JF - Journal of Spacecraft and Rockets. 44 (2007), H. 1 Y1 - 2007 SN - 0022-4650 SP - 273 EP - 276 ER - TY - JOUR A1 - Leipold, M. A1 - Fichtner, H. A1 - Heber, B. A1 - Groepper, P. A1 - Lascar, S. A1 - Burger, F. A1 - Eiden, M. A1 - Niederstadt, T. A1 - Sickinger, C. A1 - Herbeck, L. A1 - Dachwald, Bernd A1 - Seboldt, W. T1 - Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System JF - Acta Astronautica. 59 (2006), H. 8-11 Y1 - 2006 SN - 0094-5765 N1 - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; Selected Proceedings SP - 786 EP - 796 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Leipold, M. A1 - Fichtner, H. T1 - Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System / M. Leipold ; H. Fichtner ; B. Heber ... B. Dachwald ... JF - Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris] Y1 - 2003 SN - 92-9092-853-0 N1 - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; International Academy of Astronautics ; European Space Research and Technology Centre SP - 367 EP - 375 PB - ESA CY - Noordwijk ER - TY - JOUR A1 - Probst, M. A1 - Behbahani, Mehdi A1 - Borrmann, E. A1 - Elgeti, S. A1 - Nicolai, M. A1 - Behr, M. T1 - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices Y1 - 2010 N1 - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany ER - TY - JOUR A1 - Stadler, A. M. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Embs, Jan P. A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature JF - Biophysical Journal. 95 (2008), H. 11 Y1 - 2008 SN - 1542-0086 SP - 5449 EP - 5461 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya T1 - Hemoglobin Senses Body Temperature JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 415 EP - 447 PB - Springer CY - Berlin ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Zerlin, Kay A1 - Maggakis-Kelemen, Christina A1 - Linder, Peter A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Stadler, David A1 - Dikta, Gerhard A1 - Temiz Artmann, Aysegül T1 - Hemoglobin senses body temperature JF - European Biophysics Journal Y1 - 2009 SN - 0175-7571 VL - 38 IS - 5 SP - 589 EP - 600 ER - TY - JOUR A1 - Li, Anlan A1 - Shi, Young de A1 - Landsmann, B. A1 - Schankowski-Bouvier, P. A1 - Dikta, Gerhard A1 - Bauer, U. A1 - Artmann, Gerhard T1 - Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract JF - Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5 Y1 - 1998 SN - 1745-7254 N1 - ISSN der parallelen Ausgabe 1671-4083; China-Zs.-Code: CN31-1347 abstract frei unter SP - 417 EP - 421 ER - TY - JOUR A1 - Linder, Peter A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Kayser, Peter A1 - Porst, Dariusz A1 - Artmann, Gerhard T1 - High-throughput testing of mechanical forces generated in thin cell and tissue layers JF - Tissue Engineering. 13 (2007), H. 7 Y1 - 2007 SN - 1076-3279 N1 - Meeting abstract 433 SP - 1778 EP - 1778 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Spaltofski, R. A1 - Steinhilper, W. T1 - Hochmolekulare Additive für die Gleitlagerschmierung. Spaltofski, R.; Sponagel, S.; Steinhilper, W. JF - Tribologie und Schmierungstechnik. 35 (1988), H. 5 Y1 - 1988 SN - 0036-6218 SP - 236 EP - 241 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Spaltofski, R. T1 - Hochmolekulare Zusätze verbessern die Leichtlaufeigenschaft und die Tragfähigkeit von Schmierfilmen / Sponagel, S. ; Spaltofski, R. JF - Mineralöltechnik. 32 (1987), H. 3 Y1 - 1987 SN - 0341-1893 SP - 28 S. ER - TY - JOUR A1 - Baroud, G. A1 - Wu, J.Z. A1 - Bohner, M A1 - Sponagel, Stefan A1 - Steffen, T. T1 - How to determine the permeability for cement infiltration into osteoporotic cancellous bone JF - Medical Engineering & Physics. 25 (2003), H. 4 N2 - Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice. KW - Osteoporose KW - Permeabilität KW - Viskose Strömung KW - Viskosität KW - Vertebroplastie KW - Cement infiltration KW - Vertebroplasty KW - Osteoporosis KW - Permeability KW - Experiment KW - Analysis KW - Viscous flow Y1 - 2003 SN - 1350-4533 SP - 283 EP - 288 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Gorbatenkova, E. A. A1 - Panasenko, O. M. T1 - Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M. JF - Membrane and cell biology. 13 (2000), H. 4 Y1 - 2000 SN - 1023-6597 SP - 537 EP - 546 ER - TY - JOUR A1 - Doorschodt, B. M. A1 - Schreinemachers, M. C. J. M. A1 - Behbahani, Mehdi A1 - Florquin, S. A1 - Weis, J. A1 - Staat, Manfred A1 - Tolba, R. H. T1 - Hypothermic machine perfusion of kidney grafts: which pressure is preferred JF - Annals of Biomedical Engineering. 39 (2011), H. 3 Y1 - 2011 SN - 1573-9686 SP - 1051 EP - 1059 PB - Springer CY - Berlin ER - TY - JOUR A1 - Sponagel, Stefan A1 - Unger, J. A1 - Spies, K. H. T1 - Härtebegriff im Zusammenhang mit Vernetzung, Bruchdehnung und Dauerfestigkeit eines Elastomers JF - Kautschuk Gummi Kunststoffe. 56 (2003), H. 11 Y1 - 2003 SN - 0948-3276 SP - 608 EP - 613 ER - TY - JOUR A1 - Dachwald, Bernd A1 - Mikucki, Jill A1 - Tulaczyk, Slawek A1 - Digel, Ilya A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Kowalski, Julia A1 - Xu, Changsheng T1 - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems JF - Annals of Glaciology N2 - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample. KW - Antarctic Glaciology KW - Extraterrestrial Glaciology KW - Glaciological instruments and methods KW - Subclacial exploration KW - Subglacial lakes Y1 - 2014 U6 - http://dx.doi.org/10.3189/2014AoG65A004 SN - 1727-5644 VL - 55 IS - 65 SP - 14 EP - 22 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Werfel, Stanislas A1 - Günthner, Roman A1 - Hapfelmeier, Alexander A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Heemann, Uwe A1 - Schmaderer, Christoph ED - Guzik, Tomasz J. T1 - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning JF - Cardiovascular Research N2 - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations. KW - Machine learning KW - Retinal vessels KW - Microcirculation KW - Haemodialysis KW - Myocardial infarction and cardiac death Y1 - 2022 U6 - http://dx.doi.org/10.1093/cvr/cvab040 SN - 0008-6363 VL - 118 IS - 2 SP - 612 EP - 621 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Bogoyavlenskiy, A. P. A1 - Berezin, V. E. A1 - Ogneva, A. V. A1 - Tolmacheva, V. P. A1 - Digel, Ilya A1 - Khudyakova, S. S. T1 - Immunostimulating activity of a saponin-containing extract of Saponaria officinalis JF - Voprosy virusologii Y1 - 1999 SN - 0507-4088 VL - 44 IS - 5 SP - 229 EP - 232 ER - TY - JOUR A1 - Dachwald, Bernd A1 - McDonald, Malcolm A1 - McInnes, Colin R. A1 - Mengali, Giovanni T1 - Impact of Optical Degradation on Solar Sail Mission Performance JF - Journal of Spacecraft and Rockets. 44 (2007), H. 4 Y1 - 2007 SN - 0022-4650 N1 - 2. ISSN: 1533-6794 SP - 740 EP - 749 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Resmi, Halil A1 - Akhunlar, Hülya A1 - Güner, Gül T1 - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül JF - Cell biochemistry and function. 23 (2005), H. 3 Y1 - 2005 SN - 0263-6484 SP - 163 EP - 168 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Baskurt, O. K. A1 - Edremitlioglu, M. T1 - In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A. JF - Clinical Hemorheology. 14 (1994), H. 4 Y1 - 1994 SP - 591 EP - 596 ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - http://dx.doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Increased shoulder muscle stretch reflex elicitability in supine subject posture JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate. Y1 - 2020 U6 - http://dx.doi.org/10.3233/IES-192219 SN - 1878-5913 VL - 28 IS - 2 SP - 139 EP - 146 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Nguyen, Nhu Huynh A1 - Duong, Minh Tuan A1 - Tran, Thanh Ngoc A1 - Pham, Phu Tinh A1 - Grottke, O. A1 - Tolba, R. A1 - Staat, Manfred T1 - Influence of a freeze–thaw cycle on the stress–stretch curves of tissues of porcine abdominal organs JF - Journal of Biomechanics N2 - The paper investigates both fresh porcine spleen and liver and the possible decomposition of these organs under a freeze–thaw cycle. The effect of tissue preservation condition is an important factor which should be taken into account for protracted biomechanical tests. In this work, tension tests were conducted for a large number of tissue specimens from twenty pigs divided into two groups of 10. Concretely, the first group was tested in fresh state; the other one was tested after a freeze-thaw cycle which simulates the conservation conditions before biomechanical experiments. A modified Fung model for isotropic behavior was adopted for the curve fitting of each kind of tissues. Experimental results show strong effects of the realistic freeze–thaw cycle on the capsule of elastin-rich spleen but negligible effects on the liver which virtually contains no elastin. This different behavior could be explained by the autolysis of elastin by elastolytic enzymes during the warmer period after thawing. Realistic biomechanical properties of elastin-rich organs can only be expected if really fresh tissue is tested. The observations are supported by tests of intestines. KW - Autolysis KW - Decomposition KW - Freeze–thaw process KW - Spleen KW - Liver Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jbiomech.2012.07.008 SN - 1873-2380 VL - 45 IS - 14 SP - 2382 EP - 2386 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Artmann, Gerhard A1 - Schmid-Schönbein, H. A1 - Schröder, Susanne A1 - Grebe, R. [u.a.] T1 - Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Schönbein, H.; Schröder, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P. JF - Arzneimittelforschung. 38 (1988), H. 5 Y1 - 1988 SN - 0004-4172 SP - 710 EP - 716 ER -