TY - JOUR A1 - Digel, Ilya T1 - Controlling microbial adhesion : a surface engineering approach JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 601 EP - 625 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716–722] JF - Journals of Biomechanics Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.jbiomech.2018.02.001 SN - 0021-9290 N1 - refers to Journal of Biomechanics Vol 47, Issue 3, Pages 716-722: https://doi.org/10.1016/j.jbiomech.2013.11.021 SP - 313 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Alnemer, Momin Sami Mohammad A1 - Kotliar, Konstantin A1 - Neuhaus, Valentin A1 - Pape, Hans-Christoph A1 - Ciritsis, Bernhard D. T1 - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model JF - Cost Effectiveness and Resource Allocation N2 - Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks. KW - Hip fractures KW - Prevention KW - Geriatric KW - Cost-effectiveness KW - Prophylaxis Y1 - 2023 U6 - http://dx.doi.org/10.1186/s12962-023-00482-4 SN - 1478-7547 N1 - Corresponding author: Momin S. Alnemer IS - 21, Article number: 77 PB - Springer Nature ER - TY - JOUR A1 - Heieis, Jule A1 - Böcker, Jonas A1 - D'Angelo, Olfa A1 - Mittag, Uwe A1 - Albracht, Kirsten A1 - Schönau, Eckhard A1 - Meyer, Andreas A1 - Voigtmann, Thomas A1 - Rittweger, Jörn T1 - Curvature of gastrocnemius muscle fascicles as function of muscle–tendon complex length and contraction in humans JF - Physiological Reports N2 - It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle–tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle–tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle–tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5%, 25%, 50%, and 75% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle–tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m−1 from 0% to 100%; p = 0.006). Muscle–tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m−1 per 10°; p < 0.001), inverse mean fascicle length (20 m−1 per cm−1; p = 0.003), and mean fascicle strain (−0.07 m−1 per +10%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure. KW - biomechanics KW - connective tissue KW - physiology KW - ultrasound Y1 - 2023 U6 - http://dx.doi.org/10.14814/phy2.15739 SN - 2051-817X VL - 11 IS - 11 SP - e15739, Seite 1-11 PB - Wiley ER - TY - JOUR A1 - Staat, Manfred T1 - Cyclic plastic deformation tests to verify FEM-based shakedown analyses N2 - Fatigue analyses are conducted with the aim of verifying that thermal ratcheting is limited. To this end it is important to make a clear distintion between the shakedown range and the ratcheting range (continuing deformation). As part of an EU-supported research project, experiments were carried out using a 4-bar model. The experiment comprised a water-cooled internal tube, and three insulated heatable outer test bars. The system was subjected to alternating axial forces, superimposed with alternating temperatures at the outer bars. The test parameters were partly selected on the basis of previous shakedown analyses. During the test, temperatures and strains were measured as a function of time. The loads and the resulting stresses were confirmed on an ongoing basis during performance of the test, and after it. Different material models were applied for this incremental elasto-plastic analysis using the ANSYS program. The results of the simulation are used to verify the FEM-based shakedown analysis. KW - Materialermüdung KW - Einspielen KW - Materialermüdung KW - shakedown analyses KW - thermal ratcheting KW - fatigue analyses Y1 - 2001 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Unruh, Tobias A1 - Büldt, Georg A1 - Zaccai, Guiseppe T1 - Cytoplasmic water and hydration layer dynamics in human red blood cells JF - Journal of the American Chemical Society. 50 (2008), H. 130 Y1 - 2008 SN - 1520-5126 SP - 16852 EP - 16853 ER - TY - JOUR A1 - Malik, A. M. A1 - Abdieva, G. Zh. A1 - Ualieva, P. S. A1 - Zhubanova, A. A. A1 - Temiz Artmann, Aysegül T1 - CКPИНИНГ МИКPOOPГAНИЗМOВ-ДECТPУКТOPOВ XЛOРOPГAНИЧECКИX ЗAГPЯЗНИТEЛEЙ T1 - Screening of microorganisms – destructors of chlororganic pollutants JF - Eurasian Journal of Ecology Y1 - 2019 SN - 2617-7358 VL - 61 IS - 4 SP - 61 EP - 71 ER - TY - JOUR A1 - Digel, Ilya A1 - Kurulgan Demirci, Eylem A1 - Linder, Peter A1 - Kayser, Peter T1 - Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts JF - Medical and Biological Engineering and Computing. 45 (2007), H. 1 Y1 - 2007 SN - 1741-0444 SP - 91 EP - 97 ER - TY - JOUR A1 - Malan, Leone A1 - Hamer, Mark A1 - Känel, Roland von A1 - Kotliar, Konstantin A1 - Wyk, Roelof D. van A1 - Lambert, Gavin W. A1 - Vilser, Walthard A1 - Ziemssen, Tjalf A1 - Schlaich, Markus P. A1 - Smith, Wayne A1 - Magnusson, Martin A1 - Wentzel, Annemarie A1 - Myburgh, Carlien E. A1 - Steyn, Hendrik S. A1 - Malan, Nico T. T1 - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study JF - Cardiovascular Journal of Africa Y1 - 2020 U6 - http://dx.doi.org/10.5830/CVJA-2020-031 SN - 1680-0745 VL - 26 IS - 31 SP - 1 EP - 12 PB - Clinics Cardive Publishing CY - Durbanville ER - TY - JOUR A1 - Digel, Ilya A1 - Kern, Inna A1 - Geenen, Eva-Maria A1 - Akimbekov, Nuraly T1 - Dental plaque removal by ultrasonic toothbrushes JF - dentistry journal N2 - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness. Y1 - 2020 U6 - http://dx.doi.org/10.3390/dj8010028 SN - 2304-6767 VL - 8 IS - 28 SP - 1 EP - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Defosse, Jerome A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Staat, Manfred A1 - Gatzweiler, Karl-Heinz A1 - Wappler, Frank A1 - Schieren, Mark T1 - Dental strain on maxillary incisors during tracheal intubation with double-lumen tubes and different laryngoscopy techniques - a blinded manikin study JF - Journal of Cardiothoracic and Vascular Anesthesia KW - anaesthetic complications KW - dental trauma KW - difficult airway KW - double-lumen tube intubation KW - videolaryngoscopy Y1 - 2022 U6 - http://dx.doi.org/10.1053/j.jvca.2022.02.017 SN - 1053-0770 VL - 36 IS - 8, Part B SP - 3021 EP - 3027 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Sponagel, Stefan T1 - Der Mensch als Läufer JF - Orthopädie und Sport : [Bericht zum Stolberger Orthopädietag, 13. Juni 1998] Y1 - 1999 SN - 978-3-89124-540-8 N1 - Inhaltsverzeichnis unter http://www.m-m-sports.com/mm_objects/previews/978-3-89124-540-8p.pdf SP - 15 EP - 21 PB - Meyer & Meyer CY - Aachen ER - TY - JOUR A1 - Staat, Manfred A1 - Schwartz, M. A1 - Lang, H. A1 - Wirtz, K. A1 - Heitzer, M. T1 - Design by Analysis of Pressure Components by non-linear Optimization JF - The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed] Y1 - 2003 SN - 3950152814 SP - 59 EP - 65 PB - ÖGS, Österreichische Gesellschaft für Schweißtechnik CY - Wien ER - TY - JOUR A1 - Zhubanova, А. A1 - Mansurov, Z.A. A1 - Digel, Ilya A1 - Saviskaya, I.S. A1 - Akimbekov, N.Sh. T1 - Designing of Heterogeneous Nanobiocomposites for Biotechnology JF - KazNU Bulletin. Biology series Y1 - 2013 SN - 1563-0218 VL - 59 IS - No 3/1 SP - 89 EP - 93 ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Biselli, Manfred A1 - Artmann, Gerhard T1 - Determination of the elastic shear modulus of cultured human red blood cells JF - Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1 Y1 - 2002 SN - 0013-5585 N1 - Druckausgabe unter 63 Z 471 vorhanden SP - 106 EP - 109 ER - TY - JOUR A1 - Hasan, Istabrak A1 - Keil, Ludger A1 - Staat, Manfred A1 - Wahl, Gerhard A1 - Bourauel, Christoph T1 - Determination of the frictional coefficient of the implant-antler interface : experimental approach JF - Biomedical Engineering / Biomedizinische Technik N2 - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens. Y1 - 2012 SN - 1862-278X VL - 57 IS - 5 SP - 359 EP - 363 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Krämer, Stefan A1 - Daab, Dominique Jonas A1 - Müller, Brigitte A1 - Wagner, Tobias A1 - Baader, Fabian A1 - Hessel, Joana A1 - Gdalewitsch, Georg A1 - Plescher, Engelbert A1 - Dachwald, Bernd A1 - Wahle, Michael A1 - Gierse, Andreas A1 - Vetter, Rudolf A1 - Pfützenreuter, Lysan T1 - Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets JF - 21st ESA Symposium on Rocket and Balloon Research Y1 - 2013 SP - 1 EP - 8 ER - TY - JOUR A1 - Seifarth, Volker A1 - Goßmann, Matthias A1 - Grosse, J. O. A1 - Becker, C. A1 - Heschel, I. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds JF - Urologia Internationalis Y1 - 2015 U6 - http://dx.doi.org/10.1159/000368419 SN - 0042-1138 VL - 2015 IS - 95 SP - 106 EP - 113 PB - Karger CY - Basel ER - TY - JOUR A1 - Artmann, Gerhard A1 - Montanus, M. A1 - Teitel, P. T1 - Die photometrische Kapillaraggregation- ein neues Verfahren zur Messung der Erythrozytenaggregation. Montanus, M.; Artmann, Gerhard Michael; Teitel, P. JF - Biomedizinische Technik = Biomedical engineering. 36 (1991) Y1 - 1991 SN - 0013-5585 SP - 213 EP - 215 ER -