TY - CHAP A1 - Bayer, Robin A1 - Hescheler, Jürgen A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül ED - Staat, Manfred ED - Erni, Daniel T1 - Treating arterial hypertension in a cell culture well T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW N2 - Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 5 EP - 6 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kurulgan demirci, Eylem A1 - Fırat, Ipek Seda A1 - Oflaz, Hakan A1 - Artmann, Gerhard T1 - Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers JF - SHOCK KW - Septic cardiomyopathy KW - LPS KW - cardiomyocyte biomechanics KW - CellDrum KW - actin cytoskeleton Y1 - 2021 U6 - http://dx.doi.org/10.1097/SHK.0000000000001845 SN - 1540-0514 PB - Wolters Kluwer CY - Köln ER - TY - JOUR A1 - Uysal, Karya A1 - Creutz, Till A1 - Firat, Ipek Seda A1 - Artmann, Gerhard A1 - Teusch, Nicole A1 - Temiz Artmann, Aysegül T1 - Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments JF - Polymers N2 - Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3–4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications. Y1 - 2022 SN - 2073-4360 VL - 14 IS - 11 SP - 2213 PB - MDPI CY - Basel ER - TY - JOUR A1 - Uysal, Karya A1 - Firat, Ipek Serat A1 - Creutz, Till A1 - Aydin, Inci Cansu A1 - Artmann, Gerhard A1 - Teusch, Nicole A1 - Temiz Artmann, Aysegül T1 - A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes JF - membranes N2 - Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here. Y1 - 2022 U6 - http://dx.doi.org/10.3390/membranes13010022 N1 - This article belongs to the Special Issue "Latest Scientific Discoveries in Polymer Membranes" VL - 2023 IS - 13(1) PB - MDPI CY - Basel ER - TY - JOUR A1 - Staat, Manfred A1 - Baroud, G. A1 - Topcu, M. A1 - Sponagel, Stefan T1 - Soft Materials in Technology and Biology – Characteristics, Properties, and Parameter Identification JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 253 EP - 315 PB - Springer CY - Berlin ER - TY - JOUR A1 - Staat, Manfred A1 - Sponagel, Stefan A1 - Nguyen, Nhu Huynh T1 - Experiment and material model for soft tissue materials JF - Constitutive models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ... Y1 - 2010 SN - 978-0-415-56327-7 SP - 465 EP - 470 PB - CRC Press CY - Boca Raton [u.a.] ER - TY - JOUR A1 - Kühn, Raoul-Roman A1 - Haugner, Werner A1 - Staat, Manfred A1 - Sponagel, Stefan T1 - A Two Phase Mixture Model based on Bone Observation N2 - An optimization method is developed to describe the mechanical behaviour of the human cancellous bone. The method is based on a mixture theory. A careful observation of the behaviour of the bone material leads to the hypothesis that the bone density is controlled by the principal stress trajectories (Wolff’s law). The basic idea of the developed method is the coupling of a scalar value via an eigenvalue problem to the principal stress trajectories. On the one hand this theory will permit a prediction of the reaction of the biological bone structure after the implantation of a prosthesis, on the other hand it may be useful in engineering optimization problems. An analytical example shows its efficiency. KW - Knochen KW - Knochenbildung KW - Knochenchirugie KW - Strukturanalyse KW - Schwammknochen KW - Knochendichte KW - Wolffsches Gesetz KW - bone structure KW - bone density KW - Wolff's Law KW - cancellous bone Y1 - 2004 ER - TY - JOUR A1 - Doorschodt, B. M. A1 - Schreinemachers, M. C. J. M. A1 - Behbahani, Mehdi A1 - Florquin, S. A1 - Weis, J. A1 - Staat, Manfred A1 - Tolba, R. H. T1 - Hypothermic machine perfusion of kidney grafts: which pressure is preferred JF - Annals of Biomedical Engineering. 39 (2011), H. 3 Y1 - 2011 SN - 1573-9686 SP - 1051 EP - 1059 PB - Springer CY - Berlin ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayatekin, Muammer B. A1 - Uysal, N. A1 - Resmi, H. T1 - Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats? Kayatekin, Muammer B.; Uysal N.; Resmi, H.; Bediz, Seref C.; Temiz Artmann, A.; Genç, S.; Tugyan, K. JF - International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4 Y1 - 2005 SN - 0300-9831 SP - 243 EP - 250 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Resmi, Halil A1 - Akhunlar, Hülya A1 - Güner, Gül T1 - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül JF - Cell biochemistry and function. 23 (2005), H. 3 Y1 - 2005 SN - 0263-6484 SP - 163 EP - 168 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Cavdar, C. A1 - Yenicerioglu, Y. A1 - Caliskan, S. T1 - The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in haemodialysis patients. Cavdar, C.; Temiz, A.; Yenicerioglu, Y.; Caliskan, S.; Celik, A.; Sifil, A.; Onvural, B.; Camsari, T. JF - Scandinavian Journal of Urology and Nephrology. 37 (2003), H. 1 Y1 - 2003 SN - 0036-5599 SP - 77 EP - 82 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Yalcin, Ozlem A1 - Resmi, Halil A1 - Baskurt, Oguz K. T1 - Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise? JF - Clinical Hemorheology and Microcirculation. 26 (2002), H. 3 Y1 - 2002 SN - 1386-0291 N1 - = The 11th European Symposium on Clinical Hemorheology, Rouen, France, 19-22 September 2000 SP - 189 EP - 193 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Akhisaroglu, M. A1 - Sercan, Z. A1 - Kayatekin, B. M. T1 - Adhesion of Erythrocytes to Endothelial Cells After Acute Exercise: Differences in Red Blood Cells from Juvenile and Adult Rats. Temiz Artmann, A.; Akhisaroglu, M.; Sercan, Z.; Kayatekin, BM.; Yorukoglu, K.; Kirkali, G. JF - Physiological Research (2005) Y1 - 2005 SN - 0862-8408 N1 - pre-press article ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayser, Peter T1 - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ; Kayser, Peter JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 497 EP - 508 PB - Springer CY - Berlin ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Saklamaz, Ali A1 - Comlekci, Abdurrahman A1 - Caliskan, Sezer T1 - The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia / Saklamaz, Ali ; Comlekci, Abdurrahman ; Temiz, Aysegu JF - Metabolism. 54 (2005), H. 5 Y1 - 2005 SN - 0026-0495 SP - 677 EP - 681 ER - TY - JOUR A1 - Erbayraktar, Zubeyde A1 - Yilmaz, Osman A1 - Temiz Artmann, Aysegül A1 - Cehreli, Ruksan A1 - Coker, Canan T1 - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus JF - Biological Trace Element Research Y1 - 2007 SN - 1559-0720 VL - 118 IS - 3 SP - 217 EP - 226 ER - TY - JOUR A1 - Cehreli, Ruksan A1 - Akpinar, Hale A1 - Temiz Artmann, Aysegül A1 - Sagol, Ozgul T1 - Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis JF - Gastroenterology Research Y1 - 2015 U6 - http://dx.doi.org/10.14740/gr683w SN - 1918-2813 VL - 8 IS - 5 SP - 265 EP - 273 ER - TY - JOUR A1 - Niedermeyer, Angela A1 - Zhou, Bei A1 - Dursun, Gözde A1 - Temiz Artmann, Aysegül A1 - Markert, Bernd T1 - An examination of tissue engineered scaffolds in a bioreactor JF - Proceedings in Applied Mathematics and Mechanics PAMM N2 - Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pamm.201610038 SN - 1617-7061 N1 - Joint Annual Meeting of DMV and GAMM 2016, 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung (DMV), Braunschweig, DE, Mar 7-11, 2016 VL - 16 IS - 1 SP - 99 EP - 100 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Dachwald, Bernd A1 - Mikucki, Jill A. A1 - Tulaczyk, Slawek A1 - Digel, Ilya A1 - Feldmann, Marco A1 - Espe, Clemens A1 - Plescher, Engelbert A1 - Xu, Changsheng T1 - IceMole - a maneuverable probe for clean in-situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems : extended abstract / SCAR Open Science Conference 2012, Session 29: Advancing Clean Technologies for Exploration of Glacial Aquatic Ecosystems N2 - The ”IceMole“ is a novel maneuverable subsurface ice probe for clean in-situ analysis and sampling of subsurface ice and subglacial water/brine. It is developed and build at FH Aachen University of Applied Sciences’ Astronautical Laboratory. A first prototype was successfully tested on the Swiss Morteratsch glacier in 2010. Clean sampling is achieved with a hollow ice screw (as it is used in mountaineering) at the tip of the probe. Maneuverability is achieved with a differentially heated melting head. Funded by the German Space Agency (DLR), a consortium led by FH Aachen currently develops a much more advanced IceMole probe, which includes a sophisticated system for obstacle avoidance, target detection, and navigation in the ice. We intend to use this probe for taking clean samples of subglacial brine at the Blood Falls (McMurdo Dry Valleys, East Antarctica) for chemical and microbiological analysis. In our conference contribution, we 1) describe the IceMole design, 2) report the results of the field tests of the first prototype on the Morteratsch glacier, 3) discuss the probe’s potential for the clean in-situ analysis and sampling of subsurface ice and subglacial liquids, and 4) outline the way ahead in the development of this technology. KW - Eisschicht KW - Sonde KW - subsurface ice KW - subglacial aquatic ecosystems Y1 - 2012 ER - TY - JOUR A1 - Konstantinidis, Konstantinos A1 - Flores Martinez, Claudio A1 - Dachwald, Bernd A1 - Ohndorf, Andreas A1 - Dykta, Paul A1 - Bowitz, Pascal A1 - Rudolph, Martin A1 - Digel, Ilya A1 - Kowalski, Julia A1 - Voigt, Konstantin A1 - Förstner, Roger T1 - A lander mission to probe subglacial water on Saturn's moon enceladus for life JF - Acta astronautica Y1 - 2015 SN - 1879-2030 (E-Journal); 0094-5765 (Print) VL - Vol. 106 SP - 63 EP - 89 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dachwald, Bernd A1 - Mikucki, Jill A1 - Tulaczyk, Slawek A1 - Digel, Ilya A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Kowalski, Julia A1 - Xu, Changsheng T1 - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems JF - Annals of Glaciology N2 - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample. KW - Antarctic Glaciology KW - Extraterrestrial Glaciology KW - Glaciological instruments and methods KW - Subclacial exploration KW - Subglacial lakes Y1 - 2014 U6 - http://dx.doi.org/10.3189/2014AoG65A004 SN - 1727-5644 VL - 55 IS - 65 SP - 14 EP - 22 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Zhubanova, Azhar A. A1 - Digel, Ilya A1 - Nojima, H. A1 - Artmann, Gerhard T1 - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology N2 - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. KW - Clusterion KW - Raumluft KW - Luftreiniger KW - Plasmacluster ion technology KW - Air purification Y1 - 2007 ER - TY - CHAP A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Effect of nitric oxide on protein thermal stability : [abstract] N2 - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not. KW - Stickstoffmonoxid KW - Proteine KW - Hämoglobin KW - nitric oxide gas KW - protein KW - hemoglobin Y1 - 2009 ER - TY - CHAP A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster] N2 - Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells KW - Erythrozyt KW - Hämoglobin KW - cytosolic water diffusion KW - hemoglobin dynamics Y1 - 2007 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya T1 - Hemoglobin Senses Body Temperature JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 415 EP - 447 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stadler, A. M. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Embs, Jan P. A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature JF - Biophysical Journal. 95 (2008), H. 11 Y1 - 2008 SN - 1542-0086 SP - 5449 EP - 5461 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Garvey, G. J. A1 - Bocahut, A. A1 - Sacquin-Mora, S. A1 - Digel, Ilya A1 - Schneider, G. J. A1 - Natali, F. A1 - Artmann, Gerhard A1 - Zaccai, G. T1 - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics JF - Journal of the Royal Society Interface N2 - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits. Y1 - 2012 U6 - http://dx.doi.org/10.1098/rsif.2012.0364 SN - 1742-5689 VL - 9 IS - 76 SP - 2845 EP - 2855 PB - The Royal Society CY - London ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Digel, Ilya A1 - Embs, Jan P. A1 - Unruh, Tobias A1 - Tehei, M. A1 - Zaccai, G. A1 - Büldt, G. A1 - Artmann, Gerhard T1 - From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature JF - Biophysical Journal. 96 (2009), H. 12 Y1 - 2009 SN - 0006-3495 SP - 5073 EP - 5081 PB - Cell Press CY - Cambridge, Mass. ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Unruh, Tobias A1 - Büldt, Georg A1 - Zaccai, Guiseppe T1 - Cytoplasmic water and hydration layer dynamics in human red blood cells JF - Journal of the American Chemical Society. 50 (2008), H. 130 Y1 - 2008 SN - 1520-5126 SP - 16852 EP - 16853 ER - TY - JOUR A1 - Digel, Ilya A1 - Kayser, Peter A1 - Artmann, Gerhard T1 - Molecular processes in biological thermosensation JF - Journal of Biophysics. 2008 (2008) Y1 - 2008 SN - 1687-8000 SP - 1 EP - 9 ER - TY - JOUR A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions JF - Regenerative medicine. 2 (2007), H. 5 Y1 - 2007 SN - 1746-0751 N1 - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany SP - 573 EP - 573 ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility JF - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1 Y1 - 2005 SP - 324 EP - 326 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in red blood cells JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 724 EP - 724 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Linder, Peter A1 - Porst, Dariusz T1 - Mechanism of haemoglobin sensing body temperature JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 754 EP - 754 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. T1 - Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA JF - Tissue Engineering. 13 (2007), H. 7 Y1 - 2007 SN - 1076-3279 N1 - TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007 SP - 1778 EP - 1778 ER - TY - JOUR A1 - Digel, Ilya A1 - Zhubanova, Azhar A. A1 - Nojima, H. A1 - Artmann, Gerhard T1 - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology JF - Biotechnologija : teorija i praktika (2004) Y1 - 2004 SN - 1028-9399 SP - 46 EP - 52 ER - TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - BOOK A1 - Staat, Manfred A1 - Digel, Ilya A1 - Trzewik, Jürgen A1 - Sielemann, Stefanie A1 - Erni, Daniel A1 - Zylka, Waldemar T1 - Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen Y1 - 2024 SN - 978-3-940402-65-3 U6 - http://dx.doi.org/10.17185/duepublico/81475 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Steffen, T. A1 - Wu, J. T1 - Parameter identification for cement infiltration of osteoporotic bone JF - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ... Y1 - 2002 SN - 90-5809-394-8 SP - 55 EP - 58 PB - Balkema CY - Lisse [u.a.] ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 189 EP - 196 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Baroud, G. A1 - Wu, J.Z. A1 - Bohner, M A1 - Sponagel, Stefan A1 - Steffen, T. T1 - How to determine the permeability for cement infiltration into osteoporotic cancellous bone JF - Medical Engineering & Physics. 25 (2003), H. 4 N2 - Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice. KW - Osteoporose KW - Permeabilität KW - Viskose Strömung KW - Viskosität KW - Vertebroplastie KW - Cement infiltration KW - Vertebroplasty KW - Osteoporosis KW - Permeability KW - Experiment KW - Analysis KW - Viscous flow Y1 - 2003 SN - 1350-4533 SP - 283 EP - 288 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Hormes, M. A1 - Steinseifer, U. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - A Review of Computational Fluid Dynamics Analysis of Blood Pumps JF - European Journal of Applied Mathematics. 20 (2009), H. 4 Y1 - 2009 SP - 363 EP - 397 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Finocchiaro, Thomas A1 - Heinke, Stefanie A1 - Leßmann, Marc T1 - Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma JF - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 Y1 - 2009 SN - 0013-5585 N1 - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 SP - 269 EP - 281 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Nicolai, Mike A1 - Probst, Markus T1 - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM JF - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.) Y1 - 2008 SN - 978-3-9810843-5-1 N1 - NIC series ; 39 SP - 325 EP - 332 PB - Forschungszentrum CY - Jülich ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Nicolai, M. A1 - Probst, M. A1 - Behr, M. T1 - Simulation of Blood Flow in a Ventricular Assist Device JF - inSIDE. 5 (2007), H. 1 Y1 - 2007 SP - 28 EP - 31 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M. JF - Artificial Organs. 30 (2006), H. 11 Y1 - 2006 SN - 1525-1594 N1 - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4 SP - A45 EP - A46 ER - TY - JOUR A1 - Steinseifer, Ulrich A1 - Kashefi, Ali A1 - Hormes, Marcus A1 - Schoberer, Mark A1 - Orlikowsky, Thorsten A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Schmitz-Rode, Thomas T1 - Miniaturization of ECMO Systems : Engineering Challenges and Methods JF - Artificial Organs. 33 (2009), H. 5 Y1 - 2009 SN - 1525-1594 N1 - Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts SP - A55 EP - A55 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Probst, M. A1 - Mai, A. A1 - Tran, L. A1 - Vonderstein, K. A1 - Keschenau, P. A1 - Linde, T. A1 - Steinseifer, U. A1 - Behr, M. A1 - Mottaghy, K. T1 - The influence of high shear on thrombosis and hemolysis in artificial organs JF - Artificial Organs Y1 - 2010 SN - 0391-3988 N1 - Special Issue: SI ; Meeting abstract VL - 33 IS - 7 SP - 426 EP - 426 ER - TY - JOUR A1 - Jansen, Sebastian A1 - Behbahani, Mehdi A1 - Laumen, Marco A1 - Kaufmann, Tim A1 - Hormes, Marcus A1 - Schmitz-Rode, Thomas A1 - Behr, Marek A1 - Steinseifer, Ulrich T1 - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques Y1 - 2010 N1 - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010 ER -