TY  - JOUR
A1  - Niedermeyer, Angela
A1  - Zhou, Bei
A1  - Dursun, Gözde
A1  - Temiz Artmann, Aysegül
A1  - Markert, Bernd
T1  - An examination of tissue engineered scaffolds in a bioreactor
JF  - Proceedings in Applied Mathematics and Mechanics PAMM
N2  - Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pamm.201610038
SN  - 1617-7061
N1  - Joint Annual Meeting of DMV and GAMM 2016, 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung (DMV), Braunschweig, DE, Mar 7-11, 2016
VL  - 16
IS  - 1
SP  - 99
EP  - 100
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Konstantinidis, Konstantinos
A1  - Flores Martinez, Claudio
A1  - Dachwald, Bernd
A1  - Ohndorf, Andreas
A1  - Dykta, Paul
A1  - Bowitz, Pascal
A1  - Rudolph, Martin
A1  - Digel, Ilya
A1  - Kowalski, Julia
A1  - Voigt, Konstantin
A1  - Förstner, Roger
T1  - A lander mission to probe subglacial water on Saturn's moon enceladus for life
JF  - Acta astronautica
Y1  - 2015
SN  - 1879-2030 (E-Journal); 0094-5765 (Print)
VL  - Vol. 106
SP  - 63
EP  - 89
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Mikucki, Jill
A1  - Tulaczyk, Slawek
A1  - Digel, Ilya
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Kowalski, Julia
A1  - Xu, Changsheng
T1  - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems
JF  - Annals of Glaciology
N2  - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.
KW  - Antarctic Glaciology
KW  - Extraterrestrial Glaciology
KW  - Glaciological instruments and methods
KW  - Subclacial exploration
KW  - Subglacial lakes
Y1  - 2014
U6  - http://dx.doi.org/10.3189/2014AoG65A004
SN  - 1727-5644
VL  - 55
IS  - 65
SP  - 14
EP  - 22
PB  - Cambridge University Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - http://dx.doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Digel, Ilya
A1  - Embs, Jan P.
A1  - Unruh, Tobias
A1  - Tehei, M.
A1  - Zaccai, G.
A1  - Büldt, G.
A1  - Artmann, Gerhard
T1  - From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature
JF  - Biophysical Journal. 96 (2009), H. 12
Y1  - 2009
SN  - 0006-3495
SP  - 5073
EP  - 5081
PB  - Cell Press
CY  - Cambridge, Mass.
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Unruh, Tobias
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
T1  - Cytoplasmic water and hydration layer dynamics in human red blood cells
JF  - Journal of the American Chemical Society. 50 (2008), H. 130
Y1  - 2008
SN  - 1520-5126
SP  - 16852
EP  - 16853
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kayser, Peter
A1  - Artmann, Gerhard
T1  - Molecular processes in biological thermosensation
JF  - Journal of Biophysics. 2008 (2008)
Y1  - 2008
SN  - 1687-8000
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Stadler, Andreas M.
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
A1  - Artmann, Gerhard
T1  - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 573
EP  - 573
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, Christina
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility
JF  - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1
Y1  - 2005
SP  - 324
EP  - 326
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
A1  - Artmann, Gerhard
T1  - Dynamics and interactions of hemoglobin in red blood cells
JF  - Tissue Engineering Part A. 14 (2008), H. 5
Y1  - 2008
SN  - 1937-3341
N1  - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal
SP  - 724
EP  - 724
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Porst, Dariusz
T1  - Mechanism of haemoglobin sensing body temperature
JF  - Tissue Engineering Part A. 14 (2008), H. 5
Y1  - 2008
SN  - 1937-3341
N1  - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal
SP  - 754
EP  - 754
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Stadler, Andreas M.
T1  - Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA
JF  - Tissue Engineering. 13 (2007), H. 7
Y1  - 2007
SN  - 1076-3279
N1  - TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007
SP  - 1778
EP  - 1778
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
JF  - Biotechnologija : teorija i praktika (2004)
Y1  - 2004
SN  - 1028-9399
SP  - 46
EP  - 52
ER  - 
TY  - CHAP
A1  - Schlemmer, Katharina
A1  - Porst, Dariusz
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
A1  - Digel, Ilya
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 100
EP  - 101
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - BOOK
A1  - Staat, Manfred
A1  - Digel, Ilya
A1  - Trzewik, Jürgen
A1  - Sielemann, Stefanie
A1  - Erni, Daniel
A1  - Zylka, Waldemar
T1  - Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen
Y1  - 2024
SN  - 978-3-940402-65-3
U6  - http://dx.doi.org/10.17185/duepublico/81475
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Akbay, U.
A1  - Becker, E.
A1  - Krozer, S.
T1  - Instability of slow viscometric flow
JF  - Mechanics Research Communications. 7 (1980), H. 4
Y1  - 1980
SN  - 0093-6413
SP  - 199
EP  - 204
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Adbay, U.
A1  - Becker, E.
A1  - Krozer, S.
T1  - A possible cause of viscoelastic turbulence
JF  - Rheology : proceedings of the 8th International Congress of Rheology, held in Naples, Italy, September 1 - 5, 1980 / Hrsg. von Giovanni Astarita, Vol. 2
Y1  - 1980
SN  - 0-306-40465-6
SP  - 79
EP  - 84
PB  - Plenum Pr.
CY  - New York
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Baroud, G.
A1  - Steffen, T.
A1  - Wu, J.
T1  - Parameter identification for cement infiltration of osteoporotic bone
JF  - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...
Y1  - 2002
SN  - 90-5809-394-8
SP  - 55
EP  - 58
PB  - Balkema
CY  - Lisse [u.a.]
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Akbay, U.
A1  - Becker, E.
T1  - Instability of plane Couette flow of viscoelastic liquids
JF  - Journal of non-Newtonian fluid mechanics. 18 (1985), H. 2
Y1  - 1985
SN  - 0377-0257
SP  - 123
EP  - 141
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Baroud, G.
A1  - Falk, R.
A1  - Crookshank, M.
T1  - Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen
JF  - Journal of Biomechanics. 37 (2004), H. 2
Y1  - 2004
SN  - 0021-9290
SP  - 189
EP  - 196
ER  - 
TY  - PAT
A1  - Sponagel, Stefan
A1  - Graf, Günter
A1  - Groß, Heinz
T1  - Method for manufacturing a sealing ring : United States Patent 4,861,536 ; date of patent: Aug. 12, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel
Y1  - 1989
N1  - Barcode: US004861536A ; Volltext über Datenbank: http://www.google.com/patents
PB  - [United States Patent and Trademark Office]
CY  - [Alexandria, VA]
ER  - 
TY  - PAT
A1  - Sponagel, Stefan
A1  - Graf, Günter
A1  - Groß, Heinz
T1  - Method for the manufacture of a sealing ring with a sealing lip having hydrodynamically acting return elements : United States Patent 4,850,097 ; date of patent: Jul. 25, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel
Y1  - 1989
N1  - Barcode: US004850097A ; Volltext über Datenbank: http://www.google.com/patents
PB  - [United States Patent and Trademark Office]
CY  - [Alexandria, VA]
ER  - 
TY  - PAT
A1  - Sponagel, Stefan
A1  - Wachowitz, Waldemar
T1  - Shaft seal : United States Patent 5,143,385 ; date of patent: Sep. 1, 1992 / assignee: Firma Carl Freudenberg
Y1  - 1992
N1  - Barcode: US005143385A ; Volltext über Datenbank: http://www.google.com/patents
PB  - [United States Patent and Trademark Office]
CY  - [Alexandria, VA]
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Baroud, G.
A1  - Falk, R.
A1  - Crookshank, M.
T1  - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T.
JF  - Journal of Biomechanics. 37 (2004), H. 2
Y1  - 2004
SN  - 0021-9290
SP  - 1802
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Kilthau, G.
A1  - Spies, K. H.
T1  - Sealing mechanism of lip seals
JF  - Eleventh 11th International Conference on Fluid Sealing : proceedings of the 11th Internat. Conference on Fluid Sealing, held at Cannes, France 8 - 10 April, 1987 / organised and sponsored by BHRA, the Fluid Engineering Centre. Ed. B. S. Nau
Y1  - 1987
SN  - 3-540-51383-3
N1  - International Conference on Fluid Sealing <11, 1987, Cannes>
SP  - 748
EP  - 772
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, M.
A1  - Hormes, M.
A1  - Steinseifer, U.
A1  - Arora, D.
A1  - Coronado, O.
A1  - Pasquali, M.
T1  - A Review of Computational Fluid Dynamics Analysis of Blood Pumps
JF  - European Journal of Applied Mathematics. 20 (2009), H. 4
Y1  - 2009
SP  - 363
EP  - 397
PB  - Cambridge Univ. Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Finocchiaro, Thomas
A1  - Heinke, Stefanie
A1  - Leßmann, Marc
T1  - Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma
JF  - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5
Y1  - 2009
SN  - 0013-5585
N1  - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471
SP  - 269
EP  - 281
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, Marek
A1  - Nicolai, Mike
A1  - Probst, Markus
T1  - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM
JF  - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.)
Y1  - 2008
SN  - 978-3-9810843-5-1
N1  - NIC series ; 39
SP  - 325
EP  - 332
PB  - Forschungszentrum
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Nicolai, M.
A1  - Probst, M.
A1  - Behr, M.
T1  - Simulation of Blood Flow in a Ventricular Assist Device
JF  - inSIDE. 5 (2007), H. 1
Y1  - 2007
SP  - 28
EP  - 31
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, M.
A1  - Arora, D.
A1  - Coronado, O.
A1  - Pasquali, M.
T1  - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.
JF  - Artificial Organs. 30 (2006), H. 11
Y1  - 2006
SN  - 1525-1594
N1  - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4
SP  - A45
EP  - A46
ER  - 
TY  - JOUR
A1  - Steinseifer, Ulrich
A1  - Kashefi, Ali
A1  - Hormes, Marcus
A1  - Schoberer, Mark
A1  - Orlikowsky, Thorsten
A1  - Behbahani, Mehdi
A1  - Behr, Marek
A1  - Schmitz-Rode, Thomas
T1  - Miniaturization of ECMO Systems : Engineering Challenges and Methods
JF  - Artificial Organs. 33 (2009), H. 5
Y1  - 2009
SN  - 1525-1594
N1  - Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts <May 28, 2009>
SP  - A55
EP  - A55
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Mai, A.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Keschenau, P.
A1  - Linde, T.
A1  - Steinseifer, U.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - The influence of high shear on thrombosis and hemolysis in artificial organs
JF  - Artificial Organs
Y1  - 2010
SN  - 0391-3988
N1  - Special Issue: SI ; Meeting abstract
VL  - 33
IS  - 7
SP  - 426
EP  - 426
ER  - 
TY  - JOUR
A1  - Jansen, Sebastian
A1  - Behbahani, Mehdi
A1  - Laumen, Marco
A1  - Kaufmann, Tim
A1  - Hormes, Marcus
A1  - Schmitz-Rode, Thomas
A1  - Behr, Marek
A1  - Steinseifer, Ulrich
T1  - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques
Y1  - 2010
N1  - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Simulation of Blood Damage
Y1  - 2010
N1  - Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Waluga, C.
A1  - Arlt, S.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Computational Analysis of Platelet Aggregation in a Taylor-Couette System
JF  - The International Journal of Artificial Organs. 31 (2008), H. 7
Y1  - 2008
SN  - 0391-3988
N1  - Posterpresentation ; European Society of Artificial Organs (ESAO), Geneva, Switzerland
SP  - 643
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Mai, A.
A1  - Waluga, C.
A1  - Bergmann, B.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions
JF  - Acta Physiologica
Y1  - 2010
SN  - 1748-1716
N1  - Joint Congress of the Scandinavian and German Physiological Societies, Copenhagen, Denmark, March 27-30, 2010
VL  - 198
IS  - Supplement 677
SP  - 185
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Tran, L.
A1  - Jockenhövel, S.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - Numerical prediction of thrombocyte reactions for application to a vascular flow model
JF  - British Journal of Surgery
Y1  - 2011
SN  - 1365-2168
N1  - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5
VL  - 98
IS  - S5
SP  - S17
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Tran, L.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices
JF  - The International Journal of Artificial Organs. 32 (2009), H. 7
Y1  - 2009
SN  - 0391-3988
N1  - Abstracts - Oral Presentations: XXXVI Annual ESAO Congress, 2-5 September 2009, Compiègne - France; European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009
SP  - 398
EP  - 398
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Nam, J.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Pasquali, M.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs
Y1  - 2010
U6  - http://dx.doi.org/10.1097/01.mat.0000369377.65122.a3
N1  - Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Jansen, S. V.
A1  - Behbahani, Mehdi
A1  - Laumen, M.
A1  - Kaufmann, T.
A1  - Hormes, M.
A1  - Behr, M.
A1  - Schmitz-Rode, T.
A1  - Steinseifer, U.
T1  - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Nam, J.
A1  - Arora, D.
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Benkowski, R.
A1  - Behr, M.
A1  - Pasquali, M.
T1  - New computational method in hemolysis analysis for artificial heart pump
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Mai, A.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Mottaghy, K.
T1  - Numerical Prediction of Blood Damage in Biomedical Devices
Y1  - 2010
N1  - Posterpresentation ; Biomedica Congress, Aachen, March 17-18, 2010
ER  - 
TY  - JOUR
A1  - Probst, M.
A1  - Behbahani, Mehdi
A1  - Borrmann, E.
A1  - Elgeti, S.
A1  - Nicolai, M.
A1  - Behr, M.
T1  - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices
Y1  - 2010
N1  - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Waluga, C.
A1  - Stock, S.
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Scheidt, H.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth
Y1  - 2009
N1  - Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009
ER  - 
TY  - JOUR
A1  - Jiminez German, Salvador
A1  - Behbahani, Mehdi
A1  - Miettinen, Susanna
A1  - Grijpma, Dirk W.
A1  - Haimi, Suvi P.
T1  - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes
JF  - Macromolecular symposia
Y1  - 2013
SN  - 0258-0322
VL  - Vol. 334
IS  - Iss. 1
SP  - 133
EP  - 142
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Pookhalil, Ali
A1  - Amoabediny, Ghassem
A1  - Tabesh, Hadi
A1  - Behbahani, Mehdi
A1  - Mottaghy, Khosrow
T1  - A new approach for semiempirical modeling of mechanical blood trauma
JF  - The international journal of artificial organs
N2  - Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
Y1  - 2016
U6  - http://dx.doi.org/10.5301/ijao.5000474
SN  - 1724-6040
VL  - 39
IS  - 4
SP  - 171
EP  - 177
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Tran, Linda
A1  - Mottaghy, K.
A1  - Arlt-Körfer, Sabine
A1  - Waluga, Christian
A1  - Behbahani, Mehdi
T1  - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
JF  - Biomedizinische Technik
Y1  - 2017
U6  - http://dx.doi.org/10.1515/bmt-2015-0034
SN  - 0013-5585
VL  - 62
IS  - 4
SP  - 383
EP  - 392
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Behbahani, Mehdi
T1  - An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress
T2  - Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014
Y1  - 2014
SP  - Paper 125
ER  - 
TY  - CHAP
A1  - Behbahani, Mehdi
A1  - Rible, Sebastian
A1  - Moulinec, Charles
A1  - Fournier, Yvan
A1  - Nicolai, Mike
A1  - Crosetto, Paolo
T1  - Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing
T2  - World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering
Y1  - 2015
VL  - 9
IS  - 5
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - http://dx.doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - THES
A1  - Behbahani, Mehdi
T1  - Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices
Y1  - 2011
SN  - 978-3-8439-0134-5
PB  - Verlag Dr. Hut
CY  - München
ER  - 
TY  - CHAP
A1  - Mandekar, Swati
A1  - Jentsch, Lina
A1  - Lutz, Kai
A1  - Behbahani, Mehdi
A1  - Melnykowycz, Mark
T1  - Earable design analysis for sleep EEG measurements
T2  - UbiComp '21
N2  - Conventional EEG devices cannot be used in everyday life and
hence, past decade research has been focused on Ear-EEG for mobile,
at-home monitoring for various applications ranging from
emotion detection to sleep monitoring. As the area available for
electrode contact in the ear is limited, the electrode size and location
play a vital role for an Ear-EEG system. In this investigation, we
present a quantitative study of ear-electrodes with two electrode
sizes at different locations in a wet and dry configuration. Electrode
impedance scales inversely with size and ranges from 450 kΩ to
1.29 MΩ for dry and from 22 kΩ to 42 kΩ for wet contact at 10 Hz.
For any size, the location in the ear canal with the lowest impedance
is ELE (Left Ear Superior), presumably due to increased contact
pressure caused by the outer-ear anatomy. The results can be used
to optimize signal pickup and SNR for specific applications. We
demonstrate this by recording sleep spindles during sleep onset
with high quality (5.27 μVrms).
KW  - EEG
KW  - sensors
KW  - Impedance Spectroscopy
KW  - Sleep EEG
KW  - biopotential electrodes
Y1  - 2021
U6  - http://dx.doi.org/10.1145/3460418.3479328
N1  - UbiComp '21: Adjunct Proceedings of the 2021 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2021 ACM International Symposium on Wearable Computers, September 21–26, 2021, Virtual, USA
SP  - 171
EP  - 175
ER  - 
TY  - JOUR
A1  - Malinowski, Daniel
A1  - Fournier, Yvan
A1  - Horbach, Andreas
A1  - Frick, Michael
A1  - Magliani, Mirko
A1  - Kalverkamp, Sebastian
A1  - Hildinger, Martin
A1  - Spillner, Jan
A1  - Behbahani, Mehdi
A1  - Hima, Flutura
T1  - Computational fluid dynamics analysis of endoluminal aortic perfusion
JF  - Perfusion
N2  - Introduction: In peripheral percutaneous (VA) extracorporeal membrane oxygenation (ECMO) procedures the femoral arteries perfusion route has inherent disadvantages regarding poor upper body perfusion due to watershed. With the advent of new long flexible cannulas an advancement of the tip up to the ascending aorta has become feasible. To investigate the impact of such long endoluminal cannulas on upper body perfusion, a Computational Fluid Dynamics (CFD) study was performed considering different support levels and three cannula positions.

Methods: An idealized literature-based- and a real patient proximal aortic geometry including an endoluminal cannula were constructed. The blood flow was considered continuous. Oxygen saturation was set to 80% for the blood coming from the heart and to 100% for the blood leaving the cannula. 50% and 90% venoarterial support levels from the total blood flow rate of 6 l/min were investigated for three different positions of the cannula in the aortic arch. 

Results: For both geometries, the placement of the cannula in the ascending aorta led to a superior oxygenation of all aortic blood vessels except for the left coronary artery. Cannula placements at the aortic arch and descending aorta could support supra-aortic arteries, but not the coronary arteries. All positions were able to support all branches with saturated blood at 90% flow volume.

Conclusions: In accordance with clinical observations CFD analysis reveals, that retrograde advancement of a long endoluminal cannula can considerably improve the oxygenation of the upper body and lead to oxygen saturation distributions similar to those of a central cannulation.
KW  - computational fluid dynamics analysis
KW  - simulation
KW  - endoluminal
KW  - aortic perfusion
KW  - extracorporeal membrane oxygenation
Y1  - 2022
U6  - http://dx.doi.org/10.1177/02676591221099809
SN  - 1477-111X
VL  - 0
IS  - 0
SP  - 1
EP  - 8
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Lenz, Maximilian
A1  - Kahmann, Stephanie Lucina
A1  - Behbahani, Mehdi
A1  - Pennig, Lenhard
A1  - Hackl, Michael
A1  - Leschinger, Tim
A1  - Müller, Lars Peter
A1  - Wegmann, Kilian
T1  - Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation
JF  - Archives of Orthopaedic and Trauma Surgery
N2  - Introduction
In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration.

Materials and methods
Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures.

Results
In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities.

Conclusion
A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education.
KW  - Proximal humerus fracture
KW  - Biomechanical simulation
KW  - Fracture configuration
KW  - Fracture simulation
KW  - Rotator cuff
Y1  - 2022
U6  - http://dx.doi.org/10.1007/s00402-022-04471-9
SN  - 1434-3916
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Chloé, Radermacher
A1  - Malyaran, Hanna
A1  - Craveiro, Rogerio Bastos
A1  - Peglow, Sarah
A1  - Behbahani, Mehdi
A1  - Pufe, Thomas
A1  - Wolf, Michael
A1  - Neuss, Sabine
T1  - Mechanical loading on cementoblasts: a mini review
JF  - Osteologie
N2  - Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments.
KW  - Cementoblast
KW  - Compression
KW  - Tension
KW  - Mechanotransduction
KW  - Forces
Y1  - 2022
U6  - http://dx.doi.org/10.1055/a-1826-0777
SN  - 1019-1291
VL  - 31
IS  - 2
SP  - 111
EP  - 118
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schunck, Laura
A1  - Gosau, Martin
A1  - Smeets, Ralf
A1  - Burg, Simon
A1  - Fuest, Sandra
A1  - Kröger, Nadja
A1  - Zinser, Max
A1  - Krohn, Sebastian
A1  - Behbahani, Mehdi
A1  - Köpf, Marius
A1  - Lauts, Lisa
A1  - Rutkowski, Rico
T1  - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes
JF  - International Journal of Molecular Sciences
N2  - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/ijms21186704
SN  - 1422-0067
N1  - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine
VL  - 21
IS  - 18 art. no. 6704
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Brockhaus, Moritz K.
A1  - Behbahani, Mehdi
A1  - Muris, Farina
A1  - Jansen, Sebastian V.
A1  - Schmitz- Rode, Thomas
A1  - Steinseifer, Ulrich
A1  - Clauser, Johanna C.
T1  - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept
JF  - Artificial Organs
N2  - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Y1  - 2021
U6  - http://dx.doi.org/10.1111/aor.14046
SN  - 1525-1594
VL  - 45
IS  - 12
SP  - 1513
EP  - 1521
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Mandekar, Swati
A1  - Holland, Abigail
A1  - Thielen, Moritz
A1  - Behbahani, Mehdi
A1  - Melnykowycz, Mark
T1  - Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG
JF  - Sensors
N2  - Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG.
KW  - in-ear EEG
KW  - correlation
KW  - forehead EEG
KW  - impedance spectroscopy
KW  - biopotential electrodes
Y1  - 2022
U6  - http://dx.doi.org/10.3390/s22041568
SN  - 1424-8220
VL  - 22
IS  - 4
SP  - 1
EP  - 19
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Schmitz, Annika
A1  - Apandi, Shah Eiman Amzar Shah
A1  - Spillner, Jan
A1  - Hima, Flutura
A1  - Behbahani, Mehdi
ED  - Digel, Ilya
ED  - Staat, Manfred
ED  - Trzewik, Jürgen
ED  - Sielemann, Stefanie
ED  - Erni, Daniel
ED  - Zylka, Waldemar
T1  - Effect of different cannula positions in the pulmonary artery on blood flow and gas exchange using computational fluid dynamics analysis
T2  - 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen
N2  - Pulmonary arterial cannulation is a common and effective method for percutaneous mechanical circulatory support for concurrent right heart and respiratory failure [1]. However, limited data exists to what effect the positioning of the cannula has on the oxygen perfusion throughout the pulmonary artery (PA). This study aims to evaluate, using computational fluid dynamics (CFD), the effect of different cannula positions in the PA with respect to the oxygenation of the different branching vessels in order for an optimal cannula position to be determined. The four chosen different positions (see Fig. 1) of the cannulas are, in the lower part of the main pulmonary artery (MPA), in the MPA at the junction between the right pulmonary artery (RPA) and the left pulmonary artery (LPA), in the RPA at the first branch of the RPA and in the LPA at the first branch of the LPA.
Y1  - 2024
SN  - 978-3-940402-65-3
U6  - http://dx.doi.org/10.17185/duepublico/81475
SP  - 29
EP  - 30
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Thiebes, Anja Lena
A1  - Klein, Sarah
A1  - Zingsheim, Jonas
A1  - Möller, Georg H.
A1  - Gürzing, Stefanie
A1  - Reddemann, Manuel A.
A1  - Behbahani, Mehdi
A1  - Cornelissen, Christian G.
T1  - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio
JF  - pharmaceutics
N2  - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing.
KW  - tri-lineage differentiation
KW  - survival
KW  - twin-fluid atomizer
KW  - adipose-derived stromal cells (ASCs)
KW  - cell atomization
KW  - cell aerosolization
Y1  - 2022
U6  - http://dx.doi.org/10.3390/pharmaceutics14112421
N1  - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells"
VL  - 14
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Belavy, Daniel L.
A1  - Albracht, Kirsten
A1  - Bruggemann, Gert-Peter
A1  - Vergroesen, Pieter-Paul A.
A1  - Dieen, Jaap H. van
T1  - Can exercise positively influence the intervertebral disc?
JF  - Sports Medicine
N2  - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.
KW  - Intradiscal Pressure
KW  - Annulus Fibrosus
KW  - Disc Degeneration
KW  - Nucleus Pulposus
KW  - Intervertebral Disc
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s40279-015-0444-2
SN  - 1179-2035
VL  - 46
IS  - 4
SP  - 473
EP  - 485
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Yang, Peng-Fei
A1  - Kriechbaumer, Andreas
A1  - Albracht, Kirsten
A1  - Sanno, Maximilian
A1  - Ganse, Bergita
A1  - Koy, Timmo
A1  - Shang, Peng
A1  - Brüggemann, Gert-Peter
A1  - Müller, Lars Peter
A1  - Rittweger, Jörn
T1  - On the relationship between tibia torsional deformation and regional muscle contractions in habitual human exercises in vivo
JF  - Journal of Biomechanics
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.jbiomech.2014.12.031
SN  - 0021-9290
VL  - 48
IS  - 3
SP  - 456
EP  - 464
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Seynnes, O. R.
A1  - Bojsen-Moller, J.
A1  - Albracht, Kirsten
A1  - Arndt, A.
A1  - Cronin, N. J.
A1  - Finni, T.
A1  - Magnusson, S. P.
T1  - Ultrasound-based testing of tendon mechanical properties: a critical evaluation
JF  - Journal of Applied Physiology
Y1  - 2015
U6  - http://dx.doi.org/10.1152/japplphysiol.00849.2014
SN  - 8750-7587
VL  - 118
IS  - 2
SP  - 133
EP  - 141
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans
JF  - European Journal of Applied Physiology
Y1  - 2013
U6  - http://dx.doi.org/10.1007/s00421-012-2585-4
SN  - 1439-6327
VL  - 113
IS  - 6
SP  - 1605
EP  - 1615
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Catala, Maria Moreno
A1  - Goldmann, Jan-Peter
A1  - Brüggemann, Gert-Peter
T1  - Lower leg musculoskeletal geometry and sprint performance
JF  - Gait and Posture
N2  - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009
SN  - 0966-6362
VL  - 34
IS  - 1
SP  - 138
EP  - 141
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Mademli, Lida
A1  - Albracht, Kirsten
T1  - Plasticity of the human tendon to short and long-term mechanical loading
JF  - Exercise and Sport Sciences Reviews
Y1  - 2009
U6  - http://dx.doi.org/10.1097/JES.0b013e31819c2e1d
SN  - 1538-3008
VL  - 37
IS  - 2
SP  - 66
EP  - 72
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, A.
A1  - Baltzopoulos, V.
T1  - Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo
JF  - Journal of Biomechanics
Y1  - 2008
U6  - http://dx.doi.org/10.1016/j.jbiomech.2008.04.020
SN  - 0021-9290
VL  - 41
SP  - 2211
EP  - 2218
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
T1  - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude
JF  - Journal of Experimental Biology
Y1  - 2007
U6  - http://dx.doi.org/10.1242/jeb.003814
SN  - 0022-0949
VL  - 210
IS  - 15
SP  - 2743
EP  - 2753
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy
JF  - Biological Cybernetics
Y1  - 2006
U6  - http://dx.doi.org/10.1007/s00422-006-0070-z
SN  - 1432-0770
VL  - 95
IS  - 1
SP  - 87
EP  - 96
ER  - 
TY  - CHAP
A1  - Goldmann, Jan-Peter
A1  - Braunstein, Bjoern
A1  - Heinrich, Kai
A1  - Sanno, Maximilian
A1  - Stäudle, Benjamin
A1  - Ritzdorf, Wolfgang
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Joint work of the take-off leg during elite high jump
T2  - Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS)
Y1  - 2015
ER  - 
TY  - CHAP
A1  - Droszez, Anna
A1  - Sanno, Maximilian
A1  - Goldmann, Jan-Peter
A1  - Albracht, Kirsten
A1  - Brüggemann, Gerd-Peter
A1  - Braunstein, Bjoern
T1  - Differences between take-off behavior during vertical jumps and two artistic elements
T2  - 34th International Conference of Biomechanics in Sport, Tsukuba, Japan, July 18-22, 2016
Y1  - 2016
SN  - 1999-4168
SP  - 577
EP  - 580
ER  - 
TY  - CHAP
A1  - Abel, Thomas
A1  - Bonin, Dominik
A1  - Albracht, Kirsten
A1  - Zeller, Sebastian
A1  - Brüggemann, Gert-Peter
A1  - Burkett, Brendan
A1  - Strüder, Heiko K.
T1  - Kinematic profile of the elite handcyclist
T2  - 28th  International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 – 23, 2010
Y1  - 2017
SN  - 1999-4168
SP  - 140
EP  - 141
ER  - 
TY  - CHAP
A1  - Braunstein, Bjoern
A1  - Goldmann, Jan-Peter
A1  - Albracht, Kirsten
A1  - Sanno, Maximilian
A1  - Willwacher, Steffen
A1  - Heinrich, Kai
A1  - Herrmann, Volker
A1  - Brüggemann, Gert-Peter
T1  - Joint specific contribution of mechanical power and work during acceleration and top speed in elite sprinters
T2  - 31 International Conference on Biomechanics in Sports, Taipei, Taiwan, July 07 - July 22, 2013
Y1  - 2013
SN  - 1999-4168
ER  - 
TY  - THES
A1  - Albracht, Kirsten
T1  - Influence of mechanical properties of the leg extensor muscletendon units on running economy
Y1  - 2010
N1  - Cologne, German Sport Univ., Diss., 2010
PB  - Deutsche Sporthochschule Köln
CY  - Köln
ER  - 
TY  - CHAP
A1  - Kolditz, Melanie
A1  - Albracht, Kirsten
A1  - Fasse, Alessandro
A1  - Albin, Thivaharan
A1  - Brüggemann, Gert-Peter
A1  - Abel, Dirk
T1  - Evaluation of an industrial robot as a leg press training device
T2  - XV International Symposium on Computer Simulation in Biomechanics July 9th – 11th 2015, Edinburgh, UK
Y1  - 2015
SP  - 41
EP  - 42
ER  - 
TY  - CHAP
A1  - Kolditz, Melanie
A1  - Albin, Thivaharan
A1  - Fasse, Alessandro
A1  - Brüggemann, Gert-Peter
A1  - Abel, Dirk
A1  - Albracht, Kirsten
T1  - Simulative Analysis of Joint Loading During Leg Press Exercise for Control Applications
T2  - IFAC-PapersOnLine
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.ifacol.2015.10.179
N1  - IFAC-PapersOnLine 48-20;
Conference Paper Archive
VL  - 48
IS  - 20
SP  - 435
EP  - 440
ER  - 
TY  - JOUR
A1  - Zange, Jochen
A1  - Schopen, Kathrin
A1  - Albracht, Kirsten
A1  - Gerlach, Darius A.
A1  - Frings-Meuthen, Petra
A1  - Maffiuletti, Nicola A.
A1  - Bloch, Wilhelm
A1  - Rittweger, Jörn
T1  - Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial
JF  - Plos one
Y1  - 2017
U6  - http://dx.doi.org/10.1371/journal.pone.0171562
VL  - 12
IS  - 2
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - http://dx.doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - JOUR
A1  - Rittweger, Jörn
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Longa, Emanuela
A1  - Moriggi, Manuela
A1  - Seynnes, Olivier
A1  - Di Giulio, Irene
A1  - Tenori, Leonardo
A1  - Vignoli, Alessia
A1  - Capri, Miriam
A1  - Gelfi, Cecilia
A1  - Luchinat, Claudio
A1  - Franceschi, Claudio
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Narici, Marco
T1  - Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight
JF  - npj Microgravity
Y1  - 2018
U6  - http://dx.doi.org/10.1038/s41526-018-0052-1
SN  - 2373-8065
VL  - 4
IS  - 1
SP  - 1
EP  - 9
PB  - Nature Portfolio
ER  - 
TY  - CHAP
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Stäudle, Benjamin
A1  - Attias, Julia
A1  - Suess, Alexander
A1  - Weber, T.
A1  - Rittweger, Joern
A1  - Green, David A.
A1  - Albracht, Kirsten
T1  - In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices
T2  - 23rd Annual Congress of the European College of Sport Science, Dublin, Irland
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.
Y1  - 2018
U6  - http://dx.doi.org/10.3233/IES-184111
SN  - 1878-5913
VL  - 26
IS  - 4
SP  - 265
EP  - 274
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - http://dx.doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Abel, Thomas
A1  - Albracht, Kirsten
A1  - Strüder, Heiko K.
T1  - Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants
JF  - Sports Biomechanics
Y1  - 2019
U6  - http://dx.doi.org/10.1080/14763141.2019.1593496
SN  - 1752-6116
IS  - Article in press
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Increased shoulder muscle stretch reflex elicitability in supine subject posture
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate.
Y1  - 2020
U6  - http://dx.doi.org/10.3233/IES-192219
SN  - 1878-5913
VL  - 28
IS  - 2
SP  - 139
EP  - 146
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men
JF  - Journal of Electromyography and Kinesiology
N2  - Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall “good” relative reliability. SRD 95% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended.
KW  - stretch reflex
KW  - shoulder
KW  - test-retest reliability
KW  - intraclass correlation coefficient
KW  - standard error of measurement
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.jelekin.2021.102611
SN  - 1050-6411
VL  - 62
IS  - Article 102611
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Liphardt, Anna-Maria
A1  - Fernandez-Gonzalo, Rodrigo
A1  - Albracht, Kirsten
A1  - Rittweger, Jörn
A1  - Vico, Laurence
T1  - Musculoskeletal research in human space flight – unmet needs for the success of crewed deep space exploration
JF  - npj Microgravity
N2  - Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper “Human Physiology – Musculoskeletal system”, this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.
Y1  - 2023
U6  - http://dx.doi.org/10.1038/s41526-023-00258-3
SN  - 2373-8065
VL  - 9
IS  - Article number: 9
SP  - 1
EP  - 9
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Schoenrock, Britt
A1  - Muckelt, Paul E.
A1  - Hastermann, Maria
A1  - Albracht, Kirsten
A1  - MacGregor, Robert
A1  - Martin, David
A1  - Gunga, Hans-Christian
A1  - Salanova, Michele
A1  - Stokes, Maria J.
A1  - Warner, Martin B.
A1  - Blottner, Dieter
T1  - Muscle stiffness indicating mission crew health in space
JF  - Scientific Reports
N2  - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.
KW  - Ageing
KW  - Anatomy
KW  - Muscle
KW  - Musculoskeletal system
KW  - Physiology
Y1  - 2024
U6  - http://dx.doi.org/10.1038/s41598-024-54759-6
SN  - 2045-2322
N1  - Corresponding author: Dieter Blottner
VL  - 14
IS  - Article number: 4196
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Meskemper, Joshua
A1  - Albracht, Kirsten
A1  - Abel, Thomas
A1  - Foitschik, Tina
A1  - Strüder, Heiko K.
T1  - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs
JF  - Journal of Electromyography and Kinesiology
N2  - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.jelekin.2020.102402
SN  - 1050-6411
VL  - 51
IS  - Article 102402
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Abel, Thomas
A1  - Albracht, Kirsten
A1  - Meskemper, Joshua
A1  - Foitschik, Tina
A1  - Strüder, Heiko K.
T1  - Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants
JF  - European Journal of Applied Physiology
N2  - Purpose
This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise.

Methods
Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography.

Results
During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors.

Conclusion
Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training.
Y1  - 2020
U6  - http://dx.doi.org/10.1007/s00421-020-04373-x
SN  - 1439-6327
IS  - 120
SP  - 1403
EP  - 1415
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - CHAP
A1  - Pohle-Fröhlich, Regina
A1  - Dalitz, Christoph
A1  - Richter, Charlotte
A1  - Hahnen, Tobias
A1  - Stäudle, Benjamin
A1  - Albracht, Kirsten
T1  - Estimation of muscle fascicle orientation in ultrasonic images
T2  - VISIGRAPP 2020 - Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications, 5
Y1  - 2020
SP  - 79
EP  - 86
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Distinct muscle-tendon interaction during running at different speeds and in different loading conditions
JF  - Journal of Applied Physiology
Y1  - 2019
U6  - http://dx.doi.org/10.1152/japplphysiol.00710.2018
SN  - 1522-1601
VL  - 127
IS  - 1
SP  - 246
EP  - 253
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Ritzmann, Ramona
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Albracht, Kirsten
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco
T1  - The Anticipation of Gravity in Human Ballistic Movement
JF  - Frontiers in Physiology
N2  - Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fphys.2021.614060
SN  - 1664-042X
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Morat, Mareike
A1  - Faude, Oliver
A1  - Hanssen, Henner
A1  - Ludyga, Sebastian
A1  - Zacher, Jonas
A1  - Eibl, Angi
A1  - Albracht, Kirsten
A1  - Donath, Lars
T1  - Agility Training to Integratively Promote Neuromuscular, Cognitive, Cardiovascular and Psychosocial Function in Healthy Older Adults: A Study Protocol of a One-Year Randomized-Controlled Trial
JF  - International Journal of Environmental Research and Public Health
N2  - Exercise training effectively mitigates aging-induced health and fitness impairments. Traditional training recommendations for the elderly focus separately on relevant physiological fitness domains, such as balance, flexibility, strength and endurance. Thus, a more holistic and functional training framework is needed. The proposed agility training concept integratively tackles spatial orientation, stop and go, balance and strength. The presented protocol aims at introducing a two-armed, one-year randomized controlled trial, evaluating the effects of this concept on neuromuscular, cardiovascular, cognitive and psychosocial health outcomes in healthy older adults. Eighty-five participants were enrolled in this ongoing trial. Seventy-nine participants completed baseline testing and were block-randomized to the agility training group or the inactive control group. All participants undergo pre- and post-testing with interim assessment after six months. The intervention group currently receives supervised, group-based agility training twice a week over one year, with progressively demanding perceptual, cognitive and physical exercises. Knee extension strength, reactive balance, dual task gait speed and the Agility Challenge for the Elderly (ACE) serve as primary endpoints and neuromuscular, cognitive, cardiovascular, and psychosocial meassures serve as surrogate secondary outcomes. Our protocol promotes a comprehensive exercise training concept for older adults, that might facilitate stakeholders in health and exercise to stimulate relevant health outcomes without relying on excessively time-consuming physical activity recommendations.
KW  - agility
KW  - prevention
KW  - healthy aging
KW  - community dwelling
KW  - psychosocial
Y1  - 2020
U6  - http://dx.doi.org/10.3390/ijerph17061853
SN  - 1660-4601
VL  - 17
IS  - 6
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Blottner, Dieter
A1  - Hastermann, Maria
A1  - Muckelt, Paul
A1  - Albracht, Kirsten
A1  - Schoenrock, Britt
A1  - Salanova, Michele
A1  - Warner, Martin
A1  - Gunga, Hans-Christian
A1  - Stokes, Maria
T1  - MYOTONES - Inflight muscle health status monitoring during long-duration space missions onboard the International Space Station: a single case study
T2  - IAC Papers Archive
N2  - The MYOTONES experiment is the first to monitor changes in the basic biomechanical properties (tone, elasticity and stiffness) of the resting human myofascial system due to microgravity with a oninvasive, portable device on board the ISS. The MyotonPRO device applies several brief mechanical stimuli to the surface of the skin, and the natural oscillation signals of the tissue beneath are detected and computed by the MyotonPRO. Thus, an objective, quick and easy determination of the state of the underlying tissue is possible.
Two preflight, four inflight and four post flight measurements were performed on a male astronaut using the same 10 measurement points (MP) for each session. MPs were located on the plantar fascia, Achilles tendon, M. soleus, M. gastrocnemius, M. multifidus, M. splenius capitis, M. deltoideus anterior, M. rectus femoris, infrapatellar tendon, M. tibialis anterior. Subcutaneous tissues thickness above the MPs was measured using ultrasound imaging. Magnetic resonance images (MRI) of lower limb muscles and functional tests were also performed pre- and postflight. 
Our first measurements on board the ISS confirmed increased tone and stiffness of the lumbar multifidus muscle, an important trunk stabilizer, dysfunction of which is known to be associated with back pain. Furthermore, reduced tone and stiffness of Achilles tendon and plantar fascia were observed inflight vs. preflight, confirming previous findings from terrestrial analog studies and parabolic 
flights. Unexpectedly, the deltoid showed negative inflight changes in tone and stiffness, and increased elasticity, suggesting a potential risk of muscle atrophy in longer spaceflight that should be addressed by adequate inflight countermeasure protocols. Most values from limb and back MPS showed deflected patterns (in either directions) from inflight shortly after the re-entry phase on the landing day and one week later. Most parameter values then normalized to baseline after 3 weeks likely due to 1G re-adaptation and possible outcome of the reconditioning protocol. No major changes in subcutaneous tissues thickness above the MPs were found inflight vs preflight, suggesting no bias (i.e., fluid shift, extreme tissue thickening or loss). Pre- and postflight MRI and functional tests showed negligible changes in calf muscle size, power and force, which is likely due to training effects from current inflight exercise protocols.
The MYOTONES experiment is currently ongoing to collect data from further crew members. The potential impact of this research is to better understand the effects of microgravity and countermeasures over the time course of an ISS mission cycle. This will enable exercise countermeasures to be tailored
Y1  - 2019
SN  - 00741795
N1  - International Astronautical Congress: space: the power of the past, the promise of the future - Washington DC, USA/Vereinigte Staaten von Amerika
Dauer: 21.10.2019 → 25.10.2019
PB  - Pergamon
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Paulsen, Gøran
A1  - Larsen, Askild V.
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
JF  - PeerJ
N2  - Background
During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus.
Methods 
Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics.
Results 
Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training.
Discussion 
These results show that a training-induced increase in Achilles tendon
stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.
KW  - Achilles tendon
KW  - Stiffness
KW  - Running
KW  - Tendon properties
KW  - Architectural gear ratio
Y1  - 2019
U6  - http://dx.doi.org/10.7717/peerj.6764
SN  - 21678359
PB  - Peer
CY  - London
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Göll, Fabian
A1  - Braunstein, Björn
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Comparison of different training algorithms for the leg extension training with an industrial robot
JF  - Current Directions in Biomedical Engineering
N2  - In the past, different training scenarios have been developed and implemented on robotic research platforms, but no systematic analysis and comparison have been done so far. This paper deals with the comparison of an isokinematic (motion with constant velocity) and an isotonic (motion against constant weight) training algorithm. Both algorithms are designed for a robotic research platform consisting of a 3D force plate and a high payload industrial robot, which allows leg extension training with arbitrary six-dimensional motion trajectories. In the isokinematic as well as the isotonic training algorithm, individual paths are defined i n C artesian s pace by sufficient s upport p oses. I n t he i sotonic t raining s cenario, the trajectory is adapted to the measured force as the robot should only move along the trajectory as long as the force applied by the user exceeds a minimum threshold. In the isotonic training scenario however, the robot’s acceleration is a function of the force applied by the user. To validate these findings, a simulative experiment with a simple linear trajectory is performed. For this purpose, the same force path is applied in both training scenarios. The results illustrate that the algorithms differ in the force dependent trajectory adaption.
KW  - Rehabilitation Technology and Prosthetics
KW  - Surgical Navigation and Robotics
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0005
SN  - 2364-5504
VL  - 4
IS  - 1
SP  - 17
EP  - 20
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J
A1  - Paulsen, Gøran
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R
T1  - Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing
JF  - Frontiers in physiology
N2  - During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.
KW  - achilles tendon
KW  - energy absorption
KW  - energy dissipation
KW  - mechanical buffer
KW  - stiffness
Y1  - 2018
U6  - http://dx.doi.org/10.3389/fphys.2018.00794
SN  - 1664-042X
IS  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Yang, Peng-Fei
A1  - Kriechbaumer, Andreas
A1  - Albracht, Kirsten
A1  - Sanno, Maximilian
A1  - Ganse, Bergita
A1  - Koy, Timmo
A1  - Shang, Peng
A1  - brüggemann, Gert-Peter
A1  - Müller, Lars Peter
A1  - Rittweger, Jörn
T1  - A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans
JF  - Journal of Orthopaedic Translation
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.jot.2014.07.078
SN  - 2214-0328
SN  - 2214-031X
VL  - 2
IS  - 4
SP  - 238
EP  - 238
PB  - Elsevier
CY  - Singapore
ER  -