TY - JOUR A1 - Niedermeyer, Angela A1 - Zhou, Bei A1 - Dursun, Gözde A1 - Temiz Artmann, Aysegül A1 - Markert, Bernd T1 - An examination of tissue engineered scaffolds in a bioreactor JF - Proceedings in Applied Mathematics and Mechanics PAMM N2 - Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pamm.201610038 SN - 1617-7061 N1 - Joint Annual Meeting of DMV and GAMM 2016, 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung (DMV), Braunschweig, DE, Mar 7-11, 2016 VL - 16 IS - 1 SP - 99 EP - 100 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Konstantinidis, Konstantinos A1 - Flores Martinez, Claudio A1 - Dachwald, Bernd A1 - Ohndorf, Andreas A1 - Dykta, Paul A1 - Bowitz, Pascal A1 - Rudolph, Martin A1 - Digel, Ilya A1 - Kowalski, Julia A1 - Voigt, Konstantin A1 - Förstner, Roger T1 - A lander mission to probe subglacial water on Saturn's moon enceladus for life JF - Acta astronautica Y1 - 2015 SN - 1879-2030 (E-Journal); 0094-5765 (Print) VL - Vol. 106 SP - 63 EP - 89 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dachwald, Bernd A1 - Mikucki, Jill A1 - Tulaczyk, Slawek A1 - Digel, Ilya A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Kowalski, Julia A1 - Xu, Changsheng T1 - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems JF - Annals of Glaciology N2 - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample. KW - Antarctic Glaciology KW - Extraterrestrial Glaciology KW - Glaciological instruments and methods KW - Subclacial exploration KW - Subglacial lakes Y1 - 2014 U6 - http://dx.doi.org/10.3189/2014AoG65A004 SN - 1727-5644 VL - 55 IS - 65 SP - 14 EP - 22 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya T1 - Hemoglobin Senses Body Temperature JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 415 EP - 447 PB - Springer CY - Berlin ER - TY - JOUR A1 - Stadler, A. M. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Embs, Jan P. A1 - Zaccai, Joe A1 - Büldt, Georg T1 - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature JF - Biophysical Journal. 95 (2008), H. 11 Y1 - 2008 SN - 1542-0086 SP - 5449 EP - 5461 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Garvey, G. J. A1 - Bocahut, A. A1 - Sacquin-Mora, S. A1 - Digel, Ilya A1 - Schneider, G. J. A1 - Natali, F. A1 - Artmann, Gerhard A1 - Zaccai, G. T1 - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics JF - Journal of the Royal Society Interface N2 - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits. Y1 - 2012 U6 - http://dx.doi.org/10.1098/rsif.2012.0364 SN - 1742-5689 VL - 9 IS - 76 SP - 2845 EP - 2855 PB - The Royal Society CY - London ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Digel, Ilya A1 - Embs, Jan P. A1 - Unruh, Tobias A1 - Tehei, M. A1 - Zaccai, G. A1 - Büldt, G. A1 - Artmann, Gerhard T1 - From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature JF - Biophysical Journal. 96 (2009), H. 12 Y1 - 2009 SN - 0006-3495 SP - 5073 EP - 5081 PB - Cell Press CY - Cambridge, Mass. ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Unruh, Tobias A1 - Büldt, Georg A1 - Zaccai, Guiseppe T1 - Cytoplasmic water and hydration layer dynamics in human red blood cells JF - Journal of the American Chemical Society. 50 (2008), H. 130 Y1 - 2008 SN - 1520-5126 SP - 16852 EP - 16853 ER - TY - JOUR A1 - Digel, Ilya A1 - Kayser, Peter A1 - Artmann, Gerhard T1 - Molecular processes in biological thermosensation JF - Journal of Biophysics. 2008 (2008) Y1 - 2008 SN - 1687-8000 SP - 1 EP - 9 ER - TY - JOUR A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions JF - Regenerative medicine. 2 (2007), H. 5 Y1 - 2007 SN - 1746-0751 N1 - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany SP - 573 EP - 573 ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility JF - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1 Y1 - 2005 SP - 324 EP - 326 ER - TY - JOUR A1 - Stadler, Andreas M. A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Büldt, Georg A1 - Zaccai, Guiseppe A1 - Artmann, Gerhard T1 - Dynamics and interactions of hemoglobin in red blood cells JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 724 EP - 724 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Linder, Peter A1 - Porst, Dariusz T1 - Mechanism of haemoglobin sensing body temperature JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 754 EP - 754 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zerlin, Kay A1 - Digel, Ilya A1 - Stadler, Andreas M. T1 - Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA JF - Tissue Engineering. 13 (2007), H. 7 Y1 - 2007 SN - 1076-3279 N1 - TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007 SP - 1778 EP - 1778 ER - TY - JOUR A1 - Digel, Ilya A1 - Zhubanova, Azhar A. A1 - Nojima, H. A1 - Artmann, Gerhard T1 - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology JF - Biotechnologija : teorija i praktika (2004) Y1 - 2004 SN - 1028-9399 SP - 46 EP - 52 ER - TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - BOOK A1 - Staat, Manfred A1 - Digel, Ilya A1 - Trzewik, Jürgen A1 - Sielemann, Stefanie A1 - Erni, Daniel A1 - Zylka, Waldemar T1 - Symposium Proceedings; 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen Y1 - 2024 SN - 978-3-940402-65-3 U6 - http://dx.doi.org/10.17185/duepublico/81475 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Sponagel, Stefan A1 - Akbay, U. A1 - Becker, E. A1 - Krozer, S. T1 - Instability of slow viscometric flow JF - Mechanics Research Communications. 7 (1980), H. 4 Y1 - 1980 SN - 0093-6413 SP - 199 EP - 204 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Adbay, U. A1 - Becker, E. A1 - Krozer, S. T1 - A possible cause of viscoelastic turbulence JF - Rheology : proceedings of the 8th International Congress of Rheology, held in Naples, Italy, September 1 - 5, 1980 / Hrsg. von Giovanni Astarita, Vol. 2 Y1 - 1980 SN - 0-306-40465-6 SP - 79 EP - 84 PB - Plenum Pr. CY - New York ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Steffen, T. A1 - Wu, J. T1 - Parameter identification for cement infiltration of osteoporotic bone JF - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ... Y1 - 2002 SN - 90-5809-394-8 SP - 55 EP - 58 PB - Balkema CY - Lisse [u.a.] ER - TY - JOUR A1 - Sponagel, Stefan A1 - Akbay, U. A1 - Becker, E. T1 - Instability of plane Couette flow of viscoelastic liquids JF - Journal of non-Newtonian fluid mechanics. 18 (1985), H. 2 Y1 - 1985 SN - 0377-0257 SP - 123 EP - 141 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 189 EP - 196 ER - TY - PAT A1 - Sponagel, Stefan A1 - Graf, Günter A1 - Groß, Heinz T1 - Method for manufacturing a sealing ring : United States Patent 4,861,536 ; date of patent: Aug. 12, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel Y1 - 1989 N1 - Barcode: US004861536A ; Volltext über Datenbank: http://www.google.com/patents PB - [United States Patent and Trademark Office] CY - [Alexandria, VA] ER - TY - PAT A1 - Sponagel, Stefan A1 - Graf, Günter A1 - Groß, Heinz T1 - Method for the manufacture of a sealing ring with a sealing lip having hydrodynamically acting return elements : United States Patent 4,850,097 ; date of patent: Jul. 25, 1989 / assignee: Firma Carl Freudenberg. Inventors: Gunter Graf ; Heinz Gross ; Stefan Sponagel Y1 - 1989 N1 - Barcode: US004850097A ; Volltext über Datenbank: http://www.google.com/patents PB - [United States Patent and Trademark Office] CY - [Alexandria, VA] ER - TY - PAT A1 - Sponagel, Stefan A1 - Wachowitz, Waldemar T1 - Shaft seal : United States Patent 5,143,385 ; date of patent: Sep. 1, 1992 / assignee: Firma Carl Freudenberg Y1 - 1992 N1 - Barcode: US005143385A ; Volltext über Datenbank: http://www.google.com/patents PB - [United States Patent and Trademark Office] CY - [Alexandria, VA] ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, G. A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Kilthau, G. A1 - Spies, K. H. T1 - Sealing mechanism of lip seals JF - Eleventh 11th International Conference on Fluid Sealing : proceedings of the 11th Internat. Conference on Fluid Sealing, held at Cannes, France 8 - 10 April, 1987 / organised and sponsored by BHRA, the Fluid Engineering Centre. Ed. B. S. Nau Y1 - 1987 SN - 3-540-51383-3 N1 - International Conference on Fluid Sealing <11, 1987, Cannes> SP - 748 EP - 772 PB - Elsevier CY - London ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Hormes, M. A1 - Steinseifer, U. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - A Review of Computational Fluid Dynamics Analysis of Blood Pumps JF - European Journal of Applied Mathematics. 20 (2009), H. 4 Y1 - 2009 SP - 363 EP - 397 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Finocchiaro, Thomas A1 - Heinke, Stefanie A1 - Leßmann, Marc T1 - Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma JF - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 Y1 - 2009 SN - 0013-5585 N1 - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 SP - 269 EP - 281 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Nicolai, Mike A1 - Probst, Markus T1 - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM JF - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.) Y1 - 2008 SN - 978-3-9810843-5-1 N1 - NIC series ; 39 SP - 325 EP - 332 PB - Forschungszentrum CY - Jülich ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Nicolai, M. A1 - Probst, M. A1 - Behr, M. T1 - Simulation of Blood Flow in a Ventricular Assist Device JF - inSIDE. 5 (2007), H. 1 Y1 - 2007 SP - 28 EP - 31 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M. JF - Artificial Organs. 30 (2006), H. 11 Y1 - 2006 SN - 1525-1594 N1 - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4 SP - A45 EP - A46 ER - TY - JOUR A1 - Steinseifer, Ulrich A1 - Kashefi, Ali A1 - Hormes, Marcus A1 - Schoberer, Mark A1 - Orlikowsky, Thorsten A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Schmitz-Rode, Thomas T1 - Miniaturization of ECMO Systems : Engineering Challenges and Methods JF - Artificial Organs. 33 (2009), H. 5 Y1 - 2009 SN - 1525-1594 N1 - Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts SP - A55 EP - A55 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Probst, M. A1 - Mai, A. A1 - Tran, L. A1 - Vonderstein, K. A1 - Keschenau, P. A1 - Linde, T. A1 - Steinseifer, U. A1 - Behr, M. A1 - Mottaghy, K. T1 - The influence of high shear on thrombosis and hemolysis in artificial organs JF - Artificial Organs Y1 - 2010 SN - 0391-3988 N1 - Special Issue: SI ; Meeting abstract VL - 33 IS - 7 SP - 426 EP - 426 ER - TY - JOUR A1 - Jansen, Sebastian A1 - Behbahani, Mehdi A1 - Laumen, Marco A1 - Kaufmann, Tim A1 - Hormes, Marcus A1 - Schmitz-Rode, Thomas A1 - Behr, Marek A1 - Steinseifer, Ulrich T1 - 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques Y1 - 2010 N1 - abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Mai, A. A1 - Bergmann, B. A1 - Waluga, C. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Mottaghy, K. T1 - Modeling and Numerical Simulation of Blood Damage Y1 - 2010 N1 - Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Waluga, C. A1 - Arlt, S. A1 - Behr, M. A1 - Mottaghy, K. T1 - Computational Analysis of Platelet Aggregation in a Taylor-Couette System JF - The International Journal of Artificial Organs. 31 (2008), H. 7 Y1 - 2008 SN - 0391-3988 N1 - Posterpresentation ; European Society of Artificial Organs (ESAO), Geneva, Switzerland SP - 643 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Mai, A. A1 - Waluga, C. A1 - Bergmann, B. A1 - Tran, L. A1 - Vonderstein, K. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions JF - Acta Physiologica Y1 - 2010 SN - 1748-1716 N1 - Joint Congress of the Scandinavian and German Physiological Societies, Copenhagen, Denmark, March 27-30, 2010 VL - 198 IS - Supplement 677 SP - 185 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Tran, L. A1 - Jockenhövel, S. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical prediction of thrombocyte reactions for application to a vascular flow model JF - British Journal of Surgery Y1 - 2011 SN - 1365-2168 N1 - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5 VL - 98 IS - S5 SP - S17 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Tran, L. A1 - Waluga, C. A1 - Behr, M. A1 - Oedekoven, B. A1 - Mottaghy, K. T1 - Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices JF - The International Journal of Artificial Organs. 32 (2009), H. 7 Y1 - 2009 SN - 0391-3988 N1 - Abstracts - Oral Presentations: XXXVI Annual ESAO Congress, 2-5 September 2009, Compiègne - France; European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009 SP - 398 EP - 398 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Nam, J. A1 - Waluga, C. A1 - Behr, M. A1 - Pasquali, M. A1 - Mottaghy, K. T1 - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs Y1 - 2010 U6 - http://dx.doi.org/10.1097/01.mat.0000369377.65122.a3 N1 - Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 ER - TY - JOUR A1 - Jansen, S. V. A1 - Behbahani, Mehdi A1 - Laumen, M. A1 - Kaufmann, T. A1 - Hormes, M. A1 - Behr, M. A1 - Schmitz-Rode, T. A1 - Steinseifer, U. T1 - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation Y1 - 2010 N1 - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 ER - TY - JOUR A1 - Nam, J. A1 - Arora, D. A1 - Behbahani, Mehdi A1 - Probst, M. A1 - Benkowski, R. A1 - Behr, M. A1 - Pasquali, M. T1 - New computational method in hemolysis analysis for artificial heart pump Y1 - 2010 N1 - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Probst, M. A1 - Mai, A. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Mottaghy, K. T1 - Numerical Prediction of Blood Damage in Biomedical Devices Y1 - 2010 N1 - Posterpresentation ; Biomedica Congress, Aachen, March 17-18, 2010 ER - TY - JOUR A1 - Probst, M. A1 - Behbahani, Mehdi A1 - Borrmann, E. A1 - Elgeti, S. A1 - Nicolai, M. A1 - Behr, M. T1 - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices Y1 - 2010 N1 - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Waluga, C. A1 - Stock, S. A1 - Mai, A. A1 - Bergmann, B. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Scheidt, H. A1 - Oedekoven, B. A1 - Mottaghy, K. T1 - Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth Y1 - 2009 N1 - Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009 ER - TY - JOUR A1 - Jiminez German, Salvador A1 - Behbahani, Mehdi A1 - Miettinen, Susanna A1 - Grijpma, Dirk W. A1 - Haimi, Suvi P. T1 - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes JF - Macromolecular symposia Y1 - 2013 SN - 0258-0322 VL - Vol. 334 IS - Iss. 1 SP - 133 EP - 142 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Pookhalil, Ali A1 - Amoabediny, Ghassem A1 - Tabesh, Hadi A1 - Behbahani, Mehdi A1 - Mottaghy, Khosrow T1 - A new approach for semiempirical modeling of mechanical blood trauma JF - The international journal of artificial organs N2 - Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis. Y1 - 2016 U6 - http://dx.doi.org/10.5301/ijao.5000474 SN - 1724-6040 VL - 39 IS - 4 SP - 171 EP - 177 PB - Sage CY - London ER - TY - JOUR A1 - Tran, Linda A1 - Mottaghy, K. A1 - Arlt-Körfer, Sabine A1 - Waluga, Christian A1 - Behbahani, Mehdi T1 - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system JF - Biomedizinische Technik Y1 - 2017 U6 - http://dx.doi.org/10.1515/bmt-2015-0034 SN - 0013-5585 VL - 62 IS - 4 SP - 383 EP - 392 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Behbahani, Mehdi T1 - An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress T2 - Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014 Y1 - 2014 SP - Paper 125 ER -