TY  - JOUR
A1  - Bayer, Robin
A1  - Temiz Artmann, Aysegül
A1  - Digel, Ilya
A1  - Falkenstein, Julia
A1  - Artmann, Gerhard
A1  - Creutz, Till
A1  - Hescheler, Jürgen
T1  - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
JF  - Cellular Physiology and Biochemistry
N2  - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
Y1  - 2020
U6  - https://doi.org/10.33594/000000225
SN  - 1421-9778
VL  - 54
SP  - 371
EP  - 383
PB  - Cell Physiol Biochem Press
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kern, Inna
A1  - Geenen, Eva-Maria
A1  - Akimbekov, Nuraly S.
T1  - Dental plaque removal by ultrasonic toothbrushes
JF  - dentistry journal
N2  - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.
Y1  - 2020
U6  - https://doi.org/10.3390/dj8010028
SN  - 2304-6767
VL  - 8
IS  - 28
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Zhanadilovna, Abdieva G.
A1  - Ualieva, Perizat S.
A1  - Abaihanovna, Zhusipova D.
A1  - Digel, Ilya
A1  - Savitskaya, Irina S.
A1  - Zhubanova, Azhar Achmet
T1  - Functionalization of Carbon Based Wound Dressings with Antimicrobial Phytoextracts for Bioactive Treatment of Septic Wounds
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-11
SP  - 211
EP  - 228
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Shokatayeva, Dina
A1  - Zhubanova, Azhar Achmet
T1  - Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-12
SP  - 229
EP  - 267
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Zhubanova, Azhar A.
A1  - Mansurov, Zulkhair A.
A1  - Digel, Ilya
T1  - Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-18
SP  - 353
EP  - 378
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Lutfor, Afzalunnessa B.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and the Host-Gut Microbiome: A Brief Overview
JF  - Acta Histochemica et Cytochemica
N2  - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.
Y1  - 2020
U6  - https://doi.org/10.1267/ahc.20011
SN  - 1347-5800
VL  - 53
IS  - 3
SP  - 33
EP  - 42
PB  - Japan Society of Histochemistry and Cytochemistry
CY  - Osaka
ER  - 
TY  - CHAP
A1  - Mansurov, Zulkhair A.
A1  - Jandosov, Jakpar
A1  - Chenchik, D.
A1  - Azat, Seitkhan
A1  - Savitskaya, Irina S.
A1  - Kistaubaeva, Aida
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Zhubanova, Azhar Achmet
T1  - Biocomposite Materials Based on Carbonized Rice Husk in Biomedicine and Environmental Applications
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - This chapter describes the prospects for biomedical and environmental engineering applications of heterogeneous materials based on nanostructured carbonized rice husk. Efforts in engineering enzymology are focused on the following directions: development and optimization of immobilization methods leading to novel biotechnological and biomedical applications; construction of biocomposite materials based on individual enzymes, multi-enzyme complexes and whole cells, targeted on realization of specific industrial processes. Molecular biological and biochemical studies on cell adhesion focus predominantly on identification, isolation and structural analysis of attachment-responsible biological molecules and their genetic determinants. The chapter provides a short overview of applications of the biocomposite materials based of nanostructured carbonized adsorbents. It emphasizes that further studies and better understanding of the interactions between CNS and microbial cells are necessary. The future use of living cells as biocatalysts, especially in the environmental field, needs more systematic investigations of the microbial adsorption phenomenon.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-2
SP  - 3
EP  - 32
PB  - Jenny Stanford Publishing Pte. Ltd.
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Pogorelova, Natalia
A1  - Rogachev, Evgeniy
A1  - Digel, Ilya
A1  - Chernigova, Svetlana
A1  - Nardin, Dmitry
T1  - Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties
JF  - Materials
N2  - Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150–160 nm in diameter and about 15 µm in length) constituted by 50–60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500–700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young’s modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure.
Y1  - 2020
SN  - 1996-1944
U6  - https://doi.org/10.3390/ma13122849
VL  - 13
IS  - 12
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Abel, Alexander
A1  - Kahmann, Stephanie Lucina
A1  - Mellon, Stephen
A1  - Staat, Manfred
A1  - Jung, Alexander
T1  - An open-source tool for the validation of finite element models using three-dimensional full-field measurements
JF  - Medical Engineering & Physics
N2  - Three-dimensional (3D) full-field measurements provide a comprehensive and accurate validation of finite element (FE) models. For the validation, the result of the model and measurements are compared based on two respective point-sets and this requires the point-sets to be registered in one coordinate system. Point-set registration is a non-convex optimization problem that has widely been solved by the ordinary iterative closest point algorithm. However, this approach necessitates a good initialization without which it easily returns a local optimum, i.e. an erroneous registration. The globally optimal iterative closest point (Go-ICP) algorithm has overcome this drawback and forms the basis for the presented open-source tool that can be used for the validation of FE models using 3D full-field measurements. The capability of the tool is demonstrated using an application example from the field of biomechanics. Methodological problems that arise in real-world data and the respective implemented solution approaches are discussed.
Y1  - 2020
U6  - https://doi.org/10.1016/j.medengphy.2019.10.015
SN  - 1350-4533
VL  - 77
SP  - 125
EP  - 129
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Qiao, Xiaohui
A1  - Digel, Ilya
A1  - Abdieva, Gulzhamal
A1  - Ualieva, Perizat
A1  - Zhubanova, Azhar
T1  - The effect of leonardite-derived amendments on soil microbiome structure and potato yield
JF  - Agriculture
N2  - Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9%) and tuber yield (66.4%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants.
Y1  - 2020
U6  - https://doi.org/10.3390/agriculture10050147
VL  - 10
IS  - Art. 147
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Gossmann, Matthias
A1  - Thomas, Ulrich
A1  - Horváth, András
A1  - Dragicevic, Elena
A1  - Stoelzle-Feix, Sonja
A1  - Jung, Alexander
A1  - Raman, Aravind Hariharan
A1  - Staat, Manfred
A1  - Linder, Peter
T1  - A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2020
U6  - https://doi.org/10.1016/j.vascn.2020.106843
VL  - 105
IS  - Article 106843
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
T1  - Direct plastic structural design under lognormally distributed strength by chance constrained programming
JF  - Optimization and Engineering
N2  - We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements.
Y1  - 2020
U6  - https://doi.org/10.1007/s11081-019-09437-2
SN  - 1573-2924
VL  - 21
IS  - 1
SP  - 131
EP  - 157
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Chand, Suditi
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Heiligers, Jeannette
A1  - Herčík, David
A1  - Hérique, Alain
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin
A1  - Meß, Jan-Gerd
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Tóth, Norbert
A1  - Vergaaij, Merel
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wiedemann, Carsten
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Flights are ten a sail – Re-use and commonality in the design and system engineering of small spacecraft solar sail missions with modular hardware for responsive and adaptive exploration
T2  - 70th International Astronautical Congress (IAC)
KW  - system engineering
KW  - small solar system body characterisation
KW  - small spacecraft solar sail
KW  - small spacecraft asteroid lander
KW  - responsive space
Y1  - 2019
SN  - 9781713814856
N1  - 70th International Astronautical Congress (IAC), Washington D.C., United States, 21-25 October 2019
SP  - 1
EP  - 7
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, D.
A1  - Herique, A.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Responsive integrated small spacecraft solar sail and payload design concepts and missions
T2  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)
N2  - Asteroid mining has the potential to greatly reduce the cost of in-space manufacturing, production of propellant for space transportation and consumables for crewed spacecraft, compared to launching the required resources from Earth’s deep gravity well. This paper discusses the top-level mission architecture and trajectory design for these resource-return missions, comparing high-thrust trajectories with continuous low-thrust solar-sail trajectories. This work focuses on maximizing the economic Net Present Value, which takes the time-cost of finance into account and therefore balances the returned resource mass and mission duration. The different propulsion methods will then be compared in terms of maximum economic return, sets of attainable target asteroids, and mission flexibility. This paper provides one more step towards making commercial asteroid mining an economically viable reality by integrating trajectory design, propulsion technology and economic modelling.
Y1  - 2019
N1  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)At: Aachen, Germany
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Wlademar
A1  - Borchers, Kai
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Koch, Aaron D.
A1  - Lange, Caroline
A1  - Maiwald, Volker
A1  - Meß, Jan-Gerd
A1  - Mikulz, Eugen
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Sasaki, Kaname
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Ceriotti, Matteo
A1  - McInnes, Colin
A1  - Peloni, Alessandro
A1  - Biele, Jens
A1  - Krause, Christian
A1  - Dachwald, Bernd
A1  - Hercik, David
A1  - Lichtenheldt, Roy
A1  - Wolff, Friederike
A1  - Koncz, Alexander
A1  - Pelivan, Ivanka
A1  - Schmitz, Nicole
A1  - Boden, Ralf
A1  - Riemann, Johannes
A1  - Seboldt, Wolfgang
A1  - Wejmo, Elisabet
A1  - Ziach, Christian
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Ruffer, Michael
A1  - Cordero, Federico
A1  - Tardivel, Simon
T1  - Solar sails for planetary defense & high-energy missions
T2  - IEEE Aerospace Conference Proceedings
N2  - 20 years after the successful ground deployment test of a (20 m) 2 solar sail at DLR Cologne, and in the light of the upcoming U.S. NEAscout mission, we provide an overview of the progress made since in our mission and hardware design studies as well as the hardware built in the course of our solar sail technology development. We outline the most likely and most efficient routes to develop solar sails for useful missions in science and applications, based on our developed `now-term' and near-term hardware as well as the many practical and managerial lessons learned from the DLR-ESTEC Gossamer Roadmap. Mission types directly applicable to planetary defense include single and Multiple NEA Rendezvous ((M)NR) for precursor, monitoring and follow-up scenarios as well as sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation. Other mission types such as the Displaced L1 (DL1) space weather advance warning and monitoring or Solar Polar Orbiter (SPO) types demonstrate the capability of near-term solar sails to achieve asteroid rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. Some of these mission types such as SPO, (M)NR and RKI include separable payloads. For one-way access to the asteroid surface, nanolanders like MASCOT are an ideal match for solar sails in micro-spacecraft format, i.e. in launch configurations compatible with ESPA and ASAP secondary payload platforms. Larger landers similar to the JAXA-DLR study of a Jupiter Trojan asteroid lander for the OKEANOS mission can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. The high impact velocities and re-try capability achieved by the RKI mission type on a final orbit identical to the target asteroid's but retrograde to its motion enables small spacecraft size impactors to carry sufficient kinetic energy for deflection.
Y1  - 2019
U6  - https://doi.org/10.1109/AERO.2019.8741900
N1  - AERO 2019; Big Sky; United States; 2 March 2019 through 9 March 2019
SP  - 1
EP  - 21
ER  - 
TY  - JOUR
A1  - Campen, R.
A1  - Kowalski, Julia
A1  - Lyons, W.B.
A1  - Tulaczyk, S.
A1  - Dachwald, Bernd
A1  - Pettit, E.
A1  - Welch, K. A.
A1  - Mikucki, J.A.
T1  - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert
JF  - Environmental Microbiology
Y1  - 2019
U6  - https://doi.org/10.1111/1462-2920.14607
SN  - 1462-2920
IS  - accepted article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schael, S.
A1  - Atanasyan, A.
A1  - Berdugo, J.
A1  - Bretz, T.
A1  - Czupalla, Markus
A1  - Dachwald, Bernd
A1  - Doetinchem, P. von
A1  - Duranti, M.
A1  - Gast, H.
A1  - Karpinski, W.
A1  - Kirn, T.
A1  - Lübelsmeyer, K.
A1  - Maña, C.
A1  - Marrocchesi, P.S.
A1  - Mertsch, P.
A1  - Moskalenko, I.V.
A1  - Schervan, T.
A1  - Schluse, M.
A1  - Schröder, K.-U.
A1  - Schultz von Dratzig, A.
A1  - Senatore, C.
A1  - Spies, L.
A1  - Wakely, S.P.
A1  - Wlochal, M.
A1  - Uglietti, D.
A1  - Zimmermann, J.
T1  - AMS-100: The next generation magnetic spectrometer in space – An international science platform for physics and astrophysics at Lagrange point 2
JF  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Y1  - 2019
U6  - https://doi.org/10.1016/j.nima.2019.162561
SN  - 0168-9002
VL  - 944
IS  - 162561
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
T1  - A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse
JF  - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization
Y1  - 2019
U6  - https://doi.org/10.1080/21681163.2019.1670095
SN  - 2168-1171
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Savitskaya, I.S.
A1  - Kistaubayeva, A.S.
A1  - Ignatova, L.V.
A1  - Digel, Ilya
T1  - Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
JF  - Heliyon
Y1  - 2019
U6  - https://doi.org/10.1016/j.heliyon.2019.e02592
SN  - 2405-8440
VL  - 5
IS  - 10
SP  - Artikelnummer e02592
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Meyer, Carolin
A1  - Gaalen, Kerstin van
A1  - Leschinger, Tim
A1  - Scheyerer, Max J.
A1  - Neiss, Wolfram F.
A1  - Staat, Manfred
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
JF  - BioMed Research International
Y1  - 2019
U6  - https://doi.org/10.1155/2019/9232813
SP  - Article ID 9232813
ER  -