TY  - JOUR
A1  - Scheer, Nico
A1  - Mclaughlin, Lesley A.
A1  - Rode, Anja
A1  - MacLeod, Alastair Kenneth
A1  - Henderson, Colin J.
A1  - Wolf, Roland C.
T1  - Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
JF  - Drug Metabolism and Disposition
N2  - In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15%) and larger livers (20%). Changes in hepatic morphology and a decreased blood glucose (30%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.
Y1  - 2014
U6  - https://doi.org/10.1124/dmd.114.057885
SN  - 1521-009X
VL  - 42
IS  - 6
SP  - 1022
EP  - 1030
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - CHAP
A1  - Eggert, Mathias
T1  - Big Data Research - How to Structure the Changes of the Past Decade?
T2  - The Art of Structuring
N2  - In the past decade, many IS researchers focused on researching the phenomenon of Big Data. At the same time, the relevance of data protection gets more attention than ever before. In particular, since the enactment of the European General Data Protection Regulation in May 2018 Information Systems research should provide answers for protecting personal data. The article at hand presents a structuring framework for Big Data research outcome and the consideration of data protection. IS Researchers might use the framework in order to structure Big Data literature and to identify research gaps that should be addressed in the future.
Y1  - 2019
SN  - 978-3-030-06234-7
U6  - https://doi.org/10.1007/978-3-030-06234-7_26
SP  - 271
EP  - 281
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Rübbelke, Dirk
A1  - Govorukha, Kristina
A1  - Grajewski, Matthias
T1  - Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany
JF  - Climatic Change
Y1  - 2019
U6  - https://doi.org/10.1007/s10584-019-02366-0
SN  - 0165-0009
SP  - 1
EP  - 16
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Campen, R.
A1  - Kowalski, Julia
A1  - Lyons, W.B.
A1  - Tulaczyk, S.
A1  - Dachwald, Bernd
A1  - Pettit, E.
A1  - Welch, K. A.
A1  - Mikucki, J.A.
T1  - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert
JF  - Environmental Microbiology
Y1  - 2019
U6  - https://doi.org/10.1111/1462-2920.14607
SN  - 1462-2920
IS  - accepted article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Lyons, W. Berry
A1  - Mikucki, Jill A.
A1  - German, Laura A.
A1  - Welch, Kathleen A.
A1  - Welch, Susan A.
A1  - Gardener, Christopher B.
A1  - Tulaczyk, Slawek M.
A1  - Pettit, Erin C.
A1  - Kowalski, Julia
A1  - Dachwald, Bernd
T1  - The Geochemistry of Englacial Brine from Taylor Glacier, Antarctica
JF  - Journal of Geophysical Research: Biogeosciences
Y1  - 2019
U6  - https://doi.org/10.1029/2018JG004411
SN  - 2169-8961
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - CHAP
A1  - Franzen, Julian
A1  - Stecken, Jannis
A1  - Pfaff, Raphael
A1  - Kuhlenkötter, Bernd
T1  - Using the Digital Shadow for a Prescriptive Optimization of Maintenance and Operation : The Locomotive in the Context of the Cyber-Physical System
T2  - Advances in Production, Logistics and Traffic
N2  - In competition with other modes of transport, rail freight transport is looking for solutions to become more attractive. Short-term success can be achieved through the data-driven optimization of operations and maintenance as well as the application of novel strategies such as prescriptive maintenance. After introducing the concept of prescriptive maintenance, this paper aims to prove that vehicle-focused applications of this approach indeed have the potential to increase attractiveness. However, even greater advantages can be activated if data from the horizontal network of the vehicle is available. Drawing on the state of the art in research and technology in the field of cyber-physical systems (CPS) as well as digital twins and shadows, our work serves to design a system of systems for the horizontal interconnection of a rail vehicle and to conceptualize a draft for a digital twin of a locomotive.
Y1  - 2019
SN  - 978-3-030-13535-5
U6  - https://doi.org/10.1007/978-3-030-13535-5_19
SP  - 265
EP  - 276
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Beckmann, Nils
A1  - Abanteriba, Sylvester
T1  - An overview on dry low NOx micromix combustor development for hydrogen-rich gas turbine applications
JF  - International Journal of Hydrogen Energy
Y1  - 2019
U6  - https://doi.org/10.1016/j.ijhydene.2019.01.161
SN  - 0360-3199
VL  - 44
IS  - 13
SP  - 6978
EP  - 6990
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Pilas, Johanna
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels
JF  - Sensor and Actuators B: Chemical
Y1  - 2019
U6  - https://doi.org/10.1016/j.snb.2019.02.086
SN  - 0925-4005
VL  - 288
SP  - 579
EP  - 585
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - https://doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Borchers, Kai
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Lange, Caroline
A1  - Maiwald, Volker
A1  - Mikulz, Eugen
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Sasaki, Kaname
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Toth, Norbert
A1  - Wejmo, Elisabet
A1  - Biele, Jens
A1  - Krause, Christian
A1  - Cerotti, Matteo
A1  - Peloni, Alessandro
A1  - Dachwald, Bernd
T1  - Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing
T2  - 2018 IEEE Aerospace Conference : 3-10 March 2018
Y1  - 2018
SN  - 978-1-5386-2014-4
ER  -