TY  - JOUR
A1  - Lempiäinen, Harri
A1  - Couttet, Philippe
A1  - Bolognani, Federico
A1  - Müller, Arne
A1  - Dubost, Valérie
A1  - Luisier, Raphaëlle
A1  - Rio-Espinola, Alberto del
A1  - Vitry, Veronique
A1  - Unterberger, Elif B.
A1  - Thomson, John P.
A1  - Treindl, Fridolin
A1  - Metzger, Ute
A1  - Wrzodek, Clemens
A1  - Hahne, Florian
A1  - Zollinger, Tulipan
A1  - Brasa, Sarah
A1  - Kalteis, Magdalena
A1  - Marcellin, Magali
A1  - Giudicelli, Fanny
A1  - Braeuning, Albert
A1  - Morawiec, Laurent
A1  - Zamurovic, Natasa
A1  - Längle, Ulrich
A1  - Scheer, Nico
A1  - Schübeler, Dirk
A1  - Goodman, Jay
A1  - Chibout, Salah-Dine
A1  - Marlowe, Jennifer
A1  - Theil, Dietlinde
A1  - Heard, David J.
A1  - Grenet, Olivier
A1  - Zell, Andreas
A1  - Templin, Markus F.
A1  - Meehan, Richard R.
A1  - Wolf, Roland C.
A1  - Elcombe, Clifford R.
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Rémi
A1  - Moggs, Jonathan G.
T1  - Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion
JF  - Toxicological Sciences
N2  - The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.
Y1  - 2012
U6  - http://dx.doi.org/10.1093/toxsci/kfs303
SN  - 1094-2025
VL  - 131
IS  - 2
SP  - 375
EP  - 386
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Leurs, Ulrike
A1  - Mezo, Gabor
A1  - Öhlschläger, Peter
A1  - Orban, Erika
A1  - Marquard, Andrea
A1  - Manea, Marilena
T1  - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety
JF  - Peptide Science
N2  - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/bip.21640
SN  - 1097-0282
VL  - 98
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Lind, Thorsten Patric
T1  - Zur Rechtsscheinhaftung bei Handeln einer Unternehmergesellschaft unter dem Rechtsformzusatz „GmbH“ : Urteil vom 12.06.2012 - II ZR 256/11 : Anmerkung
JF  - Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-Möhring
Y1  - 2012
SN  - 1611-1095
IS  - Ausg. 11
SP  - 339268
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Lind, Thorsten Patric
T1  - Rechtsprobleme bei der Liquidation der GmbH und der Gewinnausschüttung trotz bestehenden Anspruchs gegen den Gesellschafter : BGH, Urteil vom 23.04.2012 - II ZR 252/10 : Anmerkung
JF  - Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-Möhring
Y1  - 2012
SN  - 1611-1095
IS  - Ausg. 10
SP  - 338415
PB  - Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Lind, Thorsten Patric
T1  - Vollzug der Schenkung einer Unterbeteiligung : BGH, Urteil vom 29.11.2011 - II ZR 306/09 : Anmerkung
JF  - Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-Möhring
Y1  - 2012
SN  - 1611-1095
IS  - Ausg. 4
SP  - 330150
PB  - Beck
CY  - München
ER  - 
TY  - CHAP
A1  - Lind, Thorsten Patric
T1  - Wirkungen der Eröffnung des Insolvenzverfahrens : §§ 129, 132, 133, 144, 145
T2  - Bankenkommentar zum Insolvenzrecht. - 2. Aufl.
Y1  - 2012
SN  - 978-3-943170-03-0
SP  - 1145
EP  - 1585
PB  - Finanz Colloquium
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Lind, Thorsten Patric
T1  - Die Kostentragungspflicht bei der Aussonderung von Gegenständen, insbesondere bei Aufwendungen für den Ausbau einer Sache
JF  - Insbüro : Zeitschrift für Insolvenzsachbearbeitung und Entschuldungsverfahren
Y1  - 2012
SN  - 1863-0731
IS  - H. 3
SP  - 88
EP  - 89
PB  - Wolters Kluwer
CY  - Köln
ER  - 
TY  - CHAP
A1  - Lo Piparo, G. B.
A1  - Kern, Alexander
A1  - Mazzetti, C.
T1  - Some masterpoints about risk due to lightning
T2  - International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna
Y1  - 2012
SN  - 978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)
SP  - 1
EP  - 6
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Loeb, Horst Wolfgang
A1  - Schartner, Karl-Heinz
A1  - Dachwald, Bernd
A1  - Ohndorf, Andreas
A1  - Seboldt, Wolfgang
T1  - Interstellar heliopause probe
JF  - Труды МАИ
N2  - There is common agreement within the scientific community that in order to understand our local galactic environment it will be necessary to send a spacecraft into the region beyond the solar wind termination shock. Considering distances of 200 AU for a new mission, one needs a spacecraft traveling at a speed of close to 10 AU/yr in order to keep the mission duration in the range of less than 25 yrs, a transfer time postulated by European Space Agency (ESA). Two propulsion options for the mission have been proposed and discussed so far: the solar sail propulsion and the ballistic/radioisotope-electric propulsion (REP). As a further alternative, we here investigate a combination of solar-electric propulsion (SEP) and REP. The SEP stage consists of six 22-cms diameter RIT-22 ion thrusters working with a high specific impulse of 7377 s corresponding to a positive grid voltage of 5 kV. Solar power of 53 kW at begin of mission (BOM) is provided by a lightweight solar array.
Y1  - 2012
IS  - 60
SP  - 2
EP  - 2
PB  - Moskauer Staatliches Luftfahrtinstitut (МАИ)
CY  - Moskau
ER  - 
TY  - CHAP
A1  - Logen, Steffen
A1  - Höfken, Hans
A1  - Schuba, Marko
T1  - Simplifying RAM Forensics : A GUI and Extensions for the Volatility Framework
T2  - 2012 Seventh International Conference on Availability, Reliability and Security (ARES), 20-24 August 2012, Prague, Czech Republic
N2  - The Volatility Framework is a collection of tools for the analysis of computer RAM. The framework offers a multitude of analysis options and is used by many investigators worldwide. Volatility currently comes with a command line interface only, which might be a hinderer for some investigators to use the tool. In this paper we present a GUI and extensions for the Volatility Framework, which on the one hand simplify the usage of the tool and on the other hand offer additional functionality like storage of results in a database, shortcuts for long Volatility Framework command sequences, and entirely new commands based on correlation of data stored in the database.
Y1  - 2012
SN  - 978-1-4673-2244-7
U6  - http://dx.doi.org/10.1109/ARES.2012.12
SP  - 620
EP  - 624
PB  - IEEE
CY  - New York
ER  -