TY - JOUR A1 - Özsoylu, Dua A1 - Aliazizi, Fereshteh A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Template bacteria-free fabrication of surface imprinted polymer-based biosensor for E. coli detection using photolithographic mimics: Hacking bacterial adhesion JF - Biosensors and Bioelectronics N2 - As one class of molecular imprinted polymers (MIPs), surface imprinted polymer (SIP)-based biosensors show great potential in direct whole-bacteria detection. Micro-contact imprinting, that involves stamping the template bacteria immobilized on a substrate into a pre-polymerized polymer matrix, is the most straightforward and prominent method to obtain SIP-based biosensors. However, the major drawbacks of the method arise from the requirement for fresh template bacteria and often non-reproducible bacteria distribution on the stamp substrate. Herein, we developed a positive master stamp containing photolithographic mimics of the template bacteria (E. coli) enabling reproducible fabrication of biomimetic SIP-based biosensors without the need for the “real” bacteria cells. By using atomic force and scanning electron microscopy imaging techniques, respectively, the E. coli-capturing ability of the SIP samples was tested, and compared with non-imprinted polymer (NIP)-based samples and control SIP samples, in which the cavity geometry does not match with E. coli cells. It was revealed that the presence of the biomimetic E. coli imprints with a specifically designed geometry increases the sensor E. coli-capturing ability by an “imprinting factor” of about 3. These findings show the importance of geometry-guided physical recognition in bacterial detection using SIP-based biosensors. In addition, this imprinting strategy was employed to interdigitated electrodes and QCM (quartz crystal microbalance) chips. E. coli detection performance of the sensors was demonstrated with electrochemical impedance spectroscopy (EIS) and QCM measurements with dissipation monitoring technique (QCM-D). KW - Surface imprinted polymer KW - E. coli detection KW - Photolithographic mimics KW - Master stamp KW - Quartz crystal microbalance Y1 - 2024 U6 - https://doi.org/10.1016/j.bios.2024.116491 SN - 1873-4235 (eISSN) SN - 0956-5663 N1 - Corresponding author: Michael J. Schöning VL - 261 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Özmen, Emel T1 - ALIGN : ein adaptives Regalsystem N2 - „ALIGN“ ist ein smartes Möbelsystem, das den individuellen Lebensstil und die Werte der heutigen Gesellschaft widerspiegelt. Es bietet ausreichend Stauraum und ermöglicht es, Objekte gezielt in Szene zu setzen oder in den Hintergrund zu rücken. Das vielseitige System passt sich an unterschiedliche Raum- und Nutzungsszenarien an. Es ermöglicht die individuelle Gestaltung des Wohnraums nach persönlichen Vorlieben und hilft, den Herausforderungen des modernen Lebens gerecht zu werden. „ALIGN“ – eine passende Lösung für jedes Problem. KW - Regalsystem KW - Nachhaltigkeit KW - Minimalismus KW - Modular KW - Abwechslung Y1 - 2023 PB - FH Aachen CY - Aachen ER - TY - THES A1 - Zosgornik, Julia T1 - Temporärer, mobiler Lebensraum: ein Wohnkonzept für Tinyhouses aus alten, ungenutzten Bahnwaggons N2 - Das Olympiagelände in München wurde im Jahre 1972 durch die Münchener S-Bahn erreichbar. Nach der Nutzung während der Olympischen Spiele wurde die Strecke weiterhin von der Linie S3angefahren, aber schließlich 1988 stillgelegt und steht seither unter Denkmalschutz. Das umfassende Gelände ist bis heute gut ausgebaut und bietet viel Raum für Freizeitaktivitäten. Nun bietet sich dieser Standort für ein neues Wohnkonzept an. Aus alten, nicht mehr nutzbaren Bahnwaggons entstehen Tinyhouse-Module. Aus dem alten Olympiabahnhof der S3 wird ein neues Viertel für junge Leute, Studenten und alle anderen, die sich vorstellen können in einem Tinyhouse zu wohnen. KW - Wohnkonzept KW - Denkmalschutz KW - Bahnwaggons KW - Tinyhouse-Module Y1 - 2021 PB - FH Aachen CY - Aachen ER - TY - CHAP A1 - Zischank, Wolfgang J. A1 - Kern, Alexander A1 - Frentzel, Ralf A1 - Heidler, Fridolin A1 - Seevers, M. T1 - Assessment of the lightning transient coupling to control cables interconnecting structures in large industrial facilities and power plants N2 - Large industrial facilities and power plants often require a huge number fo information and control cables between the differnet structures. These I&C-cables can be routed in reinforced concrete cable ducts or in isolated buried cable runs. KTA 2206 is the German lightning protection standard for nuclear power plants. During the last several years considerable effort has been made to revise this standard. Despite the well established principles and design guidelines for the construction of the lightning protection system, this standard puts special emphasis on the coupling of transient overvoltages to I&C-cables. KW - Blitzschutz KW - Elektromagnetische Kopplung KW - Überspannung KW - Kraftwerke KW - Industrieanlagen KW - Lightning KW - current distribution KW - electromagnetic coupling KW - overvoltages Y1 - 2000 ER - TY - CHAP A1 - Zischank, Wolfgang J. A1 - Heidler, Fridolin A1 - Wiesinger, J. A1 - Stimper, K. A1 - Kern, Alexander A1 - Seevers, M. T1 - Magnetic Fields and Induced Voltages inside LPZ 1 Measured at a 1:6 Scale Model Building N2 - Laborexperimente zu Blitzschutzzonen in Stahlbetongebäuden anhand eines Modells im Maßstab 1:6 N2 - For the application of the concept of Lightning Protection Zones (LPZ), the knowledge of the magnetic fields and induced voltages inside a structure is necessary. Laboratory experiments have been conducted at a downscaled model of a building (scale factor 1:6) to determine these electromagnetic quantities in case of a direct strike to the structure. The model (3 m x 2 m x 2 m) represented a small industrial building using the reinforcement of the concrete as electromagnetic shield. The magnetic fields and magnetic field derivatives were measured at several location inside the scaled model. Further, the voltages induced on three typical cable routes inside the model was determined. The influence of the lightning current waveshape, point-of-strike, bonding of the cable routes, and bridging of an expansion joint in the middle of the building on these quantities was studied. KW - Blitzschlag KW - Elektromagnetischer Schutzschild KW - Stahlbeton KW - Maßstabsgetreues Modell KW - Lightning KW - electromagnetic shielding KW - reinforced concrete KW - scaled model Y1 - 2004 ER - TY - CHAP A1 - Zischank, Wolfgang J. A1 - Heidler, Fridolin A1 - Kern, Alexander A1 - Metwally, I. A. A1 - Wiesinger, J. A1 - Seevers, M. T1 - Laboratory simulation of direct lightning strokes to a modelled building - measurement of magnetic fields and induced voltages N2 - In IEC 61312-2 equations for the assessment of the magnetic fields inside structures due to a direct lightning strike are given. These equations are based on computer simulations for shields consisting of a single-layer steel grid of a given mesh width. Real constructions, however, contain at least two layers of reinforcement steel grids. The objective of this study was to experimentally determine the additional shielding effectiveness of a second reinforcement layer compared to a single-layer grid. To this end, simulated structures were set up in the high current laboratory. The structures consisted of cubic cages of 2 m side length with one or with two reinforcement grids, respectively. The structures were exposed to direct lightning currents representing the variety of anticipated lightning current waveforms. The magnetic fields and their derivatives at several positions inside the structure as well as the voltage between “floor” and “roof” in the center were determined for different current injection points. From these data the improvement of the shielding caused by a second reinforcement layer is derived. KW - Direkter Blitzschlag KW - Elektromagnetischer Schutzschild KW - Magnetische Felder KW - Induzierte Spannungen KW - Stahlbetonkonstruktion KW - Lightning KW - electromagnetic shielding KW - magnetic field KW - reinforced concrete KW - induced voltage Y1 - 2002 ER - TY - JOUR A1 - Zhubanova, Azhar A. A1 - Digel, Ilya A1 - Nojima, H. A1 - Artmann, Gerhard T1 - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology N2 - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. KW - Clusterion KW - Raumluft KW - Luftreiniger KW - Plasmacluster ion technology KW - Air purification Y1 - 2007 ER - TY - JOUR A1 - Zhubanova, Azhar A. A1 - Aknazarov, S. K. A1 - Mansurov, Zulkhair A1 - Digel, Ilya A1 - Kozhalakova, A. A. A1 - Akimbekov, Nuraly S. A1 - O'Heras, Carlos A1 - Tazhibayeva, S. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials N2 - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. KW - Kohlenstofffaser KW - Lipopolysaccharide KW - nanostrukturierte carbonisierte Pflanzenteile KW - lipopolysaccharides KW - nanostructured carbonized plant parts Y1 - 2010 ER - TY - THES A1 - Yilmaz, Dilara T1 - Deutsches Hygiene-Museum Dresden: Entwicklung und Konzeption eines neuen Erscheinungsbildes N2 - In Zeiten der COVID-19-Pandemie ist die Aufklärung der Bevölkerung, besonders in Hygiene- und Gesundheitsfragen, wichtiger denn je. Das Deutsche Hygiene-Museum macht sich genau das zur Aufgabe. Unter Einbeziehung des Museumsprofils „Das Museum vom Menschen“ und der Architektur zwischen Bauhaus und Neoklassizismus erhält das Museum ein neues Erscheinungsbild. Dabei wird der Sammlungsaspekt gezielt visualisiert, denn das Museum zeichnet sich durch einen umfangreichen Sammlungsbestand aus. Die heterogene Sammlungsbreite macht es europaweit zu einem Unikat. Da das Museum einen Teil des Gesundheitssystems darstellt, ist das überwiegend rot gehaltene Corporate Design und die Wort-Bild-Marke eine Anlehnung an das Deutsche Rote Kreuz. Das medienübergreifende Erscheinungsbild unterstreicht somit die Werte und Besonderheiten des Museums und hat zusätzlich den Auftrag, über Hygiene und Gesundheit aufzuklären. KW - Hygiene KW - Museum KW - Neoklassizismus KW - Gesundheit KW - Forschung Y1 - 2021 PB - FH Aachen CY - Aachen ER - TY - THES A1 - Wrutniak, Sophia Stefanie T1 - Monitoring-System für die Luftrettung: ergonomisches Designkonzept für den medizinischen Anwender N2 - Bei einem Luftrettungseinsatz hat die Herstellung der Transportfähigkeit des Patienten Priorität. Im Anschluss erfolgt das Monitoring während des Fluges. Das Problem dabei ist: Es gibt keine einheitliche Basis zur ergonomischen Nutzung und Datenverwertung der medizinischen Geräte. Kabel, Positionierung und individuelle Displays beeinträchtigen die Anwendenden. Dies kann im schlimmsten Fall die erfolgreiche Patientenbehandlung gefährden und die Übergabe des Patienten verzögern. Im Konzept wurden die Geräte drahtlos gestaltet. Mittels Knopfdruck am Gerät werden Daten an den Monitor übertragen. Schnell und sicher können EKG, Blutdruck, SPO2 und Temperatur gemessen und Stethoskop, Ultraschall und Videolaryngoskop verwendet werden. Ein Barcode-Scanner dokumentiert Medikamente und verbrauchte Materialien. Im Anschluss wird ein Zielkrankenhaus ausgewählt, die Ankunftszeit angezeigt und Daten protokolliert und übertragen. KW - Luftrettung KW - Diagnostik KW - Ergonomie KW - medizinische Geräte KW - Medical Design Y1 - 2021 PB - FH Aachen CY - Aachen ER -