TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - https://doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an asymptotic relative efficiency concept based on expected volumes of confidence regions
JF  - Statistics - A Journal of Theoretical and Applied Statistic
N2  - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
KW  - Volume of confidence regions
KW  - asymptotic relative efficiency
KW  - likelihood ratio test
KW  - multivariate normal distribution
KW  - multinomial distribution
Y1  - 2019
U6  - https://doi.org/10.1080/02331888.2019.1683560
SN  - 1029-4910
VL  - 53
IS  - 6
SP  - 1396
EP  - 1436
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - https://doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - https://doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - https://doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - https://doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  -