TY - JOUR A1 - Weber, Hans-Joachim A1 - Laco, Filip A1 - Kun, Ma A1 - Ramakrishna, S. T1 - The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K. JF - Journal of Dermatological Science. 55 (2009), H. 3 Y1 - 2009 SN - 0923-1811 SP - 150 EP - 160 ER - TY - JOUR A1 - Schmidt, K. A1 - Forkmann, K. A1 - Sinke, C. A1 - Gratz, M. A1 - Bitz, Andreas A1 - Bingel, U. T1 - The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear JF - NeuroImage N2 - Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity was measured in 23 healthy subjects performing a visual categorization task that was immediately followed by a surprise recognition task. During the categorization task subjects received concomitant noxious electrical stimulation on the forehead or hand. Our data show that fear ratings were significantly higher for trigeminal pain. Categorization and recognition performance did not differ between pictures that were presented with trigeminal and peripheral pain. However, object categorization in the presence of trigeminal pain was associated with stronger activity in task-relevant visual areas (lateral occipital complex, LOC), memory encoding areas (hippocampus and parahippocampus) and areas implicated in emotional processing (amygdala) compared to peripheral pain. Further, individual differences in neural activation between the trigeminal and the peripheral condition were positively related to differences in fear ratings between both conditions. Functional connectivity between amygdala and LOC was increased during trigeminal compared to peripheral painful stimulation. Fear-driven compensatory resource activation seems to be enhanced for trigeminal stimuli, presumably due to their exceptional biological relevance. Y1 - 2016 U6 - https://doi.org/10.1016/j.neuroimage.2016.03.026 SN - 1053-8119 VL - 134 SP - 386 EP - 395 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Terstegge, Andreas A1 - Weber, Stefan A1 - Herzog, H. A1 - Reinartz, R. [u.a.] T1 - The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity JF - IEEE transactions on medical imaging. 16 (1997), H. 5 Y1 - 1997 SN - 0278-0062 SP - 684 EP - 689 ER - TY - JOUR A1 - Streun, M. A1 - Brandenburg, G. A1 - Larue, H. A1 - Parl, C. A1 - Ziemons, Karl T1 - The data acquisition system of ClearPET neuro - a small animal PET scanner JF - IEEE Transactions on Nuclear Science N2 - The Crystal Clear Collaboration has developed a modular system for a small animal PET scanner (ClearPET). The modularity allows the assembly of scanners of different sizes and characteristics in order to satisfy the specific needs of the individual member institutions. The system performs depth of interaction detection by using a phoswich arrangement combining LSO and LuYAP scintillators which are coupled to Multichannel Photomultipliers (PMTs). For each PMT a free running 40 MHz ADC digitizes the signal and the complete scintillation pulse is sampled by an FPGA and sent with 20 MB/s to a PC for preprocessing. The pulse provides information about the gamma energy and the scintillator material which identifies the interaction layer. Furthermore, the exact pulse starting time is obtained from the sampled data. This is important as no hardware coincidence detection is implemented. All single events are recorded and coincidences are identified by software. The system in Jülich (ClearPET Neuro) is equipped with 10240 crystals on 80 PMTs. The paper will present an overview of the data acquisition system. Y1 - 2006 SN - 0018-9499 VL - 53 IS - 3 SP - 700 EP - 703 ER - TY - JOUR A1 - Herzog, Hans A1 - Pietrzyk, Uwe A1 - Shah, N. Jon A1 - Ziemons, Karl T1 - The current state, challenges and perspectives of MR-PET JF - Neuroimage N2 - Following the success of PET/CT during the last decade and the recent increasing proliferation of SPECT/CT, another hybrid imaging instrument has been gaining more and more interest: MR-PET. First combined, simultaneous PET and MR studies carried out in small animals demonstrated the feasibility of the new approach. Concurrently, some prototypes of an MR-PET scanner for simultaneous human brain studies have been built, their performance is being tested and preliminary applications have already been shown. Through this pioneering work, it has become clear that advances in the detector design are necessary for further optimization. Recently, the different issues related to the present state and future prospects of MR-PET were presented and discussed during an international 2-day workshop at the Forschungszentrum Jülich, Germany, held after, and in conjunction with, the 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference in Dresden, Germany on October 27–28, 2008. The topics ranged from small animal MR-PET imaging to human MR-BrainPET imaging, new detector developments, challenges/opportunities for ultra-high field MR-PET imaging and considerations of possible future research and clinical applications. This report presents a critical summary of the contributions made to the workshop. Y1 - 2010 U6 - https://doi.org/10.1016/j.neuroimage.2009.10.036 SN - 1053-8119 VL - 49 IS - 3 SP - 2072 EP - 2082 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hardt, Arno A1 - Martin, S. A1 - Meißburger, J. A1 - Retz, R. A1 - Wimmer, J. T1 - The cryopump system of the QQDDQ magnet spectrometer BIG KARL JF - Vacuum N2 - Cryopumps without liquid nitrogen shielding are used to provide a vacuum of 10−6 torr in the spectrometer. The vacuum system is subdivided in three sections that can be separated by valves. The first section (scattering chamber) has a volume of 60 l, two rotation transmissions with 35 cm dia and a sliding seal that allows a rotation of 160° without deteriorating the vacuum. The second section includes the vacuum chambers inside the magnets with 6 × 80 cm cross-section and a length of 1200 cm. The third section (detector box) has a volume of 4300 l and contains a moveable detector system. The gas inside the detector with a pressure of 760 torr is separated from the vacuum by a 15 μm mylar foil with an area of 300 cm2. The detector box can be valved off by a valve with the dimension of 10 × 100 cm. The layout of system is given. The instrumentation and the interlock system are described. First experiences with this system are presented. Y1 - 1978 U6 - https://doi.org/10.1016/S0042-207X(78)80026-8 SN - 1879-2715 (E-Journal); 0042-207X (Print) VL - 28 IS - 10-11 SP - 483 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dethloff, Nina A1 - Kroll-Ludwigs, Kathrin T1 - The Constitutional Court as Driver of Reforms in German Family Law JF - International Survey of Family Law Y1 - 2018 SP - 217 EP - 234 ER - TY - JOUR A1 - Hellwig, Angelika A1 - Volkmann, Lutz T1 - The connectivity of a graph and its complement JF - Discrete applied mathematics Y1 - 2008 SN - 0166-218X (E-Journal); 1872-6771 (E-Journal); 0166-218X (Print) VL - Vol. 156 IS - Iss. 17 SP - 3325 EP - 3328 ER - TY - JOUR A1 - Czupalla, Markus A1 - Horneck, G. A1 - Blome, Hans-Joachim T1 - The conceptual design of a hybrid life support system based on the evaluation and comparison of terrestrial testbeds JF - Advances in Space Research Y1 - 2005 SN - 0273-1177 VL - 35 IS - 9 SP - 1609 EP - 1620 ER - TY - JOUR A1 - Öhlschläger, Peter A1 - Spies, Elmar A1 - Alvarez, Gerardo A1 - Quetting, Michael A1 - Groettrup, Marcus T1 - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA JF - International Journal of Cancer. 128 (2011), H. 2 Y1 - 2011 SN - 1097-0215 SP - 473 EP - 481 PB - Wiley CY - Weinheim ER -