TY  - JOUR
A1  - Ermolaev, A.P.
A1  - Nivokov, I.A.
A1  - Melnikova, L.I.
A1  - Kotliar, Konstantin
T1  - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой
T1  - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma
JF  - Vestnik oftalmologii
N2  - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.
Y1  - 2018
U6  - http://dx.doi.org/10.17116/oftalma2018134051195
VL  - 5
IS  - 2
SP  - 195
EP  - 201
PB  - Media Sfera
CY  - Moskau
ER  - 
TY  - BOOK
A1  - Iomdina, E. N.
A1  - Bauer, S. M.
A1  - Kotliar, Konstantin
T1  - БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ
T2  - Eye biomechanics : theoretical aspects and clinical applications
Y1  - 2015
SN  - 978-5-903025-57-2
PB  - Real Time
CY  - Moscow
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Vilser, W.
A1  - Schmidt-Trucksäss, A.
A1  - Halle, M.
A1  - Lanzl, I. M.
T1  - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse
JF  - Der Ophthalmologe
Y1  - 2009
SN  - 1433-0423
VL  - 106
IS  - 7
SP  - 609
EP  - 618
PB  - -
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Wind and fairness in ski jumping: A computer modelling analysis
JF  - Journal of Biomechanics
N2  - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.jbiomech.2018.05.001
SN  - 0021-9290
IS  - 75
SP  - 147
EP  - 153
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
T1  - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ;  Kayser, Peter
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 497
EP  - 508
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Lutfor, Afzalunnessa B.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and the Host-Gut Microbiome: A Brief Overview
JF  - Acta Histochemica et Cytochemica
N2  - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.
Y1  - 2020
U6  - http://dx.doi.org/10.1267/ahc.20011
SN  - 1347-5800
VL  - 53
IS  - 3
SP  - 33
EP  - 42
PB  - Japan Society of Histochemistry and Cytochemistry
CY  - Osaka
ER  - 
TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and Phosphate Interactions in Health and Disease
T2  - Phosphate Metabolism
N2  - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.
KW  - Vitamin D
KW  - PTH
KW  - Phosphate
KW  - FGF23
KW  - Klotho
Y1  - 2022
SN  - 978-3-030-91621-3
U6  - http://dx.doi.org/10.1007/978-3-030-91623-7_5
SP  - 37
EP  - 46
PB  - Springer
CY  - Cham
ER  - 
TY  - BOOK
A1  - Digel, Ilya
A1  - Zhubanova, Azhar Ahmetovna
A1  - Akimbekov, Nuraly Shardarbekovich
T1  - Visual Virology
Y1  - 2012
SN  - 978-601-247-298-1
N1  - Text kasachisch, russisch, englisch
CY  - Almaty
ER  - 
TY  - JOUR
A1  - Ullrich, Sebastian
A1  - Grottke, Oliver
A1  - Rossaint, Rolf
A1  - Staat, Manfred
A1  - Deserno, Thomas M.
A1  - Kuhlen, Torsten
T1  - Virtual Needle Simulation with Haptics for Regional Anaesthesia
Y1  - 2010
N1  - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010
SP  - 1
EP  - 3
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - Horbach, Andreas
A1  - Staat, Manfred
A1  - Kowalczyk, Wojciech
A1  - Tran, Thanh Ngoc
T1  - Virgin passive colon biomechanics and a literature review of active contraction constitutive models
JF  - Biomechanics
N2  - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine.
KW  - virgin passive
KW  - strain energy function
KW  - smooth muscle contraction
KW  - viscoelasticity
KW  - damage
Y1  - 2022
U6  - http://dx.doi.org/10.3390/biomechanics2020013
SN  - 2673-7078
VL  - 2
IS  - 2
SP  - 138
EP  - 157
PB  - MDPI
CY  - Basel
ER  -