TY  - JOUR
A1  - Hamad, E. M.
A1  - Bilatto, S. E. R.
A1  - Adly, N. Y.
A1  - Correa, D. S.
A1  - Wolfrum, B.
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
A1  - Yakushenko, A.
T1  - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices
JF  - Lab on a Chip
N2  - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.
Y1  - 2016
U6  - https://doi.org/10.1039/C5LC01195G
SN  - 1473-0189
VL  - 16
IS  - 1
SP  - 70
EP  - 74
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Yu, Bing
A1  - Isoda, Hiroko
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor
JF  - Sensors and Actuators B: Chemical
N2  - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed.
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.04.018
SN  - 0925-4005
VL  - 236
SP  - 965
EP  - 969
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Takenaga, Shoko
A1  - Wagner, Patrick
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system
JF  - Physica status solidi (a)
N2  - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.
Y1  - 2016
U6  - https://doi.org/10.1002/pssa.201533043
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1479
EP  - 1485
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Schreiber, Marc
A1  - Kraft, Bodo
A1  - Zündorf, Albert
T1  - Cost-efficient quality assurance of natural language processing tools through continuous monitoring with continuous integration
T2  - 3rd International Workshop on Software Engineering Research and Industrial Practice
Y1  - 2016
U6  - https://doi.org/10.1145/2897022.2897029
N1  - SER&IP’16, May 17 2016, Austin, TX, USA
SP  - 46
EP  - 52
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Strobel, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems
JF  - Physica status solidi (a)
N2  - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.
Y1  - 2016
U6  - https://doi.org/10.1002/pssa.201533056
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1520
EP  - 1525
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Pookhalil, Ali
A1  - Amoabediny, Ghassem
A1  - Tabesh, Hadi
A1  - Behbahani, Mehdi
A1  - Mottaghy, Khosrow
T1  - A new approach for semiempirical modeling of mechanical blood trauma
JF  - The international journal of artificial organs
N2  - Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
Y1  - 2016
U6  - https://doi.org/10.5301/ijao.5000474
SN  - 1724-6040
VL  - 39
IS  - 4
SP  - 171
EP  - 177
PB  - Sage
CY  - London
ER  - 
TY  - CHAP
A1  - Bialonski, Stephan
T1  - Are interaction clusters in epileptic networks predictive of seizures?
T2  - Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics
Y1  - 2016
SN  - 978-143983886-0
SP  - 349
EP  - 355
PB  - CRC Press
ER  - 
TY  - JOUR
A1  - Ngamga, Eulalie Joelle
A1  - Bialonski, Stephan
A1  - Marwan, Norbert
A1  - Kurths, Jürgen
A1  - Geier, Christian
A1  - Lehnertz, Klaus
T1  - Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data
JF  - Physics Letters A
N2  - We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database.
Y1  - 2016
U6  - https://doi.org/10.1016/j.physleta.2016.02.024
SN  - 0375-9601
VL  - 380
IS  - 16
SP  - 1419
EP  - 1425
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Natal Jorge, Renato
T1  - Significance of fibre geometry on passive-active response of pelvic muscles to evaluate pelvic dysfunction
T2  - BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health
Y1  - 2016
SN  - 978-1-138-02910-1
SP  - 185
EP  - 188
PB  - CRC Press
CY  - Boca Raton
ER  - 
TY  - JOUR
A1  - Kowalski, Julia
A1  - Linder, Peter
A1  - Zierke, S.
A1  - Wulfen, B. van
A1  - Clemens, J.
A1  - Konstantinidis, K.
A1  - Ameres, G.
A1  - Hoffmann, R.
A1  - Mikucki, J.
A1  - Tulaczyk, S.
A1  - Funke, O.
A1  - Blandfort, D.
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Hiecker, S.
A1  - Plescher, Engelbert
A1  - Schöngarth, Sarah
A1  - Dachwald, Bernd
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Eliseev, D.
A1  - Heinen, D.
A1  - Scholz, F.
A1  - Wiebusch, C.
A1  - Macht, S.
A1  - Bestmann, U.
A1  - Reineking, T.
A1  - Zetzsche, C.
A1  - Schill, K.
A1  - Förstner, R.
A1  - Niedermeier, H.
A1  - Szumski, A.
A1  - Eissfeller, B.
A1  - Naumann, U.
A1  - Helbing, K.
T1  - Navigation technology for exploration of glacier ice with maneuverable melting probes
JF  - Cold Regions Science and Technology
N2  - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
Y1  - 2016
U6  - https://doi.org/10.1016/j.coldregions.2015.11.006
SN  - 0165-232X
IS  - 123
SP  - 53
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  -