TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - https://doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
ED  - Abdelghani, Adnane
ED  - Schöning, Michael Josef
T1  - (Bio-­)chemical sensor array based on nanoplate SOI capacitors
T2  - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012
Y1  - 2012
SP  - 31
EP  - 31
ER  - 
TY  - CHAP
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
ED  - Abdelghani, Adnane
ED  - Schöning, Michael Josef
T1  - Towards a paradigm change – mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air
T2  - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012
Y1  - 2012
SP  - 44
EP  - 44
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hasan, Istabrak
A1  - Keil, Ludger
A1  - Staat, Manfred
A1  - Wahl, Gerhard
A1  - Bourauel, Christoph
T1  - Determination of the frictional coefficient of the implant-antler interface : experimental approach
JF  - Biomedical Engineering / Biomedizinische Technik
N2  - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.
Y1  - 2012
SN  - 1862-278X
VL  - 57
IS  - 5
SP  - 359
EP  - 363
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Raatschen, Hans-Jürgen
A1  - Staat, Manfred
ED  - Eberhardsteiner, J.
T1  - Application of an edge-based smoothed finite element method on geometrically non-linear plates of non-linear material
T2  - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)
Y1  - 2012
N1  - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
ED  - Eberhardsteiner, J.
T1  - Numerical stability enhancement of modeling hyperelastic materials
T2  - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)
Y1  - 2012
N1  - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
ED  - Eberhardsteiner, J.
T1  - A primal-dual shakedown analysis of 3D structures using the face-based smoothed finite element method
T2  - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)
Y1  - 2012
N1  - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012
ER  - 
TY  - CHAP
A1  - Pham, Phu Tinh
A1  - Nguyen, Thanh Ngoc
A1  - Staat, Manfred
T1  - FEM based shakedown analysis of hardening structures
T2  - Proceedings International Conference on Advances in Computational Mechanics (ACOME)
Y1  - 2012
N1  - International Conference on Advances in Computational Mechanics (ACOME), August 14-16, 2012, Ho Chi Minh City, Vietnam
SP  - 870
EP  - 882
ER  - 
TY  - CHAP
A1  - Staat, Manfred
T1  - Limit and shakedown analysis under uncertainty
T2  - Proceedings International Conference on Advances in Computational Mechanics (ACOME)
Y1  - 2012
N1  - International Conference on Advances in Computational Mechanics (ACOME), August 14-16, 2012, Ho Chi Minh City, Vietnam
SP  - 837
EP  - 861
ER  -