TY  - JOUR
A1  - Pinkenburg, Olaf
A1  - Schiffels, Johannes
A1  - Selmer, Thorsten
T1  - Das CoLibry-Konzept – ein Werkzeugkasten für die Synthetische Biologie: Bioproduktion
JF  - BIOspektrum
N2  - Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.
Y1  - 2016
U6  - https://doi.org/10.1007/s12268-016-0734-8
VL  - 22
IS  - 6
SP  - 593
EP  - 595
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ghosch, S.
A1  - Baier, M.
A1  - Schütz, J.
A1  - Schneider, Felix
A1  - Scherer, Ulrich W.
T1  - Analysis of electronic autoradiographs by mathematical post-processing
JF  - Radiation Effects and Defects in Solids: Incorporating plasma science and plasma technology
N2  - Autoradiography is a well-established method of nuclear imaging. When different radionuclides are present simultaneously, additional processing is needed to distinguish distributions of radionuclides. In this work, a method is presented where aluminium absorbers of different thickness are used to produce images with different cut-off energies. By subtracting images pixel-by-pixel one can generate images representing certain ranges of β-particle energies. The method is applied to the measurement of irradiated reactor graphite samples containing several radionuclides to determine the spatial distribution of these radionuclides within pre-defined energy windows. The process was repeated under fixed parameters after thermal treatment of the samples. The greyscale images of the distribution after treatment were subtracted from the corresponding pre-treatment images. Significant changes in the intensity and distribution of radionuclides could be observed in some samples. Due to the thermal treatment parameters the most significant differences were observed in the ³H and ¹⁴C inventory and distribution.
Y1  - 2016
U6  - https://doi.org/10.1080/10420150.2016.1155587
SN  - 1029-4953
VL  - 171
IS  - 1-2
SP  - 161
EP  - 172
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 5: Elektrochemie
Y1  - 2016
SN  - 978-3-662-47559-1
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 4: Reaktionskinetik
Y1  - 2016
SN  - 978-3-662-47674-1
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 3: Phasengleichgewichte
Y1  - 2016
SN  - 978-3-662-47571-3
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 2: Chemische Thermodynamik
Y1  - 2016
SN  - 978-3-662-47621-5
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
T1  - Physikalische Chemie, 1: Grundlagen der Thermodynamik und Verhalten der Gase
Y1  - 2016
SN  - 978-3-662-47676-5
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Kowalczyk, Jürgen
T1  - Einführung in die Physik und Chemie der Grenzflächen und Kolloide
Y1  - 2016
SN  - 978-3-662-47018-3
U6  - https://doi.org/10.1007/978-3-662-47018-3
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Feuerriegel, Uwe
T1  - Verfahrenstechnik mit EXCEL: Verfahrenstechnische Berechnungen effektiv durchführen und professionell dokumentieren
Y1  - 2016
SN  - 978-3-658-02902-9
U6  - https://doi.org/10.1007/978-3-658-02903-6
N1  - 152 Abbildungen, 94 Abbildungen in Farbe

Gedruckt in der Bibliothek unter der Signatur: 21 ZNK 11
PB  - Springer Fachmedien
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wilson, Ian D.
T1  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
JF  - Drug Discovery Today
N2  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
Y1  - 2016
U6  - https://doi.org/10.1016/j.drudis.2015.09.002
SN  - 1359-6446
VL  - 21
IS  - 2
SP  - 250
EP  - 263
PB  - Elsevier
CY  - Amsterdam
ER  -