TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel ED - Crookston, B. ED - Tullis, B. T1 - Application of the optical flow method to velocity determination in hydraulic structure models BT - Session 11: Fish passage and shiplocks T2 - Hydraulic Structures and Water System Management. 6th IAHR International Symposium on Hydraulic Structures, Portland, OR, 27-30 June 2016 Y1 - 2016 SN - 978-1-884575-75-4 U6 - http://dx.doi.org/10.15142/T3150628160853 SP - 223 EP - 232 ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel ED - Dewals, Benjamin T1 - Image processing techniques for velocity estimation in highly aerated flows: bubble image velocimetry vs. optical flow T2 - Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016) Y1 - 2016 SN - 978-1-138-02977-4 SN - 978-1-4987-8149-7 (eBook) U6 - http://dx.doi.org/10.1201/b21902-31 SP - 151 EP - 157 PB - CRC Press ER - TY - JOUR A1 - Bung, Daniel B. A1 - Valero, Daniel T1 - Optical flow estimation in aerated flows JF - Journal of Hydraulic Research N2 - Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents the first study on application of the optical flow method to aerated stepped spillway flows. For this purpose, the flow is captured with a high-speed camera and illuminated with a synchronized LED light source. The flow velocities, obtained using a basic Horn–Schunck method for estimation of the optical flow coupled with an image pyramid multi-resolution approach for image filtering, compare well with data from intrusive conductivity probe measurements. Application of the Horn–Schunck method yields densely populated flow field data sets with velocity information for every pixel. It is found that the image pyramid approach has the most significant effect on the accuracy compared to other image processing techniques. However, the final results show some dependency on the pixel intensity distribution, with better accuracy found for grey values between 100 and 150. Y1 - 2016 U6 - http://dx.doi.org/10.1080/00221686.2016.1173600 VL - 54 IS - 5 SP - 575 EP - 580 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Kubalski, Thomas A1 - Klinkel, Sven T1 - Masonry infilled reinforced concrete frames under horizontal loading T1 - Stahlbetonrahmen mit Ausfachungen aus Mauerwerk unter horizontalen Belastungen JF - Mauerwerk N2 - The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures. Y1 - 2016 U6 - http://dx.doi.org/10.1002/dama.201600703 SN - 1437-1022 VL - 20 IS - 4 SP - 305 EP - 312 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Bäcker, Matthias A1 - Koch, C. A1 - Geiger, F. A1 - Eber, F. A1 - Gliemann, H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier T2 - Procedia Engineering Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.proeng.2016.11.228 SN - 1877-7058 N1 - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary VL - Vol. 168 SP - 618 EP - 621 ER - TY - CHAP A1 - Capitain, C. A1 - Hering, T. A1 - Tippkötter, Nils A1 - Ulber, R. T1 - Enzymatic polymerization of lignin model compounds and solubilized lignin in an aqueous ethanol extract T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 151 EP - 152 PB - DECHEMA CY - Frankfurt am Main ER - TY - JOUR A1 - Chen, Bixia A1 - Schoemberg, Tobias A1 - Kraff, Oliver A1 - Dammann, Philipp A1 - Bitz, Andreas A1 - Schlamann, Marc A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Sure, Ulrich A1 - Wrede, Karsten H. T1 - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10334-016-0548-1 SN - 1352-8661 VL - 29 IS - 3 SP - 389 EP - 398 PB - Springer CY - Berlin ER - TY - CHAP A1 - Dalguer, Luis A. A1 - Renault, Philippe A1 - Churilov, Sergey A1 - Butenweg, Christoph T1 - Evaluation of fragility curves for a three-storey-reinforced-concrete mock-up of SMART 2013 project T2 - Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015 Y1 - 2016 SP - 1 EP - 9 ER - TY - JOUR A1 - Dallas, Shannon A1 - Salphati, Laurent A1 - Gomez-Zepeda, David A1 - Wanek, Thomas A1 - Chen, Liangfu A1 - Chu, Xiaoyan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Menet, Marie-Claude A1 - Chasseigneaux, Stephanie A1 - Declèves, Xavier A1 - Langer, Oliver A1 - Pierre, Esaie A1 - DiLoreto, Karen A1 - Hoft, Carolin A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Pereira, Tony A1 - Andonian, Clara A1 - Simic, Damir A1 - Rode, Anja A1 - Yabut, Jocelyn A1 - Zhang, Xiaolin A1 - Scheer, Nico T1 - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model JF - Molecular Pharmacology N2 - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP. Y1 - 2016 U6 - http://dx.doi.org/10.1124/mol.115.102079 SN - 1521-0111 VL - 89 IS - 5 SP - 492 EP - 504 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Dantism, Shahriar A1 - Takenaga, Shoko A1 - Wagner, Patrick A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system JF - Physica status solidi (a) N2 - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pssa.201533043 SN - 1862-6300 VL - 213 IS - 6 SP - 1479 EP - 1485 PB - Wiley-VCH CY - Weinheim ER -