TY - JOUR A1 - Kotliar, Konstantin A1 - Ortner, Marion A1 - Conradi, Anna A1 - Hacker, Patricia A1 - Hauser, Christine A1 - Günthner, Roman A1 - Moser, Michaela A1 - Muggenthaler, Claudia A1 - Diehl-Schmid, Janine A1 - Priller, Josef A1 - Schmaderer, Christoph A1 - Grimmer, Timo T1 - Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance JF - Neurobiology of Aging N2 - Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis. KW - Alzheimer's disease KW - Retinal vessel analysis KW - Vasomotions KW - Pulsations KW - Mild cognitive impairment Y1 - 2022 U6 - https://doi.org/10.1016/j.neurobiolaging.2022.08.012 SN - 0197-4580 VL - 120 SP - 117 EP - 127 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Makarov, F. N. A1 - Zaseeva, M. V. T1 - Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in JF - Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3 Y1 - 2003 SN - 1026-3543 N1 - Original in Russisch, English abstract SP - 7 EP - 16 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Sourjikov, A. V. A1 - Zaseeva, M. V. T1 - Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N. JF - Glaukoma (2004) Y1 - 2004 N1 - Original in Russisch SP - 66 EP - 76 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Stegaev, V. A. A1 - Parkhomov, S. D. T1 - Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A. ; Koshitz, I. N. JF - Glaukoma (2004) Y1 - 2004 N1 - Original in Russisch SP - 29 EP - 39 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Halle, M. A1 - Lanzl, I. M. T1 - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse JF - Der Ophthalmologe Y1 - 2009 SN - 1433-0423 VL - 106 IS - 7 SP - 609 EP - 618 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, Walthatd A1 - Nagel, Edgar A1 - Lanzl, Ines M. T1 - Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M. JF - Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5 Y1 - 2004 SN - 1435-702X SP - 377 EP - 392 PB - - ER - TY - JOUR A1 - Kowalski, Julia A1 - Linder, Peter A1 - Zierke, S. A1 - Wulfen, B. van A1 - Clemens, J. A1 - Konstantinidis, K. A1 - Ameres, G. A1 - Hoffmann, R. A1 - Mikucki, J. A1 - Tulaczyk, S. A1 - Funke, O. A1 - Blandfort, D. A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Hiecker, S. A1 - Plescher, Engelbert A1 - Schöngarth, Sarah A1 - Dachwald, Bernd A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Eliseev, D. A1 - Heinen, D. A1 - Scholz, F. A1 - Wiebusch, C. A1 - Macht, S. A1 - Bestmann, U. A1 - Reineking, T. A1 - Zetzsche, C. A1 - Schill, K. A1 - Förstner, R. A1 - Niedermeier, H. A1 - Szumski, A. A1 - Eissfeller, B. A1 - Naumann, U. A1 - Helbing, K. T1 - Navigation technology for exploration of glacier ice with maneuverable melting probes JF - Cold Regions Science and Technology N2 - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept. Y1 - 2016 U6 - https://doi.org/10.1016/j.coldregions.2015.11.006 SN - 0165-232X IS - 123 SP - 53 EP - 70 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kozhalakova, A. A. A1 - Zhubanova, Azhar A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Tazhibayeva, S. M. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Adsorption of bacterial lipopolysaccharides on carbonized rice shell JF - Science of Central Asia (2010) Y1 - 2010 SP - 50 EP - 54 ER - TY - JOUR A1 - Krämer, Stefan A1 - Daab, Dominique Jonas A1 - Müller, Brigitte A1 - Wagner, Tobias A1 - Baader, Fabian A1 - Hessel, Joana A1 - Gdalewitsch, Georg A1 - Plescher, Engelbert A1 - Dachwald, Bernd A1 - Wahle, Michael A1 - Gierse, Andreas A1 - Vetter, Rudolf A1 - Pfützenreuter, Lysan T1 - Development and flight-testing of a system to isolate vibrations for microgravity experiments on sounding rockets JF - 21st ESA Symposium on Rocket and Balloon Research Y1 - 2013 SP - 1 EP - 8 ER - TY - JOUR A1 - Kuchler, Timon A1 - Günthner, Roman A1 - Ribeiro, Andrea A1 - Hausinger, Renate A1 - Streese, Lukas A1 - Wöhnl, Anna A1 - Kesseler, Veronika A1 - Negele, Johanna A1 - Assali, Tarek A1 - Carbajo-Lozoya, Javier A1 - Lech, Maciej A1 - Adorjan, Kristina A1 - Stubbe, Hans Christian A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Haller, Berhard A1 - Heemann, Uwe A1 - Schmaderer, Christoph T1 - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation N2 - Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management. KW - Endothelial dysfunction KW - Long COVID KW - Post-COVID-19 syndrome KW - retinal microvasculature Y1 - 2023 U6 - https://doi.org/10.1007/s10456-023-09885-6 N1 - Corresponding author: Christoph Schmaderer VL - 26 SP - 547 EP - 563 PB - Springer Nature CY - Dordrecht ER -