TY  - JOUR
A1  - Kodomskoi, Leonid
A1  - Kotliar, Konstantin
A1  - Schröder, Andreas
A1  - Weiss, Michael
A1  - Hille, Konrad
T1  - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter
JF  - Journal of Glaucoma
Y1  - 2019
U6  - http://dx.doi.org/10.1097/IJG.0000000000001321
SN  - 1057-0829
IS  - Epub ahead of print
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Attar, Mandana Hossein Zadeh
A1  - Merk, Hans F.
A1  - Kotliar, Konstantin
A1  - Wurpts, Gerda
A1  - Röseler, Stefani
A1  - Moll-Slodowy, Silke
A1  - Plange, Johann
A1  - Baron, Jens Malte
A1  - Balakirski, Galina
T1  - The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria
JF  - European Journal of Dermatology
Y1  - 2019
U6  - http://dx.doi.org/10.1684/ejd.2019.3680
VL  - 29
IS  - 6
SP  - 614
EP  - 618
ER  - 
TY  - JOUR
A1  - Garhofer, Gerhard
A1  - Bek, Toke
A1  - Boehm, Andreas G.
A1  - Gherghel, Doina
A1  - Grundwald, Juan
A1  - Jeppesen, Peter
A1  - Kergoat, Hélène
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines
A1  - Lovasik, John V.
A1  - Nagel, Edgar
A1  - Vilser, Walthard
A1  - Orgul, Selim
A1  - Schmetterer, Leopold
T1  - Use of the retinal vessel analyzer in ocular blood flow research
JF  - Acta Ophthalmol
N2  - The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed.
Y1  - 2010
U6  - http://dx.doi.org/10.1111/j.1755-3768.2009.01587.x
SN  - 1755-3768
VL  - 88
IS  - 7
SP  - 717
EP  - 722
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Conzen, Catharina
A1  - Albanna, Walid
A1  - Weiss, Miriam
A1  - Kürten, David
A1  - Vilser, Walthard
A1  - Kotliar, Konstantin
A1  - Zäske, Charlotte
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
T1  - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes
JF  - Translational Stroke Research
N2  - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s12975-017-0585-8
SN  - 1868-601X
IS  - 9
SP  - 284
EP  - 293
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Blum, Yannik
A1  - Albanna, Walid
A1  - Benninghaus, Anne
A1  - Kotliar, Konstantin
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 38
EP  - 39
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  -