TY  - JOUR
A1  - Manea, Marilena
A1  - Leurs, Ulrike
A1  - Orban, Erika
A1  - Baranyai, Zsuzsa
A1  - Öhlschläger, Peter
A1  - Marquardt, Andreas
A1  - Schulcz, Akos
A1  - Tejeda, Miguel
T1  - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4
JF  - Bioconjugate Chemistry
Y1  - 2011
SN  - 1520-4812
VL  - 22
IS  - 7
SP  - 1320
EP  - 1329
PB  - ACS
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - http://dx.doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Oosterhuis, Koen
A1  - Öhlschläger, Peter
A1  - Berg, Joost H. van den
A1  - Toebes, Mireille
A1  - Gomez, Raquel
A1  - Schumacher, Ton N.
A1  - Haanen, John B.
T1  - Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7
JF  - International Journal of Cancer
Y1  - 2011
SN  - 1097-0215
VL  - 129
IS  - 2
SP  - 397
EP  - 406
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Spies, Elmar
A1  - Alvarez, Gerardo
A1  - Quetting, Michael
A1  - Groettrup, Marcus
T1  - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA
JF  - International Journal of Cancer. 128 (2011), H. 2
Y1  - 2011
SN  - 1097-0215
SP  - 473
EP  - 481
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Krott, Daniel
A1  - Gerhards, Michael
A1  - Skorupa, Sascha
A1  - Sander, Volker
T1  - NHiLA - Bridging the Gap Between .NET and UNICORE
JF  - UNICORE Summit 2011 : proceedings, 7-8 July 2011, Torun, Poland / Mathilde Romberg ... (Eds.)
Y1  - 2011
SN  - 9783893367504
N1  - UNICORE Summit ; (2011 ; 2011.07.07-08 ; Torun) ; Schriften des Forschungszentrums Jülich IAS Series 9
SP  - 77
EP  - 86
PB  - Forschungszentrum Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Gerhards, M.
A1  - Skorupa, S.
A1  - Sander, Volker
A1  - Pfeiffer, P.
A1  - Belloum, A.
T1  - Towards a security framework for a WS-HumanTask processor
JF  - 7th International Conference on  Network and Service Management (CNSM), 2011 Paris
Y1  - 2011
SN  - 978-3-901882-44-9
SP  - 1
EP  - 5
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Bergmann, Sandra
A1  - Demuth, Bastian
A1  - Sander, Volker
T1  - A Web Framework for Workflow Submission and Monitoring via UNICORE 6 based on Distributable Scientific Workflow Templates
JF  - UNICORE Summit 2011 : proceedings, 7-8 July 2011, Torun, Poland / Mathilde Romberg ... (Eds.)
Y1  - 2011
SN  - 9783893367504
N1  - UNICORE Summit ; (2011 ; 2011.07.07-08 ; Torun) ; Schriften des Forschungszentrums Jülich IAS Series 9
SP  - 45
EP  - 50
PB  - Forschungszentrum Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Börner, Sebastian
A1  - Falk, F.
A1  - Hendrick, P.
T1  - Control system modifications and their effects on the operation of a hydrogen-fueled Auxiliary Power Unit
JF  - XX international symposium on air breathing engines 2011 : ISABE 2011, Gothenburg, Sweden, 12-16 September, 2011. Vol. 2.
Y1  - 2011
SN  - 9781618391803
N1  - 20th International Symposium on Air Breathing Engines 2011 : (ISABE 2011) : Gothenburg, Sweden, 12-16 September, 2011.
SP  - 929
EP  - 938
PB  - American Institute of Aeronautics and Astronautics
CY  - Reston, VA
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Funke, Harald
A1  - Roosen, Peter
A1  - Jarolimek, Ulrich
T1  - Biogenic Vehicle Fuels in General Aviation Aircrafts
JF  - MTZ worldwide. 72 (2011), H. 1
Y1  - 2011
N1  - recherchierbar für Angehörige der FH Aachen
SP  - 38
EP  - 43
PB  - Springer Automotive Media
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Recker, E.
A1  - Bosschaerts, W.
A1  - Boonen, Q.
A1  - Börner, Sebastian
T1  - Parametrical study of the „Micromix“ hydrogen combustion principle
JF  - 10th International Symposium on Experimental and Computational Aerothermodynamics of Internal Flows, ISAIF10-049, Brussels, Belgium, 4-7 July 2011
Y1  - 2011
ER  -