TY - THES A1 - Schusser, Sebastian T1 - Sensor-based degradation monitoring for the evaluation of (bio)degradable polymers Y1 - 2015 N1 - Universiteit Hasselt, FH Aachen, Dissertation, 2015; Printausgabe in der Bibliothek vorhanden: 61 UWJ 5 PB - Universiteit Hasselt ; FH Aachen CY - Hasselt ; Aachen ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, Maximillian A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors JF - Analytical Chemistry N2 - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers. Y1 - 2015 U6 - http://dx.doi.org/10.1021/acs.analchem.5b00617 SN - 1520-6882 VL - 87 IS - 13 SP - 6607 EP - 6613 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Leinhos, Marcel A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers JF - Sensors and actuators B: Chemical N2 - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13). Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.snb.2014.10.058 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 207, Part B SP - 954 EP - 959 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Schänzle, Christian A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. T1 - As good as it can be: Ventilation system design by a combined scaling and discrete optimization method T2 - Proceedings of FAN 2015 N2 - The understanding that optimized components do not automatically lead to energy-efficient systems sets the attention from the single component on the entire technical system. At TU Darmstadt, a new field of research named Technical Operations Research (TOR) has its origin. It combines mathematical and technical know-how for the optimal design of technical systems. We illustrate our optimization approach in a case study for the design of a ventilation system with the ambition to minimize the energy consumption for a temporal distribution of diverse load demands. By combining scaling laws with our optimization methods we find the optimal combination of fans and show the advantage of the use of multiple fans. Y1 - 2015 N1 - Proceedings of FAN 2015, Lyon (France), 15 – 17 April 2015 SP - 1 EP - 11 ER - TY - CHAP A1 - Schänzle, Christian A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Pelz, Peter T1 - TOR – Towards the energetically optimal ventilation system KW - Energy KW - Efficiency KW - Ventilation System KW - Discrete Optimisation KW - TGA Y1 - 2015 N1 - EST 2015, Karlsruhe, 19-21 Mai 2015 ER - TY - CHAP A1 - Seefeldt, Patric A1 - Bauer, Waldemar A1 - Dachwald, Bernd A1 - Grundmann, Jan Thimo A1 - Straubel, Marco A1 - Sznajder, Maciej A1 - Tóth, Norbert A1 - Zander, Martin E. T1 - Large lightweight deployable structures for planetary defence: solar sail propulsion, solar concentrator payloads, large-scale photovoltaic power T2 - 4th IAA Planetary Defense Conference - PDC 2015, 13-17 April 2015, Frascati, Roma, Italy Y1 - 2015 N1 - IAA-PDC-15-P-20 ER - TY - THES A1 - Seifarth, Volker T1 - Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids Y1 - 2015 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2015 PB - Universitätsbibliothek Duisburg-Essen CY - Duisburg ; Essen ER - TY - JOUR A1 - Seifarth, Volker A1 - Goßmann, Matthias A1 - Grosse, J. O. A1 - Becker, C. A1 - Heschel, I. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds JF - Urologia Internationalis Y1 - 2015 U6 - http://dx.doi.org/10.1159/000368419 SN - 0042-1138 VL - 2015 IS - 95 SP - 106 EP - 113 PB - Karger CY - Basel ER - TY - JOUR A1 - Seynnes, O. R. A1 - Bojsen-Moller, J. A1 - Albracht, Kirsten A1 - Arndt, A. A1 - Cronin, N. J. A1 - Finni, T. A1 - Magnusson, S. P. T1 - Ultrasound-based testing of tendon mechanical properties: a critical evaluation JF - Journal of Applied Physiology Y1 - 2015 U6 - http://dx.doi.org/10.1152/japplphysiol.00849.2014 SN - 8750-7587 VL - 118 IS - 2 SP - 133 EP - 141 ER -