TY  - JOUR
A1  - Wilke, Thomas
T1  - Newly found plans for the chapel of the Holy Shroud
JF  - Studi Piemontesi
Y1  - 2017
SN  - 0392-7261
VL  - XLVI
IS  - 1
SP  - 75
EP  - 85
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - https://doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Samuelsson, K.
A1  - Scheer, Nico
A1  - Wilson, I.
A1  - Wolf, C.R.
A1  - Henderson, C.J.
ED  - Chackalamannil, Samuel
T1  - Genetically Humanized Animal Models
T2  - Comprehensive Medicinal Chemistry III. 3rd Edition
N2  - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
KW  - Chimeric liver-humanized mice
KW  - Drug distribution
KW  - Drug metabolism
KW  - Toxicology
KW  - Knockout mice
Y1  - 2017
SN  - 978-0-12-803201-5
U6  - https://doi.org/10.1016/B978-0-12-409547-2.12376-5
SP  - 130
EP  - 149
PB  - Elsevier
CY  - Saint Louis
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Baumann, Martin
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia
JF  - Current Directions in Biomedical Engineering
Y1  - 2017
U6  - https://doi.org/10.1515/cdbme-2017-0096
SN  - 2364-5504
VL  - 3
IS  - 2
SP  - 457
EP  - 460
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Chen, Chao
A1  - Jost, Peter
A1  - Volker, Hanno
A1  - Kaminski, Marvin
A1  - Wirtssohn, Matti R.
A1  - Engelmann, Ulrich M.
A1  - Krüger, K.
A1  - Schlich, Franziska F.
A1  - Schlockermann, Carl
A1  - Lobo, Ricardo P.S.M.
A1  - Wuttig, Matthias
T1  - Dielectric properties of amorphous phase-change materials
JF  - Physical Review B
Y1  - 2017
U6  - https://doi.org/10.1103/PhysRevB.95.094111
SN  - 2469-9950
VL  - 95
IS  - 9
SP  - Article number 094111
ER  - 
TY  - JOUR
A1  - Sousa, Marcos A. M.
A1  - Siqueira, Jose R. Jr.
A1  - Vercik, Andres
A1  - Schöning, Michael Josef
A1  - Oliveira, Osvaldo N. Jr.
T1  - Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors
JF  - IEEE Sensors Journal
N2  - The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.
Y1  - 2017
U6  - https://doi.org/10.1109/JSEN.2017.2653238
SN  - 1558-1748
VL  - 17
IS  - 6
SP  - 1735
EP  - 1740
PB  - IEEE
CY  - New York
ER  - 
TY  - CHAP
A1  - Schreiber, Marc
A1  - Kraft, Bodo
A1  - Zündorf, Albert
ED  - Bilof, Randall
T1  - Metrics driven research collaboration: focusing on common project goals continuously
T2  - Proceedings : 2017 IEEE/ACM 4th International Workshop on Software Engineering Research and Industrial Practice : SER&IP 2017 : 21 May 2017 Buenos Aires, Argentina
Y1  - 2017
SN  - 978-1-5386-2797-6
U6  - https://doi.org/10.1109/SER-IP.2017..6
SP  - 41
EP  - 47
PB  - IEEE Press
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Schwanke, Peter
A1  - Höfken, Hans-Wilhelm
A1  - Schuba, Marko
T1  - Security Analysis of the ADS Protocol of a Beckhoff CX2020 PLC
N2  - ICSs (Industrial Control Systems) and its subset SCADA systems (Supervisory Control and Data Acquisition) are getting exposed to a constant stream of new threats. The increasing importance of IT security in ICS requires viable methods to assess the security of ICS, its individual components, and its protocols. This paper presents a security analysis with focus on the communication protocols of a single PLC (Programmable Logic Controller). The PLC, a Beckhoff CX2020, is examined and new vulnerabilities of the system are revealed. Based on these findings recommendations are made to improve security of the Beckhoff system and its protocols.
Y1  - 2017
N1  - International Conference on Computer, Network Security and Communication Engineering (CNSCE 2017), March 26-27, 2017, Bangkok, Thailand
SP  - 1
EP  - 5
ER  - 
TY  - CHAP
A1  - Granat, Andreas
A1  - Höfken, Hans-Wilhelm
A1  - Schuba, Marko
T1  - Intrusion Detection of the ICS Protocol EtherCAT
N2  - Control mechanisms like Industrial Controls Systems (ICS) and its subgroup SCADA (Supervisory Control and Data Acquisition) are a prerequisite to automate industrial processes. While protection of ICS on process management level is relatively straightforward – well known office IT security mechanisms can be used – protection on field bus level is harder to achieve as there are real-time and production requirements like 24x7 to consider. One option to improve security on field bus level is to introduce controls that help to detect and to react on attacks. This paper introduces an initial set of intrusion detection mechanisms for the field bus protocol EtherCAT. To this end existing Ethernet attack vectors including packet injection and man-in-the-middle attacks are tested in an EtherCAT environment, where they could interrupt the EtherCAT network and may even cause physical damage. Based on the signatures of such attacks, a preprocessor and new rule options are defined for the open source intrusion detection system Snort demonstrating the general feasibility of intrusion detection on field bus level.
Y1  - 2017
N1  - International Conference on Computer, Network Security and Communication Engineering (CNSCE 2017), March 26-27, 2017, Bangkok, Thailand
SP  - 1
EP  - 5
ER  - 
TY  - GEN
A1  - Nobisrath, Ulrich
A1  - Zündorf, Albert
A1  - George, Tobias
A1  - Ruben, Jubeh
A1  - Kraft, Bodo
T1  - Software Stories Guide
N2  - Software Stories are a simple graphical notation for requirements analysis and design in agile software projects. Software Stories are based on example scenarios. Example scenarios facilitate the communication between lay people or domain experts and software experts.
Y1  - 2017
ER  -