TY - JOUR A1 - Poghossian, Arshak A1 - Berndsen, L. A1 - Schultze, J. W. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - „High order“ hybrid sensor module based on an identical transducer principle JF - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler Y1 - 2001 SN - 1-56677-351-2 N1 - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.) SP - 143 EP - 152 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Wagner, Torsten A1 - Yoshinobu, T. A1 - Rao, C. A1 - Otto, R. A1 - Schöning, Michael Josef T1 - „All-in-one“ solid-state device based on a lightaddressable potentiometric sensor platform JF - Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society Y1 - 2005 SN - 0-7803-83995-6 N1 - International Conference on Solid State Sensors, Actuators and Microsystems ; (13, 2005, Seoul) SP - 1872 EP - 1875 PB - IEEE Operations Center CY - Piscataway, NJ ER - TY - JOUR A1 - Wagner, Torsten A1 - Rao, C. A1 - Kloock, Joachim P. A1 - Yoshinobu, T. A1 - Otto, R. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - “LAPS Card”—A novel chip card-based light-addressable potentiometric sensor (LAPS) JF - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2 Y1 - 2006 SN - 0925-4005 N1 - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers SP - 33 EP - 40 ER - TY - JOUR A1 - Ermolaev, A.P. A1 - Nivokov, I.A. A1 - Melnikova, L.I. A1 - Kotliar, Konstantin T1 - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой T1 - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma JF - Vestnik oftalmologii N2 - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP. Y1 - 2018 U6 - http://dx.doi.org/10.17116/oftalma2018134051195 VL - 5 IS - 2 SP - 195 EP - 201 PB - Media Sfera CY - Moskau ER - TY - JOUR A1 - Werner, Frederik A1 - Groebel, Simone A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Selmer, Thorsten A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter JF - Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt Y1 - 2011 SN - 978-3-18-092121-1 N1 - Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; VDI-Berichte ; 2121 SP - 285 EP - 286 PB - VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Staat, Manfred A1 - Wolters, J A1 - Bongarts, W. A1 - Hennings, W. (u.a.) T1 - Überarbeitete probabilistisch orientierte Sicherheitsanalyse für den HTR-Modul JF - Jahrestagung Kerntechnik '90 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V Y1 - 1990 SP - 143 EP - 146 PB - INFORUM CY - Bonn ER - TY - JOUR A1 - Reißel, Martin T1 - Über die Äquivalenz zweier Transmissionsrandwertprobleme aus der elektromagnetischen Streutheorie JF - ZAMM - Zeitschrift für Angewandte Mathematik und Mechanik. 74 (1994), H. 6 Y1 - 1994 SN - 0044-2267 N1 - Minisymposium 4 SP - T610 EP - T612 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Akbay, S. T1 - Über die Stabilität viskometrischer Strömungen JF - Rheologica acta. 20 (1981), H. 6 Y1 - 1981 SN - 0035-4511 SP - 579 EP - 590 ER - TY - JOUR A1 - Pawelke, Siegfried T1 - Über die Approximationsordnung bei Kugelfunktionen und algebraischen Polynomen JF - Tohoku Mathematical Journal (2) N2 - Für die Approximation stetiger, 2π-periodischer Funktionen auf der reellen Achse durch trigonometrische Polynome wurde ein direkter Satz von D. Jackson 1911 [8] und die Umkehrung von S. N. Bernstein 1912 [1] bewiesen und die Ergebnisse von A. Zygmund [25] 1945 verallgemeinert. 1949 stellte M. Zamansky [25] eine Beziehung zwischen der Approximationsordnung und dem Wachstum bezϋglich n der Ableitungen der Approximationspolynome her; auf die Approximationsordnung für die Ableitungen der Funktion schloβ S. B. Steckin 1951. Die Umkehrung des Ergebnisses von M. Zamansky bewies G. Sunouchi 1968 [21,22], womit die Aquivalenz aller Aussagen gezeigt ist. Die Übertragung der Ergebnisse auf Approximationsoperatoren in Banachräumen stammt von K. Scherer und P. L. Butzer [3, 4], wobei gewisse Voraussetzungen an die Operatorfolge (eine verallgemeinerte Bernsteinsche Ungleichung und eine sogenannte Jacksonsche Ungleichung) gestellt werden. An die Stelle der strukturellen Eigenschaften der Funktion, die durch das Verhalten des Stetigkeitsmoduls der Funktion charakterisiert werden, treten in allgemeinen Banachräumen Eigenschaften des von J. Peetre [17] eingefϋhrten K-Funktionals. In dieser Arbeit wird die Approximation von Funktionen, die auf der Einheitskugel Sᵏ im Rᵏ definiert sind, durch Linearkombinationen von Kugelfunktionen untersucht. Es wird für diesen Fall eine Bernstein-Ungleichung und die Jackson-Ungleichung bewiesen, wenn man die Ableitung durch den Laplace-Operator auf Sᵏ ersetzt. Damit ist der oben zitierte allgemeine Satz von Butzer-Scherer anwendbar. Weiter kann man hier an Stelle des K-Funktionals einen verallgemeinerten Stetigkeitsmodul setzen. Anschlieβend wird der Spezialfall der zonalen Funktionen und ihre Approximation durch algebraische Polynome untersucht. Y1 - 1972 SN - 0040-8735 U6 - http://dx.doi.org/10.2748/tmj/1178241489 VL - 24 IS - 3 SP - 473 EP - 486 PB - Tohoku University CY - Sendai ER - TY - JOUR A1 - Sponagel, Stefan A1 - Akbay, U. T1 - Über den Relaxationseinfluß auf die Stabilität der ebenen Couette-Strömung. Akbay, U. ; Sponagel, S. JF - Rheologica Acta. 23 (1984), H. 2 Y1 - 1984 SN - 0035-4511 SP - 177 EP - 184 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Akbay, U. T1 - Über den Mechanismus der Oberflächeninstabilität viskosimetrischer Strömungen JF - Rheologica Acta. 23 (1984), H. 2 Y1 - 1984 SN - 0035-4511 SP - 185 EP - 188 ER - TY - JOUR A1 - Dietzel, F. A1 - Weber, Hans-Joachim A1 - Porschen, W. A1 - Feinendegen, L. E. T1 - Zur Wärmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor JF - Naturwissenschaften Y1 - 1976 U6 - http://dx.doi.org/10.1007/BF00622808 SN - 0028-1042 VL - 63 IS - 12 SP - 585 EP - 586 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Staat, Manfred A1 - Ballmann, J. T1 - Zur Problematik tensorieller Verallgemeinerungen einachsiger nichtlinearer Materialgesetze JF - Zeitschrift für angewandte Mathematik und Mechanik : ZAMM. 69 (1989), H. 2 Y1 - 1989 SN - 0946-8463 U6 - http://dx.doi.org/10.1515/9783112553169-006 SP - 73 EP - 81 ER - TY - JOUR A1 - Schäfer, Horst T1 - Zur Inhomogenität des inneren Feldes und der Flußdichte von kornorientierten Elektroblechen aus Silizium-Eisen bei Fehlorientierungen in der Blechebene JF - Electrical Engineering (Archiv fur Elektrotechnik). 72 (1989), H. 1 Y1 - 1989 SN - 0948-7921 SP - 51 EP - 57 ER - TY - JOUR A1 - Grüters, Hugo A1 - Müller, Carl Harald T1 - Zur Berechnung der Schubspannungen in Klebverbindungen JF - Automobil-Industrie. 25 (1980), H. 2 Y1 - 1980 SN - 0005-1306 SP - 65 EP - 67 ER - TY - JOUR A1 - Schäfer, Horst A1 - Lampey, H. T1 - Zum Einfluß der Streufeldkopplung auf die magnetischen Eigenschaften und den Wirkungsgrad handelsüblicher Transformatorkerne aus kornorientierten Silizium-Eisen Elektroblechen JF - Electrical Engineering (Archiv fur Elektrotechnik). 72 (1989), H. 6 Y1 - 1989 SN - 0948-7921 SP - 395 EP - 405 ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Halle, M. A1 - Lanzl, I. M. T1 - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse JF - Der Ophthalmologe Y1 - 2009 SN - 1433-0423 VL - 106 IS - 7 SP - 609 EP - 618 PB - - ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Dehnhardt, W. A1 - Mills, J. S. T1 - Yrast cascades in even mass Ce isotopes JF - Bollettino della Società Italiana di Fisica Y1 - 1974 SN - 0037-8801 VL - 1974 SP - 85 PB - Zanichelli CY - Bologna ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Dehnhardt, W. A1 - Mills, J. S. A1 - Neumann, U. T1 - Yrast cascades in even mass Ce isotopes JF - Nuclear physics A N2 - The isotopes ¹³⁰,¹³²,¹³⁴,¹³⁶ Ce are investigated by means of the reactions ¹¹⁸,¹²⁰,¹²²,¹²⁴ Sn(¹⁶O, 4n) at bombarding energies between 68 and 76 MeV. From lifetime measurements a reduction of the collective behaviour is observed with increasing neutron number. Yrast cascades of rotational structure are identified up to angular momenta I=16⁺ or I=18⁺ in ¹³⁰,¹³²,¹³⁴ Ce. These cascades show a strong “back-bending” effect. In ¹³⁶ Ce no such simple yrast cascade could be found. Y1 - 1974 SN - 0375-9474 U6 - http://dx.doi.org/10.1016/0375-9474(74)90361-3 VL - 225 IS - 1 SP - 1 EP - 15 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Akimbekov, Nuraly Shardarbekovich A1 - Mansurov, Zulkhair A1 - Jandosov, J. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. T1 - Wound healing activity of carbonized rice husk N2 - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls. KW - Wundheilung KW - Epithel KW - Fibroblast KW - carbonized rice husk KW - wound healing KW - epithelization KW - human dermal fibroblasts Y1 - 2013 PB - Trans Tech Publications, Switzerland CY - Bäch ER - TY - JOUR A1 - Doll, T. A1 - Scharnagl, K. A1 - Winter, R. A1 - Bögner, M. A1 - Eisele, I. A1 - Ostrik, B. A1 - Schöning, Michael Josef T1 - Work function gas sensors - reference layers and signal analysis JF - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1 Y1 - 1998 SN - 0-7503-0595-9 N1 - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton) SP - 143 EP - 146 PB - Inst. of Physics Publ. CY - Bristol [u.a.] ER - TY - JOUR A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Wind and fairness in ski jumping: A computer modelling analysis JF - Journal of Biomechanics N2 - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.jbiomech.2018.05.001 SN - 0021-9290 IS - 75 SP - 147 EP - 153 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Laack, Walter van T1 - Why natural constants are as they are JF - British journal of arts and social sciences Y1 - 2013 SN - 2046-9578 (E-Journal) VL - Vol. 15 IS - Nr. 2 SP - 198 EP - 203 PB - BritishJournal Publ. Inc CY - London ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayser, Peter T1 - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ; Kayser, Peter JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 497 EP - 508 PB - Springer CY - Berlin ER - TY - JOUR A1 - Schmidt, Daniela A1 - Langen, Karl-J. A1 - Herzog, Hans A1 - Wirths, Jochen A1 - Holschbach, Markus A1 - Kiwit, Jürgen C. W. A1 - Ziemons, Karl A1 - Coenen, Heinz-H. A1 - Müller-Gärtner, Hans-W. T1 - Whole-body kinetics and dosimetry of L-3[123I]-iodo-α-methyltyrosine JF - European Journal of Nuclear Medicine Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1162 EP - 1166 ER - TY - JOUR A1 - Malzahn, Kerstin A1 - Windmiller, Joshua Ray A1 - Valdés-Ramírez, Gabriela A1 - Wang, Joseph A1 - Schöning, Michael Josef T1 - Wearable electrochemical sensors for in situ analysis in marine environments JF - Analyst. 136 (2011), H. 14 Y1 - 2011 SN - 0003-2654 SP - 2912 EP - 2917 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Pawelke, Siegfried T1 - Weak smoothness conditions for the uniform convergence of Fourier-Jacobi series JF - Functiones et Approximatio. Commentarii Mathematici. 9 (1980) Y1 - 1980 SN - 0208-6573 N1 - Zentralblatt MATH: http://www.emis.de/MATH-item?0471.42018 SP - 9 EP - 13 ER - TY - JOUR A1 - Dikta, Gerhard T1 - Weak Representation of the Cumulative Hazard Function under Semiparametric Random Censorship Models JF - Statistics. 35 (2001), H. 4 Y1 - 2001 SN - 0233-1888 SP - 395 EP - 410 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Haenni, D. R. A1 - Beuscher, H. A1 - Lieder, R. M. T1 - Weak coupling and high-spin states in ¹⁴⁵ Eu JF - Nuclear physics / A. 331 (1979), H. 1 Y1 - 1979 SN - 0375-9474 SP - 141 EP - 154 ER - TY - JOUR A1 - Staat, Manfred A1 - Ballmann, J. T1 - Wave Propagation and Focussing in Plates JF - Impact loading and dynamic behaviour of materials : Papers presented at the International Conference on Impact Loading and Dynamic Behaviour of Materials, Vol. 2 / Chiem, C. Y.; Kunze, L. (u.a.) [eds] Y1 - 1988 PB - DGM Informationsges. CY - Oberursel ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Schöning, Michael Josef T1 - Voltohmmetry – An alternative detection principle at ultrathin metal electrodes in solution JF - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler Y1 - 2001 SN - 1-56677-351-2 N1 - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.) SP - 1 EP - 3 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Hüllenkremer, B. A1 - Glück, O. A1 - Lüth, H. A1 - Emons, H. T1 - Voltohmmetry – a novel sensing principle for heavy metal determination in aqueous solutions JF - Sensors and Actuators B. 78 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 275 EP - 280 ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Hüllenkremer, B. A1 - Schöning, Michael Josef T1 - Voltohmmetry as an alternative detection method at polycrystalline metal film electrodes JF - Electroanalysis. 13 (2001), H. 8-9 Y1 - 2001 SN - 1040-0397 SP - 677 EP - 680 ER - TY - JOUR A1 - Hüllenkremer, B. A1 - Glück, O. A1 - Emons, H. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Voltohmmetrie an polykristallinen Goldelektroden JF - Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. März 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik Y1 - 2000 SN - 3-18-091530-7 N1 - VDI-Berichte; 1530 SP - 45 EP - 54 PB - VDI-Verl. CY - Düsseldorf: ER - TY - JOUR A1 - Emons, H. A1 - Baade, A. A1 - Schöning, Michael Josef T1 - Voltammetric determination of heavy metals in microvolumes of rain water JF - Electroanalysis. 12 (2000), H. 15 Y1 - 2000 SN - 1040-0397 SP - 1171 EP - 1176 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zang, Werner T1 - Vollautomatische Messung rheologischer Parameter roter Blutzellen JF - Biomedizinische Technik / Biomedical Engineering Y1 - 1990 SN - 0013-5585 VL - 35 IS - S3 SP - 94 EP - 96 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Lutfor, Afzalunnessa B. A1 - Razzaque, Mohammed S. T1 - Vitamin D and the Host-Gut Microbiome: A Brief Overview JF - Acta Histochemica et Cytochemica N2 - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression. Y1 - 2020 U6 - http://dx.doi.org/10.1267/ahc.20011 SN - 1347-5800 VL - 53 IS - 3 SP - 33 EP - 42 PB - Japan Society of Histochemistry and Cytochemistry CY - Osaka ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yu, Bing A1 - Isoda, Hiroko A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.snb.2016.04.018 SN - 0925-4005 VL - 236 SP - 965 EP - 969 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Hirayama, Yuji A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of enzymatic reaction in a microfluidic channel using chemical imaging sensor JF - Electrochimica acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) SP - Publ. online PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Bing, Yu A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor JF - Procedia Engineering N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.806 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 936 EP - 939 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kraft, Bodo A1 - Nagl, Manfred T1 - Visual Knowledge Specification for Conceptual Design: Definition and Tool Support N2 - In: Advanced Engineering Informatics. Vol 21, Issue 1, 2007, Pages 67-83 http://dx.doi.org/10.1016/j.aei.2006.10.001 eds. J.C. Kunz, I.F.C. Smith and T. Tomiyama, Elsevier, Seite 1-22 Current CAD tools are not able to support the conceptual design phase, and none of them provides a consistency analysis for sketches produced by architects. This phase is fundamental and crucial for the whole design and construction process of a building. To give architects a better support, we developed a CAD tool for conceptual design and a knowledge specification tool. The knowledge is specific to one class of buildings and it can be reused. Based on a dynamic and domain-specific knowledge ontology, different types of design rules formalize this knowledge in a graph-based form. An expressive visual language provides a user-friendly, human readable representation. Finally, a consistency analysis tool enables conceptual designs to be checked against this formal conceptual knowledge. In this article, we concentrate on the knowledge specification part. For that, we introduce the concepts and usage of a novel visual language and describe its semantics. To demonstrate the usability of our approach, two graph-based visual tools for knowledge specification and conceptual design are explained. KW - CAD KW - CAD KW - Bauingenieurwesen KW - CAD KW - civil engineering Y1 - 2007 ER - TY - JOUR A1 - Ullrich, Sebastian A1 - Grottke, Oliver A1 - Rossaint, Rolf A1 - Staat, Manfred A1 - Deserno, Thomas M. A1 - Kuhlen, Torsten T1 - Virtual Needle Simulation with Haptics for Regional Anaesthesia Y1 - 2010 N1 - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010 SP - 1 EP - 3 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Virgin passive colon biomechanics and a literature review of active contraction constitutive models JF - Biomechanics N2 - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine. KW - virgin passive KW - strain energy function KW - smooth muscle contraction KW - viscoelasticity KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/biomechanics2020013 SN - 2673-7078 VL - 2 IS - 2 SP - 138 EP - 157 PB - MDPI CY - Basel ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen bei verschiedenen Versagensmoden Y1 - 1991 N1 - 17. MPA-Seminar : Sicherheit und Verfügbarkeit in der Anlagentechnik mit dem Schwerpunkt Kerntechnik, Stuttgart (1991), 22.1-22.20 ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen JF - Jahrestagung Kerntechnik '91 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V Y1 - 1991 SP - 123 EP - 126 PB - INFORUM CY - Bonn ER - TY - JOUR A1 - Weber, Hans-Joachim T1 - Verbundforschungsprojekt Multimediale 3D-Visualisierung der Herzmuskelerregung JF - Intelligente, innovative Produktentwicklung für die industrielle Praxis. Stenzel, Horst [Hrsg.] Y1 - 2001 N1 - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen SP - 99 EP - 112 PB - Forschungverbund Multimedia an Fachhochschulen CY - Köln ER - TY - JOUR A1 - Conzen, Catharina A1 - Albanna, Walid A1 - Weiss, Miriam A1 - Kürten, David A1 - Vilser, Walthard A1 - Kotliar, Konstantin A1 - Zäske, Charlotte A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes JF - Translational Stroke Research N2 - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s12975-017-0585-8 SN - 1868-601X IS - 9 SP - 284 EP - 293 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines T1 - Vaskuläre Biomarker der retinalen Gefäβanalyse T1 - Vascular Biomarkers in Retinal Vessel Analysis JF - Klinische Monatsblätter fur Augenheilkunde N2 - Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gefäßveränderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gefäße beeinflussen im prä-, post- und kapillaren Bereich den Blutfluss und strömungsbedingte Stoffwechselverhältnisse passiv und aktiv über den Gefäßdurchmesser. Retinale Gefäße gleichen von Aufbau und Funktion den zerebralen Gefäßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gefäßweiten berechneten Biomarkern soll eine Aussage über die Prognose von systemischen vaskulär bedingten Erkrankungen getroffen werden. Die statische retinale Gefäßanalyse befasst sich mit der Untersuchung des Zustandes der prä- und postkapillaren Gefäßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gefäßanalyse wird der Längsschnitt eines retinalen Gefäßes nicht invasiv funktionell und strukturell über einen Zeitraum vor, während und nach einer spezifischen vaskulären Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ansätzen. Mittels retinaler Gefäßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gynäkologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgeführt. Mit der statischen retinalen Gefäßanalyse steht eine kostengünstige, reproduzierbare, nicht invasive Screeningtechnik zur Verfügung, um eine prognostische Aussage über die Gefäßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gefäßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gefäße zeitkontinuierlich untersucht. Die Evaluation vaskulärer Erkrankungen sowie zerebro- bzw. kardiovaskulärer Morbidität und Mortalität mittels mehrerer methodologischer Modalitäten retinaler Gefäßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftsträchtige diagnostische Perspektive. Die interdisziplinäre klinische Anwendung dieser vaskulären Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten. Y1 - 2018 U6 - http://dx.doi.org/10.1055/a-0774-7987 SN - 0023-2165 VL - 235 IS - 12 SP - 1352 EP - 1359 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Artmann, Gerhard A1 - Teitel, P. A1 - Schmid-Schönbein, H. T1 - Variable rheologische Antwort der Erythrozyten auf den Einfluß von Xantinderivaten (Coffein): Experimentelle Differenzierung von "Responders" und "Nonresponders" JF - 11. Jahrestagung der Gesellschaft für Mikrozirkulation Y1 - 1987 SP - 100 EP - 105 PB - Karger [u.a.] CY - Basel [u.a.] ER - TY - JOUR A1 - Ziemons, Karl A1 - Heinrichs, U. A1 - Streun, M. A1 - Pietrzyk, U. T1 - Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype JF - 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5 N2 - The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6% in axial direction and 3.6% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry. Y1 - 2004 SN - 1082-3654 SP - 3053 EP - 3056 ER - TY - JOUR A1 - Müller, Martin A1 - Hirschfeld, Julian A1 - Lambertz, Rita A1 - Schulze Lohoff, Andreas A1 - Lustfeld, Hans A1 - Pfeifer, Heinz A1 - Reißel, Martin T1 - Validation of a novel method for detecting and stabilizing malfunctioning areas in fuel cell stacks JF - Journal of power sources N2 - In this paper a setup for detecting malfunctioning areas of MEAs in fuel cell stacks is described. Malfunctioning areas generate electric cross currents inside bipolar plates. To exploit this we suggest bipolar plates consisting not of two but of three layers. The third one is a highly conducting layer and segmented such that the cross currents move along the segments to the surface of the stack where they can be measured by an inductive sensor. With this information a realistic model can be used to detect the malfunctioning area. Furthermore the third layer will prevent any current inhomogeneity of a malfunctioning cell to spread to neighbouring cells in the stack. In this work the results of measurements in a realistic cell setup will be compared with the results obtained in simulation studies with the same configuration. The basis for the comparison is the reliable characterisation of the electrical properties of the cell components and the implication of these results into the simulation model. The experimental studies will also show the limits in the maximum number of segments, which can be used for a reliable detection of cross currents. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.jpowsour.2014.08.045 SN - 1873-2755 (E-Journal); 0378-7753 (Print) VL - 272 SP - 225 EP - 232 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Y1 - 2011 U6 - http://dx.doi.org/10.1166/sl.2011.1620 VL - 9 IS - 2 SP - 812 EP - 815 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Zange, Jochen A1 - Schopen, Kathrin A1 - Albracht, Kirsten A1 - Gerlach, Darius A. A1 - Frings-Meuthen, Petra A1 - Maffiuletti, Nicola A. A1 - Bloch, Wilhelm A1 - Rittweger, Jörn T1 - Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial JF - Plos one Y1 - 2017 U6 - http://dx.doi.org/10.1371/journal.pone.0171562 VL - 12 IS - 2 ER - TY - JOUR A1 - Bohrn, Ulrich A1 - Stütz, Evamaria A1 - Fleischer, Maximilian A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Using a cell-based gas biosensor for investigation of adverse effects of acetone vapors in vitro JF - Biosensors and Bioelectronics. 40 (2013), H. 1 Y1 - 2013 SN - 0956-5663 SP - 393 EP - 400 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Garhofer, Gerhard A1 - Bek, Toke A1 - Boehm, Andreas G. A1 - Gherghel, Doina A1 - Grundwald, Juan A1 - Jeppesen, Peter A1 - Kergoat, Hélène A1 - Kotliar, Konstantin A1 - Lanzl, Ines A1 - Lovasik, John V. A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Orgul, Selim A1 - Schmetterer, Leopold T1 - Use of the retinal vessel analyzer in ocular blood flow research JF - Acta Ophthalmol N2 - The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed. Y1 - 2010 U6 - http://dx.doi.org/10.1111/j.1755-3768.2009.01587.x SN - 1755-3768 VL - 88 IS - 7 SP - 717 EP - 722 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Maki, Rafael M. A1 - Paulovich, Fernando V. A1 - Werner, Frederik A1 - Poghossian, Arshak A1 - Oliveira, Maria C. F. de A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor JF - Analytical Chemistry (2010) Y1 - 2010 SN - 0003-2700 SP - 61 EP - 65 ER - TY - JOUR A1 - Akimbekov, N. Sh. A1 - Zhubanova, A. A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Use of Carbonized Rise Shell for the local treatment of wounds JF - Eurasian ChemTech Journal N2 - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis. Y1 - 2010 U6 - http://dx.doi.org/10.18321/ectj35 SN - 2522-4867 VL - 12 IS - 2 SP - 133 EP - 138 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Digel, Ilya A1 - Akimbekov, N. A1 - Turalieva, M. A1 - Mansurov, Z. A1 - Temiz Artmann, Aysegül A1 - Eshibaev, A. A1 - Zhubanova, A. T1 - Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions JF - Journal of Industrial Technology and Engineering Y1 - 2013 VL - 2 IS - 07 SP - 47 EP - 54 ER - TY - JOUR A1 - Seifarth, Volker A1 - Schehl, D. A1 - Linder, Peter A1 - Gossmann, Matthias A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Porst, Dariusz A1 - Preiß, C. A1 - Kayser, Peter A1 - Pack, O. A1 - Temiz Artmann, Aysegül T1 - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds N2 - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days. KW - Tissue Engineering KW - Bioreaktor KW - Organkultur KW - Harnleiter Y1 - 2011 ER - TY - JOUR A1 - Tran, Thanh Ngoc A1 - Kreißig, R. A1 - Vu, Duc Khoi A1 - Staat, Manfred T1 - Upper bound limit and shakedown analysis of shells using the exact Ilyushin yield surface JF - Computer & Structures. 86 (2008) Y1 - 2008 SN - 0045-7949 SP - 1683 EP - 1695 ER - TY - JOUR A1 - Laack, Walter van T1 - Untersuchungen über die Druckverteilung durch Schienbeinschoner im Fußballsport JF - Deutsche Zeitschrift für Sportmedizin. 36 (1985), H. 7 Y1 - 1985 SN - 0371-3059 SP - 203 EP - 208 ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Beuscher, H. A1 - Davidson, W. F. A1 - Lieder, R. M. T1 - Untersuchungen des Backbendingeffektes in der Os-Gegend JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. (VI) 10 (1975) Y1 - 1975 N1 - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1975 = 6.R.10 ; SP - 853 PB - Physik-Verlag CY - Weinheim ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Dehnhardt, W. A1 - Mills, J. S. T1 - Untersuchung von Yrast-Kaskaden in geraden Ce-Isotopen JF - Jahresbericht / Max-Planck-Institut für Kernphysik Y1 - 1973 SP - 83 PB - MPI CY - Heidelberg ER - TY - JOUR A1 - Keutmann, Sabine A1 - Staat, Manfred A1 - Laack, Walter van T1 - Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall N2 - Zusammenfassung: In der Orthopädie zählt der therapeutische Ultraschall als Mittel zur Prävention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen Körper. Um mehr Erkenntnisse über die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgeführt. Dabei entstand eine signifikante Erwärmung des Gewebes, welche beim Probandenversuch an der Oberfläche und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test. T2 - Research about the thermal effects of therapeutic ultrasound Y1 - 2018 SN - 2193-5793 SN - 2193-5785 (Druckausgabe) VL - 7 IS - 10 SP - 518 EP - 522 PB - Deutscher Ärzte-Verl. CY - Köln ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Jannsens, R. A1 - Masri, Y. El. A1 - Michel, C. T1 - Untersuchung der Hochspinzustände in ¹⁷⁸,¹⁸⁰ Os JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976) Y1 - 1976 N1 - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1976=6.R.11,8 SP - 950 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wendler, Martin A1 - Lehnertz, Klaus T1 - Unraveling spurious properties of interaction networks with tailored random networks JF - Plos one N2 - We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erdös-Rényi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures – known for their complex spatial and temporal dynamics – we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis. Y1 - 2011 U6 - http://dx.doi.org/10.1371/journal.pone.0022826 VL - 6 IS - 8 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Stulpe, Werner T1 - Unitary Operator JF - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed. Y1 - 2009 SN - 978-3-540-70622-9 SP - 807 EP - 809 PB - Springer CY - Berlin ER - TY - JOUR A1 - Reißel, Martin A1 - Lustfeld, H. A1 - Hirschfeld, J. A1 - Steffen, B. T1 - Uniqueness of magnetotomography for fuel cells and fuel cell stacks / Lustfeld, H. ; Hirschfeld, J. ; Reißel, M ; Steffen, B. JF - Journal of Physics A: Mathematical and Theoretical. 42 (2009), H. 495205 Y1 - 2009 SN - 0022-3689 SP - 9 S. ER - TY - JOUR A1 - Schäfer, Horst A1 - Worschech, L. A1 - Ossau, W. A1 - Landwehr, G. T1 - Uniaxiale und planare Verspannung von Störstellenkomplexen in ZnSe/GaAs Schichten Y1 - 1997 N1 - Als Poster vorgelegt auf der Frühjahrstagung der DPG in Münster, 17.-21. März 1997, Verhandl. DPG (VI) 32, HL 11.51 / Physikalisches Institut der Universität Würzburg. ER - TY - JOUR A1 - Seynnes, O. R. A1 - Bojsen-Moller, J. A1 - Albracht, Kirsten A1 - Arndt, A. A1 - Cronin, N. J. A1 - Finni, T. A1 - Magnusson, S. P. T1 - Ultrasound-based testing of tendon mechanical properties: a critical evaluation JF - Journal of Applied Physiology Y1 - 2015 U6 - http://dx.doi.org/10.1152/japplphysiol.00849.2014 SN - 8750-7587 VL - 118 IS - 2 SP - 133 EP - 141 ER - TY - JOUR A1 - Laack, Walter van A1 - Albrecht, T. A1 - Casser, H. R. T1 - Ultraschalltherapie in der Praxis JF - Physikalische Therapie in Theorie und Praxis Y1 - 1987 SN - 0178-9201 VL - 8 IS - 10 SP - 628 EP - 631 ER - TY - JOUR A1 - Laack, Walter van A1 - Albrecht, T. T1 - Ultraschalltherapie in der Praxis JF - ZFA - Zeitschrift für Allgemeinmedizin Y1 - 1987 SN - 0341-9835 VL - 63 IS - 19 SP - 605 EP - 608 ER - TY - JOUR A1 - Schäfer, Horst A1 - Scholl, S. A1 - Waag, A. A1 - Hommel, D. (u.a.) T1 - Two-dimensional Shubnikov–de Haas oscillations in modulation-doped CdTe/CdMnTe quantum-well structures JF - Applied Physics Letters. 62 (1993), H. 23 Y1 - 1993 SP - 3010 EP - 3012 ER - TY - JOUR A1 - Näther, Niko A1 - Rolka, David A1 - Poghossian, Arshak A1 - Koudelka-Hep, M. A1 - Schöning, Michael Josef T1 - Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors JF - Electrochimica Acta. 51 (2005), H. 5 Y1 - 2005 SN - 0013-4686 U6 - http://dx.doi.org/10.1016/j.electacta.2005.04.066 SP - 924 EP - 929 ER - TY - JOUR A1 - Streun, M. A1 - Chavan, U. A1 - Lame, H. A1 - Parl, C. A1 - Müller-Veggian, Mattea A1 - Ziemons, Karl T1 - Treating the Gain Non-Uniformity of Multi Channel PMTs by Channel-Specific Trigger Levels JF - 2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2. Y1 - 2006 SN - 1082-3654 SP - 1301 EP - 1304 CY - San Diego, CA ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia K. A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Transport through Redox-Active Ru-Terpyridine Complexes Integrated in Single Nanoparticle Devices JF - The Journal of Physical Chemistry C N2 - Transition metal complexes are electrofunctional molecules due to their high conductivity and their intrinsic switching ability involving a metal-to-ligand charge transfer. Here, a method is presented to contact reliably a few to single redox-active Ru-terpyridine complexes in a CMOS compatible nanodevice and preserve their electrical functionality. Using hybrid materials from 14 nm gold nanoparticles (AuNP) and bis-{4′-[4-(mercaptophenyl)-2,2′:6′,2″-terpyridine]}-ruthenium(II) complexes a device size of 30² nm² inclusive nanoelectrodes is achieved. Moreover, this method bears the opportunity for further downscaling. The Ru-complex AuNP devices show symmetric and asymmetric current versus voltage curves with a hysteretic characteristic in two well separated conductance ranges. By theoretical approximations based on the single-channel Landauer model, the charge transport through the formed double-barrier tunnel junction is thoroughly analyzed and its sensibility to the molecule/metal contact is revealed. It can be verified that tunneling transport through the HOMO is the main transport mechanism while decoherent hopping transport is present to a minor extent. Y1 - 2020 U6 - http://dx.doi.org/10.1021/acs.jpcc.9b11716 SN - 1932-7455 VL - 124 IS - 8 SP - 4881 EP - 4889 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Janus, Kevin Alexander A1 - Achtsnicht, Stefan A1 - Drinic, Aleksander A1 - Kopp, Alexander A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Transient magnesium-based thin-film temperature sensor on a flexible, bioabsorbable substrate for future medical applications JF - Applied Research N2 - In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin-film magnesium-based meander-like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium-based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue-like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium-based layers. The 3-layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C. KW - Silk fibroin KW - Polylactide acid KW - Bioabsorbable KW - Resistive temperature detector Y1 - 2023 U6 - http://dx.doi.org/10.1002/appl.202300102 SN - 2702-4288 (Print) N1 - Corresponding author: Michael Josef Schöning IS - Accepted manuscript PB - Wiley-VCH ER - TY - JOUR A1 - Reißel, Martin A1 - Bitsch, G. A1 - Mawick, G. A1 - Tokar, G. T1 - Transient FEM Simulation of a Door Closing Process and Application to Fatigue / Bitsch, G. ; Mawick, G. ; Reißel, M. ; Tokar, G. JF - Proceedings of the 20. CAD-FEM Users Meeting, 2002 Y1 - 2002 N1 - 2.11.10 SP - 1 EP - 8 ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Cronin, Neil J. A1 - Albracht, Kirsten A1 - Paulsen, Gøran A1 - Larsen, Askild V. A1 - Bojsen-Møller, Jens A1 - Seynnes, Olivier R. T1 - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running JF - PeerJ N2 - Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics. Results Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training. Discussion These results show that a training-induced increase in Achilles tendon stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running. KW - Achilles tendon KW - Stiffness KW - Running KW - Tendon properties KW - Architectural gear ratio Y1 - 2019 U6 - http://dx.doi.org/10.7717/peerj.6764 SN - 21678359 PB - Peer CY - London ER - TY - JOUR A1 - Staat, Manfred A1 - Heitzer, M. T1 - Traglastanalyse - ein strukturmechanisches Verfahren zur Beurteilung von gerissenen Bauteilen und Verbindungen JF - Festigkeits- und Bruchverhalten von Fügeverbindungen : 32. Tagung des DVM-Arbeitskreises Bruchvorgänge ; 22. und 23. Februar 2000 in Berlin / Richard, H. A. [Hrsg] Y1 - 2000 N1 - DVM-Bericht 232 SP - 183 EP - 192 PB - Deutscher Verband für Materialforschung und -prüfung CY - Berlin ER - TY - JOUR A1 - Sander, Volker A1 - Fidler, Markus A1 - Klimala, Wojciech T1 - Traffic shaping in aggregate-based networks: implementation and analysis / Fidler, Markus ; Sander, Volker ; Klimala, Wojciech JF - Computer Communications. 28 (2005), H. 3 Y1 - 2005 SN - 0140-3664 SP - 274 EP - 286 ER - TY - JOUR A1 - Gun, Jenny A1 - Gutkin, Vitaly A1 - Lev, Ovadia A1 - Boyen, Hans-Gerd A1 - Saitner, Marc A1 - Wagner, Patrick A1 - Olieslaeger, Marc D´ A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices JF - Journal of Physical Chemistry C. 115 (2011), H. 11 Y1 - 2011 SN - 1932-7455 SP - 4439 EP - 4445 PB - American Cemical Society CY - Washington, DC ER - TY - JOUR A1 - Glück, O. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Emons, H. A1 - Hanewinkel, C. A1 - Schumacher, D. A1 - Otto, A. T1 - Trace metal determination with gold microelectrodes fabricated by silicon technology JF - Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2. Y1 - 1997 SN - 83-908335-0-6 N1 - Eurosensors ; (11, 1997, Warszawa) ; Eurosensors - European Conference on Solid-State Transducers ; (11 : ; 1997.09.21-24 : ; Warsaw) SP - 615 EP - 618 PB - Sensor Lab Sp. CY - Warsaw ER - TY - JOUR A1 - Glück, O. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Otto, A. A1 - Emons, H. T1 - Trace metal determination by dc resistance changes of microstructured thin gold film electrodes JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3761 EP - 3768 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Nicolai, Mike A1 - Probst, Markus T1 - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM JF - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.) Y1 - 2008 SN - 978-3-9810843-5-1 N1 - NIC series ; 39 SP - 325 EP - 332 PB - Forschungszentrum CY - Jülich ER - TY - JOUR A1 - Poghossian, Arshak A1 - Platen, J. A1 - Schöning, Michael Josef T1 - Towards self-aligned nanostructures by means of layerexpansion technique JF - Electrochimica Acta. 51 (2005), H. 5 Y1 - 2005 SN - 0013-4686 SP - 838 EP - 843 ER - TY - JOUR A1 - Breuer, Lars A1 - Pilas, Johanna A1 - Guthmann, Eric A1 - Schöning, Michael Josef A1 - Thoelen, Ronald A1 - Wagner, Torsten T1 - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels JF - Sensor and Actuators B: Chemical Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.snb.2019.02.086 SN - 0925-4005 VL - 288 SP - 579 EP - 585 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Ingebrandt, Sven A1 - Platen, Johannes A1 - Offenhäusser, Andreas A1 - Poghossian, Arshak ED - Comini, Elisabetta T1 - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 IS - paper 0915-R05-04 SP - 89 EP - 94 ER - TY - JOUR A1 - Molinnus, Denise A1 - Sorich, Maren A1 - Bartz, Alexander A1 - Siegert, Petra A1 - Willenberg, Holger S. A1 - Lisdat, Fred A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate JF - Sensors and Actuators B: Chemical N2 - An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer’s solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.snb.2016.06.064 SN - 0925-4005 VL - 237 SP - 190 EP - 195 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Berretz, F. A1 - Skorupa, S. A1 - Sander, Volker A1 - Belloum, A. T1 - Towards an actor-driven workflow management system for grids JF - International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE Y1 - 2010 SN - 978-1-4244-6619-1 SP - 611 EP - 616 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Poghossian, Arshak A1 - Werner, Frederik A1 - Buniatyan, V. V. A1 - Wagner, Torsten A1 - Miamoto, K. A1 - Yoshinobu, T. A1 - Schöning, Michael Josef T1 - Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk JF - Sensor and Actuators B: Chemical N2 - The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems. Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.snb.2017.01.047 SN - 0925-4005 IS - 244 SP - 1071 EP - 1079 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Suso, Henri-Pierre A1 - Rysstad, Gunnar A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes JF - Physica status solidi (a) N2 - A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests. KW - calorimetric gas sensor;hydrogen peroxide;wireless sensor system Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200920 SN - 1862-6319 VL - 210 IS - 5 SP - 877 EP - 883 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, S. A1 - Sander, Volker A1 - Pfeiffer, P. A1 - Belloum, A. T1 - Towards a security framework for a WS-HumanTask processor JF - 7th International Conference on Network and Service Management (CNSM), 2011 Paris Y1 - 2011 SN - 978-3-901882-44-9 SP - 1 EP - 5 PB - IEEE CY - New York ER - TY - JOUR A1 - Reisert, Steffen A1 - Geissler, Hanno A1 - Flörke, Rudolf A1 - Näther, Niko A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2) JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1351 EP - 1356 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Molinnus, Denise A1 - Drinic, Aleksander A1 - Iken, Heiko A1 - Kröger, Nadja A1 - Zinser, Max A1 - Smeets, Ralf A1 - Köpf, Marius A1 - Kopp, Alexander A1 - Schöning, Michael Josef T1 - Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk JF - Biosensors and Bioelectronics Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.bios.2021.113204 SN - 0956-5663 VL - 183 IS - Art. 113204 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Arzdorf, M. A1 - Mulchandani, P. A1 - Chen, W. A1 - Mulchandani, A. T1 - Towards a capacitive enzyme sensor for direct determination of organophosphorus pesticides: Fundamentals studies and aspects of development JF - Sensors. 3 (2003), H. 6 Y1 - 2003 SN - 1424-8220 SP - 119 EP - 127 ER - TY - JOUR A1 - Oberländer, Jan A1 - Bromm, Alexander A1 - Wendeler, Luisa A1 - Iken, Heiko A1 - Palomar Duran, Marlena A1 - Greeff, Anton A1 - Kirchner, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines JF - Physica status solidi (a) N2 - Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected. Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431900 SN - 1862-6319 VL - 212 IS - 6 SP - 1299 EP - 1305 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Arreola, Julio A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Toward an immobilization method for spore-based biosensors in oxidative environment JF - Electrochimica Acta Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.electacta.2019.01.148 VL - 302 SP - 394 EP - 401 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Dahmen, Markus A1 - Keusgen, Michael A1 - Selmer, Thorsten A1 - Schöning, Michael Josef T1 - Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes JF - Frontiers in Chemistry N2 - Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes. Y1 - 2018 U6 - http://dx.doi.org/10.3389/fchem.2018.00284 IS - 6 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Hirschfeld, J. A. A1 - Lustfeld, H. A1 - Reißel, Martin A1 - Steffen, B. T1 - Tomographic diagnostics of current distributions in a fuel cell stack JF - International Journal of Energy Research Y1 - 2010 SN - 0363-907X VL - 34 IS - 3 SP - 284 EP - 292 ER -