TY  - JOUR
A1  - Stulpe, Werner
A1  - Singer, Matthias
T1  - Informational Incompleteness of the Observables Sx,Sy,Sz for Spin-1 Systems. Singer, Matthias; Stulpe, W.
JF  - Foundations of Physics. 20 (1990), H. 4
Y1  - 1990
SN  - 1572-9516
SP  - 471
EP  - 472
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Singer, Matthias
T1  - Some Remarks on the Determination of Quantum States by Measurements
JF  - Foundations of Physics Letters. 3 (1990), H. 2
Y1  - 1990
SN  - 1572-9524
SP  - 153
EP  - 166
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Singer, Matthias
T1  - Phase-Space Representations of General Statistical Physical Theories. Singer, Matthias; Stulpe, Werner
JF  - Journal of Mathematical Physics. 33 (1992), H. 1
Y1  - 1992
SN  - 1089-7658
SP  - 131
EP  - 142
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Swat, Maciej
T1  - Quantum States as Probability Measures
JF  - Foundations of Physics Letters. 14 (2001), H. 3
Y1  - 2001
SN  - 1572-9524
SP  - 285
EP  - 293
ER  - 
TY  - JOUR
A1  - Stäudle, Benjamin
A1  - Seynnes, Olivier
A1  - Laps, Guido
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Altered gastrocnemius contractile behavior in former achilles tendon rupture patients during walking
JF  - Frontiers in Physiology
N2  - Achilles tendon rupture (ATR) remains associated with functional limitations years after injury. Architectural remodeling of the gastrocnemius medialis (GM) muscle is typically observed in the affected leg and may compensate force deficits caused by a longer tendon. Yet patients seem to retain functional limitations during—low-force—walking gait. To explore the potential limits imposed by the remodeled GM muscle-tendon unit (MTU) on walking gait, we examined the contractile behavior of muscle fascicles during the stance phase. In a cross-sectional design, we studied nine former patients (males; age: 45 ± 9 years; height: 180 ± 7 cm; weight: 83 ± 6 kg) with a history of complete unilateral ATR, approximately 4 years post-surgery. Using ultrasonography, GM tendon morphology, muscle architecture at rest, and fascicular behavior were assessed during walking at 1.5 m⋅s–1 on a treadmill. Walking patterns were recorded with a motion capture system. The unaffected leg served as control. Lower limbs kinematics were largely similar between legs during walking. Typical features of ATR-related MTU remodeling were observed during the stance sub-phases corresponding to series elastic element (SEE) lengthening (energy storage) and SEE shortening (energy release), with shorter GM fascicles (36 and 36%, respectively) and greater pennation angles (8° and 12°, respectively). However, relative to the optimal fascicle length for force production, fascicles operated at comparable length in both legs. Similarly, when expressed relative to optimal fascicle length, fascicle contraction velocity was not different between sides, except at the time-point of peak series elastic element (SEE) length, where it was 39 ± 49% lower in the affected leg. Concomitantly, fascicles rotation during contraction was greater in the affected leg during the whole stance-phase, and architectural gear ratios (AGR) was larger during SEE lengthening. Under the present testing conditions, former ATR patients had recovered a relatively symmetrical walking gait pattern. Differences in seen AGR seem to accommodate the profound changes in MTU architecture, limiting the required fascicle shortening velocity. Overall, the contractile behavior of the GM fascicles does not restrict length- or velocity-dependent force potentials during this locomotor task.
KW  - tendon rupture
KW  - muscle fascicle behavior
KW  - walking gait
KW  - force generation
KW  - ultrasound imaging
Y1  - 2022
U6  - https://doi.org/10.3389/fphys.2022.792576
SN  - 1664-042X
VL  - 13
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Stäudle, Benjamin
A1  - Seynnes, Olivier
A1  - Laps, Guido
A1  - Göll, Fabian
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Recovery from achilles tendon repair: a combination of Postsurgery Outcomes and Insufficient remodeling of muscle and tendon
JF  - Medicine & Science in Sports & Exercise
N2  - Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle–tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force–length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force–length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13% ± 10%, 105% ± 28%, and 54% ± 24%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32% ± 12%) and with greater pennation angles (31% ± 26%). A mean deficit in plantarflexion moment of 31% ± 10% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.
KW  - Tendon Rupture
KW  - Stiffness
KW  - Simulation
KW  - Muscle Force
KW  - Muscle Fascicle
Y1  - 2021
U6  - https://doi.org/10.1249/MSS.0000000000002592
SN  - 1530-0315
VL  - 53
IS  - 7
SP  - 1356
EP  - 1366
PB  - American College of Sports Medicine
CY  - Philadelphia, Pa.
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Schneider, Benno
A1  - Erbay, E.
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
JF  - Physica status solidi (a)
N2  - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201532053
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1347
EP  - 1352
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Taylor, J. G.
A1  - Schmitz, N.
A1  - Ziemons, Karl
A1  - Grosse-Ruyken, M.-L.
A1  - Gruber, O.
A1  - Müller-Gärtner, H.-W.
A1  - Shah, N. J.
T1  - The network of brain areas involved in the motion aftereffect
JF  - Neuroimage
N2  - A network of brain areas is expected to be involved in supporting the motion aftereffect. The most active components of this network were determined by means of an fMRI study of nine subjects exposed to a visual stimulus of moving bars producing the effect. Across the subjects, common areas were identified during various stages of the effect, as well as networks of areas specific to a single stage. In addition to the well-known motion-sensitive area MT the prefrontal brain areas BA44 and 47 and the cingulate gyrus, as well as posterior sites such as BA37 and BA40, were important components during the period of the motion aftereffect experience. They appear to be involved in control circuitry for selecting which of a number of processing styles is appropriate. The experimental fMRI results of the activation levels and their time courses for the various areas are explored. Correlation analysis shows that there are effectively two separate and weakly coupled networks involved in the total process. Implications of the results for awareness of the effect itself are briefly considered in the final discussion.
Y1  - 2000
SN  - 1053-8119
VL  - 11
IS  - 4
SP  - 257
EP  - 270
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Akhisaroglu, M.
A1  - Sercan, Z.
A1  - Kayatekin, B. M.
T1  - Adhesion of Erythrocytes to Endothelial Cells After Acute Exercise: Differences in Red Blood Cells from Juvenile and Adult Rats. Temiz Artmann, A.; Akhisaroglu, M.; Sercan, Z.; Kayatekin, BM.; Yorukoglu, K.; Kirkali, G.
JF  - Physiological  Research (2005)
Y1  - 2005
SN  - 0862-8408
N1  - pre-press article
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Ates, H.
A1  - Üretmen, Ö.
A1  - Andac, K.
T1  - Erythrocyte deformability in high-tension and normal tension glaucoma. Ates, H.; Üretmen, Ö.; Temiz, A.; Andac, K.
JF  - International Ophthalmology. 22 (1998), H. 1
Y1  - 1998
SN  - 0165-5701
SP  - 7
EP  - 12
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Edremitlioglu, M.
T1  - Effect of erythrocyte deformability on myocardial hematocrit gradient. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A.
JF  - American Journal of Physiology: Heart and Circulatory Physiology. 268 (1995), H. 1
Y1  - 1995
SN  - 0363-6135
SP  - 260
EP  - 264
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Edremitlioglu, M.
T1  - In vitro effects of in vivo activated leukocytes on red blood cell filterability and lipid peroxidation. Baskurt, O.K.; Edremitlioglu, M.; Temiz, A.
JF  - Clinical Hemorheology. 14 (1994), H. 4
Y1  - 1994
SP  - 591
EP  - 596
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Meiselman, H. J.
T1  - Effect of superoxide anions on red blood cell rheologic properties. Baskurt, O. K.; Temiz, A.; Meiselman, H. J.
JF  - Free Radical Biology and Medicine. 24 (1998), H. 1
Y1  - 1998
SN  - 0891-5849
SP  - 102
EP  - 110
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Meiselman, H. J.
T1  - Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J.
JF  - Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2
Y1  - 1997
SN  - 0022-2143
SP  - 183
EP  - 190
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, Oguz K.
A1  - Pekcetin, C.
A1  - Kandemir, F.
T1  - Leukocyte activation, oxidant stress and red blood cell properties after acute, exhausting exercise in rats. Temiz, A.; Baskurt, O. K., Pekcetin, C.; Kandemir, F.; Güre, A.
JF  - Clinical Hemorheology and Microcirculation. 22 (2000), H. 4
Y1  - 2000
SN  - 1386-0291
SP  - 253
EP  - 259
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Cavdar, C.
A1  - Yenicerioglu, Y.
A1  - Caliskan, S.
T1  - The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in haemodialysis patients. Cavdar, C.; Temiz, A.; Yenicerioglu, Y.; Caliskan, S.; Celik, A.; Sifil, A.; Onvural, B.; Camsari, T.
JF  - Scandinavian Journal of Urology and Nephrology. 37 (2003), H. 1
Y1  - 2003
SN  - 0036-5599
SP  - 77
EP  - 82
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kayatekin, Muammer B.
A1  - Uysal, N.
A1  - Resmi, H.
T1  - Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats? Kayatekin, Muammer B.; Uysal N.; Resmi, H.; Bediz, Seref C.; Temiz Artmann, A.; Genç, S.; Tugyan, K.
JF  - International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4
Y1  - 2005
SN  - 0300-9831
SP  - 243
EP  - 250
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
T1  - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ;  Kayser, Peter
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 497
EP  - 508
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kurulgan demirci, Eylem
A1  - Fırat, Ipek Seda
A1  - Oflaz, Hakan
A1  - Artmann, Gerhard
T1  - Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers
JF  - SHOCK
KW  - Septic cardiomyopathy
KW  - LPS
KW  - cardiomyocyte biomechanics
KW  - CellDrum
KW  - actin cytoskeleton
Y1  - 2021
U6  - https://doi.org/10.1097/SHK.0000000000001845
SN  - 1540-0514
PB  - Wolters Kluwer
CY  - Köln
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Digel, Ilya
T1  - NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts
JF  - Methods and findings in Experimental and Clinical Pharmacology. 27 (2005), H. 6
Y1  - 2005
SN  - 0379-0355
SP  - 391
EP  - 394
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Resmi, Halil
A1  - Akhunlar, Hülya
A1  - Güner, Gül
T1  - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül
JF  - Cell biochemistry and function. 23 (2005), H. 3
Y1  - 2005
SN  - 0263-6484
SP  - 163
EP  - 168
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Saklamaz, Ali
A1  - Comlekci, Abdurrahman
A1  - Caliskan, Sezer
T1  - The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia / Saklamaz, Ali ; Comlekci, Abdurrahman ; Temiz, Aysegu
JF  - Metabolism. 54 (2005), H. 5
Y1  - 2005
SN  - 0026-0495
SP  - 677
EP  - 681
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Yalcin, Ozlem
A1  - Resmi, Halil
A1  - Baskurt, Oguz K.
T1  - Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise?
JF  - Clinical Hemorheology and Microcirculation. 26 (2002), H. 3
Y1  - 2002
SN  - 1386-0291
N1  - = The 11th European Symposium on Clinical Hemorheology, Rouen, France, 19-22 September 2000
SP  - 189
EP  - 193
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Yolcuoglu, B.
A1  - Onal, M. A.
A1  - Sipahi, O.
T1  - The effect of skin transplantation on tumour growth in mice. Yolcuoglu, B.; Onal, M. A.; Sipahi, O.; Temiz, A.; Pekcetin, C.; Acikgöz, O.; Kar,  H.; Güre A.
JF  - The American Journal of Surgery. 178 (1999), H. 4
Y1  - 1999
SN  - 0002-9610
SP  - 329
EP  - 330
ER  - 
TY  - JOUR
A1  - Terstegge, Andreas
A1  - Flachskampf, F. A.
A1  - Franke, A.
A1  - Job, F. P. [u.a.]
T1  - Three-dimensional reconstruction of cardiac structures from transesophageal echocardiography
JF  - American journal of cardiac imaging. 9 (1995), H. 2
Y1  - 1995
SN  - 0887-7971
SP  - 141
EP  - 147
ER  - 
TY  - JOUR
A1  - Terstegge, Andreas
A1  - Weber, Stefan
A1  - Herzog, H.
A1  - Müller-Gärtner, Hans- W. [u.a.]
T1  - High resolution and better quantification by tube of responsemodelling in 3D PET reconstruction
JF  - Selected papers from the 1996 Nuclear Science Symposium : Marriott Hotel, Anaheim, California, November 3rd - November 9th, 1996
Y1  - 1996
N1  - Nuclear Science Symposium <1996, Anaheim, Calif.> ; (IEEE transactions on nuclear science ; 44,3,1)
SP  - 1603
EP  - 1607
PB  - Inst. of Electrical and Electronic Engineers
CY  - New York
ER  - 
TY  - JOUR
A1  - Terstegge, Andreas
A1  - Weber, Stefan
A1  - Herzog, H.
A1  - Reinartz, R. [u.a.]
T1  - The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity
JF  - IEEE transactions on medical imaging. 16 (1997), H. 5
Y1  - 1997
SN  - 0278-0062
SP  - 684
EP  - 689
ER  - 
TY  - JOUR
A1  - Thiebes, Anja Lena
A1  - Klein, Sarah
A1  - Zingsheim, Jonas
A1  - Möller, Georg H.
A1  - Gürzing, Stefanie
A1  - Reddemann, Manuel A.
A1  - Behbahani, Mehdi
A1  - Cornelissen, Christian G.
T1  - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio
JF  - pharmaceutics
N2  - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing.
KW  - tri-lineage differentiation
KW  - survival
KW  - twin-fluid atomizer
KW  - adipose-derived stromal cells (ASCs)
KW  - cell atomization
KW  - cell aerosolization
Y1  - 2022
U6  - https://doi.org/10.3390/pharmaceutics14112421
N1  - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells"
VL  - 14
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Naser, S.
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Crosssensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 573
EP  - 576
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Naser, S.
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors <13, 1999, 's-Gravenhage> ; Eurosensors <13, 1999, The Hague> ;  European Conference on Solid-State Transducers <13, 1999, The Hague>
SP  - 573
EP  - 576
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Schroth, P.
A1  - Töpler, A.
A1  - Schöning, Michael Josef
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Improving the detection limit of a capacitive sensor by means of a diffusion barrier
JF  - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1
Y1  - 1998
SN  - 0-7503-0595-9
N1  - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton)
SP  - 507
EP  - 510
PB  - Inst. of Physics Publ.
CY  - Bristol [u.a.]
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Schöning, Michael Josef
A1  - Schroth, P.
A1  - Malkoc, Ü.
A1  - Dicker, C. I.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Enzyme immobilisation on planar and porous silicon substrates for biosensor applications
JF  - Journal of Molecular Catalysis B: Enzymatic. 7 (1999), H. 1-4
Y1  - 1999
SN  - 1381-1177
SP  - 77
EP  - 83
ER  - 
TY  - JOUR
A1  - Thust, Marion
A1  - Schöning, Michael Josef
A1  - Frohnhoff, S.
A1  - Arens-Fischer, R.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Porous silicon as a substrate material for potentiometric biosensors
JF  - Measurement Science and Technology
Y1  - 1996
U6  - https://doi.org/10.1088/0957-0233/7/1/003
VL  - 7
IS  - 1
SP  - 26
EP  - 29
ER  - 
TY  - JOUR
A1  - Topçu, Murat
A1  - Madabhushi, Gopal S.P.
A1  - Staat, Manfred
T1  - A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius
JF  - International Journal of Solids and Structures
N2  - A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.
KW  - Natural fibres
KW  - Polymer-matrix composites
KW  - Biocomposites
KW  - Stress concentrations
KW  - Finite element analysis
Y1  - 2022
U6  - https://doi.org/10.1016/j.ijsolstr.2022.111464
SN  - 0020-7683
VL  - 239–240
IS  - Art. No. 111464
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Tran, Linda
A1  - Mottaghy, K.
A1  - Arlt-Körfer, Sabine
A1  - Waluga, Christian
A1  - Behbahani, Mehdi
T1  - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
JF  - Biomedizinische Technik
Y1  - 2017
U6  - https://doi.org/10.1515/bmt-2015-0034
SN  - 0013-5585
VL  - 62
IS  - 4
SP  - 383
EP  - 392
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
T1  - Direct plastic structural design under lognormally distributed strength by chance constrained programming
JF  - Optimization and Engineering
N2  - We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements.
Y1  - 2020
U6  - https://doi.org/10.1007/s11081-019-09437-2
SN  - 1573-2924
VL  - 21
IS  - 1
SP  - 131
EP  - 157
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Tran, Ngoc Trinh
A1  - Staat, Manfred
T1  - Direct plastic structural design under random strength and random load by chance constrained programming
JF  - European Journal of Mechanics - A/Solids
Y1  - 2021
U6  - https://doi.org/10.1016/j.euromechsol.2020.104106
SN  - 0997-7538
VL  - 85
IS  - Article 104106
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tran, Ngoc Trinh
A1  - Trinh, Tu Luc
A1  - Dao, Ngoc Tien
A1  - Giap, Van Tan
A1  - Truong, Manh Khuyen
A1  - Dinh, Thuy Ha
A1  - Staat, Manfred
T1  - FEM shakedown analysis of structures under random strength with chance constrained programming
JF  - Vietnam Journal of Mechanics
N2  - Direct methods, comprising limit and shakedown analysis, are a branch of computational mechanics. They play a significant role in mechanical and civil engineering design. The concept of direct methods aims to determine the ultimate load carrying capacity of structures beyond the elastic range. In practical problems, the direct methods lead to nonlinear convex optimization problems with a large number of variables and constraints. If strength and loading are random quantities, the shakedown analysis can be formulated as stochastic programming problem. In this paper, a method called chance constrained programming is presented, which is an effective method of stochastic programming to solve shakedown analysis problems under random conditions of strength. In this study, the loading is deterministic, and the strength is a normally or lognormally distributed variable.
KW  - limit analysis
KW  - shakedown analysis
KW  - chance constrained programming
KW  - stochastic programming
KW  - reliability of structures
Y1  - 2022
U6  - https://doi.org/10.15625/0866-7136/17943
SN  - 0866-7136
SN  - 2815-5882
VL  - 44
IS  - 4
SP  - 459
EP  - 473
PB  - Vietnam Academy of Science and Technology (VAST)
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Kreißig, R.
A1  - Staat, Manfred
T1  - Probabilistic limit and shakedown analysis of thin plates and shells
JF  - Structural safety. 31 (2009), H. 1
Y1  - 2009
SN  - 0167-4730
SP  - 1
EP  - 18
PB  - -
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Kreißig, R.
A1  - Vu, Duc Khoi
A1  - Staat, Manfred
T1  - Upper bound limit and shakedown analysis of shells using the exact Ilyushin yield surface
JF  - Computer & Structures. 86 (2008)
Y1  - 2008
SN  - 0045-7949
SP  - 1683
EP  - 1695
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Pham, Phu Tinh
A1  - Vu, D. K.
A1  - Staat, Manfred
T1  - Reliability Analysis of Inelastic Shell Structures Under Variable Loads
JF  - Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter
Y1  - 2009
SN  - 978-1-4020-9633-4
SP  - 135
EP  - 156
PB  - Springer Netherland
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - An Edge-Based Smoothed Finite Element Method for Primal-Dual Shakedown Analysis of Structures Under Uncertainties
JF  - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.)
Y1  - 2013
SN  - 978-94-007-5424-9
SP  - 89
EP  - 102
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - Shakedown analysis of two dimensional structures by an edge-based smoothed finite element method
Y1  - 2010
N1  - ECCM 2010, IV European Conference on Computational Mechanics, Paris, France, May 16-21, 2010.
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Trzewik, Jürgen
A1  - Temiz Artmann, Aysegül
A1  - Linder, Peter
A1  - Demirci, T.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Evaluation of lateral mechanical tension in thin-film tissue constructs
JF  - Annals of Biomedical Engineering. 32 (2004), H. 9
Y1  - 2004
SN  - 1573-9686
SP  - 1243
EP  - 1251
ER  - 
TY  - JOUR
A1  - Turaliyeva, M.
A1  - Yeshibaev, A.
A1  - Digel, Ilya
A1  - Elibayeva, G.
A1  - Sydykova, A.
A1  - Uspabayeva, A.
A1  - Dosybayeva, G.
A1  - Zhylysbayeva, A.
A1  - Lakhanova, K.
T1  - Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L
JF  - Life science journal
N2  - The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium – F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 % respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.
Y1  - 2014
U6  - https://doi.org/10.7537/marslsj1105s14.33
SN  - 1097-8135
VL  - 11
IS  - Spec. iss. 5s
SP  - 171
EP  - 175
PB  - Marsland Press
CY  - New York
ER  - 
TY  - JOUR
A1  - Turaliyeva, M.
A1  - Yeshibaev, A.
A1  - Saparbekova, A.
A1  - Akynova, L.
A1  - Abildayeva, R.
A1  - Sadenova, M.
A1  - Sartayeva, K.
A1  - Schieffer, Andre
A1  - Digel, Ilya
T1  - Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia
JF  - Asian journal of microbiology, biotechnology & environmental sciences : AJMBES
N2  - At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and Ñetonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested.
Y1  - 2016
SN  - 0972-3005
VL  - 18
IS  - 2
SP  - 359
EP  - 366
PB  - EM International
ER  - 
TY  - JOUR
A1  - Turek, M.
A1  - Keusgen, M.
A1  - Poghossian, Arshak
A1  - Mulchandani, A.
A1  - Wang, J.
A1  - Schöning, Michael Josef
T1  - Enzyme-modified electrolyte-insulator-semiconductor sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 82
EP  - 85
ER  - 
TY  - JOUR
A1  - Turek, Monik
A1  - Heiden, Wolfgang
A1  - Guo, Sharon
A1  - Riesen, Alfred
A1  - Schubert, Jürgen
A1  - Zander, Willi
A1  - Krüger, Peter
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 817
EP  - 823
ER  - 
TY  - JOUR
A1  - Turek, Monika
A1  - Ketterer, Lothar
A1  - Claßen, Melanie
A1  - Berndt, Heinz
A1  - Elbers, Gereon
A1  - Krüger, Peter
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Development and Electrochemical Investigations of an EIS-(Electrolyte-Insulator-Semiconductor) based Biosensor for Cyanide Detection
JF  - Sensors
Y1  - 2007
SN  - 1424-8220
VL  - 7
IS  - 8
SP  - 1415
EP  - 1426
ER  - 
TY  - JOUR
A1  - Turlybekuly, Amanzhol
A1  - Pogrebnjak, Alexander
A1  - Sukhodub, L. F.
A1  - Sukhodub, Liudmyla B.
A1  - Kistaubayeva, A. S.
A1  - Savitskaya, Irina
A1  - Shokatayeva, D. H.
A1  - Bondar, Oleksandr V.
A1  - Shaimardanov, Z. K.
A1  - Plotnikov, Sergey V.
A1  - Shaimardanova, B. H.
A1  - Digel, Ilya
T1  - Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix
JF  - Materials Science and Engineering C
Y1  - 2019
U6  - https://doi.org/10.1016/j.msec.2019.109965
VL  - 104
IS  - Article number 109965
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ullrich, Sebastian
A1  - Grottke, Oliver
A1  - Rossaint, Rolf
A1  - Staat, Manfred
A1  - Deserno, Thomas M.
A1  - Kuhlen, Torsten
T1  - Virtual Needle Simulation with Haptics for Regional Anaesthesia
Y1  - 2010
N1  - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010
SP  - 1
EP  - 3
ER  - 
TY  - JOUR
A1  - Uysal, Karya
A1  - Creutz, Till
A1  - Firat, Ipek Seda
A1  - Artmann, Gerhard
A1  - Teusch, Nicole
A1  - Temiz Artmann, Aysegül
T1  - Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments
JF  - Polymers
N2  - Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3–4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.
Y1  - 2022
SN  - 2073-4360
VL  - 14
IS  - 11
SP  - 2213
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Uysal, Karya
A1  - Firat, Ipek Serat
A1  - Creutz, Till
A1  - Aydin, Inci Cansu
A1  - Artmann, Gerhard
A1  - Teusch, Nicole
A1  - Temiz Artmann, Aysegül
T1  - A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes
JF  - membranes
N2  - Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.
Y1  - 2022
U6  - https://doi.org/10.3390/membranes13010022
N1  - This article belongs to the Special Issue "Latest Scientific Discoveries in Polymer Membranes"
VL  - 2023
IS  - 13(1)
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Vahidpour, Farnoosh
A1  - Oberländer, Jan
A1  - Schöning, Michael Josef
T1  - Flexible Calorimetric Gas Sensors for Detection of a Broad Concentration Range of Gaseous Hydrogen Peroxide: A Step Forward to Online Monitoring of Food-Package Sterilization Processes
JF  - Phys. Status Solidi A
N2  - In this study, flexible calorimetric gas sensors are developed for specificdetection of gaseous hydrogen peroxide (H₂O₂) over a wide concentrationrange, which is used in sterilization processes for aseptic packaging industry.The flexibility of these sensors is an advantage for identifying the chemical components of the sterilant on the corners of the food boxes, so-called “coldspots”, as critical locations in aseptic packaging, which are of great importance. These sensors are fabricated on flexible polyimide films by means of thin-film technique. Thin layers of titanium and platinum have been deposited on polyimide to define the conductive structures of the sensors. To detect the high-temperature evaporated H₂O₂, a differential temperature set-up is proposed. The sensors are evaluated in a laboratory-scaled sterilizationsystem to simulate the sterilization process. The concentration range of the evaporated H₂O₂ from 0 to 7.7% v/v was defined and the sensors have successfully detected high as well as low H₂O₂ concentrations with a sensitivity of 5.04 °C/% v/v. The characterizations of the sensors confirm their precise fabrication, high sensitivity and the novelty of low H₂O₂ concentration detections for future inline monitoring of food-package sterilization.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800044
VL  - 215
IS  - 15
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Vant, Christianne
A1  - Staat, Manfred
A1  - Baroud, Gamal
T1  - Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 527
EP  - 539
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Vlasov, Y. G.
A1  - Mourzina, Y. G.
A1  - Legin, A. V.
A1  - Ermelenko, Y. E.
A1  - Schubert, J.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Solid-state thin film sensors based on chalcogenide materials prepared by planar technology and pulsed laser deposition
JF  - Russian Journal of Applied Chemistry. 75 (2002), H. 3
Y1  - 2002
SN  - 1070-4272
SP  - 351
EP  - 356
ER  - 
TY  - JOUR
A1  - Vu, Duc Khoi
A1  - Staat, Manfred
T1  - Shakedown analysis of structures made of materials with temperature-dependent yield stress
JF  - International Journal of Solids and Structures. 44 (2007), H. 13
Y1  - 2007
SN  - 0020-7683
SP  - 4524
EP  - 4540
ER  - 
TY  - JOUR
A1  - Vu, Duc Khoi
A1  - Staat, Manfred
A1  - Tran, Ich Thinh
T1  - Analysis of pressure equipment by application of the primal-dual theory of shakedown
JF  - Communications in Numerical Methods in Engineering. 23 (2007), H. 3
Y1  - 2007
SN  - 1069-8299
SP  - 213
EP  - 225
ER  - 
TY  - JOUR
A1  - Vu, Duc-Khoi
A1  - Staat, Manfred
T1  - An algorithm for shakedown analysis of structure with temperature dependent yield stress
N2  - This work is an attempt to answer the question: How to use convex programming in shakedown analysis of structures made of materials with temperature-dependent properties. Based on recently established shakedown theorems and formulations, a dual relationship between upper and lower bounds of the shakedown limit load is found, an algorithmfor shakedown analysis is proposed. While the original problem is neither convex nor concave, the algorithm presented here has the advantage of employing convex programming tools.
KW  - Einspielen <Werkstoff>
KW  - Temperaturabhängigkeit
KW  - Fließgrenze
KW  - Shakedown
KW  - shakedown analysis
KW  - yield stress
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Govorukha, Kristina
A1  - Rübbelke, Dirk
T1  - Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development
JF  - Applied Energy
N2  - The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal “Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries”. By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries.
Y1  - 2020
U6  - https://doi.org/10.1016/j.apenergy.2020.114633
SN  - 0306-2619
VL  - 264
IS  - Article number: 114633
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Josyabhatla, Vishnu Teja
A1  - Ball, Christopher
A1  - Rhoden, Imke
A1  - Grajewski, Matthias
A1  - Rübbelke, Dirk
A1  - Kuckshinrichs, Wilhelm
T1  - Robust assessment of energy scenarios from stakeholders' perspectives
JF  - Energy
N2  - Using scenarios is vital in identifying and specifying measures for successfully transforming the energy system. Such transformations can be particularly challenging and require the support of a broader set of stakeholders. Otherwise, there will be opposition in the form of reluctance to adopt the necessary technologies. Usually, processes for considering stakeholders' perspectives are very time-consuming and costly. In particular, there are uncertainties about how to deal with modifications in the scenarios. In principle, new consulting processes will be required. In our study, we show how multi-criteria decision analysis can be used to analyze stakeholders' attitudes toward transition paths. Since stakeholders differ regarding their preferences and time horizons, we employ a multi-criteria decision analysis approach to identify which stakeholders will support or oppose a transition path. We provide a flexible template for analyzing stakeholder preferences toward transition paths. This flexibility comes from the fact that our multi-criteria decision aid-based approach does not involve intensive empirical work with stakeholders. Instead, it involves subjecting assumptions to robustness analysis, which can help identify options to influence stakeholders' attitudes toward transitions.
Y1  - 2023
U6  - https://doi.org/10.1016/j.energy.2023.128326
SN  - 1873-6785 (Online)
SN  - 0360-5442 (Print)
IS  - In Press, Article 128326
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Rübbelke, Dirk
A1  - Govorukha, Kristina
A1  - Grajewski, Matthias
T1  - Socio-technical scenarios for energy-intensive industries: the future of steel production in Germany
JF  - Climatic Change
Y1  - 2019
U6  - https://doi.org/10.1007/s10584-019-02366-0
SN  - 0165-0009
SP  - 1
EP  - 16
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wagner, Patrick
A1  - Doll, Theodor
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.)
JF  - Physica status solidi (A) : Applications and materials science
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201470241
SN  - 1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1339
EP  - 1339
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device
JF  - Electrochemical sensor analysis / edited by S. Alegret ...
Y1  - 2007
SN  - 978-0-444-53133-9
N1  - Wilson & Wilson's comprehensive analytical chemistry ; 49
SP  - e35
EP  - e44
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Maris, Rob J.
A1  - Ackermann, Hans-Josef
A1  - Otto, Ralph
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations
JF  - Sensors and Actuators B: Chemical  . 127 (2007), H. 1
Y1  - 2007
SN  - 0925-4005
SP  - 217
EP  - 223
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, K.
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Flexible electrochemical imaging with “zoom-in” functionality by using a new type of light-addressable potentiometric sensor
Y1  - 2011
N1  - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011
SP  - 2133
EP  - 2135
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, K.
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)
Y1  - 2011
U6  - https://doi.org/10.1166/sl.2011.1620
VL  - 9
IS  - 2
SP  - 812
EP  - 815
PB  - American Scientific Publishers
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 520
EP  - 523
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Shigihara, Noriko
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 791
EP  - 794
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, R.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells
JF  - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)
Y1  - 2007
SN  - 1-4244-0841-5
N1  - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon
SP  - 1107
EP  - 1110
PB  - IEEE
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, Roberto
A1  - Yoshinobu, Tatsuo
A1  - Kloock, Joachim P.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
T1  - Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications
JF  - Electrochimica Acta. 53 (2007), H. 2
Y1  - 2007
SN  - 0013-4686
SP  - 305
EP  - 311
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Rao, C.
A1  - Kloock, Joachim P.
A1  - Yoshinobu, T.
A1  - Otto, R.
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - “LAPS Card”—A novel chip card-based light-addressable potentiometric sensor (LAPS)
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 33
EP  - 40
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensors (LAPS): recent trends and applications
JF  - Electrochemical sensor analysis / edited by S. Alegret ...
Y1  - 2007
SN  - 978-0-444-53053-0
N1  - Wilson & Wilson's comprehensive analytical chemistry ; 49
SP  - 87
EP  - 128
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Yoshinobu, T.
T1  - A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 996
EP  - 997
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Shigiahara, N.
A1  - Miyamoto, K.
A1  - Suzurikawa, J.
A1  - Finger, F.
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Light-addressable Potentiometric Sensors and Light–addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility
JF  - Procedia Engineering
N2  - This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented.
Y1  - 2012
U6  - https://doi.org/10.1016/j.proeng.2012.09.290
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 890
EP  - 893
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Vornholt, Wolfgang
A1  - Werner, Frederik
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-Ichiro
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening
JF  - Physics in medicine
N2  - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.
Y1  - 2016
U6  - https://doi.org/10.1016/j.phmed.2016.03.001
SN  - 2352-4510
VL  - 2016
IS  - 1
SP  - 2
EP  - 7
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, K.
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - A high-density multi-point LAPS set-up using a VCSEL array and FPGA control
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 1483
EP  - 1486
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-ichiro
A1  - Ackermann, Hans-Josef
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 844
EP  - 849
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-Ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging
JF  - Sensors and Actuators B: Chemical
N2  - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2010.12.003
SN  - 0925-4005
N1  - Part of special issue "Eurosensors XXIV, 2010"
VL  - 170
SP  - 34
EP  - 39
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-Ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - A high-density multi-point LAPS set-up using a VCSEL array and FPGA control
JF  - Sensors and Actuators B: Chemical. 154 (2011), H. 2
Y1  - 2011
SN  - 1873-3077
N1  - EUROSENSORS XXIII
SP  - 124
EP  - 128
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Yoshinobu, T.
A1  - Rao, C.
A1  - Otto, R.
A1  - Schöning, Michael Josef
T1  - „All-in-one“ solid-state device based on a lightaddressable potentiometric sensor platform
JF  - Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society
Y1  - 2005
SN  - 0-7803-83995-6
N1  - International Conference on Solid State Sensors, Actuators and Microsystems ; (13, 2005, Seoul)
SP  - 1872
EP  - 1875
PB  - IEEE Operations Center
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco V.
A1  - Ritzmann, Ramona
A1  - Albracht, Kirsten
T1  - Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks
JF  - Journal of Applied Physiology
N2  - This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy.
KW  - electromyography
KW  - locomotion
KW  - overload
KW  - stretch-shortening cycle
KW  - ultrasound
Y1  - 2023
U6  - https://doi.org/10.1152/japplphysiol.00279.2022
SN  - 1522-1601 (Onlineausgabe)
SN  - 8750-7587 (Druckausgabe)
VL  - 134
IS  - 1
SP  - 190
EP  - 202
PB  - American Physiological Society
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Ritzmann, Ramona
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Albracht, Kirsten
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco
T1  - The Anticipation of Gravity in Human Ballistic Movement
JF  - Frontiers in Physiology
N2  - Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.
Y1  - 2021
U6  - https://doi.org/10.3389/fphys.2021.614060
SN  - 1664-042X
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wang, J.
A1  - Krause, R.
A1  - Block, K.
A1  - Musameh, M.
A1  - Mulchandani, A.
A1  - Schöning, Michael Josef
T1  - Flow injection amperometric detection of OP nerve agents based on organophosphorus-hydrolase biosensor detector
JF  - Biosensors & Bioelectronics. 18 (2003), H. 2-3
Y1  - 2003
SN  - 0956-5663
SP  - 255
EP  - 260
ER  - 
TY  - JOUR
A1  - Warerkar, Shashikant
A1  - Schmitz, Stefan
A1  - Göttsche, Joachim
A1  - Hoffschmidt, Bernhard
A1  - Reißel, Martin
A1  - Tamme, Rainer
T1  - Air-Sand Heat Exchanger for High-Temperature Storage
JF  - Journal of Solar Energy Engineering. 133 (2011), H. 2
Y1  - 2011
SN  - 0199-6231
N1  - 7 pages
SP  - 021010
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Warmer, Johannes
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
A1  - Kaul, Peter
T1  - Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors
JF  - Physica status solidi (a)
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431882
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1289
EP  - 1298
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Bhuju, S.
A1  - Chandra, S.
A1  - Mo, X.
T1  - Fabrication of biodegradable nanofibers for tubular scaffolds in regenerative medicine / Weber, H.-J. ; Bhuju, S. ; Chandra, S. ; Mo, X.
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2
Y1  - 2004
SP  - 1016
EP  - 1017
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Hekmat, K.
A1  - Zimmermann, T.
A1  - Kampe, S.
T1  - Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial / Hekmat, K. ; Zimmermann, T. ; Kampe, S. ; Kasper, S. M. ; Weber, H. J. ; Geissler, H. J. ; Meh
JF  - Current Medical Research and Opinion. 20 (2004), H. 1
Y1  - 2004
SN  - 0300-7995
SP  - 121
EP  - 126
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Laco, Filip
A1  - Kun, Ma
A1  - Ramakrishna, S.
T1  - The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K.
JF  - Journal of Dermatological Science. 55 (2009), H. 3
Y1  - 2009
SN  - 0923-1811
SP  - 150
EP  - 160
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
T1  - Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber
JF  - Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder
Y1  - 2004
N1  - Österreichische Polymertage <6, 2003, Wien>. - (Macromolecular symposia ; 217,1)
SP  - 413
EP  - 416
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Chen, Zonggang
T1  - Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber
JF  - Frontiers of materials science in China. 1 (2007), H. 1
Y1  - 2007
SN  - 1673-7377
SP  - 20
EP  - 23
PB  - -
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Ramakrishna, S.
T1  - PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna
JF  - The International journal of artificial organs. 29 (2006), H. 8
Y1  - 2006
SP  - 790
EP  - 799
PB  - -
ER  - 
TY  - JOUR
A1  - Weckesser, Martin
A1  - Grießmeier, Martin
A1  - Schmidt, Daniela
A1  - Sonnenberg, Frank
A1  - Ziemons, Karl
A1  - Kemna, Lars
A1  - Holschbach, Marcus
A1  - Langen, Karl-J.
A1  - Müller-Gärtner, Hans-W.
T1  - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent
JF  - European Journal of Nuclear Medicine
N2  - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.
Y1  - 1998
SN  - 1619-7089
VL  - 25
IS  - 2
SP  - 150
EP  - 156
ER  - 
TY  - JOUR
A1  - Weckesser, Matthias
A1  - Hufnagel, Andreas
A1  - Ziemons, Karl
A1  - Grießmeier, Martin
A1  - Sonnenberg, Frank
A1  - Hackländer, Thomas
A1  - Langen, Karl-J.
A1  - Holschbach, Markus
A1  - Elger, Christian E.
A1  - Müller-Gärtner, Hans-W.
T1  - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy
JF  - European Journal of Nuclear Medicine
N2  - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
Y1  - 1997
SN  - 1619-7089
VL  - 24
IS  - 9
SP  - 1156
EP  - 1161
ER  - 
TY  - JOUR
A1  - Wedrowski, M.
A1  - Bruyndonckx, P.
A1  - Tavernier, S.
A1  - Zhi, L.
A1  - Dang, J.
A1  - Mendes, P. R.
A1  - Perez, J. M.
A1  - Ziemons, Karl
T1  - Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography
JF  - 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
N2  - The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 × 20 × 10 mm3 monolithic LSO crystal block.
Y1  - 2009
SN  - 1082-3654
SP  - 2625
EP  - 2628
ER  - 
TY  - JOUR
A1  - Wegmann, Kilian
A1  - Hackl, Michael
A1  - Staat, Manfred
A1  - Mayer, Katharina
A1  - Müller, Lars-Peter
T1  - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.
Y1  - 2016
U6  - https://doi.org/10.1007/s00167-016-4079-0
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 58
EP  - 59
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Nagamine Komesu, Cindy A.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment
JF  - Electrochemical Science Advances
N2  - Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.
KW  - enzymatic biosensor
KW  - penicillin
KW  - penicillinase
KW  - photoelectrochemistry
KW  - titanium dioxide photoanode
Y1  - 2021
U6  - https://doi.org/10.1002/elsa.202100131
SN  - 2698-5977
N1  - Corresponding author: Michael J. Schöning
VL  - 2
IS  - 4
SP  - 1
EP  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Scheja, Sabrina
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Wagner, Torsten
T1  - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems
JF  - physica status solidi a : applications and materials sciences
N2  - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800150
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800150
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick H.
A1  - Wagner, Torsten
T1  - Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions
JF  - Sensors
N2  - In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor–electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types.
Y1  - 2020
U6  - https://doi.org/10.3390/s20061680
SN  - 1424-8220
VL  - 20
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Wendlandt, Tim
A1  - Koch, Claudia
A1  - Britz, Beate
A1  - Liedek, Anke
A1  - Schmidt, Nora
A1  - Werner, Stefan
A1  - Gleba, Yuri
A1  - Vahidpour, Farnoosh
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System
JF  - Viruses
N2  - Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.
KW  - biosensor
KW  - horseradish peroxidase (HRP)
KW  - glucose oxidase (GOx)
KW  - enzyme cascade
KW  - turnip vein clearing virus (TVCV)
KW  - tobacco mosaic virus (TMV)
Y1  - 2023
U6  - https://doi.org/doi.org/10.3390/v15091951
SN  - 1999-4915
N1  - This article belongs to the Special Issue "Tobamoviruses 2023"
VL  - 9
IS  - 15
PB  - MDPI
CY  - Basel
ER  -