TY  - CHAP
A1  - Kotliar, Konstantin
ED  - Pallikaris, I.
ED  - Tsilimbaris, M. K.
ED  - Dastiridou, A. I.
T1  - Ocular rigidity: clinical approach
T2  - Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye
N2  - The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.
KW  - Coefficient of ocular rigidity
KW  - Eyeball
KW  - Corneo-scleral shell
KW  - Pressure-volume relationship
KW  - Differential tonometry
Y1  - 2021
SN  - 978-3-030-64422-2
U6  - http://dx.doi.org/10.1007/978-3-030-64422-2_2
SP  - 15
EP  - 43
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Neumaier, Felix
A1  - Weiss, Miriam
A1  - Veldeman, Michael
A1  - Kotliar, Konstantin
A1  - Wiesmann, Martin
A1  - Schulze-Steinen, Henna
A1  - Höllig, Anke
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
A1  - Albanna, Walid
T1  - Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage – preliminary findings from an observational cohort study
JF  - Clinical Neurology and Neurosurgery
N2  - Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.
KW  - constructive alignment
KW  - examination
KW  - long-term retention
KW  - multimodal
KW  - practical learning
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.clineuro.2021.106870
SN  - 0303-8467
VL  - 208
IS  - Article No.: 106870
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Neumaier, Felix
A1  - Kotliar, Konstantin
A1  - Haeren, Roel Hubert Louis
A1  - Temel, Yasin
A1  - Lüke, Jan Niklas
A1  - Seyam, Osama
A1  - Lindauer, Ute
A1  - Clusmann, Hans
A1  - Hescheler, Jürgen
A1  - Schubert, Gerrit Alexander
A1  - Schneider, Toni
A1  - Albanna, Walid
T1  - Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)
JF  - Frontiers in Neurology
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fneur.2021.659890
VL  - 12
SP  - 1
EP  - 11
PB  - Frontiers
ER  -