TY  - JOUR
A1  - Mang, Thomas
T1  - Abdichtmaterialien gegen drückendes Wasser
JF  - Bauchemie von der Forschung bis zur Praxis : 3. Tagung Bauchemie in Würzburg ; 27./28. September 2001 in Würzburg / GDCh-Fachgruppe Bauchemie ; [Red.: W. Hiller ...]
Y1  - 2002
SN  - 3-936028-04-4
N1  - Tagung Bauchemie <3, 2001, Würzburg> GdCh-Monographie 24 ; Monographie / GDCh, Gesellschaft Deutscher Chemiker ; 24
SP  - 65
PB  - GDCh
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Recycling von Getränkekartons aus Verbundmaterial
JF  - Kunststoffrecycling in Sachsen ; 1. ; Dresden, 26. - 27. Februar 1992
Y1  - 1992
SP  - 34
EP  - 43
PB  - Techn. Univ.
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Elastomere zum Abdichten gegen drückendes Wasser
JF  - Summaries : June 30 to July 3, 2003, Nürnberg = Kurzfassungen
Y1  - 2003
N1  - Internationale Kautschuk-Tagung ; <2003 : ; 2003.06.30-07.03 : ; Nürnberg> ;  International Rubber Conference<2003, Nürnberg>
SP  - 121
EP  - 123
PB  - DKG, Dt. Kautschuk-Ges.
CY  - Frankfurt, Main
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Elastomere zum Abdichten gegen drückendes Wasser
JF  - Kautschuk Gummi Kunststoffe. 57 (2004), H. 4
Y1  - 2004
SN  - 0022-9520
SP  - 172
EP  - 178
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Thermosensitive Magnetic Nanoparticles for Bioanalytical and Therapeutical Applications
JF  - Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2
Y1  - 2004
SN  - 0013-5585
SP  - 1006
EP  - 1007
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Polymer Magnetic Particles for Isolating Biomolecules, Especially Nucleic Acids
JF  - Biomedizinische Technik = Biomedical Engineering. 49 (2004), H. 2
Y1  - 2004
SN  - 0013-5585
SP  - 1008
EP  - 1009
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Magnetische Mikro- und Nanopartikel für Medizin und Biotechnik
JF  - Wässrige Kunststoffdispersionen und ihre Anwendung : Fachbereich Angewandte Naturwissenschaften und Technik / Fachhochschule Aachen. [Schriftleitung: Thomas Mang ...]
Y1  - 2005
N1  - FH-Texte ; 71 ; Makromolekulares Kolloquium FH Aachen
SP  - 137
EP  - 150
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Aluminium-Kunststoff-Verbundmaterial trennen und verwerten
JF  - Umwelt. 24 (1994), H. 4
Y1  - 1994
SN  - 0041-6355
SP  - 152
EP  - 153
ER  - 
TY  - JOUR
A1  - Mang, Thomas
T1  - Wässrige Kunststoffdispersionen für Medizin und Biotechnologie
JF  - Chemie und Technologie makromolekularer Stoffe. 15. Kolloquium: 25. November 1994 an der FH Aachen, Fachbereich Chemieingenieurwesen
Y1  - 1994
N1  - FH-Texte 66. Fachhochschule <Aachen>
SP  - 155
EP  - 183
ER  - 
TY  - JOUR
A1  - Manea, Marilena
A1  - Leurs, Ulrike
A1  - Orban, Erika
A1  - Baranyai, Zsuzsa
A1  - Öhlschläger, Peter
A1  - Marquardt, Andreas
A1  - Schulcz, Akos
A1  - Tejeda, Miguel
T1  - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4
JF  - Bioconjugate Chemistry
Y1  - 2011
SN  - 1520-4812
VL  - 22
IS  - 7
SP  - 1320
EP  - 1329
PB  - ACS
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, C.
A1  - Bork, M.
A1  - Kayser, Peter
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells
JF  - Medical and biological engineering and computing. 41 (2003), H. 3
Y1  - 2003
SN  - 0140-0118
SP  - 350
EP  - 356
ER  - 
TY  - JOUR
A1  - Luisier, Raphaëlle
A1  - Lempiäinen, Harri
A1  - Scherbichler, Nina
A1  - Braeuning, Albert
A1  - Geissler, Miriam
A1  - Dubost, Valerie
A1  - Müller, Arne
A1  - Scheer, Nico
A1  - Chibout, Salah-Dine
A1  - Hara, Hisanori
A1  - Picard, Frank
A1  - Theil, Diethilde
A1  - Couttet, Philippe
A1  - Vitobello, Antonio
A1  - Grenet, Olivier
A1  - Grasl-Kraupp, Bettina
A1  - Ellinger-Ziegelbauer, Heidrung
A1  - Thomson, John P.
A1  - Meehan, Richard R.
A1  - Elcombe, Clifford R.
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Remi
A1  - Moggs, Jonathan G.
T1  - Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
JF  - Toxicological Sciences
N2  - The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.
Y1  - 2014
U6  - http://dx.doi.org/https://doi.org/10.1093/toxsci/kfu038
SN  - 1094-2025
VL  - 139
IS  - 2
SP  - 501
EP  - 511
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Lowis, Carsten
A1  - Ferguson, Simon
A1  - Paulßen, Elisabeth
A1  - Hoehr, Cornelia
T1  - Improved Sc-44 production in a siphon-style liquid target on a medical cyclotron
JF  - Applied Radiation and Isotopes
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.apradiso.2021.109675
SN  - 0969-8043
VL  - 172
IS  - Art. 109675
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Liu, Z.
A1  - Schaap, K. S.
A1  - Ballemans, L.
A1  - de Blois, E.
A1  - Rohde, M.
A1  - Paulßen, Elisabeth
T1  - Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system
JF  - Dalton Transactions
Y1  - 2017
U6  - http://dx.doi.org/10.1039/C7DT01830D
SN  - 1477-9234
VL  - 46
IS  - 42
SP  - 14669
EP  - 14676
ER  - 
TY  - JOUR
A1  - Lindner, Simon
A1  - Burger, René
A1  - Rutledge, Douglas N.
A1  - Do, Xuan Tung
A1  - Rumpf, Jessica
A1  - Diehl, Bernd W. K.
A1  - Schulze, Margit
A1  - Monakhova, Yulia
T1  - Is the calibration transfer of multivariate calibration models between high- and low-field NMR instruments possible? A case study of lignin molecular weight
JF  - Analytical chemistry
N2  - Although several successful applications of benchtop nuclear magnetic resonance (NMR) spectroscopy in quantitative mixture analysis exist, the possibility of calibration transfer remains mostly unexplored, especially between high- and low-field NMR. This study investigates for the first time the calibration transfer of partial least squares regressions [weight average molecular weight (Mw) of lignin] between high-field (600 MHz) NMR and benchtop NMR devices (43 and 60 MHz). For the transfer, piecewise direct standardization, calibration transfer based on canonical correlation analysis, and transfer via the extreme learning machine auto-encoder method are employed. Despite the immense resolution difference between high-field and low-field NMR instruments, the results demonstrate that the calibration transfer from high- to low-field is feasible in the case of a physical property, namely, the molecular weight, achieving validation errors close to the original calibration (down to only 1.2 times higher root mean square errors). These results introduce new perspectives for applications of benchtop NMR, in which existing calibrations from expensive high-field instruments can be transferred to cheaper benchtop instruments to economize.
Y1  - 2022
SN  - 1520-6882
U6  - http://dx.doi.org/10.1021/acs.analchem.1c05125
VL  - 94
IS  - 9
SP  - 3997
EP  - 4004
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Leurs, Ulrike
A1  - Mezo, Gabor
A1  - Öhlschläger, Peter
A1  - Orban, Erika
A1  - Marquard, Andrea
A1  - Manea, Marilena
T1  - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety
JF  - Peptide Science
N2  - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/bip.21640
SN  - 1097-0282
VL  - 98
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Lempiäinen, Harri
A1  - Couttet, Philippe
A1  - Bolognani, Federico
A1  - Müller, Arne
A1  - Dubost, Valérie
A1  - Luisier, Raphaëlle
A1  - Rio-Espinola, Alberto del
A1  - Vitry, Veronique
A1  - Unterberger, Elif B.
A1  - Thomson, John P.
A1  - Treindl, Fridolin
A1  - Metzger, Ute
A1  - Wrzodek, Clemens
A1  - Hahne, Florian
A1  - Zollinger, Tulipan
A1  - Brasa, Sarah
A1  - Kalteis, Magdalena
A1  - Marcellin, Magali
A1  - Giudicelli, Fanny
A1  - Braeuning, Albert
A1  - Morawiec, Laurent
A1  - Zamurovic, Natasa
A1  - Längle, Ulrich
A1  - Scheer, Nico
A1  - Schübeler, Dirk
A1  - Goodman, Jay
A1  - Chibout, Salah-Dine
A1  - Marlowe, Jennifer
A1  - Theil, Dietlinde
A1  - Heard, David J.
A1  - Grenet, Olivier
A1  - Zell, Andreas
A1  - Templin, Markus F.
A1  - Meehan, Richard R.
A1  - Wolf, Roland C.
A1  - Elcombe, Clifford R.
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Rémi
A1  - Moggs, Jonathan G.
T1  - Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion
JF  - Toxicological Sciences
N2  - The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.
Y1  - 2012
U6  - http://dx.doi.org/10.1093/toxsci/kfs303
SN  - 1094-2025
VL  - 131
IS  - 2
SP  - 375
EP  - 386
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Lawson, Nathan D.
A1  - Scheer, Nico
A1  - Pham, Van N.
A1  - Kim, Ceol-Hee
A1  - Chitnis, Ajay B.
A1  - Campos-Ortega, José A.
A1  - Weinstein, Brant M.
T1  - Notch signaling is required for arterial-venous differentiation during embryonic vascular development
JF  - Development
Y1  - 2001
SN  - 1477-9129
VL  - 128
IS  - 19
SP  - 3675
EP  - 3683
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Solomun, T.
A1  - Hirschwald, W.
A1  - Christmann, K.
T1  - The interaction of carbon monoxide with a ruthenium(1010) surface
JF  - Surface Science. 210 (1989), H. 1-2
Y1  - 1989
SN  - 0039-6028
SP  - 201
EP  - 224
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Solomun, T.
A1  - Hirschwald, W.
A1  - Christmann, K.
T1  - The interaction of carbon monoxide with a ruthenium(1010) surface
JF  - Surface Science Letters. 210 (1989), H. 1-2
Y1  - 1989
SN  - 0167-2584
SP  - A74
EP  - A75
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Hoelderich, W.
A1  - Wagenblast, G.
T1  - Molecular sieves containing azo dyes
JF  - Zeolites. 15 (1995), H. 2
Y1  - 1995
SN  - 0144-2449
SP  - 184
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Hoelderich, W.
A1  - Wagenblast, G.
T1  - Crystalline zeolites containing indigo dyes
JF  - Zeolites. 15 (1995), H. 1
Y1  - 1995
SN  - 0144-2449
SP  - 86
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Christmann, K.
A1  - Schwarz, E.
T1  - Adsorption geometry of H on RU(1010) image as determined by LEED and HREELS / Christmann, K. ; Lauth, G. ; Schwarz, E.
JF  - Vacuum. 41 (1990), H. 1-3
Y1  - 1990
SN  - 0042-207X
SP  - 293
EP  - 296
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Wiechmann, H.
T1  - Untersuchungen zur Verlagerung und Immobilisierung löslicher organischer Stoffe in Sandböden
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 43 (1985)
Y1  - 1985
SN  - 0343-107x
SP  - 771
EP  - 776
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Wiechmann, H.
T1  - Untersuchungen zum Akkumulationsverhalten löslicher organischer Substanzen in Podsolen
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 55 (1987)
Y1  - 1987
SN  - 0343-107x
SP  - 791
EP  - 796
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Voigt, B.
A1  - Gabriel, B.
A1  - Ghod, Mumin M.
T1  - Quaternary events  at the Horn of Africa / Voigt, B., B. Gabriel,  B. Lassonczyk and Mumin M. Ghod
JF  - Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Paläontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universität Berlin. 120 A (1990)
Y1  - 1990
SN  - 0172-8784
SP  - 679
EP  - 694
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Herms, U.
A1  - Filipinski, M.
T1  - Arbeitsgruppe "Böden in Schleswig-Holstein" - Ziele, Aufgaben und Aktivitäten
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 76 (1993), H. 2
Y1  - 1993
SN  - 0343-107x
SP  - 1129
EP  - 1131
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Grupe, M.
A1  - Wiechmann, H.
T1  - Schwierigkeiten bei der Ausgliederung von Bodengesellschaften in typischen Landschaften des Münsterlandes / Grupe, M., B. Lassonczyk und H. Wiechmann
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 38 (1983)
Y1  - 1983
SN  - 0343-107x
SP  - 501
EP  - 506
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Grupe, M.
T1  - Umweltaudit aus der Sicht des Bodenschutzes
JF  - Umweltschutz-Management und Öko-Auditing / Manfred Sietz ... (Hrsg.)
Y1  - 1993
SN  - 3-540-56911-1
SP  - 133
EP  - 141
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Grupe, M.
T1  - Ökoaudit - ein neues Arbeitsfeld, auch für die Bodenkunde / Grupe, M. ; Lassonczyk, B.
JF  - Festschrift für Horst Wiechmann  / Pfeiffer, Eva-Maria [Hrsg.]
Y1  - 1995
N1  - Hamburger bodenkundliche Arbeiten ; 30
SP  - 63
EP  - 71
PB  - Verein zur Förderung der Bodenkunde
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
A1  - Alaily, F.
A1  - Huth, A.
A1  - Gensior, A.
T1  - Genesis of soils in the arid part of northeast Somalia / F. Alaily, B. Lassonczyk, A.Huth and A. Gensior
JF  - Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Paläontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universität Berlin. 120 A (1990)
Y1  - 1990
SN  - 0172-8784
SP  - 695
EP  - 711
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
T1  - Untersuchung einer Chronosequenz in Nord-Somalia zur Kennzeichnung der Landschaftsgeschichte
JF  - 14th International Congress of Soil Science : transactions. vol. 5. Kyoto, Japan, August 12 - 18, 1990 = 14ème Congrès International de la Science du Sol = 14. Internationaler Bodenkundlicher Kongreß / International Society of Soil Science
Y1  - 1990
N1  - International Congress of Soil Science ; <14 : ; 1990.08.12-18 : ; Kyoto>
SP  - 370
EP  - 371
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
T1  - Fossile Bodenbildung in Nord-Somalia
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 59 (1989), H. 2
Y1  - 1989
SN  - 0343-107x
SP  - 927
EP  - 930
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
T1  - Bodenentwicklung auf Terrassenschottern im ariden Bereich von NO-Somalia
JF  - Mitteilungen der Deutschen Bodenkundlichen Gesellschaft. 66 (1991), H. 2
Y1  - 1991
SN  - 0343-107x
SP  - 1153
EP  - 1156
ER  - 
TY  - JOUR
A1  - Lassonczyk, Beate
T1  - Characteristics of a fossil soil developed on the basement complex in the northeast Somalia
JF  - Berliner geowissenschaftliche Abhandlungen / Reihe A, Geologie und Paläontologie / hrsg. von d. Geowissenschaftlichen Instituten der Freien u. d. Technischen Universität Berlin. 120 A (1990)
Y1  - 1990
SN  - 0172-8784
SP  - 713
EP  - 718
ER  - 
TY  - JOUR
A1  - Küppers, Tobias
A1  - Steffen, Victoria
A1  - Hellmuth, Hendrik
A1  - O'Connell, Timothy
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Wiechert, Wolfgang
T1  - Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer
JF  - Microbial cell factories
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1475-2859-13-46
SN  - 1475-2859 (E-Journal)
VL  - 13
SP  - Article No. 46
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Kusch, Peter
A1  - Rieser, Claudia
A1  - Knupp, Gerd
A1  - Mang, Thomas
T1  - Characterization of copolymers of methacrylic acid with poly(ethylene glycol) methyl ether methacrylate macromonomers by analytical pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS)
JF  - Journal of Analytical and Applied Pyrolysis
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.jaap.2015.03.003
SN  - 0165-2370
VL  - Vol. 113
SP  - 412
EP  - 418
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kuropka, Rolf
A1  - Müller, Bettina
A1  - Höcker, Hartwig
A1  - Berndt, Heinz
T1  - Chiral stationary phases via hydrosilylation reaction of N-acryloylamino acids : I. Stationary phase with one chiral centre for high-performance liquid chromatography and development of a new derivatization pattern for amino acid enantiomers
JF  - Journal of chromatography A
Y1  - 1989
SN  - 0021-9673
IS  - 481
SP  - 380
EP  - 386
ER  - 
TY  - JOUR
A1  - Krüger, Götz
A1  - Grötzinger, Joachim
A1  - Berndt, Heinz
T1  - Enantiomeric resolution of amino acid derivatives on chiral stationary phases by high-performance liquid chromatography
JF  - Journal of Chromatography A
Y1  - 1987
U6  - http://dx.doi.org/10.1016/S0021-9673(01)85005-6
SN  - 0021-9673
VL  - 1987
IS  - 397
SP  - 223
EP  - 232
ER  - 
TY  - JOUR
A1  - Krämer, Marco
A1  - Bongaerts, Johannes
A1  - Bovenberg, Roel
A1  - Kremer, Susanne
A1  - Müller, Ulrike
A1  - Orf, Sonja
A1  - Wubbolts, Marcel
A1  - Raeven, Leon
T1  - Metabolic engineering for microbial production of shikimic acid
JF  - Metabolic engineering
Y1  - 2003
SN  - 1096-7184 (E-Journal); 1096-7176 (Print)
VL  - Vol. 5
IS  - Iss. 4
SP  - 277
EP  - 283
ER  - 
TY  - JOUR
A1  - Kowollik, S.
A1  - Schnitzler, Thomas
A1  - Biselli, Manfred
A1  - Krueger, R.
A1  - Zang, Werner
A1  - Peuscher, A.
A1  - Schillberg, S.
A1  - Fischer, R.
T1  - Die Rolle des Respirationsquotienten in der Zellkulturfermentation
JF  - Chemie Ingenieur Technik
Y1  - 2010
SN  - Chemie Ingenieur Tec
N1  - Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen
VL  - 82
IS  - 9
SP  - 1505
EP  - 1506
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Xing Li, Dong
T1  - Partielle Oxidation von o-Xylol zu Phthalsäreanhydrid an V/Ti-Schalenkatalysatoren : [Synopsis 1898]
JF  - Chemie - Ingenieur - Technik. 62 (1990), H. 11
Y1  - 1990
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640 ; Das vollständige Manuskript dieser Arbeit umfasst 33 Seiten. Es ist [lt. Verl.] als Fotokopie oder Mikrofiche MS 1898/90 erhältlich.
SP  - 950
EP  - 951
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Weyland, Friedrich
T1  - The performance of base metal oxides on ceramic carriers as catalysts for air pollution control
JF  - International chemical engineering. 25 (1985), H. 3
Y1  - 1985
SN  - 0020-6318
SP  - 418
EP  - 427
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Turek, Thomas
T1  - Entfernung von Ammoniak aus Abwässern durch Strippung und Sorption an Zeolithen : [Synopse 1724]
JF  - Chemie - Ingenieur - Technik. 61 (1989), H. 1
Y1  - 1989
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640; Das vollständige Manuskript dieser Arbeit umfasst 45 Seiten. Es ist [lt. Verl.] als Fotokopie oder Mikrofiche MS 1724/88 erhältlich.
SP  - 74
EP  - 75
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Simoncic, V.
T1  - Pristup sintezi industrijskih katalizatora
JF  - Kemija u industriji : casopis kemicara i tehnologa Jugoslavije. 35 (1986)
Y1  - 1986
SN  - 0022-9830
N1  - Hrsg.: Croatian Society of Chemical Engineers
SP  - 79
EP  - 86
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
A1  - Weyland, F.
T1  - Deposition of ternary oxides as active components by impregnation of porous carriers
JF  - Preparation of Catalysts III : scientific bases for the preparation of heterogeneous catalysts ; proceedings of the Third International Symposium, Louvain-la-Neuve, September 6-9, 1982 / ed.: G. Poncelet ... - (Studies in surface science and catalysis ; 16)
Y1  - 1983
SN  - 0-444-42184-X
N1  - International Symposium on the Scientific Bases for the Preparation of Heterogeneous Catalysts <3, 1982, Louvain-la-Neuve>
SP  - 521
EP  - 530
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
A1  - Weyland, F.
T1  - Katalytische Abgasreinigung an Nichtedelmetall-Trägerkontakten
JF  - Verfahrenstechnik  : VT ; Informationen für Planung, Bau und Betrieb von Apparaten und Anlagen. 17 (1983)
Y1  - 1983
SN  - 0049-5948
N1  - 2. ISSN: 0175-5315 , 3. ISSN: 0341-2644
SP  - 607
EP  - 615
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - The influence of impregnation, drying and activation on the activity and distribution of CuO on &#945;-Alumina
JF  - Preparation of Catalysts II : scientific bases for the preparation of heterogeneous catalysts ; Proceedings of the Second International Symposium, Louvain-la-Neuve, September 4-7, 1978 / Eds.: B. Delmon ... - (Studies in surface science and catalysis ; 3)
Y1  - 1979
SN  - 0-444-41733-8
N1  - International Symposium on the Scientific Bases for the Preparation of Heterogeneous Catalysts <2, 1978, Louvain-la-Neuve>
SP  - 51
EP  - 63
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - Impregnation-type catalysts with nonuniform distribution of the active component
JF  - Chemical engineering fundamentals. 2 (1983)
Y1  - 1983
SN  - 0723-0966
SP  - 19
EP  - 38
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - Beeinflussung der Aktivität und Selektivität von Tränkkatalysatoren durch die topographische Verteilung der Aktivkomponente
JF  - Verfahrenstechnik  : VT ; Informationen für Planung, Bau und Betrieb von Apparaten und Anlagen. 17 (1983)
Y1  - 1983
SN  - 0049-5948
N1  - 2. ISSN: 0175-5315 , 3. ISSN: 0341-2644
SP  - 639
EP  - 658
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, L.
T1  - Tränkkontakte zur partiellen Oxidation von Buten zu Maleinsäureanhydrid
JF  - Chemie - Ingenieur - Technik. 59 (1987), H. 9
Y1  - 1987
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 733
EP  - 734
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lovera, P.
A1  - Riekert, L.
T1  - Charakterisierung eines Trägerkatalysators durch effektive Diffusionskoeffizienten, Labyrinthfaktor und mittlere Porenradien
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie
N2  - Der effektive Diffusionskoeffizient Deff von Gasen in einem porösen Medium hängt im Knudsen- bzw. Übergangsgebiet vom effektiven Porenradius 〈r〉 der Struktur ab. 〈r〉 kann aus Deff ermittelt werden, sofern der Labyrinthfaktor χ der Struktur aus der Kinetik des Stoffaustausches in den mit einer flüssigen Phase gefüllten Poren separat bestimmt wird. An einem Trägerkatalysator (CuO auf γ-Al₂O₃) ergab sich auf diese Weise ein für die Diffusion maßgebender effektiver Porenradius, der in den Bereich der Makroporen fällt. Ein Vergleich mit dem aus reaktionskinetischen Daten ermittelten effektiven Diffusionskoeffizienten läßt auf eine ungleichmäßige Verteilung der aktiven Komponente im Kontaktkorn schließen.
Y1  - 1976
SN  - 0005-9021
U6  - http://dx.doi.org/10.1002/bbpc.19760800112
VL  - 80
IS  - 1
SP  - 61
EP  - 66
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Wittstock, Klaus
T1  - Untersuchung der Zwischenproduktbildung bei der katalytischen Nachverbrennung Iösemittelbeladener Abluft an Nichtedelmetall-Katalysatoren
JF  - Chemie - Ingenieur - Technik. 66 (1994), H. 10
Y1  - 1994
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 1369
EP  - 1372
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Weyland, Friedrich
T1  - Selektive Reduktion von Stickoxiden in Rauchgasen - Stand der Technik und neue Wege
JF  - Chemie - Ingenieur - Technik. 58 (1986), H. 8
Y1  - 1986
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 617
EP  - 623
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Turek, Thomas
T1  - Katalytische Stickoxid-Reduktion in einem rotierenden Wärmeübertrager
JF  - Chemie - Ingenieur - Technik. 64 (1992), H. 5
Y1  - 1992
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 446
EP  - 448
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Turek, Thomas
T1  - Selective catalytic reduction of nitrogen oxide by use of the Ljungstroem air heater as reactor : a case study
JF  - Chemical engineering science  . 47 (1992), H. 9-11
Y1  - 1992
SN  - 0009-2509
SP  - 2763
EP  - 2768
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
A1  - Riekert, Lothar
A1  - Trimm, D. L.
T1  - Structure and selectivity changes in vanadia-titania catalysts used to promote the reduction of nitric oxide with ammonia
JF  - Applied catalysis. 52 (1989), H. 1
Y1  - 1989
SN  - 0166-9834
N1  - ISSN der E-Ausg.: 0166-9834
SP  - 225
EP  - 235
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Lintz, Hans-Günther
T1  - Réduction catalytique séléktive des oxydes d'azote : une concéption originale
JF  - Entropie. 23 (1987), H. 137/138
Y1  - 1987
SN  - 0013-9084
SP  - 109
EP  - 116
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Li, D. X.
A1  - Riekert, Lothar
T1  - Partial oxidation of o-xylene to phthalic anhydride in a structured fixed bed containing a sequence of catalysts
JF  - New developments in selective oxidation : proceedings of an international symposium ; Rimini, Italy, Sept. 18 - 22, 1989 / eds.: G. Centi ... - (Studies in surface science and catalysis ; 55)
Y1  - 1990
SN  - 0-444-88694-X
SP  - 267
EP  - 274
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Li, D. X.
A1  - Riekert, Lothar
T1  - Partielle Oxidation von o-Xylol zu Phthalsäureanhydrid in einem strukturierten Festbettreaktor
JF  - Katalyse : katalytische Abgasreinigung, Zeolithe, homogene Katalyse, selektive Reaktionen, Herstellung und Charakterisierung, Ionenleiter, Elektrokatalyse, SLPC-Katalysatoren, Suspensionsphase ; Vorträge von der DECHEMA-Jahrestagung 1990, 31. Mai und 1. Juni 1990 / hrsg. von H. Kral. - (Deutsche Gesellschaft für Chemisches Apparatewesen, Chemische Technik und Biotechnologie: DECHEMA-Monographien ; 122)
Y1  - 1991
SN  - 3-527-10216-7
SP  - 93
EP  - 123
PB  - VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Kirch, M.
A1  - Riekert, Lothar
T1  - Einfluß von Dispersion und Vorgeschichte dispersen Nickels auf dessen katalytische Eigenschaften bei der Hydrierung von Benzol, CO2 und CO / R. Kirch ; M. Kotter ; L. Riekert
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 88 (1984)
Y1  - 1984
SN  - 0005-9021
SP  - 1054
EP  - 1057
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Kirch, M.
A1  - Riekert, L.
T1  - Herstellung von Tränkkatalysatoren mit Nickel als Aktivkomponente auf porösen Trägern / R. Kirch ; M. Kotter ; L. Riekert
JF  - Chemiker-Zeitung. 108 (1984), H. 4
Y1  - 1984
SN  - 0009-2894
N1  - In der Bibliothek vorhanden: 63 ZS 024-1984 (Bereichsbibliothek Jülich)
SP  - 121
EP  - 129
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Häfele, E.
A1  - Prinz, D.
A1  - Riekert, L.
T1  - Versuche zur Konvertierung von Wassergas an Zeolith-Katalysatoren / E. Häfele ; M. Kotter ; D. Prinz ; L. Riekert
JF  - Chemie - Ingenieur - Technik. 55 (1983), H. 2
Y1  - 1983
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 148
EP  - 149
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hoffmann, U.
T1  - Simulation eines geregelten Rührkessels mit LABVIEW / U. Hoffmann ; M. Kotter
JF  - Virtuelle Instrumente in der Praxis : Messtechnik, Automatisierung ; Begleitband zum Kongress VIP 2002 / Rahman Jamal ... (Hrsg.). - (Praxiswissen Elektronik-Industrie : Messtechnik - Automatisierung)
Y1  - 2002
SN  - 3-7785-2873-4
N1  - VIP <2002, München>
SP  - 65
PB  - Hüthig
CY  - Heidelberg [u.a.]
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Heering, J.
A1  - Riekert, L.
T1  - Diffusion and catalytic reaction in zeolite ZSM-5 / J. Heering ;  M. Kotter ; L. Riekert
JF  - Chemical engineering science  . 37 (1982), H. 4
Y1  - 1982
SN  - 0009-2509
SP  - 581
EP  - 584
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hammon, Ulrich
A1  - Riekert, Lothar
T1  - Gewinnung niedriger Olefine aus Methanol bei partiellem Umsatz mit Rückführung / U. Hammon ; M. Kotter ; L. Riekert
JF  - Chemie - Ingenieur - Technik. 61 (1989), H. 2
Y1  - 1989
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 151
EP  - 152
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hammon, Ulrich
A1  - Riekert, Lothar
T1  - Formation of ethene and propene from methanol on zeolite ZSM-5 II. Preparation of finished catalysts and operation of a fixed-bed pilot plant / U. Hammon ; M. Kotter ; L. Riekert
JF  - Applied catalysis. 37 (1988)
Y1  - 1988
SN  - 0166-9834
N1  - ISSN der E-Ausg.: 0166-9834
SP  - 155
EP  - 174
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hammon, Ulrich
T1  - Herstellung von Formkörpern mit definierter Porenstruktur / Ulrich Hammon ; Michael Kotter
JF  - Chemie - Ingenieur - Technik. 56 (1984), H. 6
Y1  - 1984
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 455
EP  - 463
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Hammon, U.
T1  - Preparation of pellets with well-defined pore structure / U. Hammon ; A. Kotter
JF  - International chemical engineering. 26 (1986), H. 4
Y1  - 1986
SN  - 0020-6318
SP  - 563
EP  - 573
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Greger, M.
A1  - Ihme, B.
T1  - Nonequilibrium phase transitions with hysteresis in solid catalysts : the system copper-oxygen-propene / M. Greger ; B. Ihme ; M. Kotter ...
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 88 (1984)
Y1  - 1984
SN  - 0005-9021
SP  - 427
EP  - 433
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Grazyk, J.
A1  - Geißle, W.
A1  - Roth, A.
T1  - Fließeigenschaften von Keramiken für die Herstellung von Katalysatorträgern / J. Grazyk ; W. Gleißle ; A. Roth ; M. Kotter
JF  - Erdöl & Kohle, Erdgas, Petrochemie : EKEP. 43 (1990), H. 1
Y1  - 1990
SN  - 0014-0058
N1  - 2. ISSN: 0367-0716 ; In der Bibliothek (Jülich) vorhanden unter 63 ZS 034
SP  - 27
EP  - 30
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Becker, Dieter
A1  - Riekert, Lothar
T1  - Zur Selektivität der partiellen Oxidation von Propen an Schalenkatalysatoren / Dieter Becker ; Michael Kotter ; Lothar Riekert
JF  - Chemie - Ingenieur - Technik. 61 (1989), H. 9
Y1  - 1989
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 748
EP  - 749
ER  - 
TY  - JOUR
A1  - Kotter, Michael
T1  - Herstellung von Tränkkatalysatoren als verfahrenstechnische Aufgabe
JF  - Chemie - Ingenieur - Technik. 55 (1983), H. 3
Y1  - 1983
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 179
EP  - 185
ER  - 
TY  - JOUR
A1  - Kotter, Michael
T1  - Katalytische Abluftreinigung mit integriertem regenerativem Wärmetausch
JF  - Chemie - Ingenieur - Technik. 64 (1992), H. 9
Y1  - 1992
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640 ; GVC-Jahrentreffer ; Beitrag 116
SP  - 848
ER  - 
TY  - JOUR
A1  - Kotnik, Katarina
A1  - Popova, Elena
A1  - Todiras, Mihail
A1  - Mori, Marcelo A.
A1  - Alenina, Natalia
A1  - Seibler, Jost
A1  - Bader, Michael
T1  - Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
JF  - Plos One
Y1  - 2009
U6  - http://dx.doi.org/10.1371/journal.pone.0005124
VL  - 4
IS  - 4
SP  - e5124
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Kornfeld, Jan-Wilhelm
A1  - Baitzel, Catherina
A1  - Könner, A. Christine
A1  - Nicholls, Hayley T.
A1  - Vogt, Merly C.
A1  - Herrmanns, Karolin
A1  - Scheja, Ludger
A1  - Haumaitre, Cécile
A1  - Wolf, Anna M.
A1  - Knippschild, Uwe
A1  - Seibler, Jost
A1  - Cereghini, Silvia
A1  - Heeren, Joerg
A1  - Stoffel, Markus
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
JF  - Nature
Y1  - 2013
SN  - 0028-0836
U6  - http://dx.doi.org/10.1038/nature11793
VL  - 494
IS  - 7435
SP  - 111
EP  - 115
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - http://dx.doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Kappler-Tanudyaya, Nathalie
A1  - Schmitt, Heike
A1  - Tippkötter, Nils
A1  - Meyer, Lina
A1  - Lenzen, Sigurd
A1  - Ulber, Roland
T1  - Combination of biotransformation and chromatography for the isolation and purification of mannoheptulose
JF  - Biotechnology Journal
N2  - Mannoheptulose is a seven-carbon sugar. It is an inhibitor of glucose-induced insulin secretion due to its ability to selectively inhibit the enzyme glucokinase. An improved procedure for mannoheptulose isolation from avocados is described in this study (based upon the original method by La Forge). The study focuses on the combination of biotransformation and downstream processing (preparative chromatography) as an efficient method to produce a pure extract of mannoheptulose. The experiments were divided into two major phases. In the first phase, several methods and parameters were compared to optimize the mannoheptulose extraction with respect to efficiency and purity. In the second phase, a mass balance of mannoheptulose over the whole extraction process was undertaken to estimate the yield and efficiency of the total extraction process. The combination of biotransformation and preparative chromatography allowed the production of a pure mannoheptulose extract. In a biological test, the sugar inhibited the glucokinase enzyme activity efficiently.
Y1  - 2007
U6  - http://dx.doi.org/10.1002/biot.200700004
SN  - 1860-7314
VL  - 2
IS  - 6
SP  - 692
EP  - 699
ER  - 
TY  - JOUR
A1  - Kapelyukh, Yury
A1  - Henderson, Colin James
A1  - Scheer, Nico
A1  - Rode, Anja
A1  - Wolf, Charles Roland
T1  - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - http://dx.doi.org/10.1124/dmd.119.087718
IS  - Early view
ER  - 
TY  - JOUR
A1  - Kalbe, Jochen
A1  - Kuropka, Rolf
A1  - Meyer-Stork, L. Sebastian
A1  - Berndt, Heinz
A1  - [u.a.], 
T1  - Isolation and characterization of high-molecular mass DNA from hair shafts
JF  - Biological chemistry
Y1  - 1988
SN  - 0177-3593
U6  - http://dx.doi.org/10.1515/bchm3.1988.369.1.413
VL  - 369
IS  - 1
SP  - 413
EP  - 416
ER  - 
TY  - JOUR
A1  - Kalbe, Jochen
A1  - Höcker, Hartwig
A1  - Berndt, Heinz
T1  - Design of enzyme reactors as chromatographic columns for racemic resolution of amino acid esters
JF  - Chromatographia
Y1  - 1989
SN  - 0009-5893
U6  - http://dx.doi.org/10.1007/BF02319646
VL  - 28
IS  - 3-4
SP  - 193
EP  - 196
ER  - 
TY  - JOUR
A1  - Jossek, Ralf
A1  - Bongaerts, Johannes
A1  - Sprenger, Georg A.
T1  - Characterization of a new feedback-resistant 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase AroF of Escherichia coli
JF  - FEMS microbiology letters
Y1  - 2001
SN  - 1574-6968
VL  - Vol. 202
IS  - Iss. 1
SP  - 145
EP  - 148
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Zoor, Annegreth
T1  - A new irreversible enzyme-aided esterification method in organic solvents
JF  - Biotechnology letters. 30 (2008), H. 5
Y1  - 2008
SN  - 1573-6776
SP  - 925
EP  - 928
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Welsch, Volker
T1  - Diketene a New Esterification Reagent in the Enzyme-Aided Synthesis of Chiral Alcohols and Chiral Acetoacetic Acid Esters
JF  - Tetrahedron Letters  . 36 (1995), H. 37
Y1  - 1995
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 6663
EP  - 6664
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Weise, Sven
T1  - Enzymatische Acetylierung von (±)-1-Phthalimido-2-propanol
JF  - Liebigs Annalen der Chemie (1990)
Y1  - 1990
SN  - 0947-3440
N1  - ISSN der E-Ausg.: 1099-0690
SP  - 1045
EP  - 1046
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Scheidt, Annette
T1  - Aliphatic optically active alcohols by enzyme-aided synthesis
JF  - Tetrahedron Letters  . 32 (1991), H. 48
Y1  - 1991
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 7021
EP  - 7024
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Albertz, Michael
T1  - Optically active &#945;-acetoxycarboxylic acids and &#945;-hydroxycarboxylic acids by enzyme-aided syntheses
JF  - Journal für Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6
Y1  - 1992
SN  - 1436-9966
N1  - ISSN der E-Ausg.: 1521-3897 ; In der Bibliothek (Jülich) vorhanden unter 63 ZS 024-1992
SP  - 526
EP  - 528
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Tetrabenzo[a,c,h,j]phenoxazine-18-yl a new stable neutral radical
JF  - Tetrahedron Letters  . 42 (2001), H. 10
Y1  - 2001
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 1863
EP  - 1865
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Superabsorbed alcohol dehydrogenase—a new catalyst for asymmetric reductions
JF  - Biotechnology Letters. 31 (2009), H. 11
Y1  - 2009
SN  - 0141-5492
SP  - 1717
EP  - 1721
ER  - 
TY  - JOUR
A1  - Jakob, Felix
A1  - Martinez, Ronny
A1  - Mandawe, John
A1  - Hellmuth, Hendrik
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Schwaneberg, Ulrich
T1  - Surface charge engineering of a Bacillus gibsonii subtilisin protease
JF  - Applied microbiology and biotechnology
Y1  - 2013
SN  - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)
VL  - Vol. 97
IS  - Iss. 15
SP  - 6793
EP  - 6802
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Jahnke, J.
A1  - Baumann, Marcus
T1  - Differentiation between Phaeocystis pouchetii (Har.) Lagerheim and Phaeocystis globosa Scherffel
JF  - Hydrobiological bulletin
Y1  - 1987
SN  - 0165-1404 (Print); 1573-5125 (E-Journal)
VL  - Vol. 21
IS  - Iss. 2
SP  - 141
EP  - 147
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000765
SN  - 1862-6319
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Infantino, Angelo
A1  - Paulßen, Elisabeth
A1  - Mostacci, Domiziano
A1  - Schaffer, Paul
A1  - Trinczek, Michael
A1  - Hoehr, Cornelia
T1  - Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements
JF  - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
N2  - The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.nimb.2015.10.067
SN  - 1872-9584
VL  - 366
SP  - 117
EP  - 123
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - http://dx.doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Immel, Timo
A1  - Grützke, Martin
A1  - Späte, Anne-Katrin
A1  - Groth, Ulrich
A1  - Öhlschläger, Peter
A1  - Huhn, Thomas
T1  - Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
JF  - Chemical Communications
N2  - Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Y1  - 2012
U6  - http://dx.doi.org/10.1039/C2CC31624B
SN  - 1364-548X
VL  - 48
IS  - 46
SP  - 5790
EP  - 5792
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - http://dx.doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Iding, Hans
A1  - Siegert, Petra
A1  - Mesch, K.
A1  - Pohl, Martina
T1  - Application of α-keto acid decarboxylases in biotransformations
JF  - Biochimica et biophysica acta (BBA) - Protein structure and molecular enzymology
Y1  - 1998
SN  - 1879-2588 (E-Journal); 0167-4838 (Print)
VL  - Vol. 1385
IS  - Iss. 2
SP  - 307
EP  - 322
ER  - 
TY  - JOUR
A1  - Iding, Hans
A1  - Dünnwald, Thomas
A1  - Greiner, Lasse
A1  - Liese, Andreas
A1  - Müller, Michael
A1  - Siegert, Petra
A1  - Grötzinger, Joachim
A1  - Demir, Ayhan S.
A1  - Pohl, Martina
T1  - Benzoylformate Decarboxylase from Pseudomonas putida as Stable Catalyst for the Synthesis of Chiral 2-Hydroxy Ketones
JF  - Chemistry - a European journal
Y1  - 2000
SN  - 1521-3765 (E-Journal); 0947-6539 (Print)
VL  - Vol. 6
IS  - Iss. 8
SP  - 1483
EP  - 1495
ER  - 
TY  - JOUR
A1  - Iber, Michaela
A1  - Schübeler, Dirk
A1  - Seibler, Jost
A1  - Höxter, Maria
A1  - Bode, Jürgen
T1  - Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions
JF  - Technical Tips Online
Y1  - 1998
U6  - http://dx.doi.org/10.1016/S1366-2120(08)70132-6
VL  - 4
IS  - 1
SP  - 25
EP  - 29
ER  -