TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, W.
A1  - Ulber, R.
T1  - Nitrate removal from whey concentrate with biotechnological regeneration of the waste water
JF  - European dairy magazine : EDM
Y1  - 2008
SN  - 0936-6318
IS  - 1
SP  - 30
EP  - 32
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, N.
A1  - Ulber, R.
T1  - Nitratentfernung aus Molkekonzentrat mit biotechnologischer Regeneration der Abwässer
JF  - Deutsche Milchwirtschaft
Y1  - 2007
SN  - 0012-0480
VL  - 58
IS  - 15
SP  - 540
EP  - 542
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Duwe, Anna-Maria
A1  - Wiesen, Sebastian
A1  - Sieker, Tim
A1  - Ulber, Roland
T1  - Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids
JF  - Bioresource Technology
N2  - The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9%, 17% and 23% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.biortech.2014.06.052
VL  - 167
SP  - 447
EP  - 455
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Deterding, A.
A1  - Ulber, Roland
T1  - Determination of acetic acid in fermentation broth by gas-diffusion technique
JF  - Engineering in Life Sciences
N2  - Due to the interfering effects of acetic acid in many fermentation processes, a gas-diffusion technique was developed for the online determination of acetic acid. The measurements were accomplished with a flow diffusion analysis (FDA) unit from the TRACE Analytics GmbH, Braunschweig, Germany. The diffusion analysis is based on the UV-absorbance of acetic acid at 205 nm. The measurement was achieved by the separation of an acceptor and a carrier stream (acidified fermentation broth) using a gas permeable polytetrafluoroethylene (PTFE) membrane, whereby broth constituents that would otherwise disturb the UV-measurement of acetic acid, are held back efficiently. Merely, the fermentation by-products, e.g. formic acid, is capable of diffusing through the membrane. While formic acid can disturb the measurement, carbon dioxide does not absorb at 205 nm. The method operates with time-dependent sample enrichment. During the analysis, a small volume of the acceptor stream is stopped for a defined time interval in the acceptor chamber. During this period, the gaseous acetic acid diffuses through the membrane and is enriched in the acceptor chamber. Subsequently after the enrichment, the acceptor stream flows through a UV-detector. The intensity of the signal is proportional to the acetic acid concentration. Online measurements in bioreactors via a sterile filtration probe have been accomplished. A linear calibration in the range of 0.5–5.0 g/L acetic acid with a relative standard deviation of <5 % was obtained. A sampling rate of 8 samples per hour was possible. The system was applied for the determination of acetic acid in E. coli fermentation broth. The instrument is easy to clean, very user-friendly and does not require any toxic or expensive reagents.
Y1  - 2008
U6  - http://dx.doi.org/10.1002/elsc.200820227
VL  - 8
IS  - 1, Special Issue: Technical Systems for the Use in Life Sciences
SP  - 62
EP  - 67
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Al-Kaidy, Huschyar
A1  - Wollny, Steffen
A1  - Ulber, Roland
T1  - Functionalized magnetizable particles for downstream processing in single-use systems
JF  - Chemie Ingenieur Technik
N2  - Biotechnological downstream processing is usually an elaborate procedure, requiring a multitude of unit operations to isolate the target component. Besides the disadvantageous space-time yield, the risks of cross-contaminations and product loss grow fast with the complexity of the isolation procedure. A significant reduction of unit operations can be achieved by application of magnetic particles, especially if these are functionalized with affinity ligands. As magnetic susceptible materials are highly uncommon in biotechnological processes, target binding and selective separation of such particles from fermentation or reactions broths can be done in a single step. Since the magnetizable particles can be produced from iron salts and low priced polymers, a single-use implementation of these systems is highly conceivable. In this article, the principles of magnetizable particles, their synthesis and functionalization are explained. Furthermore, applications in the area of reaction engineering, microfluidics and downstream processing are discussed focusing on established single-use technologies and development potential.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/cite.201200130
VL  - 85
IS  - 1-2: Special Issue: Single-Use Technology
SP  - 76
EP  - 86
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - New zeolite adsorbents for downstream processing of polyphenols from renewable resources
JF  - Engineering in Life Sciences
N2  - Commercial materials with polyvinylpolypyrrolidone and polymeric amberlites (XAD7HP, XAD16) are commonly used for the adsorptive downstream processing of polyphenols from renewable resources. In this study, beta-zeolite-based adsorbent systems were examined, and their properties were compared to organic resins. Batch adsorption experiments were conducted with synthetic solutions of major polyphenols. Adsorption isotherms and desorption characteristics of individual adsorbent were determined based on these results. Maximum adsorption capacities were calculated using the Langmuir model. For example, the zeolites had capacities up to 203.2 mg/g for ferulic acid. To extend these results to a complex system, additional experiments were performed on rapeseed meal and wheat seed extracts as representative renewable resources. HPLC analysis showed that with 7.5% w/v, which is regarded as the optimum amount of zeolites, zeolites A and B could bind 100% of the major polyphenols as well as release polyphenols at high yields. Additionally, regeneration experiments were performed with isopropyl alcohol at 99°C to evaluate how zeolites regenerate under mild conditions. The results showed only a negligible loss of adsorption capacity and no loss of desorption capacity. In summary, it was concluded that beta-zeolites were promising adsorbents for developing new processes to isolate polyphenols from renewable resources.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/elsc.201200188
VL  - 13
IS  - 3
SP  - 239
EP  - 246
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Muffler, Kai
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Aufarbeitung von Polyphenolen aus Weizen mittels Zeolithen am Beispiel der Ferulasäure
JF  - Chemie IngenieurTechnik
N2  - Aufarbeitung von Polyphenolen aus Weizenmittels Zeolithen am Beispiel der Ferulasa¨ ureAlexander Thiel1, Kai Muffler1, Nils Tippko¨ tter1, Kirstin Suck2, Ulrich Sohling2, Friedrich Ruf3und Roland Ulber1,*DOI: 10.1002/cite.201400031Bei der Ferulasa¨ure handelt es sich um einen Wertstoff, der aus Weizen gewonnen und in der Lebensmittel- und Pharma-industrie eingesetzt werden kann. Der Einsatz von Weizen als nachwachsende Rohstoffquelle ist allerdings nur dann wirt-schaftlich durchfu¨hrbar, wenn eine Prozessintegration in die bestehenden industriellen Verfahren gewa¨hrleistet oder einedirekte Konkurrenz zur Mehl- und Sta¨rkeindustrie vermieden werden kann. In diesem Artikel wird ein Verfahren aufge-zeigt, welches hohe Ausbeuten ermo¨glicht und eine Konkurrenz zu bestehenden Verwertungspfaden vermeidet.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/cite.201400031
N1  - Englischer Titel: Downstream Processing of Polyphenols from Wheat by Zeolites using the Example of Ferulic Acid
VL  - 87
IS  - 1-2
SP  - 128
EP  - 136
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Muffler, Kai
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Hruschka, Steffen M.
A1  - Ulber, Roland
T1  - A novel integrated downstream processing approach to recover sinapic acid, phytic acid and proteins from rapeseed meal
JF  - Journal of Chemical Technology and Biotechnology
N2  - BACKGROUND
Currently, several techniques exist for the downstream processing of protein, phytic acid and sinapic acid from rapeseed and rapeseed meal, but no technique has been developed to separate all of the components in one process. In this work, two new downstream processing strategies focusing on recovering sinapic acid, phytic acid and protein from rapeseed meal were established.

RESULTS
The sinapic acid content was enhanced by a factor of 4.5 with one method and 5.1 with the other. The isolation of sinapic acid was accomplished using a zeolite-based adsorbent with high adsorptive and optimal desorption characteristics. Phytic acid was isolated using the anion-exchange resin Purolite A200®. In addition, the processes resulted in two separated protein fractions. The ratios of globulin and albumin ratio to the total protein were 59.2% and 40.1%, respectively. The steps were then combined in two different ways: (a) a ‘sequential process’ using the zeolite and A200 in batch processes; and (b) a ‘parallel process’ using only A200 in a chromatographic system to separate all of the compounds.

CONCLUSIONS
It can be concluded that isolation of all three components was possible in both processes. These could enhance the added value of current processes using rapeseed meal as a protein source. © 2015 Society of Chemical Industry
Y1  - 2015
U6  - http://dx.doi.org/10.1002/jctb.4664
VL  - 90
IS  - 11
SP  - 1999
EP  - 2006
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Teumer, T.
A1  - Capitain, C.
A1  - Ross-Jones, J.
A1  - Tippkötter, Nils
A1  - Rädle, M.
A1  - Methner, F.-J.
T1  - In-line Haze Monitoring Using a Spectrally Resolved Back Scattering Sensor
JF  - BrewingScience
N2  - In the present work an optical sensor in combination with a spectrally resolved detection device for in-line particle-size-monitoring for quality control in beer production is presented. The principle relies on the size and wavelength dependent backscatter of growing particles in fluids. Measured interference structures of backscattered light are compared with calculated theoretical values, based on Mie-Theory, and fitted with a linear least square method to obtain particle size distributions. For this purpose, a broadband light source in combination with a process-CCD-spectrometer (charge ? coupled device spectrometer) and process adapted fiber optics are used. The goal is the development of an easy and flexible measurement device for in-line-monitoring of particle size. The presented device can be directly installed in product fill tubes or vessels, follows CIP- (cleaning in place) and removes the need of sample taking. A proof of concept and preliminary results, measuring protein precipitation, are presented.
Y1  - 2018
SN  - 1613-2041
VL  - 71
IS  - 5/6
SP  - 49
EP  - 55
PB  - Fachverlag Hans Carl
CY  - Nürnberg
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Schneider, Benno
A1  - Erbay, E.
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
JF  - Physica status solidi (a)
N2  - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201532053
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1347
EP  - 1352
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Öhlschläger, Peter
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis–Menten-like kinetics for cell culturing
JF  - Physica status solidi A : Applications and materials science
N2  - The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17–200 mM) follows a Michaelis–Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330464
SN  - 1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1410
EP  - 1415
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Svaneborg, Carsten
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Hojdis, Nils
A1  - Fleck, Franz
A1  - Everaers, Ralf
T1  - Multiscale approach to equilibrating model polymer melts
JF  - Physical Review E
N2  - We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.
Y1  - 2016
U6  - http://dx.doi.org/10.1103/PhysRevE.94.032502
SN  - 2470-0053
VL  - 94
IS  - 032502
PB  - AIP Publishing
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Svaneborg, Carsten
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Hojdis, Nils
A1  - Fleck, Franz
A1  - Everaers, Ralf
T1  - Kremer-Grest Models for Universal Properties of Specific Common Polymer Species
JF  - Soft Condensed Matter
N2  - The Kremer-Grest (KG) bead-spring model is a near standard in Molecular Dynamic simulations of generic polymer properties. It owes its popularity to its computational efficiency, rather than its ability to represent specific polymer species and conditions. Here we investigate how to adapt the model to match the universal properties of a wide range of chemical polymers species. For this purpose we vary a single parameter originally introduced by Faller and Müller-Plathe, the chain stiffness. Examples include polystyrene, polyethylene, polypropylene, cis-polyisoprene, polydimethylsiloxane, polyethyleneoxide and styrene-butadiene rubber. We do this by matching the number of Kuhn segments per chain and the number of Kuhn segments per cubic Kuhn volume for the polymer species and for the Kremer-Grest model. We also derive mapping relations for converting KG model units back to physical units, in particular we obtain the entanglement time for the KG model as function of stiffness allowing for a time mapping. To test these relations, we generate large equilibrated well entangled polymer melts, and measure the entanglement moduli using a static primitive-path analysis of the entangled melt structure as well as by simulations of step-strain deformation of the model melts. The obtained moduli for our model polymer melts are in good agreement with the experimentally expected moduli.
Y1  - 2018
IS  - 1606.05008
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
JF  - Drug Metabolism Reviews
Y1  - 2009
U6  - http://dx.doi.org/10.1080/03602530802605040
SN  - 1097-9883
VL  - 41
IS  - 1
SP  - 27
EP  - 65
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
JF  - Drug Metabolism Reviews
Y1  - 2006
U6  - http://dx.doi.org/10.1080/03602530600786232
SN  - 1097-9883
VL  - 38
IS  - 3
SP  - 515
EP  - 597
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Singh, V.
A1  - Aggarwal, P.
A1  - Schneeweiss, F.
A1  - Scherer, Ulrich W.
A1  - Friedrich, W.
T1  - Optical studies of insulating polymers for radiation dose monitoring
JF  - Indian Journal of Pure & Applied Physics
Y1  - 2010
SN  - 0019-5596
N1  - Special Issue: SI
VL  - 48
IS  - 11
SP  - 782
EP  - 786
ER  - 
TY  - JOUR
A1  - Spiess, Elmar
A1  - Wilfried, Reichardt
A1  - Alvarez, Gerardo
A1  - Gottrup, Marcus
A1  - Öhlschläger, Peter
T1  - An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma
JF  - Molecular Therapy
Y1  - 2011
SN  - 1525-0016
VL  - 20
IS  - 3
SP  - 555
EP  - 564
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Smith, Walker O.
A1  - Baumann, Marcus
A1  - Wilson, David L.
A1  - Aletsee, Ludwig
T1  - Phytoplankton biomass and productivity in the marginal ice zone of the Fram Strait during summer 1984
JF  - Journal of geophysical research
Y1  - 1987
SN  - 2156-2202 (E-Journal); 2169-9291 (E-Journal); 0148-0227 (Print); 2169-9275 (Print)
VL  - Vol. 92
IS  - Iss. C7
SP  - 6777
EP  - 6786
ER  - 
TY  - JOUR
A1  - Sieker, Tim
A1  - Ulber, Roland
A1  - Dimitrova, Darina
A1  - Bart, Hans-Jörg
A1  - Neuner, Andreas
A1  - Heinzle, Elmar
A1  - Tippkötter, Nils
T1  - Silage : Fermentationsrohstoff für die chemische Industrie?
JF  - labor&more
N2  - In Anbetracht des zu erwartenden Rückgangs der Verfügbarkeit fossiler Rohstoffe müssen nicht nur für den Energiesektor, sondern auch für die Herstellung industrieller Produkte alternative Rohstoffe gefunden werden. Ein Beispiel für einen nicht in Nahrungsmittelkonkurrenz stehenden nachwachsenden Rohstoff ist grüne Biomasse wie Gras und Klee. Diese lassen sich in Deutschland auf großen Flächen anbauen und enthalten eine Vielzahl potenzieller Substrate für Fermentationen.
Y1  - 2009
IS  - 2
SP  - 44
EP  - 45
ER  - 
TY  - JOUR
A1  - Sieker, Tim
A1  - Neuner, Andreas
A1  - Dimitrova, Darina
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Bart, Hans-Jörg
A1  - Heinzle, Elmar
A1  - Ulber, Roland
T1  - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development
JF  - Engineering in Life Sciences
N2  - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step.
Y1  - 2011
U6  - http://dx.doi.org/10.1002/elsc.201000160
N1  - Special Issue "Bioprocess‐oriented plant design"
VL  - 11
IS  - 4
SP  - 436
EP  - 442
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Sieker, Tim
A1  - Neuner, Andreas
A1  - Dimitrova, Darina
A1  - Tippkötter, Nils
A1  - Bart, Hans-Jörg
A1  - Heinzle, Elmar
A1  - Ulber, Roland
T1  - Grassilage als Rohstoff für die chemische Industrie
JF  - Chemie Ingenieur Technik
N2  - Grassilage stellt einen nachwachsenden Rohstoff mit großem Potenzial dar. Neben Cellulose und Hemicellulose enthält sie auch organische Säuren, insbesondere Milchsäure. In einem Bioraffinerie-Projekt wird die Milchsäure aus der Silage isoliert und mit gentechnisch optimierten Stämmen zu L-Lysin weiterverarbeitet. Die Lignocellulose wird hydrolysiert und zu Ethanol fermentiert. Ein besonderes Augenmerk liegt auf der Integration der unterschiedlichen Prozesse sowie der einzelnen Prozessschritte zu einem Gesamtprozess, der sämtliche Inhaltsstoffe der Silage verwertet.
Y1  - 2010
U6  - http://dx.doi.org/10.1002/cite.201000088
SN  - 1522-2640
VL  - 82
IS  - 8, Special Issue: Industrielle Nutzung nachwachsender Rohstoffe
SP  - 1153
EP  - 1159
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Siegert, Petra
A1  - McLeish, Michael J.
A1  - Baumann, Martin
A1  - Iding, Hans
A1  - Kneen, Malea M.
A1  - Kenyon, George L.
A1  - Pohl, Martina
T1  - Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida
JF  - Protein engineering, design, and selection : peds
Y1  - 2005
SN  - 1460-213X (E-Journal); 1741-0134 (E-Journal); 0269-2139 (Print); 1741-0126 (Print)
VL  - Vol. 18
IS  - Iss. 7
SP  - 345
EP  - 357
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Yu, Lihua
A1  - Blaser, Martin
A1  - Andrei, Paula I.
T1  - 4-Hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems / Yu, L. ; Blaser, M. ; Andrei, PI. ; Pierik, AJ. Selmer, T.
JF  - Biochemistry. 31 (2006), H. 45
Y1  - 2006
N1  - PMID: 16878993
SP  - 9584
EP  - 9592
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Willanzheimer, Angela
A1  - Hetzel, Marc
T1  - Propionate CoA-transferase from Clostridium propionicum. Cloning of the gene and identification of glutamate 324 at the active site
JF  - European Journal of Biochemistry. 269 (2002), H. 1
Y1  - 2002
SN  - 0014-2956
SP  - 372
EP  - 380
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Thamer, Wiebke
A1  - Cirpus, Irina
A1  - Hans, Marcus
T1  - A two [4Fe-4S]-cluster-containing ferredoxin as an alternative electron donor for 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans / Thamer, Wiebke ; Cirpus, Irina ; Hans, Marcus ; Pierik, Antonio, J. ; Selmer, Thorsten ; Bill, Eckhard ;
JF  - Archives of Microbiology. 179 (2003), H. 3
Y1  - 2003
SN  - 1432-072X
SP  - 197
EP  - 204
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Sommerlade, Hans-Jörg
A1  - Ingendoh, Arnd
A1  - Gieselmann, Volkmar
T1  - Glycosylation and phosphorylation of arylsulfatase A / Sommerlade, Hans-Jörg. ; Selmer, Thomas. ; Ingendoh, Arnd ; Gieselmann, Volkmar ; Figura, Kurt von ; Neifer, Klaus ; Schmidt, Bernhard
JF  - Journal of Biological Chemistry. 269 (1994), H. 33
Y1  - 1994
SN  - 1083-351X
SP  - 20977
EP  - 20981
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Scott, Richard
A1  - Näser, Ulrike
A1  - Friedrich, Peter
T1  - Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase / Scott, R. ; Näser, U. ; Friedrich, P. ; Selmer, T. ; Buckel, W. ; Golding, BT.
JF  - Chemical Communications : ChemCom (2004)
Y1  - 2004
SN  - 1364-548X
SP  - 1210
EP  - 1211
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Schmidt, Bernhard
A1  - Ingendoh, Arnd
A1  - Figura, Kurt von
T1  - A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency / Schmidt, Bernhard ; Selmer, Thorsten ;  Ingendoh, Arnd ;  Figurat, Kurt von
JF  - Cell. 82 (1995), H. 2
Y1  - 1995
SN  - 0092-8674
SP  - 271
EP  - 278
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Recksiek, Michael
A1  - Dierks, Thomas
A1  - Schmidt, Bernhard
T1  - Sulfatases, Trapping of the Sulfated Enzyme Intermediate by Substituting the Active Site Formylglycine / Recksiek, Michael ; Selmer, Thorsten ; Dierks, Thomas ; Schmidt, Bernhard ; Figura, Kurt von
JF  - Journal of Biological Chemistry. 273 (1998), H. 11
Y1  - 1998
SN  - 1083-351X
SP  - 6096
EP  - 6103
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pinkenburg, Olaf
T1  - Method of cloning at least one nucleic acid molecule of interest using type IIS restriction endonucleases, and corresponding cloning vectors, kits and system using type IIS restriction endonucleases / Selmer, Thorsten ; Pinkenburg, Olaf
Y1  - 2008
N1  - Patent No. WO 2008095927  	A1  	Aug 14, 2008
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pierik, Antonio J.
A1  - Heider, Johann
T1  - New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria
JF  - Biological Chemistry. 386 (2005), H. 10
Y1  - 2005
SN  - 1431-6730
SP  - 981
EP  - 988
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Netz, Daili Jacqueline Aguilar
A1  - Pohl, Regula
A1  - Beck-Sickinger, Annette G.
T1  - Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus / Netz, Daili Jacqueline Aguilar ; Pohl, Regula ; Beck-Sickinger, Annette G. ; Selmer, Thorsten ; Pierik, Antonio J. ;  Carmo de Frei
JF  - Journal of Molecular Biology. 319 (2002), H. 3
Y1  - 2002
SN  - 0022-2836
SP  - 745
EP  - 756
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Miech, Claudia
A1  - Dierks, Thomas
A1  - Figura, Kurt von
T1  - Arylsulfatase from Klebsiella pneumoniae Carries a Formylglycine Generated from a Serine / Miech, Claudia ; Dierks, Thomas ; Selmer, Thorsten ; Figura, Kurt von ; Schmidt, Bernd
JF  - Journal of Biological Chemistry. 273 (1998), H. 9
Y1  - 1998
SN  - 1083-351X
SP  - 4835
EP  - 4837
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Lukatela, G.
A1  - Krauss, N.
A1  - Theis, K.
T1  - Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis / Lukatela, G. ; Krauss, N. ; Theis, K. ; Selmer, T. ; Gieselmann, V. ; Figura, K. von ; Saenger,
JF  - Biochemistry. 37 (1998), H. 11
Y1  - 1998
SP  - 3654
EP  - 3664
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kim, Jihoe
A1  - Darley, Daniel
A1  - Buckel, Wolfgang
T1  - Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile / Kim, J. ; Darley, D. ; Selmer, T. ; Buckel, W.
JF  - Applied and Environmental Microbiology. 72 (2006), H. 9
Y1  - 2006
SN  - 0099-2240
N1  - PMID: 16957230
SP  - 6062
EP  - 6069
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kahnt, Jörg
A1  - Goubeaud, Marcel
A1  - Shima, Seigo
T1  - The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase / Selmer, Thorsten ; Kahnt, Jörg ; Goubeaud, Marcel ; Shima, Seigo ; Grabarse, Wolfgang ; Ermler, Ulrich ; Thauer, Rudolf K.
JF  - Journal of Biological Chemistry. 275 (2000), H. 6
Y1  - 2000
SN  - 1083-351X
SP  - 3775
EP  - 3760
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert
JF  - European Journal of Biochemistry. 259 (1999), H. 1-2
Y1  - 1999
SN  - 0014-2956
SP  - 331
EP  - 338
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Basidiolipids from Agaricus are novel immune adjuvants / Jennemann, R. ; Bauer, BL. ; Bertalanffy, H. ; Selmer, T. ; Wiegandt, H.
JF  - Immunobiology. 200 (1999), H. 2
Y1  - 1999
SN  - 0171-2985
N1  - PMID: 10416134
SP  - 277
EP  - 289
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hetzel, Marc
A1  - Brock, Matthias
A1  - Pierik, Antonio J.
T1  - Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein  / Hetzel, Marc ; Brock, Matthias ; Selmer, Thorsten, Pierik, Antonio J. ; Golding, Bernard T. ; Buckel, Wolfgang
JF  - European Journal of Biochemistry. 270 (2003), H. 5
Y1  - 2003
SN  - 0014-2956
SP  - 902
EP  - 910
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hermann, Gloria
A1  - Jessen, Holly
A1  - Gokarn, Ravi R.
T1  - Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum / Herrmann , G. ;  Selmer,  T. ; Jessen,  HJ. ; Gokarn,  RR. ; Selifonova,  O. ;  Gort , SJ. ; , Buckel, W.
JF  - The FEBS Journal. 272 (2005), H. 3
Y1  - 2005
SN  - 1742-464X
SP  - 813
EP  - 821
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hallmann, Armin
A1  - Schmidt, Bernhard
A1  - Sumper, Manfred
T1  - The Evolutionary Conservation of a Novel Protein Modification, the Conversion of Cysteine to Serinesemialdehyde in Arylsulfatase from Volvox carteri / Selmer, Thorsten ; Hallmann, Armin ; Schmidt, Bernhard ; Sumper, Manfred ; Figura, Kurt von
JF  - European Journal of Biochemistry. 238 (1996), H. 2
Y1  - 1996
SN  - 0014-2956
SP  - 341
EP  - 345
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Figura, Kurt von
A1  - Schmidt, Bernhard
A1  - Dierks, T.
T1  - A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease / Figura, Kurt von ; Schmidt, Bernhard ; Selmer, Thorsten ; Dierks, Thomas
JF  - Bioessays. 20 (1998), H. 6
Y1  - 1998
SN  - 1521-1878
SP  - 505
EP  - 510
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Darley, Dan J.
A1  - Clegg, William
A1  - Harrington, Ross W.
T1  - Stereocontrolled Synthesis of (2R,3S)-2-Methylisocitrate, a Central Intermediate in the Methylcitrate Cycle / Darley, Dan J. ; Selmer, Thorsten ; Clegg, William ; Harrington, Ross W. ; Buckel, Wolfgang ; Golding, Bernardt
JF  - Helvetica chimica acta. 86 (2003), H. 12
Y1  - 2003
SN  - 1522-2675
SP  - 3991
EP  - 3999
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Buckel, Wolfgang
T1  - Oxygen Exchange between Acetate and the Catalytic Glutamate Residue in Glutaconate CoA-transferase from Acidaminococcus fermentans. IMPLICATIONS FOR THE MECHANISM OF CoA-ESTER HYDROLYSIS
JF  - Journal of Biological Chemistry. 274 (1999), H. 30
Y1  - 1999
SN  - 1083-351X
SP  - 20772
EP  - 20778
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Brüser, Thomas
A1  - Dahl, Christiane
T1  - ADP Sulfurylase" from Thiobacillus denitrificans Is an Adenylylsulfate:Phosphate Adenylyltransferase and Belongs to a New Family of Nucleotidyltransferases / Brüser, Thomas ; Selmer, Thorsten ; Dahl, Christiane
JF  - Journal of Biological Chemistry. 275 (2000), H. 3
Y1  - 2000
SN  - 1083-351X
SP  - 1691
EP  - 1690
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Andrei, Paula I.
A1  - Pierik, Antonio J.
A1  - Zauner, Stefan
T1  - Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity / Andrei, PI. ;  Pierik,  AJ. ; Zauner , S. ; Andrei-Selmer, LC.  ; Selmer, T.
JF  - European Journal of Biochemistry. 271 (2004), H. 11
Y1  - 2004
SN  - 0014-2956
SP  - 2225
EP  - 2230
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Andrei, Paula I.
T1  - p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol
JF  - European Journal of Biochemistry. 268 (2001), H. 5
Y1  - 2001
SN  - 0014-2956
SP  - 1363
EP  - 1372
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Achebach, Stephanie
A1  - Unden, Gottfried
T1  - Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S]·FNR of Escherichia coli / Achebach, S. ; Selmer, T. ; Unden, G.
JF  - The FEBS Journal. 272 (2005), H. 16
Y1  - 2005
SN  - 1742-464X
SP  - 4260
EP  - 4269
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Grosse, Joachim O.
A1  - Grossmann, Matthias
A1  - Janke, Heinz Peter
A1  - Arndt, Patrick
A1  - Koch, Sabine
A1  - Epple, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation
JF  - Journal of Biomaterials Applications
Y1  - 2017
U6  - http://dx.doi.org/10.1177/0885328217723178
SN  - 1530-8022
VL  - 32
IS  - 3
SP  - 321
EP  - 330
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Goßmann, Matthias
A1  - Grosse, J. O.
A1  - Becker, C.
A1  - Heschel, I.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds
JF  - Urologia Internationalis
Y1  - 2015
U6  - http://dx.doi.org/10.1159/000368419
SN  - 0042-1138
VL  - 2015
IS  - 95
SP  - 106
EP  - 113
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Zevnik, Branko
A1  - Küter-Luks, Birgit
A1  - Andreas, Susanne
A1  - Kern, Heidrun
A1  - Hennek, Thomas
A1  - Rode, Anja
A1  - Heimann, Cornelia
A1  - Faust, Nicole
A1  - Kauselmann, Gunther
A1  - Schoor, Michael
A1  - Jaenisch, Rudolf
A1  - Rajewsky, Klaus
A1  - Kühn, Ralf
A1  - Schwenk, Frieder
T1  - Rapid generation of inducible mouse mutants
JF  - Nucleic Acids Research
Y1  - 2003
U6  - http://dx.doi.org/10.1093/nar/gng012
SN  - 1362-4962
VL  - 33
IS  - 4
SP  - e12
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Schübeler, Dirk
A1  - Fiering, Steven
A1  - Groudine, Mark
A1  - Bode, Jürgen
T1  - DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs
JF  - Biochemistry
Y1  - 1998
U6  - http://dx.doi.org/10.1021/bi980288t
SN  - 1520-4995
VL  - 37
IS  - 18
SP  - 6229
EP  - 6234
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Küter-Luks, Birgit
A1  - Kern, Heidrun
A1  - Streu, Sandra
A1  - Plum, Leona
A1  - Maurer, Jan
A1  - Kühn, Ralf
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Single copy shRNA configuration for ubiquitous gene knockdown in mice
JF  - Nucleic Acids Research
Y1  - 2005
U6  - http://dx.doi.org/10.1093/nar/gni065
SN  - 1362-4962
VL  - 33
IS  - 7
SP  - e67
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Kleinridders, Andre
A1  - Küter-Luks, Birgit
A1  - Niehaves, Sandra
A1  - Brüning, Jens C.
A1  - Schwenk, Frieder
T1  - Reversible gene knockdown in mice using a tight, inducible shRNA expression system
JF  - Nucleic Acids Research
Y1  - 2007
U6  - http://dx.doi.org/10.1093/nar/gkm122
SN  - 1362-4962
VL  - 35
IS  - 7
SP  - e54
ER  - 
TY  - JOUR
A1  - Seibler, Jost
A1  - Bode, Jürgen
T1  - Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay
JF  - Biochemistry
Y1  - 1997
SN  - 1520-4995
VL  - 36
IS  - 7
SP  - 1740
EP  - 1747
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Biselli, Manfred
A1  - Selmer, Thorsten
A1  - Öhlschläger, Peter
A1  - Baumann, Marcus
A1  - Förster, Arnold
A1  - Poghossian, Arshak
T1  - Forschung „zwischen“ den Disziplinen: das Institut für Nano- und Biotechnologien
JF  - Analytik news : das Online-Labormagazin für Labor und Analytik
N2  - "Biologie trifft Mikroelektronik", das Motto des Instituts für Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplinär geprägter Forschungsaktivitäten. Der thematische Zusammenschluss grundständiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, lässt neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierfür ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Moleküle und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen.

Vor diesem Hintergrund bündelt das im Jahre 2006 gegründete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergewöhnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zukünftig unser alltägliches Leben verändern werden.

Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgewählten, aktuellen Forschungsprojekten skizziert.
Y1  - 2012
VL  - Publ. online
PB  - Dr. Beyer Internet-Beratung
CY  - Ober-Ramstadt
ER  - 
TY  - JOUR
A1  - Schwertner, Eberhard
A1  - Berndt, Heinz
A1  - Gielen, Hans-Günter
A1  - Zahn, Helmut
T1  - Peptide 96 : Synthese einiger [2-(p-Biphenylyl)isopropyloxycarbonyl]-Aminosäurederivate
JF  - Justus Liebigs Annalen der Chemie
N2  - Die Darstellung der N-[2-(p-Biphenylyl)isopropyloxycarbonyl]-Derivate (Bpoc-Derivate) des Cysteins unter Verwendung der Thiolschutzgruppen Tetrahydropyranyl (Thp) für 1, Diphenylmethyl (Dpm) für 2, Trityl (Trt) für 3 und S-tert.-Butyl (SBut) für 4 sowie die Synthese von aktivierten Estern der Bpoc-Derivate des Glycins (5), Isoleucins (6) und Prolins (7) werden beschrieben. An einem Beispiel wird die Möglichkeit aufgezeigt, die Bpoc-Gruppe über das Bpoc-Azid nachträglich in den Peptidverband einzuführen.
Y1  - 1975
U6  - http://dx.doi.org/10.1002/jlac.197519750318
SN  - 1099-0690
VL  - 75
IS  - 3
SP  - 581
EP  - 585
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schwab, Lukas
A1  - Hojdis, Nils
A1  - Lacayo, Jorge
A1  - Wilhelm, Manfred
T1  - Fourier-Transform Rheology of Unvulcanized, Carbon Black Filled Styrene Butadiene Rubber
JF  - Macromolecular Materials and Engineering
N2  - Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/mame.201500356
SN  - 1439-2054
VL  - 301
IS  - 4
SP  - 457
EP  - 468
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schumann, Christiane
A1  - Rogin, Sabine
A1  - Schneider, Horst
A1  - Tippkötter, Nils
A1  - Oster, Jürgen
A1  - Kampeis, Percy
T1  - Simultane Atline-Quantifizierung von Magnetpartikeln und Mikroorganismen bei einer HGMS-Filtration
JF  - Chemie Ingenieur Technik
N2  - Es wird eine neue Atline-Messmethode vorgestellt, mit der während einer Hochgradienten-Magnetseparation (HGMS)-Filtration eine simultane Quantifizierung von Magnetpartikeln und Mikroorganismen im Filtrat vorgenommen werden kann. Dabei gelingt die Quantifizierung signifikant besser als mit bisher verwendeten Messmethoden. Mit dieser Methode ist es möglich, die Trennleistung einer HGMS-Filtration zu bestimmen und einen Filterdurchbruch durch Konzentrationsanstiege im Bereich einiger µg L−1 von Magnetpartikeln im Filtrat frühzeitig zu detektieren, ohne dass nennenswerte Partikelmengen verloren gehen.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/cite.201300158
N1  - Englischer Titel: Simultaneous Atline Quantification of Magnetic Particles and Microorganisms in the HGMS Filtration
VL  - 87
IS  - 1-2
SP  - 137
EP  - 149
ER  - 
TY  - JOUR
A1  - Schroeter, Rebecca
A1  - Hoffmann, Tamara
A1  - Voigt, Birgit
A1  - Meyer, Hanna
A1  - Bleisteiner, Monika
A1  - Muntel, Jan
A1  - Jürgen, Britta
A1  - Albrecht, Dirk
A1  - Becher, Dörte
A1  - Lalk, Michael
A1  - Evers, Stefan
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Putzer, Harald
A1  - Hecker, Michael
A1  - Schweder, Thomas
A1  - Bremer, Erhard
T1  - Stress responses of the industrial workhorse Bacillus licheniformis to osmotic challenges
JF  - PLoS ONE
N2  - The Gram-positive endospore-forming bacterium Bacillus licheniformis can be found widely in nature and it is exploited in industrial processes for the manufacturing of antibiotics, specialty chemicals, and enzymes. Both in its varied natural habitats and in industrial settings, B. licheniformis cells will be exposed to increases in the external osmolarity, conditions that trigger water efflux, impair turgor, cause the cessation of growth, and negatively affect the productivity of cell factories in biotechnological processes. We have taken here both systems-wide and targeted physiological approaches to unravel the core of the osmostress responses of B. licheniformis. Cells were suddenly subjected to an osmotic upshift of considerable magnitude (with 1 M NaCl), and their transcriptional profile was then recorded in a time-resolved fashion on a genome-wide scale. A bioinformatics cluster analysis was used to group the osmotically up-regulated genes into categories that are functionally associated with the synthesis and import of osmostress-relieving compounds (compatible solutes), the SigB-controlled general stress response, and genes whose functional annotation suggests that salt stress triggers secondary oxidative stress responses in B. licheniformis. The data set focusing on the transcriptional profile of B. licheniformis was enriched by proteomics aimed at identifying those proteins that were accumulated by the cells through increased biosynthesis in response to osmotic stress. Furthermore, these global approaches were augmented by a set of experiments that addressed the synthesis of the compatible solutes proline and glycine betaine and assessed the growth-enhancing effects of various osmoprotectants. Combined, our data provide a blueprint of the cellular adjustment processes of B. licheniformis to both sudden and sustained osmotic stress.
Y1  - 2014
U6  - http://dx.doi.org/10.1371/journal.pone.0080956
SN  - 1932-6203
VL  - 8
IS  - 11
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Schnitzler, Thomas
A1  - Biselli, Manfred
T1  - Cultivo de lineas celulares de hibridoma por CF-10H5 (DSMZ ACC477) en el BIOSTAT B plus
JF  - Noticias tecnicas del laboratorio
Y1  - 2005
VL  - 13
IS  - 3
SP  - 7
EP  - 8
ER  - 
TY  - JOUR
A1  - Schnitzler, Thomas
T1  - Cultivation of hybridoma cell line CF-10H5 (DSMZ ACC477)
JF  - Application notes / Sartorius stedim biotech
Y1  - 2009
SP  - 1
EP  - 4
ER  - 
TY  - JOUR
A1  - Schnitzler, Thomas
T1  - Kultivierung der Hybridomazelllinie CF-10H5 (DSMZ ACC477)
JF  - Application notes / Sartorius stedim biotech
Y1  - 2009
PB  - Sartorius Stedim Biotec
CY  - Aubagne
ER  - 
TY  - JOUR
A1  - Schnabel, Eugen
A1  - Schnabel, Henning
A1  - Berndt, Heinz
T1  - Zur selektiven acidolytischen Abspaltbarkeit der tert.-Butyloxycarbonyl-Gruppe
JF  - Justus Liebigs Annalen der Chemie
N2  - Die tert.-Butyloxycarbonyl-Gruppe (Boc) läßt sich mittels reiner Trifluoressigsäure nicht selektiv neben dem Benzyloxycarbonyl-Rest (Z) abspalten. Das gelingt auch nicht mit Lösungen von Trifluoressigsäure bzw. Chlorwasserstoff in organischen Lösungsmitteln. Kern-substituierte Z-Gruppen wie Z(pCl), Z(mCl) oder Z(pNO₂) sind zwar stabiler, werden aber von den obengenannten Reagenzien ebenfalls angegriffen bzw. sind nicht mehr acidolytisch abspaltbar. – Mit 70proz. wäßriger Trifluoressigsäure gelingt die Abspaltung von Boc neben Z dagegen fast selektiv; dabei werden aber Benzylester, besonders Glutaminsäure-γ-benzylester, teilweise hydrolysiert, während Methyl- sowie Äthylester nahezu beständig sind. Die Brauchbarkeit des Abspaltungsverfahrens wird anhand der schrittweise durchgeführten Synthese zweier Heptapeptid-Derivate gezeigt. – Ähnlich spezifisch gelingt die Abspaltung von Boc mit Bortrifluorid-ätherat in Eisessig; Benzylester sind gegenüber diesem Reagenz stabiler als gegen wäßrige Trifluoressigsäure. Das Bortrifluorid-Verfahren eignet sich besonders für die Abspaltung von Boc-Gruppen neben säurelabilen Thiol-Schutzgruppen (Tetrahydropyranyl- bzw. Trityl-Rest) sowie neben dem Cyclocystinyl-Rest. Die Leistungsfähigkeit der Methode wird durch die Synthese zweier Peptid-Derivate mit S-Trityl-Schutzgruppen belegt. Als Nebenreaktion ist die Acetylierung von aliphatischen Hydroxylgruppen möglich. Sie läßt sich vermeiden, wenn man die Spaltung in anderen Lösungsmitteln durchführt. Die als Modellverbindungen für Stabilitätsuntersuchungen verwendeten Nε-acylierten Lysin-Derivate werden mit dem Aminosäureanalysator quantitativ neben Lysin bestimmt.
Y1  - 1971
U6  - http://dx.doi.org/10.1002/jlac.19717490111
SN  - 1099-0690
VL  - 749
IS  - 1
SP  - 90
EP  - 108
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schmitz, M.
A1  - Hirsch, E.
A1  - Bongaerts, Johannes
A1  - Takors, Ralf
T1  - Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Eschericia coli
JF  - Biotechnology progress
Y1  - 2002
SN  - 1520-6033 (E-Journal); 8756-7938 (Print)
VL  - Vol. 18
IS  - Iss. 5
SP  - 935
EP  - 941
ER  - 
TY  - JOUR
A1  - Schmidt, Aaron C.
A1  - Turgut, Hatice
A1  - Le, Dao
A1  - Beloqui, Ana
A1  - Delaittre, Guillaume
T1  - Making the best of it: nitroxide-mediated polymerization of methacrylates via the copolymerization approach with functional styrenics
JF  - Polymer Chemistry
N2  - The SG1-mediated solution polymerization of methyl methacrylate (MMA) and oligo(ethylene glycol) methacrylate (OEGMA, Mₙ = 300 g mol⁻¹) in the presence of a small amount of functional/reactive styrenic comonomer is investigated. Moieties such as pentafluorophenyl ester, triphenylphosphine, azide, pentafluorophenyl, halide, and pyridine are considered. A comonomer fraction as low as 5 mol% typically results in a controlled/living behavior, at least up to 50% conversion. Chain extensions with styrene for both systems were successfully performed. Variation of physical properties such as refractive index (for MMA) and phase transition temperature (for OEGMA) were evaluated by comparing to 100% pure homopolymers. The introduction of an activated ester styrene derivative in the polymerization of OEGMA allows for the synthesis of reactive and hydrophilic polymer brushes with defined thickness. Finally, using the example of pentafluorostyrene as controlling comonomer, it is demonstrated that functional PMMA-b-PS are able to maintain a phase separation ability, as evidenced by the formation of nanostructured thin films.
Y1  - 2020
U6  - http://dx.doi.org/10.1039/C9PY01458F
VL  - 11
IS  - 2
SP  - 593
EP  - 604
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Schmich, Peter
A1  - Ederer, Hanns J.
A1  - Ebert, Klaus H.
T1  - Detection and identification of free radicals in hydrocarbon pyrolysis by an iodine trapping method
JF  - Industrial & Engineering Chemistry Research. 31 (1992), H. 1
Y1  - 1992
SN  - 1520-5045
SP  - 29
EP  - 37
ER  - 
TY  - JOUR
A1  - Schiffels, Johannes
A1  - Selmer, Thorsten
T1  - A flexible toolbox to study protein-assisted metalloenzyme assembly in vitro
JF  - Biotechnology and Bioengineering
Y1  - 2015
U6  - http://dx.doi.org/10.1002/bit.25658
SN  - 1097-0290
VL  - 112
IS  - 11
SP  - 2360
EP  - 2372
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schiffels, Johannes
A1  - Selmer, Thorsten
T1  - Combinatorial assembly of ferredoxin‐linked modules in Escherichia coli yields a testing platform for Rnf‐complexes
JF  - Biotechnology and Bioengineering
Y1  - 2019
U6  - http://dx.doi.org/10.1002/bit.27079
IS  - accepted article
SP  - 1
EP  - 36
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schiffels, Johannes
A1  - Pinkenburg, Olaf
A1  - Schelden, Maximilian
A1  - Aboulnaga, El-Hussiny A. A.
A1  - Baumann, Marcus
A1  - Selmer, Thorsten
T1  - An innovative cloning platform enables large-scale production and maturation of an oxygen-tolerant [NiFe]-hydrogenase from cupriavidus necator in Escherichia coli
JF  - PLOS one. 2013
Y1  - 2013
U6  - http://dx.doi.org/10.1371/journal.pone.0068812
SN  - 1932-6203
PB  - Public Library of Science
CY  - San Francisco, California
ER  - 
TY  - JOUR
A1  - Schiffels, Johannes
A1  - Baumann, Marcus
A1  - Selmer, Thorsten
T1  - Facile analysis of short-chain fatty acids as 4-nitrophenyl esters in complex anaerobic fermentation samples by high performance liquid chromatography
JF  - Journal of Chromatography A. 1218 (2011), H. 34
Y1  - 2011
SN  - 0021-9673
SP  - 5848
EP  - 5851
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schiedermeier, Maximilian
A1  - Rettner, Cornelius
A1  - Heilmann, Marcel
A1  - Schneider, Felix
A1  - Marz, Martin
T1  - Interference of automotive HV-DC-systems by traction voltage-source-inverters (VSI)
JF  - 2019 IEEE Transportation Electrification Conference (ITEC-India)
Y1  - 2019
U6  - http://dx.doi.org/10.1109/ITEC-India48457.2019.ITECINDIA2019-37
SP  - 1
EP  - 6
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Zimmermann, H. P.
A1  - Gober, M. K.
A1  - Kratz, J. V.
T1  - Chemical Properties of Element 105 in Aqueous Solution: Back Extraction from Triisooctyl Amine into 0.5M HCl / H.P. Zimmermann, M.K. Gober, J.V. Kratz, M. Schädel, E. Schimpf, K.E. Gregorich, A. Türler, K.R. Czerwinski, N.J. Hannink, B. Kadkhodayan, D.M.
JF  - Radiochimica Acta. 60 (1993)
Y1  - 1993
SN  - 0033-8230
SP  - 11
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Türler, A.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
T1  - Determination of the Partial Electron-Capture- and Spontaneous-Fission Half-Lives of 254No / A. Türler, H.W. Gäggeler, D.T. Jost, P. Armbruster, W. Brüchle, H. Folger, F.P. Heßberger,  S. Hofmann,
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 331 (1988), H. 3
Y1  - 1988
SN  - 0939-7922
SP  - 363
EP  - 364
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Türler, A.
A1  - Gäggeler, H. W.
A1  - Gregorich, K. E.
T1  - Gas phase chromatography of halides of elements 104 and 105 / A. Türler, H. W. Gäggeler, K. E. Gregorich, H. Barth, W. Brüchle, K. R. Czerwinski, M. K. Gober, N. J. Hannink, R. A. Henderson, D. C. Hoffman, D. T. Jost, C. D. Kacher, B. Kadkhodayan, J. Kova
JF  - Journal of Radioanalytical and Nuclear Chemistry. 160 (1992), H. 2
Y1  - 1992
SN  - 0236-5731
SP  - 327
EP  - 339
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Tomasberger, T.
A1  - Veltkamp, T. C.
A1  - Booij, A. S.
T1  - Radiocesium Removal from High Level Liquid Waste and Immobilisation in Sodium SilicoTitanate for Geological Disposal / T. Tomasberger, T.C. Veltkamp, A.S. Booij, U.W. Scherer
JF  - Radiochimica Acta. 89 (2001), H. 3
Y1  - 2001
SN  - 0033-8230
SP  - 145
EP  - 150
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Srivastava, Alok
A1  - Singh, Vivendra
A1  - Chandra, Amita
T1  - Electrical conductivity studies of swift heavy ion modified PVC and PVC-PANI composite / Alok Srivastava ,Virendra Singh, Amita Chandra, K.Witte, U.W.Scherer and T.V.Singh
JF  - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 245 (2006), H. 1
Y1  - 2006
SN  - 0168-583X
SP  - 277
EP  - 280
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Schädel, M.
A1  - Brüchle, W.
A1  - Schimpf, E.
T1  - Chemical Properties of Element 105 in Aqueous Solution: Cation Exchange Separations with &#945;-Hydroxyisobutyric Acid / M. Schädel, W. Brüchle, E. Schimpf, H.P. Zimmermann, M.K. Gober, J.V. Kratz,  N. Trautmann, H. Gäggeler, D. Jost, J. Kovacs, U.W. Sche
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 85
EP  - 92
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Schädel, M.
A1  - Brüchle, W.
A1  - Jäger, E.
T1  - ARCA II - A New Apparatus for Fast Repetitive HPLC-Separations / M. Schädel, W. Brüchle, E. Jäger, E. Schimpf, J.V. Kratz, U.W. Scherer, H.P. Zimmermann
JF  - Radiochimica Acta. 48 (1989)
Y1  - 1989
SN  - 0033-8230
SP  - 171
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Santana, H. H. S.
A1  - Maier, G.
A1  - Rodenas, J.
T1  - Analysis of mechanical strength in ceramic pellets of nuclear fuel  / Santana, H. H. S. ; Maier, G. ; Scherer, U. W. ; Rodenas, J.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 313
EP  - 318
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Zimmermann, H. P.
A1  - Schädel, M.
T1  - Chemical Properties of Element 105 in Aqueous Solutions: Halide Complex Formation and Anion Exchange into Triisooctylamine / J.V. Kratz, H.P. Zimmermann, U.W. Scherer, M. Schädel, W. Brüchle, K.E. Gregorich, C.M. Gannett, H.L. Hall, R.A. Henderson, D.M. L
JF  - Radiochimica Acta. 48 (1989)
Y1  - 1989
SN  - 0033-8230
SP  - 121
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Schädel, M.
A1  - Brüchle, W.
T1  - Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Schädel, W. Brüchle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988)
Y1  - 1988
SN  - 0020-1693
SP  - 249
EP  - 254
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Gober, M. K.
A1  - Zimmermann, H. P.
T1  - New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. Gäggeler, D. Jost, U.W. Scherer, A. Weber
JF  - Physical Review C . 45 (1992)
Y1  - 1992
SP  - 1064
EP  - 1069
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Jacobi, M.
A1  - Castillo, J.
A1  - Foerstel, D. H.
T1  - Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 382
EP  - 385
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
A1  - Kranert, W. T.
A1  - Maul, F. D.
T1  - Gated Metabolic Positron Emission Tomography (GAPET) of Myocardium: 18F-FDG/PET to optimize Recognition of Myocardial Hibernation / G. Hör, W.T. Kranert, F.D. Maul, O. Schröder,  A. Karimian-Tatriz, O. Geb, R.P. Baum, U.W.  Scherer
JF  - Nuclear Medicine Communications. 19 (1998)
Y1  - 1998
SN  - 0143-3636
SP  - 535
EP  - 545
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
A1  - Hertel, A.
T1  - Positronen-Emissions-Tomographie des Herzens / G. Hör, A. Hertel, U. W. Scherer
JF  - Herzerkrankungen und Interventionsmöglichkeiten / F. Unger [Hrsg.]
Y1  - 1998
SN  - 3-540-62916-5
SP  - 236
EP  - 263
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
T1  - Kompartimentmodelle zur Quantifizierung des myokardialen Stoffwechsels mit PET / U. W. Scherer, G. Hör
JF  - Kardiologische Nuklearmedizin / G. Hör [Hrsg.]
Y1  - 1997
SN  - 3-609-62970-3
SP  - 179
EP  - 189
PB  - ecomed
CY  - Landsberg
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
T1  - Artifacts and Pitfalls in FDG-PET Whole-Body Scans / U.W. Scherer, G. Hör
JF  - Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]
Y1  - 1997
SN  - 960-85227-6-5
SP  - 37
EP  - 42
PB  - Mediterra Publishers
CY  - Athen
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Heßberger, F. P.
A1  - Gäggeler, H. W.
A1  - Armbruster, P.
T1  - The New Nuclide 225U / F.P. Heßberger, H. Gäggeler, P. Armbruster, W. Brüchle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. Münzenberg, V. Ninov, M. Schädel, U.W. Scherer, K. Sümmerer, A. Türler, D. Ackerman
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 333 (1989), H. 1
Y1  - 1989
SN  - 0939-7922
SP  - 111
EP  - 112
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
A1  - Türler, A.
T1  - Cold Fusion Reactions with 48Ca / H.W. Gäggeler, D.T. Jost, A. Türler, P. Armbruster, W. Brüchle, H. Folger, F.P. Heßberger, S. Hofmann, G. Münzenberg, V. Ninov, W. Reisdorf, M. Schädel, K. Sümmerer, J.V. Kratz, U. Scherer, M.E. Leino
JF  - Nuclear Physics A . 502 (1989), H. 1
Y1  - 1989
SN  - 0375-9474
SP  - 561
EP  - 570
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
A1  - Kovacs, J.
T1  - Gas Phase Chromatography Experiments with Bromides of Tantalum and Element 105 / H.W. Gäggeler, D.T. Jost, J. Kovacs, U.W. Scherer, A. Weber, D. Vermeulen, A. Türler, K.E. Gregorich, R.A. Henderson, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M. Nurmia, D.
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 93
EP  - 100
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gober, M. K.
A1  - Kratz, J. V.
A1  - Zimmermann, H. P.
T1  - Chemical Properties of Element 105 in Aqueous Solution: Extractions into Diisobutylcarbinol / M.K. Gober, J.V. Kratz, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee,
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 77
EP  - 84
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Schädel, M.
A1  - Kratz, J. V.
T1  - The Hydration Enthalpies of Md3+ and Lr3+ / W. Brüchle, M. Schädel, U.W. Scherer, J.V. Kratz, K.E. Gregorich, D. Lee, M. Nurmia, R.M. Chasteler, H.L. Hall, R.A. Henderson, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988), H. 2
Y1  - 1988
SN  - 0020-1693
SP  - 267
EP  - 276
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Brügger, M.
A1  - Frink, C.
T1  - Reactions of 40Ar with 233U,,235U, and 238U at the Barrier / U.W. Scherer, W. Brüchle, M. Brügger, C. Frink, H. Gäggeler, G. Herrmann, J.V. Kratz, K.J. Moody, M. Schädel, K. Sümmerer, N. Trautmann, G. Wirth
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 335 (1990), H. 4
Y1  - 1990
SN  - 0939-7922
SP  - 421
EP  - 430
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Baltensperger, Urs
A1  - Ammann, Markus
A1  - Bochert, Ulrich K.
T1  - Use of 13N for Studies of the Selective Reduction of NO by NH3 over Vanadia/Titania Catalyst at Very Low Reactant Concentrations / Urs Baltensperger, Markus Ammann, Ulrich K. Bochert, Bernd Eichler, Heinz W. Gäggeler, Dieter T. Jost, Joseph A. Kovacs,  An
JF  - Journal of Physical Chemistry. 97 (1993)
Y1  - 1993
SN  - 0022-3654
SP  - 12325
EP  - 12330
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
T1  - Zur Radiopharmazie kardialer und kardiovaskulärer Radiopharmazeutika
JF  - Kardiologische Nuklearmedizin / G. Hör [Hrsg.]
Y1  - 1997
SN  - 3-609-62970-3
SP  - 27
EP  - 42
PB  - ecomed
CY  - Landsberg
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
T1  - Controlled ion track etching / J. George;  M. Irkens ;  S. Neumann ;  U. W. Scherer ;  A. Srivastava ;  D. Sinha ; D. Fink
JF  - Radiation Effects and Defects in Solids. 161 (2006), H. 3
Y1  - 2006
SP  - 161
EP  - 175
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
JF  - Xenobiotica
N2  - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described.

2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created.

3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment.

4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.
KW  - transporters
KW  - human metabolites
KW  - drug metabolising enzymes
KW  - drug–drug interactions
KW  - bioavailability
Y1  - 2014
U6  - http://dx.doi.org/10.3109/00498254.2013.815831
SN  - 1366-5928
VL  - 44
IS  - 2
SP  - 96
EP  - 108
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Xenobiotic receptor humanized mice and their utility
JF  - Drug Metabolism Reviews
Y1  - 2013
U6  - http://dx.doi.org/10.3109/03602532.2012.738687
SN  - 1097-9883
IS  - 1
SP  - 110
EP  - 121
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wilson, Ian D.
T1  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
JF  - Drug Discovery Today
N2  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.drudis.2015.09.002
SN  - 1359-6446
VL  - 21
IS  - 2
SP  - 250
EP  - 263
PB  - Elsevier
CY  - Amsterdam
ER  -