TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Böhnisch, Nils
A1  - Braun, Carsten
A1  - Muscarello, Vincenzo
A1  - Marzocca, Pier
T1  - A sensitivity study on aeroelastic instabilities of slender wings with a large propeller
JF  - AIAA SCITECH 2023 Forum
N2  - Next-generation aircraft designs often incorporate multiple large propellers attached along the wingspan. These highly flexible dynamic systems can exhibit uncommon aeroelastic instabilities, which should be carefully investigated to ensure safe operation. The interaction between the propeller and the wing is of particular importance. It is known that whirl flutter is stabilized by wing motion and wing aerodynamics. This paper investigates the effect of a propeller onto wing flutter as a function of span position and mounting stiffness between the propeller and wing. The analysis of a comparison between a tractor and pusher configuration has shown that the coupled system is more stable than the standalone wing for propeller positions near the wing tip for both configurations. The wing fluttermechanism is mostly affected by the mass of the propeller and the resulting change in eigenfrequencies of the wing. For very weak mounting stiffnesses, whirl flutter occurs, which was shown to be stabilized compared to a standalone propeller due to wing motion. On the other hand, the pusher configuration is, as to be expected, the more critical configuration due to the attached mass behind the elastic axis.
Y1  - 2023
U6  - http://dx.doi.org/10.2514/6.2023-1893
N1  - AIAA SCITECH 2023 Forum, 23-27 January 2023, National Harbor, MD & Online
SP  - 1
EP  - 14
PB  - AIAA
ER  - 
TY  - JOUR
A1  - Harzheim, Thomas
A1  - Mühmel, Marc
A1  - Heuermann, Holger
T1  - A SFCW harmonic radar system for maritime search and rescue using passive and active tags
JF  - International Journal of Microwave and Wireless Technologies
N2  - This paper introduces a new maritime search and rescue system based on S-band illumination harmonic radar (HR). Passive and active tags have been developed and tested while attached to life jackets and a small boat. In this demonstration test carried out on the Baltic Sea, the system was able to detect and range the active tags up to a distance of 5800 m using an illumination signal transmit-power of 100 W. Special attention is given to the development, performance, and conceptual differences between passive and active tags used in the system. Guidelines for achieving a high HR dynamic range, including a system components description, are given and a comparison with other HR systems is performed. System integration with a commercial maritime X-band navigation radar is shown to demonstrate a solution for rapid search and rescue response and quick localization.
KW  - Radar
KW  - microwave measurements
KW  - harmonic radar
KW  - harmonic radar tags
KW  - nonlinear VNA measurements
Y1  - 2021
U6  - http://dx.doi.org/10.1017/S1759078721000520
VL  - 13
IS  - Special Issue 7
SP  - 691
EP  - 707
PB  - Cambridge University Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Buß, G.
A1  - Faßbender, F.
A1  - Glück, O.
A1  - Schmitt, G.
A1  - Schultze, J. W.
A1  - Lüth, H.
T1  - A silicon-based microelectrode array for chemical analysis
JF  - Sensors and Actuators B. 65 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 284
EP  - 287
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Buß, G.
A1  - Faßbender, F.
A1  - Glück, O.
A1  - Schmitt, G.
A1  - Schultze, J. W.
A1  - Lüth, H.
T1  - A silicon-based microelectrode array for chemical analysis
JF  - Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou
Y1  - 1998
N1  - International Meeting on Chemical Sensors ; (7, 1998, Beijing) ; International Meeting on Chemical Sensors (IMCS) ; (7 : ; 1998.07.27-30 : ; Beijing)
SP  - 100
EP  - 102
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Pouyeshman, S.
A1  - Schnitzler, Thomas
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Biselli, Manfred
A1  - Schöning, Michael Josef
T1  - A silicon-based multi-sensor chip for monitoring of fermentation processes
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1364
EP  - 1369
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Weidenbrück, B.
A1  - Thust, M.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - A silicon-based sensor array with capacitive EIS structures
JF  - Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2.
Y1  - 1997
SN  - 83-908335-0-6
N1  - Eurosensors ; (11, 1997, Warszawa) ; Eurosensors - European Conference on Solid-State Transducers ; (11 : ; 1997.09.21-24 : ; Warsaw)
SP  - 871
EP  - 874
PB  - Sensor Lab Sp.
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Pieper, Martin
A1  - Klein, Peter
T1  - A simple and accurate numerical network flow model for bionic micro heat exchangers
JF  - Heat mass transfer
Y1  - 2011
SN  - 0947-7411
VL  - 47
IS  - 5
SP  - 491
EP  - 503
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Prume, Klaus
A1  - Booij, W. E.
A1  - Vogl, A. H.
A1  - Wang, D. T.
T1  - A simple and powerful analytical model for MEMS piezoelectric multimorphs  / Booij, W. E. ; Vogl, A. H. ; Wang, D. T. ; Tyholdt, F. ; Ostbo, N. P. ; Raeder, H. ; Prume, K.
JF  - Journal of Electroceramics. 19 (2007), H. 4
Y1  - 2007
SN  - 1385-3449
SP  - 387
EP  - 393
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Beck, Daniel
A1  - Lakemeyer, Gerhard
T1  - A Simulation Environment for Middle-Size Robots with Multi-level Abstraction / Beck, Daniel ; Ferrein, Alexander ; Lakemeyer, Gerhard
JF  - RoboCup 2007: Robot Soccer World Cup XI
Y1  - 2007
SN  - 978-3-540-68846-4
N1  - Lecture Notes in Computer Science ; 5001
SP  - 136
EP  - 147
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Ball, Andrew J.
A1  - Ulamec, Stephan
A1  - Price, Michael E.
T1  - A small mission for in situ exploration of a primitive binary near-Earth asteroid  / Ball, Andrew J. ; Ulamec, Stephan ; Dachwald, Bernd ; Price, Michael E. ; [u.a.]
JF  - Advances in Space Research. 43 (2009), H. 2
Y1  - 2009
SN  - 0273-1177
SP  - 317
EP  - 324
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hillen, Walter
A1  - Alper Selver, M.
A1  - Fischer, Felix
A1  - Kuntalp, Mehmet
T1  - A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter
JF  - Computer Methods and Programs in Biomedicine. 86 (2007), H. 3
Y1  - 2007
SN  - 0169-2607
SP  - 270
EP  - 280
PB  - -
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A Solution to the Scheduling Problem Taking into Account Quality
JF  - Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GMÖOR]. Peter Gritzmann ... (eds.)
Y1  - 1991
SN  - 3790806080
N1  - Symposium on Operations Research ; (16, 1991, Trier)
SP  - 373
EP  - 375
PB  - Physica-Verl.
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W. K.
T1  - A step towards optimization of the qNMR workflow: proficiency testing exercise at an GxP-accredited laboratory
JF  - Applied Magnetic Resonance
N2  - Quantitative nuclear magnetic resonance (qNMR) is considered as a powerful tool for multicomponent mixture analysis as well as for the purity determination of single compounds. Special attention is currently paid to the training of operators and study directors involved in qNMR testing. To assure that only qualified personnel are used for sample preparation at our GxP-accredited laboratory, weighing test was proposed. Sixteen participants performed six-fold weighing of the binary mixture of dibutylated hydroxytoluene (BHT) and 1,2,4,5-tetrachloro-3-nitrobenzene (TCNB). To evaluate the quality of data analysis, all spectra were evaluated manually by a qNMR expert and using in-house developed automated routine. The results revealed that mean values are comparable and both evaluation approaches are free of systematic error. However, automated evaluation resulted in an approximately 20% increase in precision. The same findings were revealed for qNMR analysis of 32 compounds used in pharmaceutical industry. Weighing test by six-fold determination in binary mixtures and automated qNMR methodology can be recommended as efficient tools for evaluating staff proficiency. The automated qNMR method significantly increases throughput and precision of qNMR for routine measurements and extends application scope of qNMR.
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00723-021-01324-3
SN  - 1613-7507
N1  - Corresponding author: Yulia Monakhova
VL  - 52
SP  - 581
EP  - 593
PB  - Springer Nature
CY  - Wien
ER  - 
TY  - JOUR
A1  - Reißel, Martin
A1  - Bitsch, G.
A1  - Stamm, H.
T1  - A Stern Door Slam Fatigue Calculation / Bitsch, G. ; Reißel, M. ; Stamm, H.
JF  - Proceedings of the 18. CAD-FEM Users Meeting
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Faßbender, Heinz
A1  - Maneth, Sebastian
T1  - A strict border for the decidability of e-unification for recursive functions / Faßbender, Heinz ; Maneth, Sebastian
JF  - Algebraic and logic programming : proceedings / 5th International Conference, ALP '96, Aachen, Germany, September 25 - 27, 1996. Michael Hanus ... (ed.)
Y1  - 1996
SN  - 3-540-61735-3
N1  - (Lecture notes in computer science ; 1139)
SP  - 194
EP  - 208
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Faßbender, Heinz
A1  - Maneth, Sebastian
T1  - A strict border for the decidability of e-unification for recursive functions / Faßbender, Heinz ; Maneth, Sebastian
JF  - Journal of functional and logic programming. 1998 (1998), H. 4
Y1  - 1998
SN  - 1080-5230
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
T1  - A Synthesis Technique for Mono- and Mixed-Mode Symmetrical Filter
JF  - Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association . Vol. 1
Y1  - 2004
SN  - 1-580-53992-0
N1  - European Microwave Conference ; (34, 2004, Amsterdam) ; European Microwave Week ; (7, 2004, Amsterdam)
SP  - 309
EP  - 312
PB  - Horizon House Publ
CY  - London
ER  - 
TY  - JOUR
A1  - Wissenbach, U.
A1  - Six, S.
A1  - Bongaerts, Johannes
A1  - Ternes, D.
A1  - Steinwachs, S.
A1  - Unden, G.
T1  - A third periplasmic transport system for l-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport
JF  - Molecular microbiology
Y1  - 1995
SN  - 1365-2958 (E-Journal); 0950-382x (Print)
VL  - Vol. 17
IS  - Iss. 4
SP  - 675
EP  - 686
ER  - 
TY  - JOUR
A1  - Gebhardt, Michael
A1  - Jarke, Matthias
A1  - Jacobs, Stephan
T1  - A Toolkit for Negotiation Support Interfaces to Multidimensional Data
JF  - SIGMOD 1997 : proceedings ACM SIGMOD International Conference on Management of Data, May 13 - 15, 1997, Tucson, Arizona, USA / ed. by Joan M. Peckman
Y1  - 1997
SN  - 0897919114
N1  - International Conference on Management of Data ; (1997, Tucson, Ariz.)
PB  - ACM Press
CY  - New York, NY
ER  -