TY  - JOUR
A1  - Gorissen, P.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport
T1  - Experimental measurement of forces as a contribution to evaluate the effectiveness of shin guards in soccer
JF  - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis
N2  - Diese Studie beschäftigte sich mit der Dämpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgeführt, der verschiedene Aufschlagkräfte auf die Schoner ermöglichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkräften unterhalb von 5kN erreichen können, dass bei größerer Belastung allerdings Verbesserungsbedarf besteht. Hierfür konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „adäquaten Zusammenspiel von Schale und Polsterung“ der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der Dämpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.
N2  - This study was conducted to test the damping effects of commercially available soccer shin guards on their damping effects. Therefore a pendulum impact apparatus with varying impact forces was used. It became clear that shin guards show the best effect at maximum forces of less than 5kN. There is however a need for improvement at greater impact forces. A good starting point was found in an „appropriate interaction of shell and padding” of the shin guard. It was further clarified that a significant improvement on the damping effect could be achieved at least partially over the last years.
KW  - Fußball
KW  - Schienbeinschoner
KW  - Aufschlagversuch
Y1  - 2012
U6  - http://dx.doi.org/10.3238/oup.2012.0010-0015
SN  - 2193-5785
VL  - 1
IS  - 1
SP  - 10
EP  - 15
PB  - Deutscher Ärzte-Verlag
CY  - Köln
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
A1  - Vassos, Stavros
T1  - Action-Based Imperative Programming with YAGI
N2  - Many tasks for autonomous agents or robots are best described by a specification of the environment and a specification of the available actions the agent or robot can perform. Combining such a specification with the possibility to imperatively program a robot or agent is what we call the actionbased imperative programming. One of the most successful such approaches is Golog. In this paper, we draft a proposal for a new robot programming language YAGI, which is based on the action-based imperative programming paradigm. Our goal is to design a small, portable stand-alone YAGI interpreter. We combine the benefits of a principled domain specification with a clean, small and simple programming language, which does not exploit any side-effects from the implementation language. We discuss general requirements of action-based programming languages and outline YAGI, our action-based language approach which particularly aims at embeddability.
Y1  - 2012
N1  - Cognitive Robotics
AAAI Technical Report WS-12-06
SP  - 24
EP  - 31
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Sensors and Actuators B: Chemical
N2  - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2011.12.102
SN  - 0925-4005
N1  - Part of special issue "Selected Papers presented at Eurosensors XXV"
VL  - 175
SP  - 118
EP  - 122
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - http://dx.doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Werner, Frederik
A1  - Miyamoto, Ko-Ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging
JF  - Sensors and Actuators B: Chemical
N2  - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2010.12.003
SN  - 0925-4005
N1  - Part of special issue "Eurosensors XXIV, 2010"
VL  - 170
SP  - 34
EP  - 39
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Vu, Duc Khoi
T1  - Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects
JF  - Engineering Fracture Mechanics ; 97(2013), H. 1
N2  - Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal–dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal–dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.engfracmech.2012.05.017
SN  - 0013-7944
VL  - 97
SP  - 314
EP  - 333
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Leurs, Ulrike
A1  - Mezo, Gabor
A1  - Öhlschläger, Peter
A1  - Orban, Erika
A1  - Marquard, Andrea
A1  - Manea, Marilena
T1  - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety
JF  - Peptide Science
N2  - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/bip.21640
SN  - 1097-0282
VL  - 98
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - http://dx.doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Timme, Michael
A1  - Günnewig, Sebastian
T1  - Betriebskostenabrechnung - Die Pflicht des Vermieters zur Beachtung des Wirtschaftlichkeitsgebots
JF  - Der Miet-Rechts-Berater : MietRB ; Miete, Immobilien, Wohnungseigentum
N2  - Mit seiner aktuellen Entscheidung (BGH v. 6.11.2011 – VIII ZR 340/10, MDR 2011, 1095 = MietRB MDR 2011, 337) hat der BGH die Darlegungs- und Beweislast für einen Verstoß gegen das Gebot der Wirtschaftlichkeit bei der Abrechnung von Betriebskosten konkretisiert. Der Beitrag erläutert anhand der Hintergründe des Gebotes der Wirtschaftlichkeit die Konsequenzen für die Praxis.
Y1  - 2012
SN  - 1612-040X
IS  - 3
SP  - 83
EP  - 88
PB  - Verlag Dr. Otto Schmidt
CY  - Köln
ER  - 
TY  - JOUR
A1  - Schneider, Bettina
A1  - Schneider, Wilhelm
T1  - Externes Rechnungswesen nach BilMoG: Grundelemente und Aufbau
JF  - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Examen, Berufseinstieg und Fortbildung
Y1  - 2012
SN  - 0340-3084
VL  - 41
IS  - 3
SP  - 332
EP  - 337
PB  - Lange
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schuba, Marko
A1  - Höfken, H.
A1  - Schaefer, T.
T1  - Smartphone Forensik
JF  - Hakin9 : Practical Protection  (2012)
Y1  - 2012
SN  - 1733-7186
SP  - 10
EP  - 20
PB  - -
ER  - 
TY  - JOUR
A1  - Chwallek, Constanze
A1  - Engelen, Andreas
A1  - Oswald, Monika
A1  - Brettel, Malte
T1  - Die Wir­kung des Füh­rungs­ver­hal­tens des Top-Ma­nage­ments auf die un­ter­neh­me­ri­sche Ori­en­tie­rung – ein 5-Län­der-Ver­gleich
JF  - Zfbf : Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung
Y1  - 2012
SN  - 0341-2687
IS  - 2
SP  - 138
EP  - 165
PB  - Springer Fachmedien
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Backes, Klaus
A1  - Adam, Mario
A1  - Gottschald, Beng Jonas
A1  - Faber, Christian
A1  - Henneböhl, Friedrich-Gregor
A1  - Lanz, Marco
A1  - Anthrakidis, Anette
T1  - KWKK-Anlagen im Feldtest. Optimaler Betrieb durch Verbesserungen bei Regelung und Hydraulik
JF  - Die Kälte- und Klimatechnik
Y1  - 2012
SN  - 0343-2246
IS  - 2
PB  - Gentner
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Trenz, Eva
A1  - Lohmann, Philipp
A1  - Frotscher, Ralf
A1  - Klinge, Uwe
A1  - Tabaza, Ruth
A1  - Kirschner-Hermanns, Ruth
T1  - New measurements to compare soft tissue anchoring systems in pelvic floor surgery
JF  - Journal of Biomedical Materials Research Part B: Applied Biomaterials
N2  - Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment
Y1  - 2012
U6  - http://dx.doi.org/10.1002/jbm.b.32654
SN  - 1552-4981
VL  - 100B
IS  - 4
SP  - 924
EP  - 933
PB  - Wiley
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Aggarwal, P.
A1  - Dhiman, S.
A1  - Kumar, G.
A1  - Scherer, Ulrich W.
A1  - Singla, M. L.
A1  - Srivastava, A.
T1  - Optical study of poly(ethyleneterephthalate) modified by different ionizing radiation dose
JF  - Indian Journal of Pure and Applied Physics
N2  - Thin films of poly(ethyleneterephthalate) [PET]were exposed to radiation dose ranging from 10 to 30 kGy by using gamma rays in the range 12.8-177.8 MGy using swift light ions of hydrogen. There was no effect of the radiation dose on the optical behaviour of PET as a result of exposure to radiation dose up to 30 kGy brought about by gamma rays but a significant decrease in the optical band gap values was observed when PET was exposed to swift light ions of hydrogen. The data obtained are discussed in terms of optical studies carried out on PET using swift heavy ions.
Y1  - 2012
SN  - 0019-5596
VL  - 50
IS  - 2
SP  - 129
EP  - 132
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Dünnschichtsensoren für die Schwermetallanalytik
JF  - GIT : Labor-Fachzeitschrift
N2  - Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online“-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt.
Y1  - 2012
SN  - 0016-3538
VL  - 56
IS  - 4
SP  - 285
EP  - 287
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Novacek, V.
A1  - Tran, Thanh Ngoc
A1  - Klinge, U.
A1  - Tolba, R. H.
A1  - Staat, Manfred
A1  - Bronson, D. G.
A1  - Miesse, A. M.
A1  - Whiffen, J.
A1  - Turquier, F.
T1  - Finite element modelling of stapled colorectal end-to-end anastomosis : Advantages of variable height stapler design
JF  - Journal of Biomechanics
N2  - The impact of surgical staplers on tissues has been studied mostly in an empirical manner. In this paper, finite element method was used to clarify the mechanics of tissue stapling and associated phenomena. Various stapling modalities and several designs of circular staplers were investigated to evaluate the impact of the device on tissues and mechanical performance of the end-to-end colorectal anastomosis. Numerical simulations demonstrated that a single row of staples is not adequate to resist leakage due to non-linear buckling and opening of the tissue layers between two adjacent staples. Compared to the single staple row configuration, significant increase in stress experienced by the tissue at the inner staple rows was observed in two and three rows designs. On the other hand, adding second and/or third staple row had no effect on strain in the tissue inside the staples. Variable height design with higher staples in outer rows significantly reduced the stresses and strains in outer rows when compared to the same configuration with flat cartridge.
KW  - Variable height stapler design
KW  - Anastomotic leakage
KW  - Finite element modelling
KW  - End-to-end colorectal anastomosis
KW  - Surgical staplers
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.jbiomech.2012.07.021
SN  - 1873-2380
VL  - 45
IS  - 115
SP  - 2693
EP  - 2697
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Nguyen, Nhu Huynh
A1  - Duong, Minh Tuan
A1  - Tran, Thanh Ngoc
A1  - Pham, Phu Tinh
A1  - Grottke, O.
A1  - Tolba, R.
A1  - Staat, Manfred
T1  - Influence of a freeze–thaw cycle on the stress–stretch curves of tissues of porcine abdominal organs
JF  - Journal of Biomechanics
N2  - The paper investigates both fresh porcine spleen and liver and the possible decomposition of these organs under a freeze–thaw cycle. The effect of tissue preservation condition is an important factor which should be taken into account for protracted biomechanical tests. In this work, tension tests were conducted for a large number of tissue specimens from twenty pigs divided into two groups of 10. Concretely, the first group was tested in fresh state; the other one was tested after a freeze-thaw cycle which simulates the conservation conditions before biomechanical experiments. A modified Fung model for isotropic behavior was adopted for the curve fitting of each kind of tissues. Experimental results show strong effects of the realistic freeze–thaw cycle on the capsule of elastin-rich spleen but negligible effects on the liver which virtually contains no elastin. This different behavior could be explained by the autolysis of elastin by elastolytic enzymes during the warmer period after thawing. Realistic biomechanical properties of elastin-rich organs can only be expected if really fresh tissue is tested. The observations are supported by tests of intestines.
KW  - Autolysis
KW  - Decomposition
KW  - Freeze–thaw process
KW  - Spleen
KW  - Liver
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.jbiomech.2012.07.008
SN  - 1873-2380
VL  - 45
IS  - 14
SP  - 2382
EP  - 2386
PB  - Elsevier
CY  - Amsterdam
ER  -