TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Maier, Mathias A1 - Schmidt-Trucksäss, Arno A1 - Halle, Martin A1 - Kotliar, Konstantin T1 - Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection JF - Acta Ophthalmologica Y1 - 2011 SN - 1755-3768 VL - 89 IS - 5 SP - 472 EP - 479 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Erben, A. A1 - Thürmel, K. A1 - Kotliar, Konstantin T1 - Diffuse stromale Hornhauttrübungen und Veränderungen der Hände JF - Der Ophthalmologe N2 - Bilaterale stromale Hornhauttrübungen sind für den Augenarzt eine differenzialdiagnostische Herausforderung. Im folgenden Beitrag werden 2 Patieninnen (30 und 36 Jahre) mit unterschiedlich stark ausgeprägter stromaler diffuser Hornhauttrübung vorgestellt. Patientin 1 war kleinwüchsig (114 cm) und Patientin 2 normal groß (172 cm). Beide Patientinnen wiesen veränderte Gelenkstrukturen an Hand und Fußgelenken sowie diffuse stromale Hornhauttrübungen auf. Des Weiteren lagen eine Mitral- und Aorteninsuffizienz (Patientin 1) bzw. eine Aorteninsuffizienz (Patientin 2) vor. Die stromalen diffusen Hornhauttrübungen ließen im Zusammenhang mit den Gelenkveränderungen ein Scheie-Syndrom vermuten. Therapeutisch ist bei Patienten mit Visusminderung eine (lamelläre) Keratoplastik sinnvoll. Y1 - 2010 U6 - http://dx.doi.org/10.1007/s00347-009-2066-2 SN - 1433-0423 VL - 107 IS - 4 SP - 363 EP - 365 PB - Springer CY - Berlin ER - TY - CHAP A1 - Lanzl, I. A1 - Seidova, S.-F. A1 - Dühring, C. von A1 - Kotliar, Konstantin ED - Erb, Carl T1 - Befunde der dynamischen Gefäßanalyse am Auge bei Gesunden und Glaukom-Patienten mit praxisrelevanter Bedeutung T2 - Mikrozirkulation beim Glaukom Y1 - 2009 N1 - Search on Glaucoma SP - 33 EP - 39 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Lanzl, I. A1 - Kotliar, Konstantin T1 - Können Anti-VEGF-Injektionen Glaukom oder okuläre Hypertension verursachen? T1 - Can Anti-VEGF Injections Cause Glaucoma or Ocular Hypertension? JF - Klinische Monatsblätter für Augenheilkunde Y1 - 2017 U6 - http://dx.doi.org/10.1055/s-0043-101819 SN - 0023-2165 VL - 234 IS - 2 SP - 191 EP - 193 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Kuerten, David A1 - Kotliar, Konstantin A1 - Fuest, Matthias A1 - Walter, Peter A1 - Hollstein, Muriel A1 - Plange, Niklas ED - Neri, Piergiorgio T1 - Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study JF - International Ophthalmology N2 - Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect. KW - Glaucoma KW - Visual field asymmetry KW - Ocular blood flow KW - RVA KW - Vascular response Y1 - 2021 SN - 1573-2630 U6 - http://dx.doi.org/10.1007/s10792-021-01876-0 VL - 41 IS - 41 SP - 3109 EP - 3119 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kuchler, Timon A1 - Günthner, Roman A1 - Ribeiro, Andrea A1 - Hausinger, Renate A1 - Streese, Lukas A1 - Wöhnl, Anna A1 - Kesseler, Veronika A1 - Negele, Johanna A1 - Assali, Tarek A1 - Carbajo-Lozoya, Javier A1 - Lech, Maciej A1 - Adorjan, Kristina A1 - Stubbe, Hans Christian A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Haller, Berhard A1 - Heemann, Uwe A1 - Schmaderer, Christoph T1 - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation N2 - Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management. KW - Endothelial dysfunction KW - Long COVID KW - Post-COVID-19 syndrome KW - retinal microvasculature Y1 - 2023 U6 - http://dx.doi.org/10.1007/s10456-023-09885-6 N1 - Corresponding author: Christoph Schmaderer VL - 26 SP - 547 EP - 563 PB - Springer Nature CY - Dordrecht ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Volkov, V. V. A1 - Koshits, I. N. A1 - Svetlova, O. V. T1 - Biomekhanicheskie osobennosti vzaimodeĭstviia drenazhno i akkomodatsionnoĭ reguliatornykh sistem glaza v norme i pri kontuzionnom podvyvikhe khrustalika / Volkov, V. V. ; Kotliar, K. E. ; Koshits, I. n. ; Svetlova, O. V. ; Smol´nikov, B. A. JF - Vestnik oftalmologii. 113 (1997), H. 3 Y1 - 1997 SN - 0042-465X N1 - Titelübersetzung: Biomechanical characteristics of interactions between the drainage and accommodation regulatory systems of the eye in health and in contusion lens subluxation ; Original in Russisch, English abstract SP - 5 EP - 7 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, Walthatd A1 - Nagel, Edgar A1 - Lanzl, Ines M. T1 - Retinal vessel reaction in response to chromatic flickering light / Kotliar, Konstantin E. ; Vilser, Walthard ; Nagel, Edgar ; Lanzl, Ines M. JF - Graefe's Archive for Clinical and Experimental Ophthalmology. 242 (2004), H. 5 Y1 - 2004 SN - 1435-702X SP - 377 EP - 392 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Halle, M. A1 - Lanzl, I. M. T1 - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse JF - Der Ophthalmologe Y1 - 2009 SN - 1433-0423 VL - 106 IS - 7 SP - 609 EP - 618 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Zinoviewa, N. V. A1 - Krylova, I. S. T1 - Elaboration of the conception of the biomechanical model of the aqueous intraocular outflow / Svetlova, O. V. ; Zinoviewa, N. V. ; Krylova, I. S. ; Koshitz, I. N. ; Smolnikov, B. A. ; Fedorova, E. M. ; Kotliar, K. E. JF - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 5 (2001), H. 3 Y1 - 2001 SN - 1812-5123 SP - 23 EP - 27 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Stegaev, V. A. A1 - Parkhomov, S. D. T1 - Biomechanical substantiation of relatively low efficiency of recurrent laser trabeculoplasty / Svetlova, O. V. ; Stagaev, V. A. ; Parkhomov, S. D. ; Kotliar, K. E. ; Makarov, F. N. ; Smolnikov, B. A. ; Koshitz, I. N. JF - Glaukoma (2004) Y1 - 2004 N1 - Original in Russisch SP - 29 EP - 39 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Sourjikov, A. V. A1 - Zaseeva, M. V. T1 - Biomechanical peculiarities of aqueous humor production system and outflow regulation system / Svetlova, O. V. ; Sourjikov, A. V. ; Kotliar, K. E. ; Zaseeva, M. V. ; Shukhaev, S. V. ; Koshitz, I. N. JF - Glaukoma (2004) Y1 - 2004 N1 - Original in Russisch SP - 66 EP - 76 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Svetlova, O. V. A1 - Makarov, F. N. A1 - Zaseeva, M. V. T1 - Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in JF - Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3 Y1 - 2003 SN - 1026-3543 N1 - Original in Russisch, English abstract SP - 7 EP - 16 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Ortner, Marion A1 - Conradi, Anna A1 - Hacker, Patricia A1 - Hauser, Christine A1 - Günthner, Roman A1 - Moser, Michaela A1 - Muggenthaler, Claudia A1 - Diehl-Schmid, Janine A1 - Priller, Josef A1 - Schmaderer, Christoph A1 - Grimmer, Timo T1 - Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance JF - Neurobiology of Aging N2 - Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis. KW - Alzheimer's disease KW - Retinal vessel analysis KW - Vasomotions KW - Pulsations KW - Mild cognitive impairment Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.neurobiolaging.2022.08.012 SN - 0197-4580 VL - 120 SP - 117 EP - 127 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Seidova, Seid-Fatima A1 - Lanzl, Ines T1 - Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension JF - Investigative Ophthalmology & Visual Science, IOVS N2 - Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530–600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation. Y1 - 2010 U6 - http://dx.doi.org/10.1167/iovs.09-3649 SN - 0146-0404 VL - 51 IS - 4 SP - 2165 EP - 2172 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M. JF - Acta Ophthalmologica. 86 (2008), H. 4 Y1 - 2008 SN - 1755-3768 SP - 424 EP - 433 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Mücke, Bruno A1 - Vilser, Walthard A1 - Schilling, Rudolf T1 - Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; Mücke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M. JF - Investigative Ophthalmology & Visual Science, IOVS. 49 (2008), H. 5 Y1 - 2008 SN - 0146-0404 SP - 2094 EP - 2102 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Mogilevskiĭ, A. Ia. A1 - Shilo, A. V. A1 - Panchekha, A. P. T1 - [Chaotic non-linear dynamics of alpha-band of the EEg and organization of the cortical activity of P300 wave] / Mogilevskiĭ, A. Ia. ; Kotliar, K. E. ; Shilo, A. V. ; Panchekha, A. P. JF - Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 58 (2008), H. 5 Y1 - 2008 SN - 0044-4677 N1 - Original in Russisch ; English abstract SP - 562 EP - 575 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Maier, Mathias A1 - Bauer, Svetlana A1 - Feucht, Nikolaus A1 - Lohmann, Chris A1 - Lanzl, Ines T1 - Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply JF - Acta Ophthalmologica Y1 - 2008 SN - 1755-3768 VL - 86 IS - 6 SP - 692 EP - 693 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Maier, Mathias A1 - Bauer, Svetlana A1 - Feucht, Nikolaus T1 - Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model / Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines JF - Acta Ophthalmologica Scandinavica. 85 (2007), H. 7 Y1 - 2007 SN - 1755-3768 SP - 777 EP - 781 PB - - ER -