TY - JOUR A1 - Schiffels, Johannes A1 - Selmer, Thorsten T1 - Combinatorial assembly of ferredoxin‐linked modules in Escherichia coli yields a testing platform for Rnf‐complexes JF - Biotechnology and Bioengineering Y1 - 2019 U6 - https://doi.org/10.1002/bit.27079 IS - accepted article SP - 1 EP - 36 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Hoffmann, Katharina A1 - Nieren, Monika A1 - Gäb, Martina A1 - Kasper, Anna A1 - Elbers, Gereon T1 - The potential of near infrared spectroscopy (NIRS) for the environmental biomonitoring of plants T2 - International conference on Life Sciences and Technology N2 - In the current environmental condition, the increase in pollution of the air, water, and soil indirectly will induce plants stress and decrease vegetation growth rate. These issues pay more attention to be solved by scientists worldwide. The higher level of chemical pollutants also induced the gradual changes in plants metabolism and decreased enzymatic activity. Importantly, environmental biomonitoring may play a pivotal contribution to prevent biodiversity degradation and plants stress due to pollutant exposure. Several previous studies have been done to monitor the effect of environmental changes on plants growth. Among that, Near Infrared spectroscopy (NIRS) offers an alternative way to observe the significant alteration of plant physiology caused by environmental damage related to pollution. Impairment of photosynthesis, nutrient and oxidative imbalances, and mutagenesis. Y1 - 2019 U6 - https://doi.org/10.1088/1755-1315/276/1/012009 SN - 1755-1315 N1 - IOP Conference Series: Earth and Environmental Science : 276 VL - 276 IS - 012009 SP - 1 EP - 3 ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Hunker, Jan A1 - Jung, Alexander A1 - Goßmann, Matthias A1 - Linder, Peter A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool. Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - BOOK A1 - Staat, Manfred A1 - Erni, Daniel T1 - Symposium Proceedings; 3rd YRA MedTech Symposium 2019: May 24 / 2019 / FH Aachen Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Kapelyukh, Yury A1 - Henderson, Colin James A1 - Scheer, Nico A1 - Rode, Anja A1 - Wolf, Charles Roland T1 - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice JF - Drug Metabolism and Disposition Y1 - 2019 U6 - https://doi.org/10.1124/dmd.119.087718 IS - Early view ER - TY - CHAP A1 - Schmidts, Oliver A1 - Kraft, Bodo A1 - Siebigteroth, Ines A1 - Zündorf, Albert T1 - Schema Matching with Frequent Changes on Semi-Structured Input Files: A Machine Learning Approach on Biological Product Data T2 - Proceedings of the 21st International Conference on Enterprise Information Systems - Volume 1: ICEIS Y1 - 2019 SN - 978-989-758-372-8 U6 - https://doi.org/10.5220/0007723602080215 SP - 208 EP - 215 ER - TY - CHAP A1 - Dachwald, Bernd A1 - Ohndorf, Andreas T1 - Global optimization of continuous-thrust trajectories using evolutionary neurocontrol T2 - Modeling and Optimization in Space Engineering N2 - Searching optimal continuous-thrust trajectories is usually a difficult and time-consuming task. The solution quality of traditional optimal-control methods depends strongly on an adequate initial guess because the solution is typically close to the initial guess, which may be far from the (unknown) global optimum. Evolutionary neurocontrol attacks continuous-thrust optimization problems from the perspective of artificial intelligence and machine learning, combining artificial neural networks and evolutionary algorithms. This chapter describes the method and shows some example results for single- and multi-phase continuous-thrust trajectory optimization problems to assess its performance. Evolutionary neurocontrol can explore the trajectory search space more exhaustively than a human expert can do with traditional optimal-control methods. Especially for difficult problems, it usually finds solutions that are closer to the global optimum. Another fundamental advantage is that continuous-thrust trajectories can be optimized without an initial guess and without expert supervision. Y1 - 2019 SN - 978-3-030-10501-3 SN - 978-3-030-10500-6 U6 - https://doi.org/10.1007/978-3-030-10501-3_2 N1 - Springer Optimization and Its Applications, vol 144 gedruckt unter der Signatur 21 ZSS 46 in der Bereichsbibliothek Eupener Str. vorhanden SP - 33 EP - 57 PB - Springer CY - Cham ER - TY - CHAP A1 - Birkl, Josef A1 - Diendorfer, Gerhard A1 - Kern, Alexander A1 - Thern, Stephan T1 - Extremely high lightning peak currents T2 - 34th International Conference on Ligntning Protection, 02-07 September 2018 Y1 - 2018 SN - 978-1-5386-6635-7 ER - TY - CHAP A1 - Rieper, Harald A1 - Gebhardt, Andreas A1 - Stucker, Brent T1 - Process parameters for Selective Laser Melting of AgCu7 T2 - DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3 Y1 - 2016 SN - 978-3-8396-1001-5 N1 - DDMC, 2016, Fraunhofer Direct Digital Manufacturing Conference, 3rd, Berlin, DE, 2016-03-16 - 2016-03-17 SP - 171 EP - 176 PB - Fraunhofer-Verlag CY - Stuttgart ER - TY - CHAP A1 - Schildt, Philipp A1 - Marzocca, Pier A1 - Braun, Carsten A1 - Dahmann, Peter A1 - Keimer, Jona T1 - Effects of atmospheric excitation on vibration based condition monitoring methods for hybrid-electric aircraft propulsion systems T2 - AIAC 2018: 18th Australian International Aerospace Congress: HUMS - 11th Defence Science and Technology (DST) International Conference on Health and Usage Monitoring (HUMS 2019): ISSFD - 27th International Symposium on Space Flight Dynamics (ISSFD) Y1 - 2019 SN - 9781925627213 SP - 923 EP - 928 ER - TY - CHAP A1 - Meskouris, Konstantin A1 - Butenweg, Christoph A1 - Hinzen, Klaus-G. A1 - Höffer, Rüdiger T1 - Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response T2 - Structural Dynamics with Applications in Earthquake and Wind Engineering N2 - Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented. KW - Wind turbulence KW - Gust wind response KW - Spectral analysis Y1 - 2019 SN - 978-3-662-57550-5 (Online) SN - 978-3-662-57548-2 (Print) U6 - https://doi.org/10.1007/978-3-662-57550-5_3 SP - 153 EP - 196 PB - Springer CY - Berlin ER - TY - BOOK A1 - Meskouris, Konstantin A1 - Butenweg, Christoph A1 - Hinzen, Klaus-G. A1 - Höffer, Rüdiger T1 - Structural Dynamics with Applications in Earthquake and Wind Engineering Y1 - 2019 SN - 978-3-662-57550-5 U6 - https://doi.org/10.1007/978-3-662-57550-5 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Poghossian, Arshak A1 - Geissler, Hanno A1 - Schöning, Michael Josef T1 - Rapid methods and sensors for milk quality monitoring and spoilage detection JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.04.040 SN - 0956-5663 VL - 140 IS - Article 111272 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Cornelis, Peter A1 - Givanoudi, Stella A1 - Yongabi, Derick A1 - Iken, Heiko A1 - Duwé, Sam A1 - Deschaume, Olivier A1 - Robbens, Johan A1 - Dedecker, Peter A1 - Bartic, Carmen A1 - Wübbenhorst, Michael A1 - Schöning, Michael Josef A1 - Heyndrickx, Marc A1 - Wagner, Patrick T1 - Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method JF - Biosensors and Bioelectronics Y1 - 2019 U6 - https://doi.org/10.1016/j.bios.2019.04.026 SN - 0956-5663 VL - 136 SP - 97 EP - 105 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Meyer, Carolin A1 - Gaalen, Kerstin van A1 - Leschinger, Tim A1 - Scheyerer, Max J. A1 - Neiss, Wolfram F. A1 - Staat, Manfred A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement JF - BioMed Research International Y1 - 2019 U6 - https://doi.org/10.1155/2019/9232813 SP - Article ID 9232813 ER - TY - PAT A1 - Artmann, Gerhard A1 - Linder, Peter A1 - Bayer, Robin A1 - Gossmann, Matthias T1 - Celldrum electrode arrangement for measuring mechanical stress [Patent of invention] N2 - The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance. Y1 - 2017 N1 - Patent auch unter EP3403090, CN109477828, US2019033245 und LU92948 veröffentlicht. PB - WIPO CY - Geneva ER - TY - JOUR A1 - Puppe, Michael A1 - Giuliano, Stefano A1 - Frantz, Cathy A1 - Uhlig, Ralf A1 - Schumacher, Ralph A1 - Ibraheem, Wagdi A1 - Schmalz, Stefan A1 - Waldmann, Barbara A1 - Guder, Christoph A1 - Peter, Dennis A1 - Schwager, Christian A1 - Teixeira Boura, Cristiano José A1 - Alexopoulos, Spiros A1 - Spiegel, Michael A1 - Wortmann, Jürgen A1 - Hinrichs, Matthias A1 - Engelhard, Manfred A1 - Aust, Michael T1 - Techno-economic optimization of molten salt solar tower plants JF - AIP Conference Proceedings art.no. 040033 N2 - In this paper the results of a techno-economic analysis of improved and optimized molten salt solar tower plants (MSSTP plants) are presented. The potential improvements that were analyzed include different receiver designs, different designs of the HTF-system and plant control, increased molten salt temperatures (up to 640°C) and multi-tower systems. Detailed technological and economic models of the solar field, solar receiver and high temperature fluid system (HTF-system) were developed and used to find potential improvements compared to a reference plant based on Solar Two technology and up-to-date cost estimations. The annual yield model calculates the annual outputs and the LCOE of all variants. An improved external tubular receiver and improved HTF-system achieves a significant decrease of LCOE compared to the reference. This is caused by lower receiver cost as well as improvements of the HTF-system and plant operation strategy, significantly reducing the plant own consumption. A novel star receiver shows potential for further cost decrease. The cavity receiver concepts result in higher LCOE due to their high investment cost, despite achieving higher efficiencies. Increased molten salt temperatures seem possible with an adapted, closed loop HTF-system and achieve comparable results to the original improved system (with 565°C) under the given boundary conditions. In this analysis all multi tower systems show lower economic viability compared to single tower systems, caused by high additional cost for piping connections and higher cost of the receivers. REFERENCES Y1 - 2019 U6 - https://doi.org/10.1063/1.5067069 VL - 2033 IS - Issue 1 PB - AIP Publishing CY - Melville, NY ER - TY - JOUR A1 - Tran, Ngoc Trinh A1 - Staat, Manfred T1 - Direct plastic structural design under lognormally distributed strength by chance constrained programming JF - Optimization and Engineering N2 - We propose the so-called chance constrained programming model of stochastic programming theory to analyze limit and shakedown loads of structures under random strength with a lognormal distribution. A dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) is used with three-node linear triangular elements. Y1 - 2020 U6 - https://doi.org/10.1007/s11081-019-09437-2 SN - 1573-2924 VL - 21 IS - 1 SP - 131 EP - 157 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Albanna, Walid A1 - Lüke, Jan Niklas A1 - Schubert, Gerrit Alexander A1 - Dibué-Adjei, Maxine A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Steiger, Hans-Jakob A1 - Hänggi, Daniel A1 - Kamp, Marcel A. A1 - Schneider, Toni A1 - Neumaier, Felix T1 - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity JF - Molecular and Cellular Neuroscience Y1 - 2019 U6 - https://doi.org/10.1016/j.mcn.2019.03.003 SN - 1044-7431 VL - 96 IS - 4 SP - 35 EP - 46 PB - Elsevier CY - Amsterdam ER -