TY - JOUR A1 - Moritz, W. A1 - Yoshinobu, T. A1 - Finger, F. A1 - Krause, S. A1 - Martin-Fernandez, M. A1 - Schöning, Michael Josef T1 - High resolution LAPS using amorphous silicon as the semiconductor material JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 436 EP - 444 ER - TY - JOUR A1 - Moritz, W. A1 - Yoshinobu, T. A1 - Finger, F. A1 - Krause, S. A1 - Xu, M. A1 - Schöning, Michael Josef T1 - Microscopy of impedance and surface ion concentrations JF - Biomedizinische Technik. 49 (2004), H. 2 Y1 - 2004 SN - 0932-4666 SP - 1000 EP - 1001 ER - TY - CHAP A1 - Moritz, Werner A1 - Yoshinobu, Tatsuo A1 - Finger, Friedhelm A1 - Krause, Steffi A1 - Schöning, Michael Josef T1 - Amorphous silicon as semiconductor material for high resolution LAPS T2 - Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003 Y1 - 2003 SP - 48 EP - 49 ER - TY - JOUR A1 - Moseley, Fiona A1 - Halamek, Jan A1 - Kramer, Friederike A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Katz, Evgeny T1 - An enzyme-based reversible CNOT logic gate realized in a flow system JF - Analyst N2 - An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications. Y1 - 2014 U6 - http://dx.doi.org/10.1039/C4AN00133H SN - 1364-5528 (E-Journal) ; 0003-2654 (Print) VL - 139 IS - 8 SP - 1839 EP - 1842 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Mourzina, I.G. A1 - Yoshinobu, T. A1 - Ermolenko, Y.E. A1 - Vlasov, Y. G. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors JF - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors Y1 - 2004 N1 - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba) SP - 788 EP - 789 PB - Japan Association of Chemical Sensors CY - Fukuoka ER - TY - JOUR A1 - Mourzina, Ioulia G. A1 - Yoshinobu, Tatsuo A1 - Ermolenko, Yuri E. A1 - Vlasov, Yuri G. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors JF - Microchimica Acta. 144 (2004), H. 1-3 Y1 - 2004 SN - 0026-3672 SP - 41 EP - 50 ER - TY - JOUR A1 - Mourzina, Y. G. A1 - Ermelenko, Y. E. A1 - Yoshinobu, T. A1 - Vlasov, Y. A1 - Iwasaki, H. A1 - Schöning, Michael Josef T1 - Anionselective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and suphate ions JF - Sensors and Actuators B. 91 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 32 EP - 38 ER - TY - JOUR A1 - Mourzina, Y. G. A1 - Legin, A. A1 - Vlasov, Y. G. A1 - Schöning, Michael Josef A1 - Schubert, J. A1 - Zander, W. A1 - Lüth, H. T1 - Thin film chemical sensors based on chalcogenide glasses for „electronic tongue“ applications JF - Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings Y1 - 2001 N1 - Sensor-Kongress ; (10, 2001, Nürnberg) Sensor 2001 Conference ; (10 : ; 2001.05.08-10 : ; Nuremberg) SP - 137 EP - 141 PB - AMA Service CY - Wunstorf ER - TY - JOUR A1 - Mourzina, Y. G. A1 - Schöning, Michael Josef A1 - Schubert, J. A1 - Zander, W. A1 - Legin, A. V. A1 - Vlasov, Y. G. A1 - Lüth, H. T1 - Copper, cadmium and thallium thin film sensors based on chalcogenide glasses JF - Analytica Chimica Acta. 433 (2001) Y1 - 2001 SN - 0378-4304 SP - 103 EP - 110 ER - TY - JOUR A1 - Mourzina, Y. G. A1 - Yoshinobu, T. A1 - Schubert, J. A1 - Lüth, H. A1 - Iwasaki, H. A1 - Schöning, Michael Josef T1 - Ion-selective lightaddressable potentiometric sensor (LAPS) with chalcogenide thin film by pulsed laser deposition JF - Sensors and Actuators B. 80 (2001), H. 2 Y1 - 2001 SN - 0925-4005 SP - 136 EP - 140 ER - TY - JOUR A1 - Mourzina, Y. A1 - Mai, T. A1 - Poghossian, Arshak A1 - Ermolenko, Y. A1 - Yoshinobu, T. A1 - Vlasov, Y. A1 - Iwasaki, H. A1 - Schöning, Michael Josef T1 - K+-selective field-effect sensors as transducers for bioelectronic applications JF - Electrochimica Acta. 48 (2003), H. 20-22 Y1 - 2003 SN - 0013-4686 SP - 3333 EP - 3339 ER - TY - JOUR A1 - Mourzina, Y. A1 - Yoshinobu, T. A1 - Ermelenko, Y. A1 - Furuichi, K. A1 - Vlasov, Y. A1 - Schöning, Michael Josef A1 - Iwasaki, H. T1 - Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST) JF - Book of abstracts / ed. by J. Saneistr. Y1 - 2002 SN - 80-01-02576-4 N1 - Eurosensors ; (16, 2002, Praha) SP - 254 EP - 257 PB - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement CY - Prague ER - TY - JOUR A1 - Mourzina, Y.G. A1 - Schöning, Michael Josef A1 - Schubert, J. A1 - Zander, W. A1 - Legin, A. V. A1 - Vlasov, Y. G. A1 - Kordos, P. A1 - Lüth, H. T1 - A new thin film Pb microsensor based on chalcogenide glasses JF - Sensors and Actuators B. 71 (2000), H. 1-2 Y1 - 2000 SN - 0925-4005 SP - 13 EP - 18 ER - TY - JOUR A1 - Mourzina, Yu. G. A1 - Schubert, J A1 - Zander, W. A1 - Legin, A. A1 - Vlasov, Y. G. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Development of multisensor systems based on chalcogenide thin film chemical sensors for the simultaneous multicomponent analysis of metal ions in complex solutions JF - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz Y1 - 2001 SN - 0-08-044014-2 SP - 251 EP - 263 PB - Elsevier [u.a.] CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Mourzina, Yu.G. A1 - Schöning, Michael Josef A1 - Schubert, J. A1 - Zander, W. A1 - Legin, A. A1 - Vlasov, Y. G. A1 - Lüth, H. T1 - Thin film microsensors for fast heavy metal analysis JF - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...] Y1 - 2000 SN - 87-89935-50-0 N1 - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen) SP - 839 EP - 840 PB - MIC, Mikroelektronik Centret CY - Lyngby, Denmark ER - TY - JOUR A1 - Muck, A. A1 - Wang, J. A1 - Jacobs, M. A1 - Chen, G. A1 - Chatrathi, M. P. A1 - Jurka, V. A1 - Vyborny, Z. A1 - Spillmann, S. D. A1 - Sridharan, G. A1 - Schöning, Michael Josef T1 - Fabrication of poly(methyl methacrylate) microfluidic chips by atmospheric molding JF - Analytical Chemistry. 76 (2004), H. 8 Y1 - 2004 SN - 0003-2700 SP - 2290 EP - 2297 ER - TY - JOUR A1 - Murib, M. S. A1 - Grinsven, B. van A1 - Grieten, L. A1 - Janssens, S. D. A1 - Vermeeren, V. A1 - Eersels, K. A1 - Broeders, J. A1 - Ameloot, M. A1 - Michiels, L. A1 - Ceuninck, W. De A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates JF - Physica Status Solidi (A). Vol. 210 (2013), iss. 5 Y1 - 2013 SN - 0031-8965 SP - 911 EP - 917 PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Murib, M. S. A1 - Yeap, W. S. A1 - Eurlings, Y. A1 - Grinsven, B. van A1 - Boyen, H.-G. A1 - Conings, B. A1 - Michiels, L. A1 - Ameloot, M. A1 - Carleer, R. A1 - Warmer, J. A1 - Kaul, P. A1 - Haenen, K. A1 - Schöning, Michael Josef A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Heat-transfer based characterization of DNA on synthetic sapphire chips JF - Sensors and Actuators B: Chemical N2 - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.snb.2016.02.027 SN - 0925-4005 VL - 230 IS - 230 SP - 260 EP - 271 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Murib, M. S. A1 - Yeap, W. S. A1 - Martens, D. A1 - Liu, X. A1 - Bienstman, P. A1 - Fahlman, M. A1 - Schöning, Michael Josef A1 - Michiels, L. A1 - Haenen, K. A1 - Serpengüzel, A. A1 - Wagner, Patrick T1 - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands JF - Sensors and actuators A: Physical N2 - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.sna.2014.11.024 SN - 1873-3069 (E-Journal); 0924-4247 (Print) VL - 222 SP - 212 EP - 219 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Murib, Mohammed S. A1 - Tran, Anh Quang A1 - Ceuninck, Ward de A1 - Schöning, Michael Josef A1 - Nesladek, Milos A1 - Serpengüzel, Ali A1 - Wagner, Patrick T1 - Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres JF - Physica Status Solidi A N2 - Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection. Y1 - 2012 U6 - http://dx.doi.org/10.1002/pssa.201100795 SN - 1862-6319 N1 - Special Issue: "Fundamentals and Applications of Diamond" VL - 209 IS - 9 SP - 1804 EP - 1810 PB - Wiley-VCH CY - Weinheim ER -