TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Epanya, P. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the bioelectronic interface of an antenna/chip biosensor – technological aspects JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 569 EP - 572 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Malkoc, Ü. A1 - Steffen, A. A1 - Marso, M. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Coupling of insect antennae to field-effect transistors for biochemical sensing JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3821 EP - 3826 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Nachweis von organischen Duftstoffen durch Biosensoren auf der Basis von Insektenantennen JF - Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. März 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik Y1 - 2000 SN - 3-18-091530-7 N1 - VDI-Berichte; 1530 SP - 107 EP - 114 PB - VDI-Verl. CY - Düsseldorf: ER - TY - JOUR A1 - Schroth, P. A1 - Weißbecker, B. A1 - Schütz, S. A1 - Ecken, H. A1 - Yoshinobu, T. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Bioelectronic signal processing - intact chemoreceptors coupled to field-effect devices JF - Lecture Notes of the ICB Seminars Y1 - 2002 SP - 28 EP - 42 PB - MCB CY - Warsaw ER - TY - JOUR A1 - Schroth, P. A1 - Weißbecker, B. A1 - Schütz, S. A1 - Ecken, H. A1 - Yoshinobu, T. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Bioelectronic signal processing - intact chemoreceptors coupled to field-effect devices JF - Biocybernetics and Biomedical Engineering. 21 (2001), H. 3 Y1 - 2001 SN - 0208-5216 SP - 27 EP - 42 ER - TY - JOUR A1 - Schubert, J. A1 - Schöning, Michael Josef A1 - Mourzina, Y. G. A1 - Legin, A. V. A1 - Vlasov, Y. G. A1 - Zander, W. A1 - Lüth, H. T1 - Multicomponent thin films for electrochemical sensor applications prepared by pulsed laser deposition JF - Sensors and Actuators B. 76 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 327 EP - 330 ER - TY - JOUR A1 - Schubert, J. A1 - Schöning, Michael Josef A1 - Schmidt, C. A1 - Siegert, M. A1 - Mesters, S. A1 - Zander, W. A1 - Kordos, P. A1 - Lüth, H. A1 - Legin, A. A1 - Mourzina, Y. G. A1 - Seleznev, B. A1 - Vlasov, Y. G. T1 - Chalcogenide-based thin film sensors prepared by pulsed laser deposition technique JF - Applied Physics A. 69, (1999), H. Supplement 1 Y1 - 1999 SN - 0947-8396 U6 - http://dx.doi.org/10.1007/s003390051534 SP - 803 EP - 805 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Wenzel, L. A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor JF - Procedia Engineering N2 - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers. KW - Field-effect sensor KW - enzymatic (bio)degradation KW - poly(d, l-lactic acid) KW - in-situ monitoring KW - impedance spectroscopy Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.proeng.2014.11.689 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 1314 EP - 1317 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Schusser, Sebastian A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Krischer, M. A1 - Wenzel, L. A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Sensorkonzept zur in vitro Echtzeitmessung des Degradationsverhaltens von biodegradierbaren Biopolymeren T2 - 11. Dresdner Sensor-Symposium : 9.-11.12.2013 Y1 - 2013 SN - 978-3-9813484-5-3 SP - 174 EP - 177 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, Maximillian A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors JF - Analytical Chemistry N2 - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers. Y1 - 2015 U6 - http://dx.doi.org/10.1021/acs.analchem.5b00617 SN - 1520-6882 VL - 87 IS - 13 SP - 6607 EP - 6613 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Schusser, Sebastian A1 - Leinhos, Marcel A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers JF - Physica Status Solidi (A) N2 - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution. Y1 - 2013 U6 - http://dx.doi.org/10.1002/pssa.201200941 SN - 1521-396X ; 0031-8965 VL - 210 IS - 5 SP - 905 EP - 910 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Schusser, Sebastian A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef ED - Abdelghani, Adnane ED - Schöning, Michael Josef T1 - Biopolymer-degradation monitoring by chip-­based impedance spectroscopy technique T2 - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012 Y1 - 2012 SP - 47 EP - 47 ER - TY - JOUR A1 - Schusser, Sebastian A1 - Menzel, S. A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements JF - Electrochimica Acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) VL - Vol. 113 SP - 779 EP - 784 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Krischer, M. A1 - Leinhos, Marcel A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers JF - Sensors and actuators B: Chemical N2 - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13). Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.snb.2014.10.058 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 207, Part B SP - 954 EP - 959 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Characterization of biodegradable polymers with capacitive field-effect sensors JF - Sensors and actuators B: Chemical N2 - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. KW - Impedance spectroscopy KW - C–V method KW - Real-time monitoring KW - Poly(d,l-lacticacid) KW - (Bio)degradation KW - Field-effect sensor Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2012.07.099 SN - 0925-4005 N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" VL - 187 SP - 2 EP - 7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Silicon-based biochemical sensors JF - CNI - The Center of Nanoelectronic Systems for Information Technology Y1 - 2003 SP - 165 EP - 170 PB - Foschungszentrum Jülich ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Novel approaches to design siliconbased field-effect sensors JF - Electrochemical Microsystem Technologies, New Trends in Electrochemistry Vol. 2 Y1 - 2002 SP - 384 EP - 408 PB - Taylor & Francis CY - London New York ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Feldeffektstrukturen mit AgI-Aufdampfschichten als chemische Sensoren JF - KfK-Bericht. 5195 (1993) Y1 - 1993 SN - 0303-4003 SP - 1 EP - 95 ER - TY - JOUR A1 - Schöning, Michael Josef T1 - "Playing around“ with field-effect sensors on the basis of EIS structures, LAPS and ISFETs JF - Sensors. 5 (2005), H. 3 Y1 - 2005 SN - 1424-8220 SP - 126 EP - 138 ER -