TY  - JOUR
A1  - Digel, Ilya
T1  - In-situ biological decontamination of an ice melting probe
Y1  - 2010
N1  - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany
Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf
ER  - 
TY  - JOUR
A1  - Brockhaus, Moritz K.
A1  - Behbahani, Mehdi
A1  - Muris, Farina
A1  - Jansen, Sebastian V.
A1  - Schmitz- Rode, Thomas
A1  - Steinseifer, Ulrich
A1  - Clauser, Johanna C.
T1  - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept
JF  - Artificial Organs
N2  - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Y1  - 2021
U6  - https://doi.org/10.1111/aor.14046
SN  - 1525-1594
VL  - 45
IS  - 12
SP  - 1513
EP  - 1521
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Resmi, Halil
A1  - Akhunlar, Hülya
A1  - Güner, Gül
T1  - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül
JF  - Cell biochemistry and function. 23 (2005), H. 3
Y1  - 2005
SN  - 0263-6484
SP  - 163
EP  - 168
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - McDonald, Malcolm
A1  - McInnes, Colin R.
A1  - Mengali, Giovanni
T1  - Impact of Optical Degradation on Solar Sail Mission Performance
JF  - Journal of Spacecraft and Rockets. 44 (2007), H. 4
Y1  - 2007
SN  - 0022-4650
N1  - 2. ISSN: 1533-6794
SP  - 740
EP  - 749
ER  - 
TY  - JOUR
A1  - Werfel, Stanislas
A1  - Günthner, Roman
A1  - Hapfelmeier, Alexander
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
ED  - Guzik, Tomasz J.
T1  - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning
JF  - Cardiovascular Research
N2  - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.
KW  - Machine learning
KW  - Retinal vessels
KW  - Microcirculation
KW  - Haemodialysis
KW  - Myocardial infarction and cardiac death
Y1  - 2022
U6  - https://doi.org/10.1093/cvr/cvab040
SN  - 0008-6363
VL  - 118
IS  - 2
SP  - 612
EP  - 621
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Mikucki, Jill
A1  - Tulaczyk, Slawek
A1  - Digel, Ilya
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Kowalski, Julia
A1  - Xu, Changsheng
T1  - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems
JF  - Annals of Glaciology
N2  - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.
KW  - Antarctic Glaciology
KW  - Extraterrestrial Glaciology
KW  - Glaciological instruments and methods
KW  - Subclacial exploration
KW  - Subglacial lakes
Y1  - 2014
U6  - https://doi.org/10.3189/2014AoG65A004
SN  - 1727-5644
VL  - 55
IS  - 65
SP  - 14
EP  - 22
PB  - Cambridge University Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Unger, J.
A1  - Spies, K. H.
T1  - Härtebegriff im Zusammenhang mit Vernetzung, Bruchdehnung und Dauerfestigkeit eines Elastomers
JF  - Kautschuk Gummi Kunststoffe. 56 (2003), H. 11
Y1  - 2003
SN  - 0948-3276
SP  - 608
EP  - 613
ER  - 
TY  - JOUR
A1  - Doorschodt, B. M.
A1  - Schreinemachers, M. C. J. M.
A1  - Behbahani, Mehdi
A1  - Florquin, S.
A1  - Weis, J.
A1  - Staat, Manfred
A1  - Tolba, R. H.
T1  - Hypothermic machine perfusion of kidney grafts: which pressure is preferred
JF  - Annals of Biomedical Engineering. 39 (2011), H. 3
Y1  - 2011
SN  - 1573-9686
SP  - 1051
EP  - 1059
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Tastambek, Kuanysh T.
A1  - Kozhahmetova, Marzhan
A1  - Sherelkhan, Dinara K.
A1  - Tauanov, Zhandos
T1  - Hydrogenotrophic methanogenesis in coal-bearing environments: Methane production, carbon sequestration, and hydrogen availability
JF  - International Journal of Hydrogen Energy
N2  - Methane is a valuable energy source helping to mitigate the growing energy demand worldwide. However, as a potent greenhouse gas, it has also gained additional attention due to its environmental impacts. The biological production of methane is performed primarily hydrogenotrophically from H2 and CO2 by methanogenic archaea. Hydrogenotrophic methanogenesis also represents a great interest with respect to carbon re-cycling and H2 storage. The most significant carbon source, extremely rich in complex organic matter for microbial degradation and biogenic methane production, is coal. Although interest in enhanced microbial coalbed methane production is continuously increasing globally, limited knowledge exists regarding the exact origins of the coalbed methane and the associated microbial communities, including hydrogenotrophic methanogens. Here, we give an overview of hydrogenotrophic methanogens in coal beds and related environments in terms of their energy production mechanisms, unique metabolic pathways, and associated ecological functions.
KW  - Coal
KW  - Methanogenesis
KW  - Methane
KW  - Hydrogenotrophic methanogens
KW  - H2
Y1  - 2024
U6  - https://doi.org/10.1016/j.ijhydene.2023.09.223
SN  - 1879-3487 (online)
SN  - 0360-3199 (print)
VL  - 52
IS  - Part D
SP  - 1264
EP  - 1277
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Baroud, G.
A1  - Wu, J.Z.
A1  - Bohner, M
A1  - Sponagel, Stefan
A1  - Steffen, T.
T1  - How to determine the permeability for cement infiltration into osteoporotic cancellous bone
JF  - Medical Engineering & Physics. 25 (2003), H. 4
N2  - Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice.
KW  - Osteoporose
KW  - Permeabilität
KW  - Viskose Strömung
KW  - Viskosität
KW  - Vertebroplastie
KW  - Cement infiltration
KW  - Vertebroplasty
KW  - Osteoporosis
KW  - Permeability
KW  - Experiment
KW  - Analysis
KW  - Viscous flow
Y1  - 2003
SN  - 1350-4533
SP  - 283
EP  - 288
ER  - 
TY  - JOUR
A1  - Linder, Peter
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Artmann, Gerhard
T1  - High-throughput testing of mechanical forces generated in thin cell and tissue layers
JF  - Tissue Engineering. 13 (2007), H. 7
Y1  - 2007
SN  - 1076-3279
N1  - Meeting abstract 433
SP  - 1778
EP  - 1778
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Stadler, A.  M.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Embs, Jan P.
A1  - Zaccai, Joe
A1  - Büldt, Georg
T1  - Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature
JF  - Biophysical Journal. 95 (2008), H. 11
Y1  - 2008
SN  - 1542-0086
SP  - 5449
EP  - 5461
ER  - 
TY  - JOUR
A1  - Probst, M.
A1  - Behbahani, Mehdi
A1  - Borrmann, E.
A1  - Elgeti, S.
A1  - Nicolai, M.
A1  - Behr, M.
T1  - Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices
Y1  - 2010
N1  - Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Leipold, M.
A1  - Fichtner, H.
T1  - Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System / M. Leipold ; H. Fichtner ; B. Heber  ... B. Dachwald ...
JF  - Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]
Y1  - 2003
SN  - 92-9092-853-0
N1  - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; International Academy of Astronautics ; European Space Research and Technology Centre
SP  - 367
EP  - 375
PB  - ESA
CY  - Noordwijk
ER  - 
TY  - JOUR
A1  - Leipold, M.
A1  - Fichtner, H.
A1  - Heber, B.
A1  - Groepper, P.
A1  - Lascar, S.
A1  - Burger, F.
A1  - Eiden, M.
A1  - Niederstadt, T.
A1  - Sickinger, C.
A1  - Herbeck, L.
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
T1  - Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System
JF  - Acta Astronautica. 59 (2006), H. 8-11
Y1  - 2006
SN  - 0094-5765
N1  - International Conference on Low Cost Planetary Missions <5, 2003, Noordwijk> ; Selected Proceedings
SP  - 786
EP  - 796
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - MacDonald, Malcolm
A1  - McInnes, Colin R.
T1  - Heliocentric Solar Sail Orbit Transfers with Locally Optimal Control Laws / Malcolm Macdonald ; Colin McInnes ; Bernd Dachwald
JF  - Journal of Spacecraft and Rockets. 44 (2007), H. 1
Y1  - 2007
SN  - 0022-4650
SP  - 273
EP  - 276
ER  - 
TY  - JOUR
A1  - Laack, Walter van
A1  - Levers, A.
A1  - Staat, Manfred
T1  - Gonarthrosetherapie auf Kernspinresonanzbasis mit MBST-Vierjahresbeobachtungen
JF  - Orthopädische Nachrichten : Zeitung für Orthopädie und Unfallchirurgie. 2013, H. 7/8
Y1  - 2013
SN  - 1437-2193
SP  - 13
PB  - Biermann
CY  - Köln
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, T.
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Karakulah, G.
A1  - Artmann, Gerhard
A1  - Sakizli, M.
A1  - Temiz Artmann, Aysegül
T1  - Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation
JF  - Cellular and molecular bioengineering. 4 (2011), H. 1
Y1  - 2011
SN  - 1865-5025
SP  - 46
EP  - 55
PB  - Springer
CY  - Berlin
ER  -