TY - RPRT A1 - Barnat, Miriam A1 - Arntz, Kristian A1 - Bernecker, Andreas A1 - Fissabre, Anke A1 - Franken, Norbert A1 - Goldbach, Daniel A1 - Hüning, Felix A1 - Jörissen, Jörg A1 - Kirsch, Ansgar A1 - Pettrak, Jürgen A1 - Rexforth, Matthias A1 - Josef, Rosenkranz A1 - Terstegge, Andreas T1 - Strategische Gestaltung von Studiengängen für die Zukunft: Ein kollaborativ entwickeltes Self-Assessment BT - Diskussionspapier Nr. 33 T2 - Hochschulforum Digitalisierung - Diskussionspapier N2 - Das Diskussionspapier beschreibt einen Prozess an der FH Aachen zur Entwicklung und Implementierung eines Self-Assessment-Tools für Studiengänge. Dieser Prozess zielte darauf ab, die Relevanz der Themen Digitalisierung, Internationalisierung und Nachhaltigkeit in Studiengängen zu stärken. Durch Workshops und kollaborative Entwicklung mit Studiendekan:innen entstand ein Fragebogen, der zur Reflexion und strategischen Weiterentwicklung der Studiengänge dient. Y1 - 2024 SN - 2365-7081 PB - Stifterverband für die Deutsche Wissenschaft CY - Berlin ER - TY - THES A1 - Bassam Abduljabbar, Rasha T1 - Physikalisch-chemische Steuerung der Proteinstabilität in biologischen Systemen T1 - Physico-chemical management of protein stability in biological systems Y1 - 2015 ER - TY - JOUR A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences JF - BMC Biophysics Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?10.1186/2046-1682-6-1 SN - 2046-1682 SP - 1 EP - 14 PB - BioMed Central CY - London ER - TY - JOUR A1 - Bassam, Rasha A1 - Hescheler, Jürgen A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Digel, Ilya T1 - Effects of spermine NONOate and ATP on the thermal stability of hemoglobin JF - BMC Biophysics N2 - Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell. KW - Nitric Oxide Donor KW - NONOate KW - Circular Dichroism KW - Nitric Oxide Y1 - 2012 U6 - https://doi.org/10.1186/2046-1682-5-16 SN - 2046-1682 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Baumann, Marcus A1 - Schwarz, Sonja A1 - Kotliar, Konstantin A1 - Eynatten, Maximilian von A1 - Trucksaess, Arno A1 - Burckhardt, Klaus A1 - Lutz, Jens A1 - Heemann, Uwe A1 - Lanzl, Ines T1 - Non-diabetic chronic kidney disease influences retinal microvasculature JF - Kidney and Blood Pressure Research Y1 - 2009 SN - 1423-0143 VL - 32 IS - 6 SP - 428 EP - 433 PB - - ER - TY - THES A1 - Bayer, Robin T1 - Development of a novel in-vitro vascular model for determination of physiological and pathophysiological mechanobiology Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:38-362212 N1 - Dissertation, Universität zu Köln, 2021 PB - Universität zu Köln CY - Köln ER - TY - CHAP A1 - Bayer, Robin A1 - Hescheler, Jürgen A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül ED - Staat, Manfred ED - Erni, Daniel T1 - Treating arterial hypertension in a cell culture well T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW N2 - Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching. Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 5 EP - 6 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Bayer, Robin A1 - Temiz Artmann, Aysegül A1 - Digel, Ilya A1 - Falkenstein, Julia A1 - Artmann, Gerhard A1 - Creutz, Till A1 - Hescheler, Jürgen T1 - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model JF - Cellular Physiology and Biochemistry N2 - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis. Y1 - 2020 U6 - https://doi.org/10.33594/000000225 SN - 1421-9778 VL - 54 SP - 371 EP - 383 PB - Cell Physiol Biochem Press CY - Düsseldorf ER - TY - JOUR A1 - Becker, C. A1 - Wallang, C. A1 - Artmann, Gerhard A1 - Jakse, G. T1 - Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis JF - International Journal of Artificial Organs, The Y1 - 2008 SN - 0391-3988 N1 - Abstracts from the XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies' - ORAL PRESENTATIONS VL - 31 IS - 7 SP - 583 EP - 583 ER - TY - JOUR A1 - Beer, S. A1 - Streun, M. A1 - Hombach, T. A1 - Buehler, J. A1 - Jahnke, S. A1 - Khodaverdi, M. A1 - Larue, H. A1 - Minwuyelet, S. A1 - Parl, C. A1 - Roeb, G. A1 - Schurr, U. A1 - Ziemons, Karl T1 - Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants JF - Physics in Medicine and Biology N2 - Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements. Y1 - 2010 U6 - https://doi.org/10.1088/0031-9155/55/3/006 SN - 1361-6560 VL - 55 IS - 3 SP - 635 EP - 646 PB - IOP CY - Bristol ER - TY - JOUR A1 - Beging, Stefan A1 - Leinhos, Marcel A1 - Jablonski, Melanie A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting JF - Physica status solidi (a) Y1 - 2015 U6 - https://doi.org/10.1002/pssa.201431891 SN - 1862-6319 VL - 212 IS - 6 SP - 1353 EP - 1358 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Beging, Stefan A1 - Mlynek, Daniela A1 - Hataihimakul, Sudkanung A1 - Poghossian, Arshak A1 - Baldsiefen, Gerhard A1 - Busch, Heinz A1 - Laube, Norbert A1 - Kleinen, Lisa A1 - Schöning, Michael Josef T1 - Field-effect calcium sensor for the determination of the risk of urinary stone formation JF - Sensors and Actuators B: Chemical. 144 (2010), H. 2 Y1 - 2010 N1 - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden) SP - 374 EP - 379 ER - TY - CHAP A1 - Beging, Stefan A1 - Poghossian, Arshak A1 - Mlynek, D. A1 - Hataihimakul, S. A1 - Pedraza, A. A1 - Dhawan, S. A1 - Laube, N. A1 - Kleinen, L. A1 - Baldsiefen, G. A1 - Busch, H. A1 - Schöning, Michael Josef T1 - Ion-selective sensors for the determination of the risk of urinary stone formation T2 - Micro- and Nanosystems in biochemical diagnosis : Principles and applications Y1 - 2010 SP - 74 EP - 80 CY - Warsaw ER - TY - JOUR A1 - Beging, Stefan A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Hataihimakul, Sudkanung A1 - Busch, H. A1 - Baldsiefen, G. A1 - Laube, N. A1 - Kleinen, L. A1 - Hosseiny, R. T1 - Feldeffektbasierender Ca2+-sensitiver Sensor für den Einsatz im Nativurin zur Bestimmung des Harnsteinbildungsrisikos JF - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2008 SN - 978-3-18-092011-5 N1 - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008 SP - 775 EP - 782 PB - VDI-Verl. CY - Düsseldorf ER - TY - THES A1 - Behbahani, Mehdi T1 - Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices Y1 - 2011 SN - 978-3-8439-0134-5 PB - Verlag Dr. Hut CY - München ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M. JF - Artificial Organs. 30 (2006), H. 11 Y1 - 2006 SN - 1525-1594 N1 - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4 SP - A45 EP - A46 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Bischof, F. A1 - Wolf, G. E. T1 - Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe / Behbahani, M. ; Behr, M. ; Bischof, F. ; Wolf, G. E. JF - RWTH-Themen (2007) Y1 - 2007 SN - 0179-079X SP - 44 EP - 46 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, M. A1 - Hormes, M. A1 - Steinseifer, U. A1 - Arora, D. A1 - Coronado, O. A1 - Pasquali, M. T1 - A Review of Computational Fluid Dynamics Analysis of Blood Pumps JF - European Journal of Applied Mathematics. 20 (2009), H. 4 Y1 - 2009 SP - 363 EP - 397 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Nicolai, Mike A1 - Probst, Markus T1 - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM JF - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.) Y1 - 2008 SN - 978-3-9810843-5-1 N1 - NIC series ; 39 SP - 325 EP - 332 PB - Forschungszentrum CY - Jülich ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Finocchiaro, Thomas A1 - Heinke, Stefanie A1 - Leßmann, Marc T1 - Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma JF - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 Y1 - 2009 SN - 0013-5585 N1 - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 SP - 269 EP - 281 ER -