TY  - JOUR
A1  - Kotter, Michael
A1  - Grazyk, J.
A1  - Geißle, W.
A1  - Roth, A.
T1  - Fließeigenschaften von Keramiken für die Herstellung von Katalysatorträgern / J. Grazyk ; W. Gleißle ; A. Roth ; M. Kotter
JF  - Erdöl & Kohle, Erdgas, Petrochemie : EKEP. 43 (1990), H. 1
Y1  - 1990
SN  - 0014-0058
N1  - 2. ISSN: 0367-0716 ; In der Bibliothek (Jülich) vorhanden unter 63 ZS 034
SP  - 27
EP  - 30
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Becker, Dieter
A1  - Riekert, Lothar
T1  - Zur Selektivität der partiellen Oxidation von Propen an Schalenkatalysatoren / Dieter Becker ; Michael Kotter ; Lothar Riekert
JF  - Chemie - Ingenieur - Technik. 61 (1989), H. 9
Y1  - 1989
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 748
EP  - 749
ER  - 
TY  - JOUR
A1  - Kotter, Michael
T1  - Herstellung von Tränkkatalysatoren als verfahrenstechnische Aufgabe
JF  - Chemie - Ingenieur - Technik. 55 (1983), H. 3
Y1  - 1983
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640
SP  - 179
EP  - 185
ER  - 
TY  - JOUR
A1  - Kotter, Michael
T1  - Katalytische Abluftreinigung mit integriertem regenerativem Wärmetausch
JF  - Chemie - Ingenieur - Technik. 64 (1992), H. 9
Y1  - 1992
SN  - 0009-286X
N1  - ISSN der E-Ausg.: 1522-2640 ; GVC-Jahrentreffer ; Beitrag 116
SP  - 848
ER  - 
TY  - JOUR
A1  - Kotnik, Katarina
A1  - Popova, Elena
A1  - Todiras, Mihail
A1  - Mori, Marcelo A.
A1  - Alenina, Natalia
A1  - Seibler, Jost
A1  - Bader, Michael
T1  - Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
JF  - Plos One
Y1  - 2009
U6  - http://dx.doi.org/10.1371/journal.pone.0005124
VL  - 4
IS  - 4
SP  - e5124
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Kornfeld, Jan-Wilhelm
A1  - Baitzel, Catherina
A1  - Könner, A. Christine
A1  - Nicholls, Hayley T.
A1  - Vogt, Merly C.
A1  - Herrmanns, Karolin
A1  - Scheja, Ludger
A1  - Haumaitre, Cécile
A1  - Wolf, Anna M.
A1  - Knippschild, Uwe
A1  - Seibler, Jost
A1  - Cereghini, Silvia
A1  - Heeren, Joerg
A1  - Stoffel, Markus
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
JF  - Nature
Y1  - 2013
SN  - 0028-0836
U6  - http://dx.doi.org/10.1038/nature11793
VL  - 494
IS  - 7435
SP  - 111
EP  - 115
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - http://dx.doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Kappler-Tanudyaya, Nathalie
A1  - Schmitt, Heike
A1  - Tippkötter, Nils
A1  - Meyer, Lina
A1  - Lenzen, Sigurd
A1  - Ulber, Roland
T1  - Combination of biotransformation and chromatography for the isolation and purification of mannoheptulose
JF  - Biotechnology Journal
N2  - Mannoheptulose is a seven-carbon sugar. It is an inhibitor of glucose-induced insulin secretion due to its ability to selectively inhibit the enzyme glucokinase. An improved procedure for mannoheptulose isolation from avocados is described in this study (based upon the original method by La Forge). The study focuses on the combination of biotransformation and downstream processing (preparative chromatography) as an efficient method to produce a pure extract of mannoheptulose. The experiments were divided into two major phases. In the first phase, several methods and parameters were compared to optimize the mannoheptulose extraction with respect to efficiency and purity. In the second phase, a mass balance of mannoheptulose over the whole extraction process was undertaken to estimate the yield and efficiency of the total extraction process. The combination of biotransformation and preparative chromatography allowed the production of a pure mannoheptulose extract. In a biological test, the sugar inhibited the glucokinase enzyme activity efficiently.
Y1  - 2007
U6  - http://dx.doi.org/10.1002/biot.200700004
SN  - 1860-7314
VL  - 2
IS  - 6
SP  - 692
EP  - 699
ER  - 
TY  - JOUR
A1  - Kapelyukh, Yury
A1  - Henderson, Colin James
A1  - Scheer, Nico
A1  - Rode, Anja
A1  - Wolf, Charles Roland
T1  - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - http://dx.doi.org/10.1124/dmd.119.087718
IS  - Early view
ER  - 
TY  - JOUR
A1  - Kalbe, Jochen
A1  - Kuropka, Rolf
A1  - Meyer-Stork, L. Sebastian
A1  - Berndt, Heinz
A1  - [u.a.], 
T1  - Isolation and characterization of high-molecular mass DNA from hair shafts
JF  - Biological chemistry
Y1  - 1988
SN  - 0177-3593
U6  - http://dx.doi.org/10.1515/bchm3.1988.369.1.413
VL  - 369
IS  - 1
SP  - 413
EP  - 416
ER  - 
TY  - JOUR
A1  - Kalbe, Jochen
A1  - Höcker, Hartwig
A1  - Berndt, Heinz
T1  - Design of enzyme reactors as chromatographic columns for racemic resolution of amino acid esters
JF  - Chromatographia
Y1  - 1989
SN  - 0009-5893
U6  - http://dx.doi.org/10.1007/BF02319646
VL  - 28
IS  - 3-4
SP  - 193
EP  - 196
ER  - 
TY  - JOUR
A1  - Jossek, Ralf
A1  - Bongaerts, Johannes
A1  - Sprenger, Georg A.
T1  - Characterization of a new feedback-resistant 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase AroF of Escherichia coli
JF  - FEMS microbiology letters
Y1  - 2001
SN  - 1574-6968
VL  - Vol. 202
IS  - Iss. 1
SP  - 145
EP  - 148
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Zoor, Annegreth
T1  - A new irreversible enzyme-aided esterification method in organic solvents
JF  - Biotechnology letters. 30 (2008), H. 5
Y1  - 2008
SN  - 1573-6776
SP  - 925
EP  - 928
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Welsch, Volker
T1  - Diketene a New Esterification Reagent in the Enzyme-Aided Synthesis of Chiral Alcohols and Chiral Acetoacetic Acid Esters
JF  - Tetrahedron Letters  . 36 (1995), H. 37
Y1  - 1995
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 6663
EP  - 6664
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Weise, Sven
T1  - Enzymatische Acetylierung von (±)-1-Phthalimido-2-propanol
JF  - Liebigs Annalen der Chemie (1990)
Y1  - 1990
SN  - 0947-3440
N1  - ISSN der E-Ausg.: 1099-0690
SP  - 1045
EP  - 1046
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Scheidt, Annette
T1  - Aliphatic optically active alcohols by enzyme-aided synthesis
JF  - Tetrahedron Letters  . 32 (1991), H. 48
Y1  - 1991
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 7021
EP  - 7024
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Albertz, Michael
T1  - Optically active α-acetoxycarboxylic acids and α-hydroxycarboxylic acids by enzyme-aided syntheses
JF  - Journal für Praktische Chemie / Chemiker-Zeitung. 334 (1992), H. 6
Y1  - 1992
SN  - 1436-9966
N1  - ISSN der E-Ausg.: 1521-3897 ; In der Bibliothek (Jülich) vorhanden unter 63 ZS 024-1992
SP  - 526
EP  - 528
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Tetrabenzo[a,c,h,j]phenoxazine-18-yl a new stable neutral radical
JF  - Tetrahedron Letters  . 42 (2001), H. 10
Y1  - 2001
SN  - 0040-4039
N1  - ISSN der E-Ausg.: 1359-8562
SP  - 1863
EP  - 1865
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
T1  - Superabsorbed alcohol dehydrogenase—a new catalyst for asymmetric reductions
JF  - Biotechnology Letters. 31 (2009), H. 11
Y1  - 2009
SN  - 0141-5492
SP  - 1717
EP  - 1721
ER  -