TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and Phosphate Interactions in Health and Disease
T2  - Phosphate Metabolism
N2  - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.
KW  - Vitamin D
KW  - PTH
KW  - Phosphate
KW  - FGF23
KW  - Klotho
Y1  - 2022
SN  - 978-3-030-91621-3
U6  - https://doi.org/10.1007/978-3-030-91623-7_5
SP  - 37
EP  - 46
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Razzaque, Mohammed S.
T1  - Role of vitamins in maintaining structure and function of intestinal microbiome
T2  - Comprehensive Gut Microbiota
N2  - The recent advances in microbiology have shed light on understanding the role of vitamins beyond the nutritional range. Vitamins are critical in contributing to healthy biodiversity and maintaining the proper function of gut microbiota. The sharing of vitamins among bacterial populations promotes stability in community composition and diversity; however, this balance becomes disturbed in various pathologies. Here, we overview and analyze the ability of different vitamins to selectively and specifically induce changes in the intestinal microbial community. Some schemes and regularities become visible, which may provide new insights and avenues for therapeutic management and functional optimization of the gut microbiota.
KW  - Vitamin A
KW  - Vitamin B
KW  - Thiamine
KW  - Riboflavin
KW  - Niacin
Y1  - 2022
SN  - 978-0-12-822036-8
U6  - https://doi.org/10.1016/B978-0-12-819265-8.00043-7
SP  - 320
EP  - 334
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Abeln, Björn
A1  - Döring, Bernd
A1  - Feldmann, Markus
A1  - Geßler, Achim
A1  - Möller, Sebastian
A1  - Paschen, Michael
A1  - Sedlacek, Gerhard
T1  - Entwicklungen zu Stahlfahrbahnen von Straßenbrücken
T2  - Festschrift zum 60. Geburtstag von Univ.-Prof. Dr.-Ing. Ingbert Mangerig. (Berichte aus dem Konstruktiven Ingenieurbau / Universität der Bundeswehr München ; 10/6)
Y1  - 2010
SP  - 65
EP  - 76
PB  - Univ. der Bundeswehr
CY  - Neubiberg
ER  - 
TY  - CHAP
A1  - Abele, Daniel
A1  - Kleefeld, Andreas
ED  - Constanda, Christian
T1  - New Numerical Results for the Optimization of Neumann Eigenvalues
T2  - Computational and Analytic Methods in Science and Engineering
N2  - We present new numerical results for shape optimization problems of interior Neumann eigenvalues. This field is not well understood from a theoretical standpoint. The existence of shape maximizers is not proven beyond the first two eigenvalues, so we study the problem numerically. We describe a method to compute the eigenvalues for a given shape that combines the boundary element method with an algorithm for nonlinear eigenvalues. As numerical optimization requires many such evaluations, we put a focus on the efficiency of the method and the implemented routine. The method is well suited for parallelization. Using the resulting fast routines and a specialized parametrization of the shapes, we found improved maxima for several eigenvalues.
Y1  - 2020
SN  - 978-3-030-48185-8 (Print)
SN  - 978-3-030-48186-5 (Online)
U6  - https://doi.org/10.1007/978-3-030-48186-5_1
SP  - 1
EP  - 20
PB  - Birkhäuser
CY  - Cham
ER  - 
TY  - CHAP
A1  - Abel, Thomas
A1  - Bonin, Dominik
A1  - Albracht, Kirsten
A1  - Zeller, Sebastian
A1  - Burkett, Brendan
T1  - Kinematische Untersuchung der Kurbelbewegung im Handcycling: Entwicklung einer sportartspezifischen Methode
T2  - Behindertensport 1951-2011 : Historische und aktuelle Aspekte im nationalen und internationalen Dialog
Y1  - 2015
SN  - 9783898997249
SP  - 82
EP  - 91
PB  - Meyer & Meyer
CY  - Aachen
ER  -