TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - https://doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Nojima, H. A1 - Artmann, Gerhard T1 - Effects of plasma generated ions on bacteria : [poster] N2 - Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death. KW - Clusterion KW - Bakterien KW - plasma generated ions Y1 - 2003 ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Biele, Jens A1 - Boden, Ralf A1 - Ceriotti, Matteo A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian A1 - Herčík, David A1 - Herique, Alain A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Koch, Aaron A1 - Kofman, Wlodek A1 - Koncz, Alexander A1 - Krause, Christian A1 - Lange, Caroline A1 - Lichtenheldt, Roy A1 - Maiwald, Volker A1 - Mikschl, Tobias A1 - Mikulz, Eugen A1 - Montenegro, Sergio A1 - Pelivan, Ivanka A1 - Peloni, Alessandro A1 - Plettemeier, Dirk A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Ruffer, Michael A1 - Sasaki, Kaname A1 - Schmitz, Nicole A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Sznajder, Maciej A1 - Tardivel, Simon A1 - Toth, Norbert A1 - Wejmo, Elisabet A1 - Wolff, Friederike A1 - Ziach, Christian T1 - Efficient massively parallel prospection for ISRU by multiple near-earth asteroid rendezvous using near-term solar sails and'now-term'small spacecraft solutions T2 - 2nd Asteroid Science Intersections with In-Space Mine Engineering – ASIME 2018 N2 - Physical interaction with small solar system bodies (SSSB) is key for in-situ resource utilization (ISRU). The design of mining missions requires good understanding of SSSB properties, including composition, surface and interior structure, and thermal environment. But as the saying goes "If you've seen one asteroid, you've seen one Asteroid": Although some patterns may begin to appear, a stable and reliable scheme of SSSB classification still has to be evolved. Identified commonalities would enable generic ISRU technology and spacecraft design approaches with a high degree of re-use. Strategic approaches require much broader in-depth characterization of the SSSB populations of interest to the ISRU community. The DLR-ESTEC GOSSAMER Roadmap Science Working Groups identified target-flexible Multiple Near-Earth asteroid (NEA) Rendezvous (MNR) as one of the missions only feasible with solar sail propulsion, showed the ability to access any inclination and a wide range of heliocentric distances as well as continuous operation close to Earth's orbit where low delta-v objects reside. Y1 - 2018 N1 - 2nd Asteroid Science Intersections with In-Space Mine Engineering – ASIME 2018 16-17 April 2018, Belval, Luxembourg SP - 1 EP - 33 ER - TY - CHAP A1 - Jung, Alexander A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample. Y1 - 2018 ER - TY - CHAP A1 - Konstantinidis, K. A1 - Dachwald, Bernd A1 - Ohndorf, A. A1 - Dykta, P. A1 - Voigt, K. A1 - Förstner, R. T1 - Enceladus explorer (ENEX): A lander mission to probe subglacial water pockets on Saturn's moon enceladus for life T2 - 64th International Astronautical Congress 2013 (IAC 2013) : Beijing, China, 23 - 27 September 2013. (Proceedings of the International Astronautical Congress, IAC ; 2) Y1 - 2013 SN - 978-1-62993-909-4 SP - 1340 EP - 1350 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Dachwald, Bernd A1 - Feldmann, Marco A1 - Espe, Clemens A1 - Plescher, Engelbert A1 - Konstantinidis, K. A1 - Forstner, R. T1 - Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice T2 - 63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3) Y1 - 2012 SN - 978-1-62276-979-7 SP - 1756 EP - 1766 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Pohle-Fröhlich, Regina A1 - Dalitz, Christoph A1 - Richter, Charlotte A1 - Hahnen, Tobias A1 - Stäudle, Benjamin A1 - Albracht, Kirsten T1 - Estimation of muscle fascicle orientation in ultrasonic images T2 - Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 5 N2 - We compare four different algorithms for automatically estimating the muscle fascicle angle from ultrasonic images: the vesselness filter, the Radon transform, the projection profile method and the gray level cooccurence matrix (GLCM). The algorithm results are compared to ground truth data generated by three different experts on 425 image frames from two videos recorded during different types of motion. The best agreement with the ground truth data was achieved by a combination of pre-processing with a vesselness filter and measuring the angle with the projection profile method. The robustness of the estimation is increased by applying the algorithms to subregions with high gradients and performing a LOESS fit through these estimates. Y1 - 2020 SN - 978-989-758-402-2 U6 - https://doi.org/10.5220/0008933900790086 N1 - 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications VISAPP 2020, Valletta, Malta SP - 79 EP - 86 PB - SciTePress CY - Setúbal, Portugal ER - TY - CHAP A1 - Frotscher, Ralf A1 - Koch, Jan-Peter A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Onate, E. T1 - Evaluation of a computational model for drug action on cardiac tissue T2 - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona Y1 - 2014 SP - 1 EP - 12 ER - TY - CHAP A1 - Kolditz, Melanie A1 - Albracht, Kirsten A1 - Fasse, Alessandro A1 - Albin, Thivaharan A1 - Brüggemann, Gert-Peter A1 - Abel, Dirk T1 - Evaluation of an industrial robot as a leg press training device T2 - XV International Symposium on Computer Simulation in Biomechanics July 9th – 11th 2015, Edinburgh, UK Y1 - 2015 SP - 41 EP - 42 ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Novacek, V. A1 - Tolba, R. A1 - Klinge, U. A1 - Turquier, F. A1 - Staat, Manfred T1 - Experimental and Computational approach to study colorectal anastomosis. ISB2011, Proceedings of the XXIII Congress of the International Society of Biomechanics, Brussels, Belgium, July 3-7, 2011 N2 - Summary: This paper presents a methodology to study and understand the mechanics of stapled anastomotic behaviors by combining empirical experimentation and finite element analysis. Performance of stapled anastomosis is studied in terms of leakage and numerical results which are compared to in vitro experiments performed on fresh porcine tissue. Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue. KW - Anastomose KW - Finite-Elemente-Methode KW - Biomechanik KW - Anastomosis KW - Finite element method KW - Biomechanics Y1 - 2011 ER - TY - CHAP A1 - Pham, Phu Tinh A1 - Nguyen, Thanh Ngoc A1 - Staat, Manfred T1 - FEM based shakedown analysis of hardening structures T2 - Proceedings International Conference on Advances in Computational Mechanics (ACOME) Y1 - 2012 N1 - International Conference on Advances in Computational Mechanics (ACOME), August 14-16, 2012, Ho Chi Minh City, Vietnam SP - 870 EP - 882 ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Staat, Manfred T1 - FEM shakedown analysis of Kirchhoff-Love plates under uncertainty of strength T2 - Proceedings of UNCECOMP 2021 N2 - A new formulation to calculate the shakedown limit load of Kirchhoff plates under stochastic conditions of strength is developed. Direct structural reliability design by chance con-strained programming is based on the prescribed failure probabilities, which is an effective approach of stochastic programming if it can be formulated as an equivalent deterministic optimization problem. We restrict uncertainty to strength, the loading is still deterministic. A new formulation is derived in case of random strength with lognormal distribution. Upper bound and lower bound shakedown load factors are calculated simultaneously by a dual algorithm. Y1 - 2021 SN - 978-618-85072-6-5 U6 - https://doi.org/10.7712/120221.8041.19047 N1 - UNCECOMP 2021, 4th International Conference on Uncertainty Quantification in Computational Sciences and Engineering, streamed from Athens, Greece, 28–30 June 2021. SP - 323 EP - 338 ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Tran, Thanh Ngoc A1 - Matthies, Hermann G. A1 - Stavroulakis, Georgios Eleftherios A1 - Staat, Manfred T1 - FEM Shakedown of uncertain structures by chance constrained programming T2 - PAMM Proceedings in Applied Mathematics and Mechanics Y1 - 2016 U6 - https://doi.org/10.1002/pamm.201610346 SN - 1617-7061 N1 - Special Issue: Joint 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung VL - 16 IS - 1 SP - 715 EP - 716 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Erni, Daniel T1 - Female pelvic floor dysfunction: progress weakening of the support system T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders. Y1 - 2016 U6 - https://doi.org/10.17185/duepublico/40821 SP - 11 EP - 12 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Digel, Ilya A1 - Demirci, Taylan A1 - Trzewik, Jürgen A1 - Linder, Peter A1 - Temiz Artmann, Aysegül T1 - Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract] N2 - Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate. KW - Fibroblast KW - Mechanische Beanspruchung KW - celldrum technology Y1 - 2004 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Hunyh A1 - Staat, Manfred T1 - Finite Element Implementation of a 3D Fung-type Model T2 - ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012 Y1 - 2012 SN - 978-3-85125-223-1 PB - Verlag d. Technischen Universität Graz CY - Graz ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred A1 - Kreißig, R. T1 - Finite element shakedown and limit reliability analysis of thin shells N2 - A procedure for the evaluation of the failure probability of elastic-plastic thin shell structures is presented. The procedure involves a deterministic limit and shakedown analysis for each probabilistic iteration which is based on the kinematical approach and the use the exact Ilyushin yield surface. Based on a direct definition of the limit state function, the non-linear problems may be efficiently solved by using the First and Second Order Reliabiblity Methods (Form/SORM). This direct approach reduces considerably the necessary knowledge of uncertain technological input data, computing costs and the numerical error. In: Computational plasticity / ed. by Eugenio Onate. Dordrecht: Springer 2007. VII, 265 S. (Computational Methods in Applied Sciences ; 7) (COMPLAS IX. Part 1 . International Center for Numerical Methods in Engineering (CIMNE)). ISBN 978-1-402-06576-7 S. 186-189 KW - Finite-Elemente-Methode KW - Limit analysis KW - shakedown analysis KW - Exact Ilyushin yield surface KW - Random variable KW - First Order Reliabiblity Method Y1 - 2007 ER - TY - CHAP A1 - Ohndorf, Andreas A1 - Dachwald, Bernd A1 - Seboldt, Wolfgang A1 - Schartner, Karl-Heinz T1 - Flight times to the heliopause using a combination of solar and radioisotope electric propulsion T2 - 32nd International Electric Propulsion Conference N2 - We investigate the interplanetary flight of a low-thrust space probe to the heliopause,located at a distance of about 200 AU from the Sun. Our goal was to reach this distance within the 25 years postulated by ESA for such a mission (which is less ambitious than the 15-year goal set by NASA). Contrary to solar sail concepts and combinations of allistic and electrically propelled flight legs, we have investigated whether the set flight time limit could also be kept with a combination of solar-electric propulsion and a second, RTG-powered upper stage. The used ion engine type was the RIT-22 for the first stage and the RIT-10 for the second stage. Trajectory optimization was carried out with the low-thrust optimization program InTrance, which implements the method of Evolutionary Neurocontrol,using Artificial Neural Networks for spacecraft steering and Evolutionary Algorithms to optimize the Neural Networks’ parameter set. Based on a parameter space study, in which the number of thrust units, the unit’s specific impulse, and the relative size of the solar power generator were varied, we have chosen one configuration as reference. The transfer time of this reference configuration was 29.6 years and the fastest one, which is technically more challenging, still required 28.3 years. As all flight times of this parameter study were longer than 25 years, we further shortened the transfer time by applying a launcher-provided hyperbolic excess energy up to 49 km2/s2. The resulting minimal flight time for the reference configuration was then 27.8 years. The following, more precise optimization to a launch with the European Ariane 5 ECA rocket reduced the transfer time to 27.5 years. This is the fastest mission design of our study that is flexible enough to allow a launch every year. The inclusion of a fly-by at Jupiter finally resulted in a flight time of 23.8 years,which is below the set transfer-time limit. However, compared to the 27.5-year transfer,this mission design has a significantly reduced launch window and mission flexibility if the escape direction is restricted to the heliosphere’s “nose". KW - low-thrust trajectory optimization KW - heliosphere KW - ion propulsion Y1 - 2011 N1 - IEPC-2011-051 32nd International Electric Propulsion Conference,September 11–15, 2011 Wiesbaden, Germany SP - 1 EP - 12 ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Boden, Ralf A1 - Ceriotti, Matteo A1 - Chand, Suditi A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Heiligers, Jeannette A1 - Herčík, David A1 - Hérique, Alain A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Kofman, Wlodek A1 - Lange, Caroline A1 - Lichtenheldt, Roy A1 - McInnes, Colin A1 - Meß, Jan-Gerd A1 - Mikschl, Tobias A1 - Mikulz, Eugen A1 - Montenegro, Sergio A1 - Moore, Iain A1 - Pelivan, Ivanka A1 - Peloni, Alessandro A1 - Plettemeier, Dirk A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Rogez, Yves A1 - Ruffer, Michael A1 - Sasaki, Kaname A1 - Schmitz, Nicole A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Sznajder, Maciej A1 - Tóth, Norbert A1 - Vergaaij, Merel A1 - Viavattene, Giulia A1 - Wejmo, Elisabet A1 - Wiedemann, Carsten A1 - Wolff, Friederike A1 - Ziach, Christian T1 - Flights are ten a sail – Re-use and commonality in the design and system engineering of small spacecraft solar sail missions with modular hardware for responsive and adaptive exploration T2 - 70th International Astronautical Congress (IAC) KW - system engineering KW - small solar system body characterisation KW - small spacecraft solar sail KW - small spacecraft asteroid lander KW - responsive space Y1 - 2019 SN - 9781713814856 N1 - 70th International Astronautical Congress (IAC), Washington D.C., United States, 21-25 October 2019 SP - 1 EP - 7 ER - TY - CHAP A1 - Kuhlen, Max A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - https://doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 102 EP - 103 PB - Universität Duisburg-Essen CY - Duisburg ER -