TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Vogt, Christian
A1  - Iwanowski-Strahser, Katha
A1  - Marquart, Gabriele
A1  - Arnold, Juliane
A1  - Mottaghy, Darius
A1  - Pechnig, Renate
A1  - Gnjezda, Daniel
A1  - Clauser, Christoph
T1  - Modeling contribution to risk assessment of thermal production power for geothermal reservoirs
JF  - Renewable Energy
Y1  - 2013
U6  - https://doi.org/10.1016/j.renene.2012.11.026
SN  - 0960-1481
VL  - 53
SP  - 230
EP  - 241
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - https://doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Rieke, Christian
A1  - Stollenwerk, Dominik
A1  - Dahmen, Markus
A1  - Pieper, Martin
T1  - Modeling and optimization of a biogas plant for a demand-driven energy supply
JF  - Energy
N2  - Due to the Renewable Energy Act, in Germany it is planned to increase the amount of renewable energy carriers up to 60%. One of the main problems is the fluctuating supply of wind and solar energy. Here biogas plants provide a solution, because a demand-driven supply is possible. Before running such a plant, it is necessary to simulate and optimize the process. This paper provides a new model of a biogas plant, which is as accurate as the standard ADM1 model. The advantage compared to ADM1 is that it is based on only four parameters compared to 28. Applying this model, an optimization was installed, which allows a demand-driven supply by biogas plants. Finally the results are confirmed by several experiments and measurements with a real test plant.
Y1  - 2018
U6  - https://doi.org/10.1016/j.energy.2017.12.073
SN  - 0360-5442
VL  - 145
SP  - 657
EP  - 664
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Simulation of Blood Damage
Y1  - 2010
N1  - Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Nam, J.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Pasquali, M.
A1  - Mottaghy, K.
T1  - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs
Y1  - 2010
U6  - https://doi.org/10.1097/01.mat.0000369377.65122.a3
N1  - Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Schäfer, Horst
A1  - Heil, Günter
T1  - Modeling and Graphic Presentation of Acid–Base Titration Curves. Presentation of an Alternative Method
JF  - The Chemical Educator. 7 (2002), H. 6
Y1  - 2002
SN  - 1430-4171
SP  - 339
EP  - 346
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Tran, L.
A1  - Waluga, C.
A1  - Behr, M.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices
JF  - The International Journal of Artificial Organs. 32 (2009), H. 7
Y1  - 2009
SN  - 0391-3988
N1  - Abstracts - Oral Presentations: XXXVI Annual ESAO Congress, 2-5 September 2009, Compiègne - France; European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009
SP  - 398
EP  - 398
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Bauer, S. M.
A1  - Zamuraev, L. A.
T1  - Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.
JF  - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2
Y1  - 2006
SN  - 1812-5123
SP  - 41
EP  - 47
PB  - -
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Zamdmer, N.
A1  - Hu, Qing
A1  - Verghese, S.
T1  - Mode-Discriminating Photoconductor and Coplanar Wave-Guide Circuits for Picosecond Sampling. Zamdmer, N.; Hu, Qing ; Verghese, S. ; Förster, A.
JF  - Applied Physics Letters. 74 (1999), H. 7
Y1  - 1999
SN  - 1077-3118
SP  - 1039
EP  - 1041
ER  - 
TY  - JOUR
A1  - Wallenborn, Ramona
A1  - Ritz, Thomas
T1  - Mobilität miteinander teilen : städtisches eCarsharing in einer vernetzten Gesellschaft ; [vernetztes Fahren von morgen]
JF  - Neue Mobilität : das Magazin vom Bundesverband eMobilität
Y1  - 2014
SN  - 2191-5636
VL  - 5
IS  - 14 (Herbstausg.)
SP  - 92
EP  - 95
PB  - Bundesverband eMobilität BEM
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
A1  - Stender, Michael
T1  - Mobilität meistern - Integration von mobilen Akteuren durch ad-hoc Integrationskonzepte
JF  - Wireless Technologien nutzbar machen: UMTS und alternative Netzwerktechnologien für innovative mobile Anwendungen in Vertrieb und Service
Y1  - 2002
N1  - IAO-Forum 5. Juni 2002, Stuttgart
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
T1  - Mobile Unternehmenssoftware
JF  - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Examen, Berufseinstieg und Weiterbildung
Y1  - 2006
SN  - 0340-3084
N1  - gedruckte Ausgabe in der Bereichsbibliothek Eupener Str. vorhanden unter 43 Z 568
VL  - 36
IS  - 10
SP  - 1212
EP  - 1218
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Horn, Uwe
A1  - Huschke, Jörg
A1  - Kampmann, Markus
T1  - Mobile TV Services in 3G Networks / Hartung, Frank ; Horn, Uwe ; Huschke, Jörg ; Kampmann, Markus ; Lohmar, Thorsten
JF  - KIVS 2007 : Kommunikation in verteilten Systemen : 15. ITG-GI-Fachtagung vom 26. Februar bis 2. März 2007 in Bern, Schweiz ; Industriebeiträge, Kurzbeiträge und Workshops / T. Braun ... (Hrsg.)
Y1  - 2007
SN  - 978-3-8007-2980-7
N1  - Communication in Distributed Systems (KiVS), 2007 ITG-GI Conference
SP  - 15
EP  - 18
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Kampmann, Markus
A1  - Horn, Uwe
A1  - Kritzner, Jan
T1  - Mobile Television / Hartung, Frank ; Kampmann, Markus ; Horn, Uwe ; Kritzner, Jan
JF  - Encyclopedia of mobile computing and commerce / David Taniar ; Bd. 2 : Mobile ICT - Z
Y1  - 2007
SN  - 978-1-59904-002-8
SP  - 611
EP  - 615
PB  - Information Science Reference
CY  - Hershey
ER  - 
TY  - JOUR
A1  - Schuba, Marko
A1  - Wrona, Konrad
A1  - Zavagli, Guido
T1  - Mobile Payments - State of the Art and Open Problems / Wrona, Konrad ; Schuba, Marko ; Zavagli, Guido
JF  - Electronic commerce : second international workshop ; proceedings / WELCOM 2001, Heidelberg, Germany, November 16-17, 2001. Ludger Fiege ... (ed.)
Y1  - 2001
SN  - 978-3-540-42878-7
N1  - Lecture Notes in Computer Science ; 2232
SP  - 88
EP  - 100
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hartung, Frank
T1  - Mobile DRM Introduction: The Need for Mobile DRM
JF  - Digital Rights Management : Technological, Economic, Legal and Political Aspects / Becker, Eberhard [u.a.]
Y1  - 2003
N1  - Lecture Notes in Computer Science ; 2770
SP  - 138
EP  - 149
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
T1  - Mobile CRM-Systeme : Customer Relationship Management zur Unterstützung des Vertriebsaußendienstes
JF  - Zeitschrift für wirtschaftlichen Fabrikbetrieb : ZWF ; Organ des VDI-Kompetenzfeldes Informationstechnik (VDI-KfIT)
Y1  - 2003
SN  - 0932-0482 (Print)
SN  - 0947-0085 (Online)
VL  - 99
IS  - 12
SP  - 699
EP  - 702
ER  - 
TY  - JOUR
A1  - Schuba, Marko
A1  - Wrona, Konrad
T1  - Mobile Chip Electronic Commerce: Enabling Credit Card Payment for Mobile Devices / Schuba, Marko ; Wrona, Konrad
Y1  - 2000
N1  - eBiz2000 Specialist Conference @ CommunicAsia2000, Singapore, June 2000
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Benkner, Thorsten
T1  - Mobile Breitband-Zugangstechniken für ATM-Netze
JF  - Konvergenz im Bereich der Telekommunikation. Beiträge der Invited Speakers und aus dem Call for Papers der gleichnamigen Tagung an der TU Graz
Y1  - 2000
SN  - 3-85133-021-8
N1  - Schriftenreihe des ÖVE, Bd. 25
PB  - Eigenverl. d. Österr. Verb. für Elektrotechnik
CY  - Wien
ER  -