TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Lengkeek, Nigel A.
A1  - Le, Van So
A1  - Pellegrini, Paul A.
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]
JF  - Applied Radiation and Isotopes
N2  - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.apradiso.2015.09.008
SN  - 1872-9800
VL  - 107
SP  - 13
EP  - 16
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Voigt, Birgit
A1  - Schroeter, Rebecca
A1  - Jürgen, Britta
A1  - Albrecht, Dirk
A1  - Evers, Stefan
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Schweder, Thomas
A1  - Hecker, Michael
T1  - The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon
JF  - Proteomics
Y1  - 2013
SN  - 1615-9861 (E-Journal); 1615-9853 (Print)
VL  - Vol. 13
IS  - Iss. 14
SP  - 2140
EP  - 2146
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kroll-Ludwigs, Kathrin
T1  - The Reform of German Maintenance Law
JF  - The International Survey of Family Law
Y1  - 2018
SP  - 85
EP  - 100
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Wilson, Thomas L.
T1  - The quantum temperature of accelerating cosmological models of an entangled Universe
JF  - Advances in Space Research. 35 (2005), H. 1
Y1  - 2005
SN  - 0273-1177
SP  - 111
EP  - 115
ER  - 
TY  - JOUR
A1  - Martin, Siegfried A.
A1  - Hardt, Arno
A1  - Meissburger, Jürgen
A1  - Berg, Georg P. A.
A1  - Hacker, Ulrich
A1  - Hürlimann, Werner
A1  - Römer, Josef G. M.
A1  - Sagefka, Thomas
A1  - Retz, Adolf
A1  - Schult, Otto W. B.
T1  - The QQDDQ magnet spectrometer “BIG KARL”
JF  - Nuclear instruments and methods in physics research. Vol. 214, iss. 2-3
Y1  - 1983
SN  - 0029-554x (E-Journal); 1872-9606 (E-Journal); 0167-5087 (Print)
SP  - 281
EP  - 303
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Bjelakovic, Igor
T1  - The Projective Hilbert Space as a Classical Phase Space for Nonrelativistic Quantum Dynamics. Bjelakovic, Igor; Stulpe, Werner
JF  - International Journal of Theoretical Physics. 44 (2005), H. 11
Y1  - 2005
SN  - 1572-9575
SP  - 2041
EP  - 2049
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Priester, Wolfgang
T1  - The problem of the primeval explosion: 'Big bang' or 'big bounce'? I
JF  - Sterne und Weltraum. 26 (1987)
Y1  - 1987
SN  - 0039-1263
SP  - 83
EP  - 89
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
A1  - Speedy, R. J.
A1  - Lüdemann, H.-D.
T1  - The pressure Dependence of Self Diffusion in Supercooled Light and Heavy Water / F.X. Prielmeier, E .W. Lang, R. J. Speedy, H.-D. Lüdemann
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 92 (1988)
Y1  - 1988
SN  - 0005-9021
SP  - 1111
ER  - 
TY  - JOUR
A1  - Eggert, Mathias
A1  - Knackstedt, Ralf
A1  - Fleischer, Stefan
A1  - Becker, Jörg
T1  - The Potential of Configurative Reference Modeling for Business to Government Reporting – A Modeling Technique and its Evaluation
JF  - e-Service Journal
Y1  - 2013
SN  - 1528-8234
VL  - 9
IS  - 1
SP  - 28
EP  - 59
PB  - Indiana University Press
CY  - Bloomington
ER  - 
TY  - JOUR
A1  - Blome, Hans-Joachim
A1  - Kosbow, Michael
T1  - The Pioneer Anomaly in the context of non-Newtonian Gravity
JF  - International Astronautical Congress : final papers : October 17-21, 2005, Fukuoka, Japan
Y1  - 2005
N1  - Proceedings IAC-2005-C1.P.20 ;International Astronautical Congress ; (56, 2005, Fukuoka, Japan)
SP  - 20
EP  - 20
PB  - International Astronautical Federation
CY  - Paris
ER  - 
TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Hagemann, Hans-Jürgen
A1  - Lade, H.
A1  - Warnier, J.
A1  - Wiechert, D. U.
T1  - The performance of Depressed-Cladding Single-Mode Fibres with Different b/a Ratios. Hagemann, H.-J.; Lade, H.; Warnier, J.; Wiechert, D. U.
JF  - Journal of Lightwave Technology (J-LT) / Institute of Electrical and Electronics Engineers (IEEE). 9 (1991), H. 6
Y1  - 1991
SN  - 0733-8724
SP  - 689
EP  - 694
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Weyland, Friedrich
T1  - The performance of base metal oxides on ceramic carriers as catalysts for air pollution control
JF  - International chemical engineering. 25 (1985), H. 3
Y1  - 1985
SN  - 0020-6318
SP  - 418
EP  - 427
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - The orange-ß-spectrometer at the external beam of the cyclotron
JF  - Annual report 1976 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ...
Y1  - 1977
SP  - 124
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Turek, M.
A1  - Colautti, P.
T1  - The new Twin mini TEPC: an advanced tool for Boron Neutron Capture Therapy
JF  - Annual report / Istituto Nazionale di Fisica Nucleare, LNL, Laboratori Nazionali di Legnaro. 2004 (2005)
Y1  - 2005
SN  - 88-7337-008-X
N1  - LNL-INFN(REP)-204/2005
SP  - 244
EP  - 245
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Heßberger, F. P.
A1  - Gäggeler, H. W.
A1  - Armbruster, P.
T1  - The New Nuclide 225U / F.P. Heßberger, H. Gäggeler, P. Armbruster, W. Brüchle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. Münzenberg, V. Ninov, M. Schädel, U.W. Scherer, K. Sümmerer, A. Türler, D. Ackerman
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 333 (1989), H. 1
Y1  - 1989
SN  - 0939-7922
SP  - 111
EP  - 112
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Moro, D.
A1  - Ferreti, A.
A1  - Colautti, P.
T1  - The new articulated twin mini TEPC
JF  - Annual Report  2006 / Istituto Nazionale di Fisica Nucleare <Frascati> / Laboratori Nazionali <Legnaro>
Y1  - 2006
SP  - 273
CY  - Legnaro
ER  - 
TY  - JOUR
A1  - Taylor, J. G.
A1  - Schmitz, N.
A1  - Ziemons, Karl
A1  - Grosse-Ruyken, M.-L.
A1  - Gruber, O.
A1  - Müller-Gärtner, H.-W.
A1  - Shah, N. J.
T1  - The network of brain areas involved in the motion aftereffect
JF  - Neuroimage
N2  - A network of brain areas is expected to be involved in supporting the motion aftereffect. The most active components of this network were determined by means of an fMRI study of nine subjects exposed to a visual stimulus of moving bars producing the effect. Across the subjects, common areas were identified during various stages of the effect, as well as networks of areas specific to a single stage. In addition to the well-known motion-sensitive area MT the prefrontal brain areas BA44 and 47 and the cingulate gyrus, as well as posterior sites such as BA37 and BA40, were important components during the period of the motion aftereffect experience. They appear to be involved in control circuitry for selecting which of a number of processing styles is appropriate. The experimental fMRI results of the activation levels and their time courses for the various areas are explored. Correlation analysis shows that there are effectively two separate and weakly coupled networks involved in the total process. Implications of the results for awareness of the effect itself are briefly considered in the final discussion.
Y1  - 2000
SN  - 1053-8119
VL  - 11
IS  - 4
SP  - 257
EP  - 270
ER  -