TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Hagemann, Hans-Jürgen
A1  - Lade, H.
A1  - Warnier, J.
A1  - Wiechert, D. U.
T1  - The performance of Depressed-Cladding Single-Mode Fibres with Different b/a Ratios. Hagemann, H.-J.; Lade, H.; Warnier, J.; Wiechert, D. U.
JF  - Journal of Lightwave Technology (J-LT) / Institute of Electrical and Electronics Engineers (IEEE). 9 (1991), H. 6
Y1  - 1991
SN  - 0733-8724
SP  - 689
EP  - 694
ER  - 
TY  - JOUR
A1  - Kotter, Michael
A1  - Riekert, Lothar
A1  - Weyland, Friedrich
T1  - The performance of base metal oxides on ceramic carriers as catalysts for air pollution control
JF  - International chemical engineering. 25 (1985), H. 3
Y1  - 1985
SN  - 0020-6318
SP  - 418
EP  - 427
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - The orange-ß-spectrometer at the external beam of the cyclotron
JF  - Annual report 1976 / Institut für Kernphysik Kernforschungsanlage Jülich / Ed. board: A. Fäßler ...
Y1  - 1977
SP  - 124
PB  - Kernforschungsanlage
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Turek, M.
A1  - Colautti, P.
T1  - The new Twin mini TEPC: an advanced tool for Boron Neutron Capture Therapy
JF  - Annual report / Istituto Nazionale di Fisica Nucleare, LNL, Laboratori Nazionali di Legnaro. 2004 (2005)
Y1  - 2005
SN  - 88-7337-008-X
N1  - LNL-INFN(REP)-204/2005
SP  - 244
EP  - 245
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Heßberger, F. P.
A1  - Gäggeler, H. W.
A1  - Armbruster, P.
T1  - The New Nuclide 225U / F.P. Heßberger, H. Gäggeler, P. Armbruster, W. Brüchle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. Münzenberg, V. Ninov, M. Schädel, U.W. Scherer, K. Sümmerer, A. Türler, D. Ackerman
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 333 (1989), H. 1
Y1  - 1989
SN  - 0939-7922
SP  - 111
EP  - 112
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Moro, D.
A1  - Ferreti, A.
A1  - Colautti, P.
T1  - The new articulated twin mini TEPC
JF  - Annual Report  2006 / Istituto Nazionale di Fisica Nucleare <Frascati> / Laboratori Nazionali <Legnaro>
Y1  - 2006
SP  - 273
CY  - Legnaro
ER  - 
TY  - JOUR
A1  - Taylor, J. G.
A1  - Schmitz, N.
A1  - Ziemons, Karl
A1  - Grosse-Ruyken, M.-L.
A1  - Gruber, O.
A1  - Müller-Gärtner, H.-W.
A1  - Shah, N. J.
T1  - The network of brain areas involved in the motion aftereffect
JF  - Neuroimage
N2  - A network of brain areas is expected to be involved in supporting the motion aftereffect. The most active components of this network were determined by means of an fMRI study of nine subjects exposed to a visual stimulus of moving bars producing the effect. Across the subjects, common areas were identified during various stages of the effect, as well as networks of areas specific to a single stage. In addition to the well-known motion-sensitive area MT the prefrontal brain areas BA44 and 47 and the cingulate gyrus, as well as posterior sites such as BA37 and BA40, were important components during the period of the motion aftereffect experience. They appear to be involved in control circuitry for selecting which of a number of processing styles is appropriate. The experimental fMRI results of the activation levels and their time courses for the various areas are explored. Correlation analysis shows that there are effectively two separate and weakly coupled networks involved in the total process. Implications of the results for awareness of the effect itself are briefly considered in the final discussion.
Y1  - 2000
SN  - 1053-8119
VL  - 11
IS  - 4
SP  - 257
EP  - 270
ER  - 
TY  - JOUR
A1  - Hautzel, H.
A1  - Taylor, J. G.
A1  - Krause, B. J.
A1  - Schmitz, N.
A1  - Tellmann, L.
A1  - Ziemons, Karl
A1  - Shah, N. J.
A1  - Herzog, H.
A1  - Müller-Gärtner, H.-W.
T1  - The motion aftereffect: more than area V5/MT? Evidence from 15O-butanol PET studies
JF  - Brain Research
N2  - The motion aftereffect is a perceptual phenomenon which has been extensively investigated both psychologically and physiologically. Neuroimaging techniques have recently demonstrated that area V5/MT is activated during the perception of this illusion. The aim of this study was to test the hypothesis if a more broadly distributed network of brain regions subserves the motion aftereffect. To identify the neuronal structures involved in the perception of the motion aftereffect, regional cerebral blood flow (rCBF) measurements with positron emission tomography were performed in six normal volunteers. Data were analysed using SPM96. The motion-sensitive visual areas including area V5/MT were activated in both hemispheres. Additionally, the lateral parietal cortex bilaterally, the right dorsolateral prefrontal cortex, the anterior cingulate cortex and the left cerebellum showed significant increases in rCBF values during the experience of the waterfall illusion. In a further reference condition with identical attentional demand but no perception of a motion aftereffect elevated rCBF were found in these regions as well. In conclusion, our findings support the notion that the perceptual illusion of motion arises exclusively in the motion-sensitive visual area V5/MT. In addition, a more widespread network of brain regions including the prefrontal and parietal cortex is activated during the waterfall illusion which represents a non-motion aftereffect-specific subset of brain areas but is involved in more basic attentional processing and cognition.
Y1  - 2001
SN  - 0006-8993
VL  - 892
IS  - 2
SP  - 281
EP  - 292
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
T1  - The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Schönbein, H.
JF  - Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987
Y1  - 1987
SN  - 0444809511
N1  - World Congress for Microcirculation (4, 1987, Tokyo;); International congress series ; 755
SP  - 475
EP  - 477
PB  - Excerpta Medica
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Schmidt, H. P.
A1  - Padeken, D.
A1  - Hildmann, B.
T1  - The Microgravity User Support Centre (MUSC)
JF  - ESA SP. 277 (1988)
Y1  - 1988
SN  - 0379-6566
N1  - Proceedings of the International Symposium on Europe in Space--the Manned Space System : 25-29 April 1988, Strasbourg, France  David, Valerie ; Longdon, Norman [ed]
SP  - 525
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
T1  - The microgravity User Support Centre
JF  - Space Technology - Industrial and Commercial Applications. 13 (1993), H. 2
Y1  - 1993
SN  - 0892-9270
SP  - 121
EP  - 124
ER  - 
TY  - JOUR
A1  - Janz, Norbert
A1  - Ebling, Günther
A1  - Gottschalk, Sandra
A1  - Niggemann, Hiltrud
T1  - The Mannheim Innovation Panels (MIP and MIP-S) of the Centre for European Economic Research (ZEW) / Janz, N., G. Ebling, S. Gottschalk und H. Niggemann
JF  - Schmollers Jahrbuch : Zeitschrift für Wirtschafts- und Sozialwissenschaften ; journal of applied social science studies. 121 (2001)
Y1  - 2001
SN  - 0342-1783
SP  - 123
EP  - 129
ER  - 
TY  - JOUR
A1  - Kern, Alexander
A1  - Lang, U.
A1  - Wiesinger, J.
A1  - Zischank, Wolfgang J.
T1  - The longitudinal voltage of cable tubes with a screening mesh caused by partial lightning currents
JF  - Proceedings / Sixth International Symposium on High Voltage Engineering : 28. August - 1. September, 1989, Westin Canal Place Hotel, New Orleans, Louisiana, USA
Y1  - 1989
N1  - International Symposium on High Voltage Engineering <6, 1989, New Orleans, La.>
PB  - Mississippi State University
CY  - Mississippi State, Miss.
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Iwasaki, H.
A1  - Ui, Y.
A1  - Furuichi, K.
A1  - Ermelenko, Y.
A1  - Mourzina, Y.
A1  - Wagner, Torsten
A1  - Näther, Niko
A1  - Schöning, Michael Josef
T1  - The light-addressable potentiometric sensor for multi-ion sensing and imaging
JF  - Methods. 37 (2005), H. 1
Y1  - 2005
SN  - 1046-2023
SP  - 99
EP  - 102
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Rousseau, V.
A1  - Vaulot, D.
A1  - Casotti, R.
T1  - The life cycle of Phaeocystis (Prymnesiophycae): evidence and hypotheses / Rousseau, V. ; Vaulot, D. ; Casotti, R. ; Cariou, V. ; Lenz, J. ; Gunkel, J. ; Baumann, M.
JF  - Journal of Marine Systems. 5 (1994), H. 1
Y1  - 1994
SN  - 0924-7963
SP  - 23
EP  - 39
ER  - 
TY  - JOUR
A1  - Kleefeld, A.
A1  - Reißel, Martin
T1  - The Levenberg–Marquardt method applied to a parameter estimation problem arising from electrical resistivity tomography
JF  - Applied Mathematics and Computation
Y1  - 2011
SN  - 0096-3003
VL  - 217
IS  - 9
SP  - 4490
EP  - 4501
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Goeyens, L.
A1  - Tréguer, P.
A1  - Baeyens, W.
T1  - The leading role of ammonium in the nitrogen uptake regime of Southern Ocean marginal ice zones / Goeyens, L. ; Tréguer, P. ; Baumann, M.E.M. ; Baeyens, W. ; Dehairs, F.
JF  - Journal of Marine Systems. 6 (1995), H. 4
Y1  - 1995
SN  - 0924-7963
SP  - 345
EP  - 361
ER  - 
TY  - JOUR
A1  - Hanrath, Wilhelm
A1  - Plesken, Wilhelm
T1  - The lattices of six-dimensional euclidean space
JF  - Mathematics of computation. 43 (1984), H. 168
Y1  - 1984
SN  - 0025-5718
SP  - 573
EP  - 587
ER  -