TY - JOUR A1 - Ermolaev, A.P. A1 - Nivokov, I.A. A1 - Melnikova, L.I. A1 - Kotliar, Konstantin T1 - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой T1 - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma JF - Vestnik oftalmologii N2 - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP. Y1 - 2018 U6 - http://dx.doi.org/10.17116/oftalma2018134051195 VL - 5 IS - 2 SP - 195 EP - 201 PB - Media Sfera CY - Moskau ER - TY - BOOK A1 - Iomdina, E. N. A1 - Bauer, S. M. A1 - Kotliar, Konstantin T1 - БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ T2 - Eye biomechanics : theoretical aspects and clinical applications Y1 - 2015 SN - 978-5-903025-57-2 PB - Real Time CY - Moscow ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Halle, M. A1 - Lanzl, I. M. T1 - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse JF - Der Ophthalmologe Y1 - 2009 SN - 1433-0423 VL - 106 IS - 7 SP - 609 EP - 618 PB - - ER - TY - JOUR A1 - Akimbekov, Nuraly Shardarbekovich A1 - Mansurov, Zulkhair A1 - Jandosov, J. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. T1 - Wound healing activity of carbonized rice husk N2 - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls. KW - Wundheilung KW - Epithel KW - Fibroblast KW - carbonized rice husk KW - wound healing KW - epithelization KW - human dermal fibroblasts Y1 - 2013 PB - Trans Tech Publications, Switzerland CY - Bäch ER - TY - JOUR A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Wind and fairness in ski jumping: A computer modelling analysis JF - Journal of Biomechanics N2 - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.jbiomech.2018.05.001 SN - 0021-9290 IS - 75 SP - 147 EP - 153 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayser, Peter T1 - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ; Kayser, Peter JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 497 EP - 508 PB - Springer CY - Berlin ER - TY - CHAP A1 - Arinkin, Vladimir A1 - Digel, Ilya T1 - Water bridge phenomenon : [abstract] N2 - One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge" KW - Hydrodynamik KW - Elektrodynamik KW - Wasserbrücke KW - water bridge phenomenon Y1 - 2009 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Lutfor, Afzalunnessa B. A1 - Razzaque, Mohammed S. T1 - Vitamin D and the Host-Gut Microbiome: A Brief Overview JF - Acta Histochemica et Cytochemica N2 - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression. Y1 - 2020 U6 - http://dx.doi.org/10.1267/ahc.20011 SN - 1347-5800 VL - 53 IS - 3 SP - 33 EP - 42 PB - Japan Society of Histochemistry and Cytochemistry CY - Osaka ER - TY - CHAP A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Razzaque, Mohammed S. T1 - Vitamin D and Phosphate Interactions in Health and Disease T2 - Phosphate Metabolism N2 - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease. KW - Vitamin D KW - PTH KW - Phosphate KW - FGF23 KW - Klotho Y1 - 2022 SN - 978-3-030-91621-3 U6 - http://dx.doi.org/10.1007/978-3-030-91623-7_5 SP - 37 EP - 46 PB - Springer CY - Cham ER - TY - BOOK A1 - Digel, Ilya A1 - Zhubanova, Azhar Ahmetovna A1 - Akimbekov, Nuraly Shardarbekovich T1 - Visual Virology Y1 - 2012 SN - 978-601-247-298-1 N1 - Text kasachisch, russisch, englisch CY - Almaty ER - TY - JOUR A1 - Ullrich, Sebastian A1 - Grottke, Oliver A1 - Rossaint, Rolf A1 - Staat, Manfred A1 - Deserno, Thomas M. A1 - Kuhlen, Torsten T1 - Virtual Needle Simulation with Haptics for Regional Anaesthesia Y1 - 2010 N1 - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010 SP - 1 EP - 3 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Virgin passive colon biomechanics and a literature review of active contraction constitutive models JF - Biomechanics N2 - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine. KW - virgin passive KW - strain energy function KW - smooth muscle contraction KW - viscoelasticity KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/biomechanics2020013 SN - 2673-7078 VL - 2 IS - 2 SP - 138 EP - 157 PB - MDPI CY - Basel ER - TY - RPRT A1 - Digel, Ilya A1 - Kayser, Peter T1 - VirEx - Eliminierung von Quarantäne relevanten Viroiden aus Kulturpflanzen Abschlussbericht des Projektes KMU-innovativ-12: Teilprojekt 3 Y1 - 2017 U6 - http://dx.doi.org/10.2314/GBV:1012136345 N1 - Druck-Ausgabe: Schlussbericht für das BMBF-Forschungsvorhaben "VirEx - Eliminierung von Quarantäne relevanten Viroiden aus Kulturpflanzen" Förderkennzeichen BMBF 031A400C PB - Institut für Bioengineering (IfB) der FH Aachen CY - Aachen ER - TY - CHAP A1 - Baader, Fabian A1 - Reiswich, M. A1 - Bartsch, M. A1 - Keller, D. A1 - Tiede, E. A1 - Keck, G. A1 - Demircian, A. A1 - Friedrich, M. A1 - Dachwald, Bernd A1 - Schüller, K. A1 - Lehmann, R. A1 - Chojetzki, R. A1 - Durand, C. A1 - Rapp, L. A1 - Kowalski, Julia A1 - Förstner, R. T1 - VIPER - Student research on extraterrestrical ice penetration technology T2 - Proceedings of the 2nd Symposium on Space Educational Activities N2 - Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process. Y1 - 2018 SP - 1 EP - 6 ER - TY - JOUR A1 - Dachwald, Bernd T1 - Verwendung eines neuronalen Reglers und evolutionärer Algorithmen zur Berechnung optimaler interplanetarer Sonnenseglerbahnen JF - Deutscher Luft- und Raumfahrtkongress 2003 : München, 17. bis 20. November 2003, Motto: 100 Jahre Motorflug - 112 Jahre Menschenflug: Visionen gestalten Zukunft / Deutsche Gesellschaft für Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 1. - (Jahrbuch ... der Deutschen Gesellschaft für Luft- und Raumfahrt) Y1 - 2003 N1 - Deutscher Luft- und Raumfahrt-Kongreß <2003, München> ; Deutsche Gesellschaft für Luft- und Raumfahrt - Lilienthal-Oberth ; DGLR-2002-089 SP - 211 EP - 218 CY - Bonn ER - TY - CHAP A1 - Blum, Yannik A1 - Albanna, Walid A1 - Benninghaus, Anne A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 38 EP - 39 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Conzen, Catharina A1 - Albanna, Walid A1 - Weiss, Miriam A1 - Kürten, David A1 - Vilser, Walthard A1 - Kotliar, Konstantin A1 - Zäske, Charlotte A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes JF - Translational Stroke Research N2 - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s12975-017-0585-8 SN - 1868-601X IS - 9 SP - 284 EP - 293 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines T1 - Vaskuläre Biomarker der retinalen Gefäβanalyse T1 - Vascular Biomarkers in Retinal Vessel Analysis JF - Klinische Monatsblätter fur Augenheilkunde N2 - Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gefäßveränderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gefäße beeinflussen im prä-, post- und kapillaren Bereich den Blutfluss und strömungsbedingte Stoffwechselverhältnisse passiv und aktiv über den Gefäßdurchmesser. Retinale Gefäße gleichen von Aufbau und Funktion den zerebralen Gefäßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gefäßweiten berechneten Biomarkern soll eine Aussage über die Prognose von systemischen vaskulär bedingten Erkrankungen getroffen werden. Die statische retinale Gefäßanalyse befasst sich mit der Untersuchung des Zustandes der prä- und postkapillaren Gefäßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gefäßanalyse wird der Längsschnitt eines retinalen Gefäßes nicht invasiv funktionell und strukturell über einen Zeitraum vor, während und nach einer spezifischen vaskulären Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ansätzen. Mittels retinaler Gefäßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gynäkologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgeführt. Mit der statischen retinalen Gefäßanalyse steht eine kostengünstige, reproduzierbare, nicht invasive Screeningtechnik zur Verfügung, um eine prognostische Aussage über die Gefäßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gefäßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gefäße zeitkontinuierlich untersucht. Die Evaluation vaskulärer Erkrankungen sowie zerebro- bzw. kardiovaskulärer Morbidität und Mortalität mittels mehrerer methodologischer Modalitäten retinaler Gefäßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftsträchtige diagnostische Perspektive. Die interdisziplinäre klinische Anwendung dieser vaskulären Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten. Y1 - 2018 U6 - http://dx.doi.org/10.1055/a-0774-7987 SN - 0023-2165 VL - 235 IS - 12 SP - 1352 EP - 1359 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - German, Laura A1 - Mikucki, Jill A. A1 - Welch, Susan A. A1 - Welch, Kathleen A. A1 - Lutton, Anthony A1 - Dachwald, Bernd A1 - Kowalski, Julia A1 - Heinen, Dirk A1 - Feldmann, Marco A1 - Francke, Gero A1 - Espe, Clemens A1 - Lyons, W. Berry T1 - Validation of sampling antarctic subglacial hypersaline waters with an electrothermal ice melting probe (IceMole) for environmental analytical geochemistry JF - International Journal of Environmental Analytical Chemistry N2 - Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe’s sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2−+NO3− from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica. Y1 - 2021 U6 - http://dx.doi.org/10.1080/03067319.2019.1704750 SN - 0306-7319 VL - 101 IS - 15 SP - 2654 EP - 2667 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Azar, Fouad A1 - Digel, Ilya ED - Staat, Manfred ED - Erni, Daniel T1 - Utilization of fluorescence spectroscopy and neural networks in clinical analysis T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 40 EP - 41 PB - Universität Duisburg-Essen CY - Duisburg ER -