TY  - JOUR
A1  - de Blois, Eric
A1  - de Zanger, Rory M. S.
A1  - Paulßen, Elisabeth
A1  - Sze Chan, Ho
A1  - Breeman, Wouter A. P.
T1  - Semi-automated system for concentrating 68Ga-eluate to obtain high molar and volume concentration of 68Ga-Radiopharmaca for preclinical applications
JF  - Nuclear Medicine and Biology
N2  - 68Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. volume
restriction, activity concentration, molar activity and osmolality. Therefore, we developed a semiautomatic system specifically to overcome these problems. A difficulty appeared unexpectedly, as intrinsic trace metals derived from eluate (Zn, Fe and Cu) are concentrated as well in amounts that influence radiochemical yield and thus lower molar activity.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.nucmedbio.2018.06.006
VL  - 64-65
SP  - 16
EP  - 21
PB  - Elsevier
CY  - Amsterdam
ER  -