TY  - JOUR
A1  - Akimbekov, Nuraly Shardarbekovich
A1  - Mansurov, Zulkhair
A1  - Jandosov, J.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Zhubanova, Azhar A.
T1  - Wound healing activity of carbonized rice husk
N2  - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.
KW  - Wundheilung
KW  - Epithel
KW  - Fibroblast
KW  - carbonized rice husk
KW  - wound healing
KW  - epithelization
KW  - human dermal fibroblasts
Y1  - 2013
PB  - Trans Tech Publications, Switzerland
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kayser, Peter
T1  - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ;  Kayser, Peter
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 497
EP  - 508
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Akimbekov, N. Sh.
A1  - Zhubanova, A. A.
A1  - Mansurov, Z. A.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Use of Carbonized Rise Shell for the local treatment of wounds
JF  - Eurasian ChemTech Journal
N2  - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.
Y1  - 2010
U6  - http://dx.doi.org/10.18321/ectj35
SN  - 2522-4867
VL  - 12
IS  - 2
SP  - 133
EP  - 138
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, N.
A1  - Turalieva, M.
A1  - Mansurov, Z.
A1  - Temiz Artmann, Aysegül
A1  - Eshibaev, A.
A1  - Zhubanova, A.
T1  - Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions
JF  - Journal of Industrial Technology and Engineering
Y1  - 2013
VL  - 2
IS  - 07
SP  - 47
EP  - 54
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Schehl, D.
A1  - Linder, Peter
A1  - Gossmann, Matthias
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Porst, Dariusz
A1  - Preiß, C.
A1  - Kayser, Peter
A1  - Pack, O.
A1  - Temiz Artmann, Aysegül
T1  - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds
N2  - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
KW  - Tissue Engineering
KW  - Bioreaktor
KW  - Organkultur
KW  - Harnleiter
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The emperor's new body : seeking for a blueprint of limb regeneration in humans
JF  - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.
Y1  - 2011
SN  - 978-3-642-11864-7
SP  - 3
EP  - 37
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Cavdar, C.
A1  - Yenicerioglu, Y.
A1  - Caliskan, S.
T1  - The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in haemodialysis patients. Cavdar, C.; Temiz, A.; Yenicerioglu, Y.; Caliskan, S.; Celik, A.; Sifil, A.; Onvural, B.; Camsari, T.
JF  - Scandinavian Journal of Urology and Nephrology. 37 (2003), H. 1
Y1  - 2003
SN  - 0036-5599
SP  - 77
EP  - 82
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Yolcuoglu, B.
A1  - Onal, M. A.
A1  - Sipahi, O.
T1  - The effect of skin transplantation on tumour growth in mice. Yolcuoglu, B.; Onal, M. A.; Sipahi, O.; Temiz, A.; Pekcetin, C.; Acikgöz, O.; Kar,  H.; Güre A.
JF  - The American Journal of Surgery. 178 (1999), H. 4
Y1  - 1999
SN  - 0002-9610
SP  - 329
EP  - 330
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Saklamaz, Ali
A1  - Comlekci, Abdurrahman
A1  - Caliskan, Sezer
T1  - The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia / Saklamaz, Ali ; Comlekci, Abdurrahman ; Temiz, Aysegu
JF  - Metabolism. 54 (2005), H. 5
Y1  - 2005
SN  - 0026-0495
SP  - 677
EP  - 681
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Kasischke, Nicole
A1  - Digel, Ilya
A1  - Maggakis-Kelemen, Christina
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Linder, Peter
A1  - Artmann, Gerhard
T1  - Structural transition temperature of hemoglobins correlates with species’ body temperature
JF  - European Biophysics Journal. 37 (2007), H. 1
Y1  - 2007
SN  - 1432-1017
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Muanghong, Danita
A1  - Dursun, Gözde
A1  - Goßmann, Matthias
A1  - Temiz Artmann, Aysegül
A1  - Staat, Manfred
T1  - Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue
JF  - Journal of Biomechanics
N2  - We present an electromechanically coupled computational model for the investigation of a thin cardiac tissue construct consisting of human-induced pluripotent stem cell-derived atrial, ventricular and sinoatrial cardiomyocytes. The mechanical and electrophysiological parts of the finite element model, as well as their coupling are explained in detail. The model is implemented in the open source finite element code Code_Aster and is employed for the simulation of a thin circular membrane deflected by a monolayer of autonomously beating, circular, thin cardiac tissue. Two cardio-active drugs, S-Bay K8644 and veratridine, are applied in experiments and simulations and are investigated with respect to their chronotropic effects on the tissue. These results demonstrate the potential of coupled micro- and macroscopic electromechanical models of cardiac tissue to be adapted to experimental results at the cellular level. Further model improvements are discussed taking into account experimentally measurable quantities that can easily be extracted from the obtained experimental results. The goal is to estimate the potential to adapt the presented model to sample specific cell cultures.
KW  - hiPS cardiomyocytes
KW  - Homogenization
KW  - Hodgkin–Huxley models
KW  - Frequency adaption
KW  - Electromechanical modeling
KW  - Drug simulation
KW  - Computational biomechanics
KW  - Cardiac tissue
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.jbiomech.2016.01.039
SN  - 0021-9290 (Print)
SN  - 1873-2380 (Online)
VL  - 49
IS  - 12
SP  - 2428
EP  - 2435
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, Taylan
A1  - Linder, Peter
A1  - Trzewik, Jürgen
A1  - Gierkowski, Jessica Ricarda
A1  - Gossmann, Matthias
A1  - Kayser, Peter
A1  - Porst, Dariusz
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells
JF  - Journal of Bioscience and Bioengineering
N2  - All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.
KW  - Cell permeability
KW  - Cellular force
KW  - Endothelial cells
KW  - Recombinant activated protein C
KW  - Lipopolysaccharide
KW  - Contractile tension
KW  - CellDrum
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.jbiosc.2012.03.019
SN  - 1347-4421
VL  - 113
IS  - 2
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Trzewik, Jürgen
A1  - Demirci, Taylan
A1  - Temiz Artmann, Aysegül
T1  - Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1042
EP  - 1043
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Baskurt, O. K.
A1  - Meiselman, H. J.
T1  - Red blood cell aggregation in experimental sepsis . Baskurt, O. K.; Temiz, A.; Meiselman, H. J.
JF  - Journal of Laboratory and Clinical Medicine. 130 (1997), H. 2
Y1  - 1997
SN  - 0022-2143
SP  - 183
EP  - 190
ER  - 
TY  - JOUR
A1  - Temiz Artmann, Aysegül
A1  - Kurulgan demirci, Eylem
A1  - Fırat, Ipek Seda
A1  - Oflaz, Hakan
A1  - Artmann, Gerhard
T1  - Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers
JF  - SHOCK
KW  - Septic cardiomyopathy
KW  - LPS
KW  - cardiomyocyte biomechanics
KW  - CellDrum
KW  - actin cytoskeleton
Y1  - 2021
U6  - http://dx.doi.org/10.1097/SHK.0000000000001845
SN  - 1540-0514
PB  - Wolters Kluwer
CY  - Köln
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Temiz Artmann, Aysegül
A1  - Engels, S.
T1  - Protein dynamics in thermosensation
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 533
EP  - 533
ER  - 
TY  - JOUR
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
A1  - Porst, Dariusz
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application
JF  - BMC bioinformatics
N2  - Background
True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN).

Results
Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm.

Conclusions
Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN.
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2105-15-55
SN  - 1471-2105
VL  - 15
IS  - 55
SP  - 1
EP  - 8
ER  - 
TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - JOUR
A1  - Sadykov, Rustam
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Artmann, Gerhard
A1  - Savitskaya, Irina
A1  - Zhubanova, Azhar
T1  - Oral lead exposure induces dysbacteriosis in rats
JF  - Journal of Occupational Health. 51 (2009) (2009), H. 1
Y1  - 2009
SN  - 1348-9585
SP  - 64
EP  - 73
ER  - 
TY  - JOUR
A1  - Micili, Serap C.
A1  - Valter, Markus
A1  - Oflaz, Hakan
A1  - Ozogul, Candan
A1  - Linder, Peter
A1  - Föckler, Nicole
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes
JF  - Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine
Y1  - 2013
SN  - 0046-2039 (Print) ; 2041-3033 (E-Journal)
VL  - Vol. 227
IS  - No. 4
SP  - 393
EP  - 401
PB  - Sage
CY  - London
ER  -