TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF  - Applied Materials Today
N2  - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW  - Electrolyte–insulator–semiconductor
KW  - Capacitive field-effect
KW  - CNOT
KW  - XOR
KW  - Enzyme logic gate
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.apmt.2017.08.003
SN  - 2352-9407
VL  - 9
SP  - 266
EP  - 270
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hebel, Christoph
T1  - Erfahrungen mit der RIN und aktuelle Weiterentwicklungen
JF  - Straßenverkehrstechnik: Organ der Forschungsgesellschaft für Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der Österreichischen Forschungsgesellschaft Straße und Verkehr; Zeitschrift für Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik
Y1  - 2017
SN  - 0039-2219
N1  - gedruckt in der Bereichsbibliothek Bayernallee vorhanden
VL  - 61
IS  - 7
SP  - 443
EP  - 448
PB  - Kirschbaum-Verlag
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Yazici, Yasemen
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate
JF  - Electrochimica Acta
N2  - The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.
KW  - Simultaneous determination
KW  - Enzymatic biosensor
KW  - Diaphorase
KW  - Dehydrogenase
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.07.119
SN  - 0013-4686
VL  - 251
SP  - 256
EP  - 262
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lueke, Jan Niklas
A1  - Sjapic, Volha
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Sjapic, Sergej
A1  - Alpdogan, Serdan
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
A1  - Neumaier, Felix
T1  - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina
JF  - Current Eye Research
Y1  - 2017
U6  - http://dx.doi.org/10.1080/02713683.2017.1339807
SN  - 1460-2202
IS  - Article in press
SP  - 1
EP  - 9
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Grosse, Joachim O.
A1  - Grossmann, Matthias
A1  - Janke, Heinz Peter
A1  - Arndt, Patrick
A1  - Koch, Sabine
A1  - Epple, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation
JF  - Journal of Biomaterials Applications
Y1  - 2017
U6  - http://dx.doi.org/10.1177/0885328217723178
SN  - 1530-8022
VL  - 32
IS  - 3
SP  - 321
EP  - 330
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Höttges, Jörg
T1  - QKan - Management of drainage system data with QGIS
JF  - Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings
Y1  - 2017
VL  - 17
IS  - Article 13
SP  - 95
EP  - 100
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Chahar, V.
A1  - Sharma, V.
A1  - Sun, Y.
A1  - Bol, R.
A1  - Knolle, F.
A1  - Schnug, E.
A1  - Hoyler, Friedrich
A1  - Naskar, N.
A1  - Lahiri, S.
A1  - Patnaik, R.
T1  - Study of uranium toxicity using low-background gamma-ray spectrometry
JF  - Journal of Radioanalytical and Nuclear Chemistry
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s10967-017-5466-9
SN  - 1588-2780
IS  - Online first
SP  - 1
EP  - 7
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Rietsch, Stefan H. G.
A1  - Pfaffenrot, Viktor
A1  - Bitz, Andreas
A1  - Orzada, Stephan
A1  - Brunheim, Sascha
A1  - Lazik-Palm, Andrea
A1  - Theysohn, Jens M.
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
A1  - Kraff, Oliver
T1  - An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T
JF  - Medical Physics
Y1  - 2017
U6  - http://dx.doi.org/10.1002/mp.12612
SN  - 0094-2405
IS  - Article in press
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hauser, Christine
A1  - Ortner, Marion
A1  - Muggenthaler, Claudia
A1  - Diehl-Schmid, Janine
A1  - Angermann, Susanne
A1  - Hapfelmeier, Alexander
A1  - Schmaderer, Christoph
A1  - Grimmer, Timo
T1  - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
JF  - Scientific Reports
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41598-017-13349-5
SN  - 2045-2322
N1  - Article 12906
VL  - 7
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Demmer, Julius K.
A1  - Chowdhury, Nilanjan Pal
A1  - Selmer, Thorsten
A1  - Ermler, Ulrich
A1  - Buckel, Wolfgang
T1  - The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
JF  - Nature Communications
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41467-017-01746-3
SN  - 2041-1723
N1  - Article number 1577
VL  - 8
IS  - 1
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - http://dx.doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - JOUR
A1  - Garibaldi, F.
A1  - Beging, Stefan
A1  - Canese, R.
A1  - Carpinelli, G.
A1  - Clinthorne, N.
A1  - Colilli, S.
A1  - Cosentino, L.
A1  - Finocchiaro, P.
A1  - Giuliani, F.
A1  - Gricia, M.
A1  - Lucentini, M.
A1  - Majewski, S.
A1  - Monno, E.
A1  - Musico, P.
A1  - Santavenere, F.
A1  - Tödter, J.
A1  - Wegener, Hans-Peter
A1  - Ziemons, Karl
T1  - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer
JF  - European Physical Journal Plus
Y1  - 2017
U6  - http://dx.doi.org/10.1140/epjp/i2017-11662-x
SN  - 2190-5444
VL  - 132
IS  - 9
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Orzada, Stephan
A1  - Bitz, Andreas
A1  - Johst, Sören
A1  - Gratz, Marcel
A1  - Völker, Maximilian N.
A1  - Kraff, Oliver
A1  - Abuelhaija, Ashraf
A1  - Fiedler, Thomas M.
A1  - Solbach, Klaus
A1  - Quick, Harald H.
A1  - Ladd, Mark E.
T1  - Analysis of an integrated 8-Channel Tx/Rx body array for use as a body coil in 7-Tesla MRI
JF  - Frontiers in Physics
Y1  - 2017
U6  - http://dx.doi.org/10.3389/fphy.2017.00017
SN  - 2296-424X
N1  - Article number 17
VL  - 5
IS  - Jun
ER  - 
TY  - JOUR
A1  - Balzer, Hermann
A1  - Streit, Daniel
A1  - Heinze, Marcel
ED  - Krause, Stefan
T1  - Implikationen der Digitalisierung für den Finanzbereich der Unternehmung und das Rollenbild des CFO
JF  - Betriebswirtschaftliche Implikationen der digitalen Transformation. ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung, Sonderheft 72
Y1  - 2017
U6  - http://dx.doi.org/10.1007/978-3-658-18751-4_14
N1  - ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung. Sonderheft 72.
Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V.
IS  - 72
SP  - 267
EP  - 283
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Niemueller, Tim
A1  - Karras, Ulrich
A1  - Ferrein, Alexander
T1  - Meisterschaft der Maschinen: Die Industrial Logistic Liga
JF  - C´t Magazin für Computertechnik
Y1  - 2017
IS  - 26
ER  - 
TY  - JOUR
A1  - Barnat, Miriam
A1  - Bosse, Elke
A1  - Mergner, Julia
T1  - Forschungsbasierte Qualitätsentwicklung für die Studieneingangsphase
JF  - Zeitschrift für Hochschulentwicklung (ZFHE)
Y1  - 2017
U6  - http://dx.doi.org/10.3217/zfhe-12-03/05
SN  - 2219-6994
VL  - 12
IS  - 3
SP  - 71
EP  - 91
ER  - 
TY  - JOUR
A1  - Peloni, Alessandro
A1  - Dachwald, Bernd
A1  - Ceriotti, Matteo
T1  - Multiple near-earth asteroid rendezvous mission: Solar-sailing options
JF  - Advances in Space Research
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.asr.2017.10.017
SN  - 0273-1177
IS  - In Press, Corrected Proof
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schäfer, Johannes
A1  - Wilms, Konrad
A1  - Schleser, Markus
T1  - Aufmischungsarmes, dickschichtiges MSG-Auftragschweißen mit entkoppelter Zweidrahttechnik
JF  - Schweißen und Schneiden
N2  - Für Auftragschweißaufgaben existiert eine Vielzahl an verfahrenstechnischen
Prozessvarianten, die je nach Charakteristik und Anwendungsfall
ausgewählt werden. Ein Nachteil der vorwiegend verwendeten Metall-
Schutzgasschweißprozesse (MSG) für das Auftragschweißen ist durch die
direkte Kopplung von Drahtvorschub zu Energieeintrag gegeben. Die vorgestellte
Zweidraht-Prozessvariante kann durch die Ausbildung eines übertragenen
und eines nicht-übertragenen Lichtbogens die elektrische Leistung
beider Lichtbögen variieren und damit einen direkten Einfluss auf
die Prozessgrößen Abschmelzleistung und Aufschmelzgrad nehmen. Im
Speziellen besteht über die Entkopplung von Drahtvorschub zu Schweißstromstärke
die Möglichkeit eines niederenergetischen Betriebs trotz hoher
Drahtvorschubgeschwindigkeit. Damit lassen sich Aufschmelzgrade
unter 2% umsetzen und Abschmelzleistungen bis zu 15 kg/h realisieren.
Y1  - 2017
SN  - 0036-7184
VL  - 69
IS  - 12
SP  - 838
EP  - 843
PB  - DVS Verlag
CY  - Düsseldorf
ER  -