TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Pourshahidi, Ali Mohammad
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique
JF  - Sensors
N2  - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements.
KW  - frequency mixing magnetic detection
KW  - magnetic sandwich immunoassay
KW  - multiparametric immunoassays
Y1  - 2019
U6  - https://doi.org/10.3390/s19112599
SN  - 1424-8220
VL  - 19
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Hüning, Felix
T1  - Nachrüstmöglichkeiten von Dieselfahrzeugen aus technischer Sicht
JF  - Zeitschrift für Verkehrsrecht : NZV
Y1  - 2019
IS  - 1
SP  - 27
EP  - 32
PB  - C.H.Beck
ER  - 
TY  - JOUR
A1  - Finger, Felix
A1  - Götten, Falk
T1  - Neue Ansätze für die Entwicklung von unbemannten Fluggeräten
JF  - Ingenieurspiegel
N2  - Wie sieht das unbemannte Flugzeug von Übermorgen aus? Dieser Frage stellen sich Forscher an der Fachhochschule Aachen. Die weltweit rasant fortschreitende Entwicklung des Marktes für unbemannte Fluggeräte (UAVs - „Unmanned Aerial Vehicles“) bietet großes Potenzial für Wachstum und Wertschöpfung. Unbemannte fliegende Systeme können – für bestimmte Anwendungsgebiete – wesentlich günstiger, kleiner und effizienter ausgelegt werden als bemannte Lösungen. Dabei sind sich viele Unternehmen über das mögliche Potential dieser Technologie noch gar nicht bewusst.
Y1  - 2019
SN  - 1868-5919
N1  - Project: UAV Design
VL  - 2019
IS  - 1
SP  - 67
EP  - 68
ER  - 
TY  - JOUR
A1  - Schwarz, Alexander
A1  - Gebhardt, Andreas
A1  - Schleser, Markus
A1  - Popoola, Patricia
T1  - New Welding Joint Geometries Manufactured by Powder Bed Fusion from 316L
JF  - Materials Performance and Characterization 8
Y1  - 2019
U6  - https://doi.org/10.1520/MPC20180096
SN  - 2379-1365
IS  - in press
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Beckmann, Nils
A1  - Keinz, Jan
A1  - Abanteriba, Sylvester
T1  - Numerical and Experimental Evaluation of a Dual-Fuel Dry-Low-NOx Micromix Combustor for Industrial Gas Turbine Applications
JF  - Journal of Thermal Science and Engineering Applications
Y1  - 2019
U6  - https://doi.org/10.1115/1.4041495
SN  - 19485085
N1  - Paper No: GT2017-64795
VL  - 11
IS  - 1
SP  - 011015
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Viti, Nicolo
A1  - Gualtieri, Carlo
T1  - Numerical Simulation of Hydraulic Jumps. Part 1: Experimental Data for Modelling Performance Assessment
JF  - Water
Y1  - 2019
U6  - https://doi.org/10.3390/w11010036
SN  - 2073-4441
VL  - 11
IS  - 1
SP  - Art. Nr. 36
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Viti, Nicolo
A1  - Valero, Daniel
A1  - Gualtieri, Carlo
T1  - Numerical Simulation of Hydraulic Jumps. Part 2: Recent Results and Future Outlook
JF  - Water
Y1  - 2019
U6  - https://doi.org/10.3390/w11010028
SN  - 2073-4441
VL  - 11
IS  - 1
SP  - Art. Nr. 28
ER  - 
TY  - JOUR
A1  - Rossi, Leonardo
A1  - Holtschoppen, Britta
A1  - Butenweg, Christoph
T1  - Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE
JF  - Bulletin of Earthquake Engineering
Y1  - 2019
U6  - https://doi.org/10.1007%2Fs10518-019-00655-8
VL  - 17
IS  - 9
SP  - 4855
EP  - 4884
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - https://doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an asymptotic relative efficiency concept based on expected volumes of confidence regions
JF  - Statistics - A Journal of Theoretical and Applied Statistic
N2  - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
KW  - Volume of confidence regions
KW  - asymptotic relative efficiency
KW  - likelihood ratio test
KW  - multivariate normal distribution
KW  - multinomial distribution
Y1  - 2019
U6  - https://doi.org/10.1080/02331888.2019.1683560
SN  - 1029-4910
VL  - 53
IS  - 6
SP  - 1396
EP  - 1436
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - https://doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Reger, Vitali
A1  - Kuhnhenne, Markus
A1  - Hachul, Helmut
A1  - Döring, Bernd
A1  - Blanke, Tobias
A1  - Göttsche, Joachim
T1  - Plusenergiegebäude 2.0 in Stahlleichtbauweise
JF  - Stahlbau
Y1  - 2019
U6  - https://doi.org/10.1002/stab.201900034
SN  - 1437-1049 (E-journal), 0038-9145 (print)
VL  - 88
IS  - 6
SP  - 522
EP  - 528
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - https://doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - https://doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - JOUR
A1  - Kunkel, Maximilian Hugo
A1  - Gebhardt, Andreas
A1  - Mpofu, Khumbulani
A1  - Kallweit, Stephan
T1  - Quality assurance in metal powder bed fusion via deep-learning-based image classification
JF  - Rapid Prototyping Journal
Y1  - 2019
U6  - https://doi.org/10.1108/RPJ-03-2019-0066
SN  - 1355-2546
VL  - 26
IS  - 2
SP  - 259
EP  - 266
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Noureddine, Yacine
A1  - Kraff, Oliver
A1  - Ladd, Mark E.
A1  - Wrede, Karsten
A1  - Chen, Bixia
A1  - Quick, Harald H.
A1  - Schaefers, Georg
A1  - Bitz, Andreas
T1  - Radiofrequency induced heating around aneurysm clips using a generic birdcage head coil at 7 Tesla under consideration of the minimum distance to decouple multiple aneurysm clips
JF  - Magnetic Resonance in Medicine
Y1  - 2019
U6  - https://doi.org/10.1002/mrm.27835
SN  - 1522-2594
IS  - Early view
SP  - 1
EP  - 17
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Gomez, Francisco
A1  - Bil, Cees
T1  - RANS Simulation Validation of a Small Sensor Turret for UAVs
JF  - Journal of Aerospace Engineering
N2  - Recent Unmanned Aerial Vehicle (UAV) design procedures rely on full aircraft steady-state Reynolds-Averaged-Navier-Stokes (RANS) analyses in early design stages. Small sensor turrets are included in such simulations, even though their aerodynamic properties show highly unsteady behavior. Very little is known about the effects of this approach on the simulation outcomes of small turrets. Therefore, the flow around a model turret at a Reynolds number of 47,400 is simulated with a steady-state RANS approach and compared to experimental data. Lift, drag, and surface pressure show good agreement with the experiment. The RANS model predicts the separation location too far downstream and shows a larger recirculation region aft of the body. Both characteristic arch and horseshoe vortex structures are visualized and qualitatively match the ones found by the experiment. The Reynolds number dependence of the drag coefficient follows the trend of a sphere within a distinct range. The outcomes indicate that a steady-state RANS model of a small sensor turret is able to give results that are useful for UAV engineering purposes but might not be suited for detailed insight into flow properties.
Y1  - 2019
U6  - https://doi.org/10.1061/(ASCE)AS.1943-5525.0001055
SN  - 1943-5525
VL  - 32
IS  - 5
PB  - ASCE
CY  - New York
ER  -