TY - JOUR A1 - Ross, Jillian A1 - Plummer, Simon M. A1 - Rode, Anja A1 - Scheer, Nico A1 - Bower, Conrad C. A1 - Vogel, Ortwin A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Elcombe, Clifford R. T1 - Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo JF - Toxicological Sciences N2 - Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained. Y1 - 2010 U6 - https://doi.org/10.1093/toxsci/kfq118 SN - 1096-0929 VL - 116 IS - 2 SP - 452 EP - 466 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Ferrein, Alexander A1 - Siebel, Nils T. A1 - Steinbauer, Gerald T1 - Hybrid control for autonomous systems — Integrating learning, deliberation and reactive control JF - Robotics and Autonomous Systems Y1 - 2010 SN - 0921-8890 VL - 58 IS - 9 SP - 1037 EP - 1038 ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Sugawara, Yuri A1 - Kanoh, Shin´ichiro A1 - Yoshinobu, Tatsuo A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Image correction method for the chemical imaging sensor JF - Sensors and Actuators B: Chemical. 144 (2010), H. 2 Y1 - 2010 N1 - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden) SP - 344 EP - 348 ER - TY - JOUR A1 - Lettini, Antonio A1 - Havermann, Marc A1 - Guidetti, Marco A1 - Fornaciari, Andrea T1 - Improved functionalities and energy saving potential on mobile machines combining electronics with flow sharing valve and variable displacement pump JF - IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010 Y1 - 2010 SN - 978-3-940565-92-1 N1 - IFK, 7, Internationales Fluidtechnisches Kolloquium, 7., Aachen, DE, 2010-03-22 - 2010-03-24 SP - 103 EP - 114 PB - - ER - TY - JOUR A1 - Schermutzki, Margret T1 - In Modulen lehren, lernen und prüfen JF - In Modulen lehren, lernen und prüfen. Herausforderungen an die Hochschuldidaktik / Terbuyken, Gregor [Hrsg.] Y1 - 2010 SN - 978-3-8172-7809-1 N1 - Loccumer Protokoll 78/09 SP - 81 EP - 106 CY - Rehburg-Loccum ER - TY - JOUR A1 - Scheer, Nico A1 - Ross, Jillian A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Wolf, C. Roland T1 - In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice JF - Drug Metabolism and Disposition N2 - Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound. Y1 - 2010 U6 - https://doi.org/10.1124/dmd.109.031872 SN - 1521-009X VL - 38 IS - 7 SP - 1046 EP - 1053 PB - ASPET CY - Bethesda ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Heinzel, Alexander A1 - Schäfer, Ralf A1 - Müller, Hans-Wilhelm A1 - Schieffer, Andre A1 - Ingenhag, Ariane A1 - Eickhoff, Simon B. A1 - Northoff, Georg A1 - Franz, Matthias A1 - Hautzel, Hubertus T1 - Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study JF - Psychotherapy and Psychosomatics N2 - Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study. Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System. Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia. Y1 - 2010 U6 - https://doi.org/10.1159/000320121 SN - 0033-3190 VL - 79 IS - 6 SP - 363 EP - 370 PB - Karger CY - Basel ER - TY - JOUR A1 - Jansen, S. V. A1 - Behbahani, Mehdi A1 - Laumen, M. A1 - Kaufmann, T. A1 - Hormes, M. A1 - Behr, M. A1 - Schmitz-Rode, T. A1 - Steinseifer, U. T1 - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation Y1 - 2010 N1 - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 ER - TY - JOUR A1 - Egli, Simon A1 - Ayer, François A1 - Peter, Martina A1 - Eilmann, Britta A1 - Rigling, Andreas T1 - Is forest mushroom productivity driven by tree growth? Results from a thinning experiment JF - Annals of Forest Science N2 - • Most of the edible forest mushrooms are mycorrhizal and depend on carbohydrates produced by the associated trees. Fruiting patterns of these fungi are not yet fully understood since climatic factors alone do not completely explain mushroom occurrence. • The objective of this study was to retrospectively find out if changing tree growth following an increment thinning has influenced the diversity patterns and productivity of associated forest mushrooms in the fungus reserve La Chanéaz, Switzerland. • The results reveal a clear temporal relationship between the thinning, the growth reaction of trees and the reaction of the fungal community, especially for the ectomycorrhizal species. The tree-ring width of the formerly suppressed beech trees and the fruit body number increased after thinning, leading to a significantly positive correlation between fruit body numbers and tree-ring width. • Fruit body production was influenced by previous annual tree growth, the best accordance was found between fruit body production and the tree-ring width two years previously. • The results support the hypothesis that ectomycorrhizal fruit body production must be linked with the growth of the associated host trees. Moreover, the findings indicate the importance of including mycorrhizal fungi as important players when discussing a tree as a carbon source or sink. Y1 - 2010 U6 - https://doi.org/10.1051/forest/2010011 SN - 1286-4560 (Print) SN - 1297-966X (Online) VL - 67 IS - 5 SP - 509 PB - Springer CY - Paris ER - TY - JOUR A1 - Hoffmann, Ulrich A1 - Schermutzki, Margret A1 - Winckelmann-Schlieper, Katja T1 - Kompetenzbasierte Verzahnung von berufspraktischem und wissenschaftlichem Lernen : Der Studiengang Prozesstechnik der FH Aachen JF - Berufsbildung in Wissenschaft und Praxis (BWP). 39 (2010), H. 2 Y1 - 2010 SN - 0341-4515 SP - 32 EP - 36 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Kurzarbeit und betriebsbedingte Kündigungen - Wissenswertes für die betriebliche Praxis JF - NWB - Steuer- und Wirtschaftsrecht N2 - Kurzarbeit war und ist eines der wesentlichen Elemente der Unternehmen, um dem durch die Finanz- und Wirtschaftskrise begründeten Arbeitskräfteüberhang begegnen zu können. Laut statistischer Mitteilung der Bundesagentur für Arbeit waren im Mai 2009 ca. 1,52 Mio. Arbeitnehmer in Kurzarbeit, im März 2010 waren es immer noch 830.000 Arbeitnehmer, die Kurzarbeitergeld bezogen haben. Bis Ende 2010 können Arbeitgeber Kurzarbeit noch für die verlängerte Höchstbezugsdauer von bis zu 18 Monaten beantragen. Zudem hat der Bundestag am 8.7.2010 eine nochmalige Verlängerung der Erstattung der Sozialversicherungsbeiträge bis März 2012 verabschiedet. Trotzdem müssen zahlreiche Arbeitgeber inzwischen feststellen, dass sie allein mit dem Mittel der Kurzarbeit nicht um einen Personalabbau herumkommen. Dies gilt insbesondere für diejenigen Unternehmen, die gleich zu Beginn der Krise im Herbst 2008 Kurzarbeit eingeführt haben und bei denen deshalb die damals noch geltende 24-monatige Höchstbezugsdauer im Herbst 2010 auslaufen wird Y1 - 2018 SN - 1860-9449 IS - 37 SP - 2966 EP - 2972 PB - NWB-Verlag CY - Herne ER - TY - JOUR A1 - Timme, Michael T1 - Kündigung des Mietverhältnisses wegen nicht gezahlter Kosten eines Rechtsstreits JF - Monatsschrift für deutsches Recht : MdR ; Zeitschrift für die Zivilrechts-Praxis. 30 (2010), H. 19 Y1 - 2010 SN - 0340-1812 SP - 1089 EP - 1091 ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Pedraza, A. M. A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Proc. Eurosensors XXIV, September 5–8, 2010, Linz, Austria SP - 918 EP - 921 ER - TY - JOUR A1 - Bouquegneau, Christian A1 - Kern, Alexander A1 - Rousseau, Alain T1 - Lightning safety guidelines Y1 - 2010 N1 - Ground´2010 International Conference on Grounding and Earthing ; 4th International Conference ond Lightning Physics and Effects, Nov. 2010 Salvador - Brazil SP - 1 EP - 6 ER - TY - JOUR A1 - Fredebeul-Krein, Markus A1 - Knoben, Werner T1 - Long term risk sharing contracts as an approach to establish public–private partnerships for investment into next generation access networks JF - Telecommunications Policy Y1 - 2010 SN - 0308-5961 VL - 34 IS - 9 SP - 528 EP - 539 ER - TY - JOUR A1 - Funke, Harald A1 - Börner, Sebastian A1 - Robinson, A. A1 - Hendrick, P. A1 - Recker, E. T1 - Low NOx H2 combustion for industrial gas turbines of various power ranges JF - 5th International Gas Turbine Conference ETN-IGTC, ETN-2010-42, Brussels, Belgium, October 2010 Y1 - 2010 ER - TY - JOUR A1 - Fornaciari, Andrea A1 - Guidetti, Marco A1 - Havermann, Marc A1 - Lettini, Antonio T1 - Maccine mobili più efficienti JF - Fluidotecnica N2 - Secondo le attuali normative tutte le macchine mobili, entro il 2012, dovranno essere soggette a un incremento di efficienza energetica. Un’evoluzione del sistema idraulico potrà contribuire in maniera significativa al miglioramento richiesto. Elettronica e idraulica sempre più protagoniste. Y1 - 2010 IS - 345 SP - 11 EP - 14 PB - Quine Business Publisher CY - Milano ER - TY - JOUR A1 - Schmitt, Robert A1 - Scholl, Ingrid A1 - Cai, Yu A1 - Xia, Ji A1 - Dziwoki, Paul A1 - Harding, Martin A1 - Pavim, Alberto T1 - Machine Vision System for Inline Inspection in Carbide Insert Production JF - Bildverarbeitung für die Medizin 2010 : Algorithmen, Systeme, Anwendungen ; Proceedings des Workshops vom 14. bis 16. März in Aachen / Thomas M. Deserno ... (Hrsg.) Y1 - 2010 SN - 978-3-642-11967-5 N1 - Proceedings of the 36th International MATADOR Conference ; Workshop Bildverarbeitung für die Medizin <2010, Aachen> SP - 339 EP - 342 PB - Springer CY - Berlin ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Jerabek, Jakub A1 - Chudoba, Rostislav T1 - Messung der Strahlqualität einer Elektronenstrahlanlage in Umgebungsatmosphäre JF - Materialwissenschaft und Werkstofftechnik N2 - In den letzten Jahrzehnten hat das Elektronenstrahlschweißen, das bereits im größeren Maßstab verwendet wird, seine Fähigkeit als qualitatives Werkzeug für die Verbindung verschiedener Materialen nachgewiesen. Das Non Vacuum Electron Beam Welding (NV-EBW) hat zahlreiche Vorteile im Vergleich zum Elektronenstrahlschweißen im Vakuum, da man unter normalem Atmosphärendruck arbeiten kann. Im Hinblick auf die reproduzierbare Qualität, insbesondere im Bereich der Massen-Fertigung, ist die Kontrolle der Strahlparameter sowie deren Einfluss auf das Schweißergebnis von großer Bedeutung. Durch eine genaue Kenntnis der Strahlkenngrößen wie des Strahldurchmessers und der Leistungsdichteverteilung kann eine Aussage über die sich ausbildende Schweißnaht sowie die Schweißbaddynamik getroffen werden. Messungen der Strahlkenngrößen im Prozess erlauben insbesondere die Untersuchung von Humping-Effekten. In diesem Beitrag wird der Prozess der Elektronenstrahlvermessung unter atmosphärischen Bedingungen beschrieben. Es wird zudem die Abhängigkeit der Elektronenstrahlcharakteristika von den verschiedenen Prozessparametern dargestellt. Y1 - 2010 SN - 1521-4052 VL - 41 IS - 1 SP - 45 EP - 52 PB - Wiley-VCH CY - Weinheim ER -