TY - JOUR A1 - Pöttgen, Philipp A1 - Ederer, Thorsten A1 - Altherr, Lena A1 - Lorenz, Ulf A1 - Pelz, Peter F. T1 - Examination and optimization of a heating circuit for energy-efficient buildings JF - Energy Technology N2 - The conference center darmstadtium in Darmstadt is a prominent example of energy efficient buildings. Its heating system consists of different source and consumer circuits connected by a Zortström reservoir. Our goal was to reduce the energy costs of the system as much as possible. Therefore, we analyzed its supply circuits. The first step towards optimization is a complete examination of the system: 1) Compilation of an object list for the system, 2) collection of the characteristic curves of the components, and 3) measurement of the load profiles of the heat and volume-flow demand. Instead of modifying the system manually and testing the solution by simulation, the second step was the creation of a global optimization program. The objective was to minimize the total energy costs for one year. We compare two different topologies and show opportunities for significant savings. KW - energy transfer KW - heating system KW - programming KW - system optimization KW - technical operations research Y1 - 2015 SN - 2194-4296 U6 - http://dx.doi.org/10.1002/ente.201500252 VL - 4 IS - 1 SP - 136 EP - 144 PB - WILEY-VCH Verlag CY - Weinheim ER - TY - CHAP A1 - Schänzle, Christian A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. T1 - As good as it can be: Ventilation system design by a combined scaling and discrete optimization method T2 - Proceedings of FAN 2015 N2 - The understanding that optimized components do not automatically lead to energy-efficient systems sets the attention from the single component on the entire technical system. At TU Darmstadt, a new field of research named Technical Operations Research (TOR) has its origin. It combines mathematical and technical know-how for the optimal design of technical systems. We illustrate our optimization approach in a case study for the design of a ventilation system with the ambition to minimize the energy consumption for a temporal distribution of diverse load demands. By combining scaling laws with our optimization methods we find the optimal combination of fans and show the advantage of the use of multiple fans. Y1 - 2015 N1 - Proceedings of FAN 2015, Lyon (France), 15 – 17 April 2015 SP - 1 EP - 11 ER - TY - JOUR A1 - Klettke, Tanja A1 - Homburg, Carsten A1 - Gell, Sebastian T1 - How to measure analyst forecast effort JF - European Accounting Review N2 - We introduce a new way to measure the forecast effort that analysts devote to their earnings forecasts by measuring the analyst's general effort for all covered firms. While the commonly applied effort measure is based on analyst behaviour for one firm, our measure considers analyst behaviour for all covered firms. Our general effort measure captures additional information about analyst effort and thus can identify accurate forecasts. We emphasise the importance of investigating analyst behaviour in a larger context and argue that analysts who generally devote substantial forecast effort are also likely to devote substantial effort to a specific firm, even if this effort might not be captured by a firm-specific measure. Empirical results reveal that analysts who devote higher general forecast effort issue more accurate forecasts. Additional investigations show that analysts' career prospects improve with higher general forecast effort. Our measure improves on existing methods as it has higher explanatory power regarding differences in forecast accuracy than the commonly applied effort measure. Additionally, it can address research questions that cannot be examined with a firm-specific measure. It provides a simple but comprehensive way to identify accurate analysts. Y1 - 2015 U6 - http://dx.doi.org/10.1080/09638180.2014.909291 SN - 0963-8180 VL - 24 IS - 1 SP - 129 EP - 146 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Hager, Jonathan A1 - Hentschke, Reinhard A1 - Hojdis, Nils A1 - Karimi-Varzaneh, Hossein Ali T1 - Computer Simulation of Particle–Particle Interaction in a Model Polymer Nanocomposite JF - Macromolecules Y1 - 2015 U6 - http://dx.doi.org/10.1021/acs.macromol.5b01864 SN - 1520-5835 VL - 48 IS - 24 SP - 9039 EP - 9049 ER - TY - CHAP A1 - Otten, D. A1 - Schmid, M. A1 - Weber, Tobias T1 - Advances In Sheet Metal-Forming: Reduction Of Tooling Cost By Methodical Optimization T2 - Proceedings of SAMPE Europe Conference, Amiens , France Y1 - 2015 ER - TY - CHAP A1 - Weber, Tobias T1 - Manufacturing Process Simulation for Tooling Optimization: Reduction of Quality Issues During Autoclave Manufacturing of Composite Parts T2 - Proceedings of SAMPE Europe Conference 2015, Amiens, France Y1 - 2015 SP - 1 EP - 8 ER - TY - CHAP A1 - Weber, Tobias A1 - Englhard, Markus A1 - Hailer, Benjamin A1 - Arent, Jan-Christoph T1 - Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling T2 - Proceedings of SAMPE Europe Conference, Amiens , France Y1 - 2015 SP - 1 EP - 10 ER - TY - PAT A1 - Stadtmüller, Ralf A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Method for production of single-stranded macronucleotides N2 - The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention. Y1 - 2015 N1 - Patent auch unter EP2774996, EP2774996, US2017145460 und US9944966 veröffentlicht. ER - TY - JOUR A1 - Pietsch, Wolfram T1 - Augmenting voice of the customer analysis by analysis of belief JF - QFD-Forum Y1 - 2015 SN - 1431-6951 IS - 30 SP - 1 EP - 5 ER - TY - JOUR A1 - Akimbekov, N.Sh. A1 - Digel, Ilya A1 - O’Heras, C. A1 - Tastambek, K.T. A1 - Savitskaya, I.S. A1 - Ualyeva, P.S. A1 - Mansurov, Z.A. A1 - Zhubanova, A.A. T1 - Adsorption of bacterial lipopol ysaccharides on carbonized ri ce husks obtained in the batch experiments JF - KazNU Bulletin. Biology series Y1 - 2015 SN - 1563-0218 VL - 60 IS - No 1/2 SP - 144 EP - 148 ER - TY - JOUR A1 - Matcha, Heike ED - Martens, B. T1 - Parametrized Systems: Conceiving of Buildings as Assemblies of Varied Parts JF - Real Time - Proceedings of the 33rd eCAADe Conference - Volume 2, Vienna University of Technology, Vienna, Austria, 16-18 September 2015 Y1 - 2015 SP - 143 EP - 148 ER - TY - THES A1 - Seifarth, Volker T1 - Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids Y1 - 2015 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2015 PB - Universitätsbibliothek Duisburg-Essen CY - Duisburg ; Essen ER - TY - THES A1 - Duong, Minh Tuan T1 - Hyperelastic modeling and soft-tissue growth integrated with the smoothed finite element method - SFEM Y1 - 2015 N1 - Aachen, Techn. Hochsch., Diss., 2014 PB - RWTH Aachen University ER - TY - CHAP A1 - Wolf, C. Roland A1 - Kapelyukh, Yury A1 - Scheer, Nico A1 - Henderson, Colin J. ED - Wilson, Alan G. E. T1 - Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs N2 - The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic. Y1 - 2015 SN - 978-1-78262-778-4 U6 - http://dx.doi.org/10.1039/9781782622376-00152 SP - 152 EP - 176 PB - RSC Publ. CY - Cambridge ER - TY - JOUR A1 - Henderson, Colin J. A1 - Mclaughlin, Lesley A. A1 - Scheer, Nico A1 - Stanley, Lesley A. A1 - Wolf, C. Roland T1 - Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo s JF - Molecular Pharmacology Y1 - 2015 U6 - http://dx.doi.org/10.1124/mol.114.097394 SN - 1521-0111 VL - 87 IS - 4 SP - 733 EP - 739 PB - ASPET CY - Bethesda ER - TY - JOUR A1 - Hough, Lindsay B. A1 - Nalwalk, Julia W. A1 - Ding, Xinxin A1 - Scheer, Nico T1 - Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms JF - Drug Metabolism and Disposition Y1 - 2015 U6 - http://dx.doi.org/10.1124/dmd.115.065490 SN - 1521-009x VL - 43 IS - 9 SP - 1326 EP - 1330 ER - TY - JOUR A1 - Scheer, Nico A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Oswald, Stefan A1 - Busch, Diana A1 - Mclaughlin, Lesley A. A1 - Lin, De A1 - Henderson, Colin J. A1 - Wolf, C. Roland T1 - Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model JF - Drug Metabolism and Disposition Y1 - 2015 U6 - http://dx.doi.org/10.1124/dmd.115.065656 SN - 1521-009x VL - 43 IS - 11 SP - 1679 EP - 1690 PB - ASPET CY - Bethesda ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Calliess, Gralf-Peter T1 - Art. 5 Rom III-Regulation (choice of applicable law by the parties) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ET - 2nd ed. ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Colliess, Gralf-Peter T1 - Art. 7 Rome III-Regulation (formal validity) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ET - 2nd ed. ER - TY - CHAP A1 - Calliess, Gralf-Peter A1 - Kroll-Ludwigs, Kathrin T1 - Art. 6 Rome III-Regulation (consent and material validity) T2 - Rome Regulations : commentary Y1 - 2015 SN - 9789041147547 PB - Wolters Kluwer ER -