TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Erben, A. A1 - Thürmel, K. A1 - Kotliar, Konstantin T1 - Diffuse stromale Hornhauttrübungen und Veränderungen der Hände JF - Der Ophthalmologe N2 - Bilaterale stromale Hornhauttrübungen sind für den Augenarzt eine differenzialdiagnostische Herausforderung. Im folgenden Beitrag werden 2 Patieninnen (30 und 36 Jahre) mit unterschiedlich stark ausgeprägter stromaler diffuser Hornhauttrübung vorgestellt. Patientin 1 war kleinwüchsig (114 cm) und Patientin 2 normal groß (172 cm). Beide Patientinnen wiesen veränderte Gelenkstrukturen an Hand und Fußgelenken sowie diffuse stromale Hornhauttrübungen auf. Des Weiteren lagen eine Mitral- und Aorteninsuffizienz (Patientin 1) bzw. eine Aorteninsuffizienz (Patientin 2) vor. Die stromalen diffusen Hornhauttrübungen ließen im Zusammenhang mit den Gelenkveränderungen ein Scheie-Syndrom vermuten. Therapeutisch ist bei Patienten mit Visusminderung eine (lamelläre) Keratoplastik sinnvoll. Y1 - 2010 U6 - https://doi.org/10.1007/s00347-009-2066-2 SN - 1433-0423 VL - 107 IS - 4 SP - 363 EP - 365 PB - Springer CY - Berlin ER - TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Maier, Mathias A1 - Schmidt-Trucksäss, Arno A1 - Halle, Martin A1 - Kotliar, Konstantin T1 - Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection JF - Acta Ophthalmologica Y1 - 2011 SN - 1755-3768 VL - 89 IS - 5 SP - 472 EP - 479 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Maier, Mathias A1 - Bauer, Svetlana A1 - Feucht, Nikolaus A1 - Lohmann, Chris A1 - Lanzl, Ines T1 - Intravitreal injection of triamcinolone acetonide and intraocular pressure: author's reply JF - Acta Ophthalmologica Y1 - 2008 SN - 1755-3768 VL - 86 IS - 6 SP - 692 EP - 693 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M. JF - Acta Ophthalmologica. 86 (2008), H. 4 Y1 - 2008 SN - 1755-3768 SP - 424 EP - 433 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. A1 - Hanssen, Henner A1 - Eberhardt, Karla A1 - Vilser, Walthard A1 - Halle, Martin A1 - Heemann, Uwe A1 - Schmidt-Trucksäss, Arno A1 - Baumann, Marcus T1 - Does increased blood pressure rather than aging influence retinal pulse wave velocity? JF - Investigative Ophthalmology & Visual Science, IOVS N2 - Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0–28.8) [median(1st quartile–3rd quartile)] and 12 senior 68.5-year-old (63.8–71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8–65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5–35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280–500] RU/s) and in validated healthy seniors (400 [320–510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV. Y1 - 2012 U6 - https://doi.org/10.1167/iovs.11-8815 SN - 0146-0404 VL - 53 IS - 4 SP - 2119 EP - 2126 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Seidova, Seid-Fatima A1 - Lanzl, Ines T1 - Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension JF - Investigative Ophthalmology & Visual Science, IOVS N2 - Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530–600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation. Y1 - 2010 U6 - https://doi.org/10.1167/iovs.09-3649 SN - 0146-0404 VL - 51 IS - 4 SP - 2165 EP - 2172 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Vilser, W. A1 - Schmidt-Trucksäss, A. A1 - Halle, M. A1 - Lanzl, I. M. T1 - Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters : Kreuz- und Autokorrelation für dynamische Gefäßanalyse JF - Der Ophthalmologe Y1 - 2009 SN - 1433-0423 VL - 106 IS - 7 SP - 609 EP - 618 PB - - ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines M. T1 - Can vascular function be assessed by the interpretation of retinal vascular diameter changes? JF - Investigative Ophthalmology & Visual Science, IOVS. 52 (2011), H. 1 Y1 - 2011 SN - 0146-0404 SP - 635 EP - 636 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Mücke, Bruno A1 - Vilser, Walthard A1 - Schilling, Rudolf T1 - Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; Mücke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M. JF - Investigative Ophthalmology & Visual Science, IOVS. 49 (2008), H. 5 Y1 - 2008 SN - 0146-0404 SP - 2094 EP - 2102 PB - - ER - TY - JOUR A1 - Nguyen, Nhu Huynh A1 - Duong, Minh Tuan A1 - Tran, Thanh Ngoc A1 - Pham, Phu Tinh A1 - Grottke, O. A1 - Tolba, R. A1 - Staat, Manfred T1 - Influence of a freeze–thaw cycle on the stress–stretch curves of tissues of porcine abdominal organs JF - Journal of Biomechanics N2 - The paper investigates both fresh porcine spleen and liver and the possible decomposition of these organs under a freeze–thaw cycle. The effect of tissue preservation condition is an important factor which should be taken into account for protracted biomechanical tests. In this work, tension tests were conducted for a large number of tissue specimens from twenty pigs divided into two groups of 10. Concretely, the first group was tested in fresh state; the other one was tested after a freeze-thaw cycle which simulates the conservation conditions before biomechanical experiments. A modified Fung model for isotropic behavior was adopted for the curve fitting of each kind of tissues. Experimental results show strong effects of the realistic freeze–thaw cycle on the capsule of elastin-rich spleen but negligible effects on the liver which virtually contains no elastin. This different behavior could be explained by the autolysis of elastin by elastolytic enzymes during the warmer period after thawing. Realistic biomechanical properties of elastin-rich organs can only be expected if really fresh tissue is tested. The observations are supported by tests of intestines. KW - Autolysis KW - Decomposition KW - Freeze–thaw process KW - Spleen KW - Liver Y1 - 2012 U6 - https://doi.org/10.1016/j.jbiomech.2012.07.008 SN - 1873-2380 VL - 45 IS - 14 SP - 2382 EP - 2386 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Novacek, V. A1 - Tran, Thanh Ngoc A1 - Klinge, U. A1 - Tolba, R. H. A1 - Staat, Manfred A1 - Bronson, D. G. A1 - Miesse, A. M. A1 - Whiffen, J. A1 - Turquier, F. T1 - Finite element modelling of stapled colorectal end-to-end anastomosis : Advantages of variable height stapler design JF - Journal of Biomechanics N2 - The impact of surgical staplers on tissues has been studied mostly in an empirical manner. In this paper, finite element method was used to clarify the mechanics of tissue stapling and associated phenomena. Various stapling modalities and several designs of circular staplers were investigated to evaluate the impact of the device on tissues and mechanical performance of the end-to-end colorectal anastomosis. Numerical simulations demonstrated that a single row of staples is not adequate to resist leakage due to non-linear buckling and opening of the tissue layers between two adjacent staples. Compared to the single staple row configuration, significant increase in stress experienced by the tissue at the inner staple rows was observed in two and three rows designs. On the other hand, adding second and/or third staple row had no effect on strain in the tissue inside the staples. Variable height design with higher staples in outer rows significantly reduced the stresses and strains in outer rows when compared to the same configuration with flat cartridge. KW - Variable height stapler design KW - Anastomotic leakage KW - Finite element modelling KW - End-to-end colorectal anastomosis KW - Surgical staplers Y1 - 2012 U6 - https://doi.org/10.1016/j.jbiomech.2012.07.021 SN - 1873-2380 VL - 45 IS - 115 SP - 2693 EP - 2697 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hüning, Felix T1 - Die Anforderungen steigen : Entwicklungstrends bei MOSFETs für den Automobilbereich JF - Elektronik-Industrie. 39 (2008), H. 5 Y1 - 2008 SN - 0174-5522 SP - 74 EP - 76 PB - - ER - TY - JOUR A1 - Caro, Abrao A1 - Mazzon, José Afonso A1 - Caemmerer, Barbara A1 - Weßling, Matthias T1 - Inovatividade, envolvimento, atitude e experiencia na adocao da compra on-line - Innovation, involvement, attitude and experience in buying online JF - Revista de administração de emprêsas : RAE Y1 - 2011 SN - 0034-7590 VL - 51 IS - 6 SP - 568 EP - 584 PB - - CY - São Paulo ER - TY - JOUR A1 - Spelthahn, Heiko A1 - Schubert, Jürgen A1 - Schöning, Michael Josef T1 - Dünnschichtsensoren für die Schwermetallanalytik JF - GIT : Labor-Fachzeitschrift N2 - Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online“-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt. Y1 - 2012 SN - 0016-3538 VL - 56 IS - 4 SP - 285 EP - 287 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Hüning, Felix T1 - Hart im Nehmen : Low-Voltage-Powermosfets mit Super-Junction-1-Technologie optimieren JF - Elektronik-Journal. 44 (2009), H. 12 Y1 - 2009 SN - 0013-5674 SP - 36 EP - 38 PB - - ER - TY - JOUR A1 - Hüning, Felix T1 - Using Trench PowerMOSFETs in Linear Mode JF - Power Electronics Europe (2012) N2 - If we think about applications for modern Power MOSFETs using trench technology, running them in linear mode may not be top of the priority list. Yet there are multiple uses for Trench Power MOSFETs in linear mode. In fact, even turning the device on and off in switching applications is a form of linear operation. Also, these components can be run in linear mode to protect the device against voltage surges. This article will illustrate the factors that need to be considered for linear operation and show how Trench Power MOSFETs are suited to it. Y1 - 2012 SN - 1748-3530 SP - 27 EP - 29 PB - DFA Media CY - Tonbridge ER - TY - JOUR A1 - Hüning, Felix T1 - PowerMOSFETs in ANL2-Technologie : Ansteuerungen bis in den kW-Bereich mit wenig Verlustleistung und Platzbedarf JF - Elektronik-Industrie Y1 - 2011 SN - 0174-5522 VL - 42 IS - 10 SP - 36 EP - 39 PB - Hüthig CY - Heidelberg ER - TY - JOUR A1 - Hüning, Felix T1 - Mosfet ottimizzati per l’automotive JF - Selezione di Elettronica (2009) Y1 - 2009 SP - 115 EP - 117 PB - - ER - TY - JOUR A1 - Hüning, Felix T1 - Entwicklungstrends bei MOSFETs für den Automobilbereich JF - Elektronik-Industrie . 39 (2008), H. 5 Y1 - 2008 SN - 0174-5522 SP - 74 EP - 76 PB - - ER - TY - JOUR A1 - Hüning, Felix T1 - SMD packages for PowerMOSFETs in automotive applications – developments and trends JF - Automotive Designline Europe (2009) Y1 - 2009 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Eifert, T. A1 - Handrick, K. A1 - Neuhausen, U. T1 - Computational Magnetochemistry: Complementary Quantum Mechanical Tools / Eifert, T. ; Handrick, K. ; Hüning, F. ; Neuhausen, U. ; Schilder, H. ; Lueken, H. JF - 20 Jahre Wilhelm-Klemm-Stiftung / Kuratorium der Wilhelm-Klemm-Stiftung (Hrsg.) Y1 - 2006 SN - 978-3-8322-5520-6 SP - 193ff PB - Shaker CY - Aachen ER - TY - JOUR A1 - Hüning, Felix T1 - Robusti affidabili per le Sfide dell’automotive JF - Selezione di Elettronica (2008) Y1 - 2008 SP - 116 EP - 117 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Luken, Heiko A1 - Schilder, Herbert A1 - Eifert, Thomas T1 - Magnetochemistry: Compounds and Concepts / Lueken, Heiko ; Schilder, Herbert ; Eifert, Thomas ; Handrick, Klaus ; Hüning, Felix JF - Advances in Solid State Physics. 201 (2001) Y1 - 2001 SP - 515 EP - 532 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Eifert, T. A1 - Lueken, H. A1 - Schmidt, P. T1 - High-temperature series expansion of the magnetic susceptibility of extended magnetic systems in a complete computer implementation / Eifert, T. ; Hüning, F. ; Lueken, H. ; Schmidt, P. ; Thiele, G. JF - Chemical Physics Letters. 364 (2002), H. 1-2 Y1 - 2002 SN - 0009-2614 SP - 69 EP - 74 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Eifert, T. A1 - Handrick, K. A1 - Neuhausen, U. T1 - Computational Magnetochemistry: Complementary Quantum Mechanical Tools / Eifert, T. ; Handrick, K. ; Hüning, F. ; Neuhausen, U. ; Schilder, H. ; Lueken, H. JF - Zeitschrift für Anorganische und Allgemeine Chemie (ZAAC) - Journal of Inorganic and General Chemistry . 632 (2006), H. 4 Y1 - 2006 SN - 1521-3749 SP - 521 EP - 529 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Leineweber, A. A1 - Jacobs, H. A1 - Lueken, H. T1 - Nitrogen Ordering and ferromagnetic properties of -Fe3N1+x (0.10  x  0.39) and -Fe3(N0.80C0.20)1.38 / Leineweber, A. ; Jacobs, H. ; Hüning, F. ; Lueken, H. ; Kockelmann, W. JF - Journal of Alloys and Compounds. 316 (2001), H. 1-2 Y1 - 2001 SN - 1873-4669 SP - 21 EP - 38 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Sparta, K. A1 - Redhammer, G. J. A1 - Roussel, P. T1 - Structural Phase Transition in the 2D Spin Dimer Compound SrCu2(BO3)2 / Sparta, K. ; Redhammer, G. J. ; Roussel, P. ; Heger, G. ; Roth, G. ; Ionescu, A. Lemmens, P. ; Grove, M. ; Güntherrodt, G. ; Hüning, F. ; Lueken, H. ; Kageyama, H. ; Onizuka, K ; Ueda JF - The European Physical Journal B - Condensed Matter and Complex Systems. 19 (2001), H. 4 Y1 - 2001 SN - 1434-6036 SP - 507 EP - 516 PB - - ER - TY - JOUR A1 - Hillen, Walter A1 - Alper Selver, M. A1 - Fischer, Felix A1 - Kuntalp, Mehmet T1 - A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter JF - Computer Methods and Programs in Biomedicine. 86 (2007), H. 3 Y1 - 2007 SN - 0169-2607 SP - 270 EP - 280 PB - - ER - TY - JOUR A1 - Hüning, Felix A1 - Wilke, I. A1 - Nakielski, G. A1 - Kotzler, J. T1 - Dynamic conductivity of YBCO thin films from low to very high frequencies / Wilke, I. ; Nakielski, G. ; Kotzler, J. ; Subke, K. O. ; Jaekel, C. ; Hüning, F. ; Roskos, H. G. ; Kurz, Heinrich JF - Applied superconductivity 1997 : proceedings of EUCAS 1997, the Third European Conference on Applied Superconductivity, held in the Netherlands, 30 June - 3 July 1997 / ed. by H. Rogalla Y1 - 1997 SN - 0-7503-0487-1 N1 - Institute of Physics conference series 158 SP - 121 EP - 124 PB - IOP CY - Bristol ER - TY - JOUR A1 - Hüning, Felix A1 - Leineweber, A. A1 - Jacobs, H. A1 - Lueken, H. T1 - ε-Fe3N: magnetic structure, magnetization and temperature dependent disorder of nitrogen / Leineweber, A. ; Jacobs, H. ; Hüning, F. ; Lueken, H. ; Schilder, H. ; Kockelmann, W. JF - Journal of Alloys and Compounds. 288 (1999), H. 1-2 N2 - ε-Fe3N has been investigated by time-of-flight neutron diffraction (temperature range 4.2–618 K) and SQUID magnetometry (2–700 K, B≤5 T). A ferromagnetic spin structure is observed with magnetic moments oriented perpendicular to the c-axis of the hexagonal nuclear structure. The magnetic saturation moment of iron is 2.2 μB at 4.2 K from neutron diffraction and 2.0 μB from magnetic measurements and decreases in a Brillouin-like manner on heating to TC=575 K. Above 450 K an increasing but reversible disorder of the nitrogen partial structure is observed. Y1 - 1999 SN - 1873-4669 VL - 288 IS - 1-2 SP - 79 EP - 87 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Klinge, Uwe A1 - Wilke, Ralf A1 - Mühl, Thomas T1 - Auswahl der Herniennetze nach der “effektiven Porosität” - warum das Gewicht weniger wichtig ist JF - Chirurgische Allgemeine : CHAZ ; Zeitung für Klinik und Praxis Y1 - 2012 SN - 1615-5378 VL - 13 IS - 12 SP - 297 EP - 301 PB - Kaden CY - Mannheim ER - TY - JOUR A1 - Bohrn, U. A1 - Stütz, E. A1 - Fuchs, K. A1 - Fleischer, M. A1 - Schöning, Michael Josef A1 - Wagner, P. T1 - Monitoring of irritant gas using a whole-cell-based sensor system JF - Sensors and Actuators B: Chemical N2 - Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security. Y1 - 2012 U6 - https://doi.org/10.1016/j.snb.2012.05.088 SN - 0925-4005 VL - 175 SP - 208 EP - 217 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schneider, Bettina A1 - Schneider, Wilhelm T1 - Due Diligence – Grundlagen und Checkliste für KMU JF - Betriebswirtschaft im Blickpunkt N2 - Im Folgenden sollen Anlass und Inhalt einer Due Diligence erläutert werden. Im Rahmen einer Checkliste werden Beratern und Unternehmen Hinweise zu möglichen Prüfungsgebieten sowie zu vorzuhaltenden oder zu prüfenden Unterlagen gegeben. Entstanden ist die Checkliste aus der langjährigen praktischen Tätigkeit der Autoren bei einer großen Wirtschaftsprüfungsgesellschaft bzw. einer deutschen Großbank. Y1 - 2012 SN - 2191-1118 SP - 148 EP - 149 PB - IWW Institut für Wissen in der Wirtschaft CY - Nordkirchen ER - TY - JOUR A1 - Blecken, Udo A1 - Holthaus-Sellheier, Ursula T1 - Quantitative Prognoseverfahren für Mietpreise von Bueroimmobilien am Beispiel Düsseldorf JF - GuG : Grundstücksmarkt und Grundstückswert Y1 - 2012 SN - 0938-0175 VL - 23 IS - 1 SP - 12 EP - 21 PB - Werner CY - Köln ER - TY - JOUR A1 - Kurulgan Demirci, Eylem A1 - Demirci, Taylan A1 - Linder, Peter A1 - Trzewik, Jürgen A1 - Gierkowski, Jessica Ricarda A1 - Gossmann, Matthias A1 - Kayser, Peter A1 - Porst, Dariusz A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells JF - Journal of Bioscience and Bioengineering N2 - All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models. KW - Cell permeability KW - Cellular force KW - Endothelial cells KW - Recombinant activated protein C KW - Lipopolysaccharide KW - Contractile tension KW - CellDrum Y1 - 2012 U6 - https://doi.org/10.1016/j.jbiosc.2012.03.019 SN - 1347-4421 VL - 113 IS - 2 SP - 212 EP - 219 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hüning, Felix A1 - Jaekel, C. A1 - Francois, I. A1 - Kyas, G. T1 - Microwave surface impedance measurements on high-Tc superconductors / Jaekel, C. ; Francois, I. ; Kyas, G. ; Hüning, F. ; Roskos, H. G. ; Borghs, G. ; Kurz, H. JF - Czechoslovak Journal of Physics. 46 (1996), H. Suppl. 2 Y1 - 1996 SN - 1572-9486 IS - 46 SP - 1117 EP - 1118 PB - Springer Science+Business Media CY - Dordrecht ER - TY - JOUR A1 - Hirschberg, Rainer T1 - Decentral pumps in heating systems - a new hydraulic approac JF - 1st International Rotating Equipment Conference - Pumps and Compressors, 9th Pump Users International Forum, 9. Internationales Pumpenanwenderforum, Final Report, Düsseldorf, DE, 28.-29. Oct, 2008 Y1 - 2008 SP - 1 EP - 10 PB - - ER - TY - JOUR A1 - Hirschberg, Rainer T1 - Wirtschaftlichkeit gebäudetechnischer Anlagen VDI 2067 - Berechnung des instationären thermischen Verhaltens von Räumen und Gebäuden nach VDI 6007 JF - Umsetzung der EU-Richtlinie (EPBD), Gesamtenergieeffizienz von Gebäuden - wie gehen wir damit um?, VDI-Gesellschaft Technische Gebäudeausrüstung (VDI-TGA), Dortmund, DE, 30.-31. Jan, 2007 Y1 - 2007 SN - 978-3-18-091952-2 N1 - VDI-Berichte 1952 PB - VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Engels, Elmar A1 - Krauskopf, S. T1 - Innovation in Motion-Logic programming - a versatile interface JF - Proceedings to the 12th International Workshop on Research and Education in Mechatronics, REM 2011, Kocaeli, Turkey, 15.09.-16.09.2011 Y1 - 2011 SN - 978-975-8047-96-3 PB - - ER - TY - JOUR A1 - Spelthahn, Heiko A1 - Kirsanov, Dmitry A1 - Legin, Andrey A1 - Osterrath, Thomas A1 - Schubert, Jürgen A1 - Zander, Willi A1 - Schöning, Michael Josef T1 - Development of a thin-film sensor array for analytical monitoring of heavy metals in aqueous solutions JF - Physica Status Solidi (a) N2 - In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed. Y1 - 2012 SN - 1862-6319 U6 - https://doi.org/10.1002/pssa.201100733 VL - 209 IS - 5 SP - 885 EP - 891 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schneider, Bettina A1 - Schneider, Wilhelm T1 - Jahresabschluss nach BilMoG : Ansatz-, Ausweis- und Bewertungsvorschriften JF - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Examen, Berufseinstieg und Fortbildung Y1 - 2012 SN - 0340-3084 VL - 41 IS - 4 SP - 529 EP - 535 PB - Lange CY - Düsseldorf ER - TY - JOUR A1 - Havermann, Marc A1 - Beylich, A. E. T1 - Combined Measurement of Velocity, Temperature and Pressure in Compressible Gas Flows Using Laser-Induced Iodine Fluorescence / Havermann, M. ; Beylich, A. E. Y1 - 1998 N1 - 9th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon (Portugal), 1998 PB - - ER - TY - JOUR A1 - Havermann, Marc A1 - Seiler, F. A1 - George, A. A1 - Leopold, F. T1 - Enhanced Doppler Picture Velocimetry (DPV) for Planar Velocity Measurements in High-Speed Shock Tunnel Flow / Seiler, F. ; George, A. ; Leopold, F. ; Havermann, M. ; Srulijes, J. JF - 10th International Symposium on Flow Visualization : Kyōto, Japan, August 26 - 29, 2002 / sponsored by International Flow Visualization Society . [Chairman:] Toshio Kobayashi Y1 - 2002 SN - 4906497829 N1 - International Symposium on Flow Visualization ; (10 ; 2002.08.26-29 ; Kyōto) PB - Visualization Society of Japan CY - Kyoto ER - TY - JOUR A1 - Foltz, Christian A1 - Schneider, Nicole A1 - Wolf, Martin R. A1 - Kausch, Bernhard A1 - Schlick, Christopher A1 - Luczak, Holger ED - Nagl, Manfred T1 - Usability engineering JF - Collaborative and distributed chemical engineering : from understanding to substantial design process support; results of the IMPROVE Project. - (Lecture notes in computer science ; 4970) Y1 - 2008 SN - 978-3-540-70552-9 U6 - https://doi.org/10.1007/978-3-540-70552-9_21 SP - 527 EP - 554 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kirchner, Patrick A1 - Reisert, Steffen A1 - Pütz, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors JF - Physica Status Solidi (a) N2 - Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors. Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100773 SN - 1862-6319 VL - 209 IS - 5 SP - 859 EP - 863 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Havermann, Marc A1 - Salve, M. de A1 - Tin, G. del A1 - Panella, B. T1 - Experimental Study of the Temperature Field along a Density Lock / Salve, M. de ; Tin, G. del ; Panella, B. ; Sansoldo, D. ; Havermann, M. JF - Proceedings : International Conference on New Trends in Nuclear System Thermohydraulics, May 30th - June 2nd, 1994, Pisa / organized by Dipartimento di Costruzioni Meccaniche e Nucleari ... . Ed. by Francesco Oriolo Y1 - 1994 N1 - International Conference on New Trends in Nuclear System Thermohydraulics ; (1994.05.30-06.02 ; Pisa) SP - 623 EP - 630 PB - - CY - Pisa ER - TY - JOUR A1 - Hanssen, H. A1 - Nickel, T. A1 - Drexel, V. A1 - Hertel, G. A1 - Emslander, I. A1 - Sisic, Z. A1 - Lorang, D. A1 - Schuster, T. A1 - Kotliar, Konstantin A1 - Pressler, A. A1 - Schmidt-Trucksäss, A. A1 - Weis, M. A1 - Halle, M. T1 - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity JF - Atherosclerosis Y1 - 2011 SN - 0021-9150 VL - 216 IS - 2 SP - 433 EP - 439 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Werner, Frederik A1 - Groebel, Simone A1 - Krumbe, Christoph A1 - Wagner, Torsten A1 - Selmer, Thorsten A1 - Yoshinobu, Tatsuo A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Nutrient concentration-sensitive microorganism-based biosensor JF - Physica Status Solidi (a) Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100801 SN - 1862-6319 VL - 209 IS - 5 SP - 900 EP - 904 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wolf, Martin R. T1 - Risiko- und Maßnahmenmanagement bei der Computervalidierung JF - Pharma-Technologie-Journal (2003) Y1 - 2003 SN - 0931-9700 SP - 50 EP - 62 PB - - ER - TY - JOUR A1 - Wolf, Martin R. A1 - Foltz, Christian A1 - Schlick, Christopher A1 - Luczak, Holger T1 - Empirische Untersuchung eines Groupware-basierten Unterstützungs-Systems für verfahrenstechnische Entwickler / Wolf, M. ; Foltz, C. ; Schlick, C. ; Luczak, H. JF - Zeitschrift für Arbeitswissenschaft. 54 (2000), H. 3-4 Y1 - 2000 SN - 0340-2444 SP - 258 EP - 266 PB - - ER -