TY  - CHAP
A1  - Pham, Phu Tinh
A1  - Staat, Manfred
T1  - A simplification for shakedown analysis of hardening structures
T2  - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon
Y1  - 2015
SP  - 1
EP  - 4
PB  - RWTH Aachen University
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Akimbekov, N.Sh.
A1  - Digel, Ilya
A1  - O’Heras, C.
A1  - Tastambek, K.T.
A1  - Savitskaya, I.S.
A1  - Ualyeva, P.S.
A1  - Mansurov, Z.A.
A1  - Zhubanova, A.A.
T1  - Adsorption of bacterial lipopol ysaccharides on carbonized ri ce husks obtained in the batch  experiments
JF  - KazNU Bulletin. Biology series
Y1  - 2015
SN  - 1563-0218
VL  - 60
IS  - No 1/2
SP  - 144
EP  - 148
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Leinhos, Marcel
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers
JF  - Sensors and actuators B: Chemical
N2  - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13).
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.snb.2014.10.058
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 207, Part B
SP  - 954
EP  - 959
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - An electromechanical model for cardiac tissue constructs
T2  - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, 20.07.2015 - 23.07.2015  / ed.: Stefanie Elgeti ; Jaan-Willem Simon
Y1  - 2015
SP  - 1
EP  - 4
PB  - RWTH Aachen University
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Miyamato, Ko-ichiro
A1  - Sakakita, Sakura
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface
JF  - Electrochimica Acta
N2  - The chemical imaging sensor was applied to in-situ pH imaging of the solution in the vicinity of a corroding surface of stainless steel under potentiostatic polarization. A test piece of polished stainless steel was placed on the sensing surface leaving a narrow gap filled with artificial seawater and the stainless steel was corroded under polarization. The pH images obtained during polarization showed correspondence between the region of lower pH and the site of corrosion. It was also found that the pH value in the gap became as low as 2 by polarization, which triggered corrosion.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.electacta.2015.07.184
SN  - 0013-4686
VL  - 183
SP  - 137
EP  - 142
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dikta, Gerhard
A1  - Kühlheim, René
A1  - Mendonca, Jorge
A1  - Una-Alcarez, Jacobo de
T1  - Asymptotic representation of presmoothed Kaplan–Meier integrals with covariates in a semiparametric censorship model
JF  - Journal of Statistical Planning and Inference
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.jspi.2015.12.001
SN  - 0378-3758
VL  - Vol. 171
SP  - 10
EP  - 37
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Biomechanical study of the female pelvic floor dysfunction using the finite element method
T2  - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen , Germany, 20.07.2015 - 23.07.2015  / ed.: Stefanie Elgeti ; Jaan-Willem Simon
Y1  - 2015
SP  - 1
EP  - 4
PB  - RWTH Aachen University
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Sadykov, R.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations
T2  - Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies
Y1  - 2015
SN  - 9781634826990
SP  - 75
EP  - 99
PB  - Nova Science Publ.
ER  - 
TY  - JOUR
A1  - Frotscher, Ralf
A1  - Koch, Jan-Peter
A1  - Staat, Manfred
T1  - Computational investigation of drug action on human-induced stem cell derived cardiomyocytes
JF  - Journal of biomechanical engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1115/1.4030173
SN  - 1528-8951 (E-Journal); 0148-0731 (Print)
VL  - Vol. 137
IS  - iss. 7
SP  - 071002-1
EP  - 071002-7
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Iken, Heiko
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Concept for a biomolecular logic chip with an integrated sensor and actuator function
JF  - Physica status solidi (a)
N2  - A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431913
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1382
EP  - 1388
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bialonski, Stephan
A1  - Ansmann, Gerrit
A1  - Kantz, Holger
T1  - Data-driven prediction and prevention of extreme events in a spatially extended excitable system
JF  - Physical Review E
Y1  - 2015
U6  - http://dx.doi.org/10.1103/PhysRevE.92.042910
SN  - 2470-0053
VL  - 92
IS  - 4
SP  - 042910
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Siegert, Petra
A1  - Willenberg, H.
A1  - Poghossian, Arshak
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Substrate Recycling Amplification
JF  - Procedia Engineering
N2  - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.708
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 540
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Warmer, Johannes
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
A1  - Kaul, Peter
T1  - Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431882
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1289
EP  - 1298
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Pöttgen, Philipp
A1  - Ederer, Thorsten
A1  - Altherr, Lena
A1  - Pelz, Peter F.
T1  - Developing a control strategy for booster stations under uncertain load
JF  - Applied Mechanics and Materials
N2  - Booster stations can fulfill a varying pressure demand with high energy-efficiency, because individual pumps can be deactivated at smaller loads. Although this is a seemingly simple approach, it is not easy to decide precisely when to activate or deactivate pumps. Contemporary activation controls derive the switching points from the current volume flow through the system. However, it is not measured directly for various reasons. Instead, the controller estimates the flow based on other system properties. This causes further uncertainty for the switching decision. In this paper, we present a method to find a robust, yet energy-efficient activation strategy.
KW  - Technical Operations Research (TOR)
KW  - Booster Station
KW  - Pump System
KW  - Discrete Optimization
Y1  - 2015
SN  - 1662-7482
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.807.241
N1  - Ebenfalls weltweit einsehbar unter:
http://wl.fst.tu-darmstadt.de/wl/publications/paper_151123_SFB805_
ICUME_Developing_a_Control_Strategy_for_Booster_Stations_under_Uncertain_Load_poettgen_ederer_pelz_altherr.pdf
VL  - 807
IS  - 807
SP  - 241
EP  - 246
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Iken, Heiko
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Development of a multi‐parameter sensor chip for the simultaneous detection of organic compounds in biogas processes
JF  - Physica status solidi (a)
N2  - An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431894
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1306
EP  - 1312
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Scheja, Sabrina
A1  - Wu, Chunsheng
A1  - Keusgen, Michael
A1  - Mewes, Dieter
A1  - Schöning, Michael Josef
T1  - DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer
JF  - Applied Materials & Interfaces
N2  - Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.
Y1  - 2015
U6  - http://dx.doi.org/10.1021/acsami.5b05146
VL  - 36
IS  - 7
SP  - 20068
EP  - 20075
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Scheja, S.
A1  - Wu, Chunsheng
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer
JF  - Procedia Engineering
N2  - Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.710
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 544
EP  - 547
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane
JF  - Chemical Communications
N2  - Capacitive field-effect sensors modified with a multi-enzyme membrane have been applied for an electronic transduction of biochemical signals processed by enzyme-based AND-Reset and OR-Reset logic gates. The local pH change at the sensor surface induced by the enzymatic reaction was used for the activation of the Reset function for the first time.
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C5CC01362C
VL  - 51
SP  - 6564
EP  - 6567
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Kolditz, Melanie
A1  - Albracht, Kirsten
A1  - Fasse, Alessandro
A1  - Albin, Thivaharan
A1  - Brüggemann, Gert-Peter
A1  - Abel, Dirk
T1  - Evaluation of an industrial robot as a leg press training device
T2  - XV International Symposium on Computer Simulation in Biomechanics July 9th – 11th 2015, Edinburgh, UK
Y1  - 2015
SP  - 41
EP  - 42
ER  - 
TY  - CHAP
A1  - Oberländer, Jan
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Wendeler, Luisa
A1  - Bromm, Alexander
A1  - Iken, Heiko
A1  - Wagner, Patrick
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Experimental and numerical evaluation of interdigitated electrode array for monitoring gaseous sterilization processes
T2  - 12. Dresdner Sensor-Symposium 2015
Y1  - 2015
U6  - http://dx.doi.org/10.5162/12dss2015/P3.11
SP  - 163
EP  - 168
ER  - 
TY  - JOUR
A1  - Mulhern, Colm
A1  - Bialonski, Stephan
A1  - Kantz, Holger
T1  - Extreme events due to localization of energy
JF  - Physical Review E
Y1  - 2015
U6  - http://dx.doi.org/10.1103/PhysRevE.91.012918
SN  - 2470-0053
VL  - 91
IS  - 1
SP  - 012918
ER  - 
TY  - JOUR
A1  - Takenaga, Shoko
A1  - Schneider, Benno
A1  - Erbay, E.
A1  - Biselli, Manfred
A1  - Schnitzler, Thomas
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process
JF  - Physica status solidi (a)
N2  - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201532053
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1347
EP  - 1352
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Mayer, Dirk
A1  - Schöning, Michael Josef
T1  - Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids
JF  - Nanoscale
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C4NR05987E
SN  - 2040-3372 (E-Journal); 2040-3364 (Print)
SP  - 1023
EP  - 1031
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Nithiarasu, Perumal
T1  - Homogenization of a cardiac tissue construct
T2  - CMBE15 : 4th International Conference on Computational & Mathematical Biomedical Engineering ; 29th June - 1st July 2015 ; École Normale Supérieure de Cachan ; Cachan (Paris), France
Y1  - 2015
SN  - 2227-9385
N1  - Konferenzband unter:
http://www.compbiomed.net/getfile.php?type=12/site_documents&id=Proceedings_2227-9385_compressed.pdf
SP  - 645
EP  - 648
PB  - CMBE
CY  - [s.l.]
ER  - 
TY  - JOUR
A1  - Geier, Christian
A1  - Bialonski, Stephan
A1  - Elger, Christian E.
A1  - Lehnertz, Klaus
T1  - How important is the seizure onset zone for seizure dynamics?
JF  - Seizure
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.seizure.2014.10.013
SN  - 1059-1311
VL  - 25
SP  - 160
EP  - 166
ER  - 
TY  - THES
A1  - Duong, Minh Tuan
T1  - Hyperelastic modeling and soft-tissue growth integrated with the smoothed finite element method - SFEM
Y1  - 2015
N1  - Aachen, Techn. Hochsch., Diss., 2014
PB  - RWTH Aachen University
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Tran, Thanh Ngoc
A1  - Tolba, R. H.
A1  - Staat, Manfred
T1  - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen
JF  - International biomechanics
Y1  - 2015
U6  - http://dx.doi.org/10.1080/23335432.2015.1049295
SN  - 2333-5432
VL  - Vol. 2
IS  - Iss. 1
SP  - 79
EP  - 88
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - CHAP
A1  - Goldmann, Jan-Peter
A1  - Braunstein, Bjoern
A1  - Heinrich, Kai
A1  - Sanno, Maximilian
A1  - Stäudle, Benjamin
A1  - Ritzdorf, Wolfgang
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Joint work of the take-off leg during elite high jump
T2  - Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS)
Y1  - 2015
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
T1  - Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer
JF  - Nanoscale
N2  - A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent–voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C4NR07225A
VL  - 14
IS  - 7
SP  - 6143
EP  - 6150
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Schöning, Michael Josef
T1  - Label-free sensing of biomolecules by their intrinsic molecular charge using field-effect devices
T2  - Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13
Y1  - 2015
SN  - 978-5-8084-1991-9
SP  - 61
EP  - 63
ER  - 
TY  - JOUR
A1  - Dantism, S.
A1  - Takenaga, S.
A1  - Wagner, P.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells
JF  - Procedia Engineering
N2  - LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.647
SN  - 1877-7058
N1  - Part of special issue "Eurosensors 2015"
VL  - 120
SP  - 384
EP  - 387
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Kirschbaum, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide
JF  - Physica status solidi (a)
N2  - Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431944
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1368
EP  - 1374
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications
T2  - 12. Dresdner Sensor-Symposium 2015
Y1  - 2015
U6  - http://dx.doi.org/10.5162/12dss2015/P5.8
SP  - 206
EP  - 209
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Nguyen, N. H.
A1  - Staat, Manfred
T1  - Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM)
T2  - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015  / ed.: Stefanie Elgeti ; Jaan-Willem Simon
Y1  - 2015
SP  - 1
EP  - 4
PB  - RWTH Aachen University
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, Maximillian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.
Y1  - 2015
U6  - http://dx.doi.org/10.1021/acs.analchem.5b00617
SN  - 1520-6882
VL  - 87
IS  - 13
SP  - 6607
EP  - 6613
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Reisert, Steffen
A1  - Kramer, Friederike
A1  - Begoyan, Vardges K.
A1  - Buniatyan, Vahe V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter sensing using high-k oxide of barium strontium titanate
JF  - Physica status solidi (a)
N2  - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431911
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1259
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Reisert, Steffen
A1  - Geissler, H.
A1  - Weiler, C.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Multiple sensor-type system for monitoring the microbicidal effectiveness of aseptic sterilisation processes
JF  - Food control
N2  - The present work describes a novel multiple sensor-type system for the real-time analysis of aseptic sterilisation processes employing gaseous hydrogen peroxide (H2O2) as a sterilant. The inactivation kinetics of Bacillus atrophaeus by gaseous H2O2 have been investigated by means of a methodical calibration experiment, taking into account the process variables H2O2 concentration, humidity and gas temperature. It has been found that the microbicidal effectiveness at H2O2 concentrations above 2% v/v is largely determined by the concentration itself, while at lower H2O2 concentrations, the gas temperature and humidity play a leading role. Furthermore, the responses of different types of gas sensors towards the influencing factors of the sterilisation process have been analysed within the same experiment. Based on a correlation established between the inactivation kinetics and the sensor responses, a calorimetric H2O2 sensor and a metal-oxide semiconductor (MOX) sensor have been identified as possible candidates for monitoring the microbicidal effectiveness of aseptic sterilisation processes employing gaseous H2O2. Therefore, two linear models that describe the relationship between sensor response and microbicidal effectiveness have been proposed.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.foodcont.2014.07.063
SN  - 1873-7129 (E-Journal); 0956-7135 (Print)
VL  - 47
SP  - 615
EP  - 622
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an independence test approach to the goodness-of-fit problem
JF  - Journal of Multivariate Analysis
N2  - Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov–Smirnov and Cramér–von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions.
KW  - Goodness-of-fit test
KW  - Independence test
KW  - Parametric bootstrap
KW  - Vapnik–Čhervonenkis class
KW  - Gamma distribution
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.jmva.2015.05.013
SN  - 0047-259X
VL  - 2015
IS  - 140
SP  - 193
EP  - 208
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Mariano, K.
A1  - Keusgen, M.
A1  - Selmer, Thorsten
A1  - Schöning, Michael Josef
T1  - Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes
JF  - Procedia Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.702
SN  - 1877-7058
N1  - Part of special issue "Eurosensors 2015"
VL  - 120
SP  - 532
EP  - 535
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schusser, Sebastian
A1  - Bäcker, M.
A1  - Leinhos, Marcel
A1  - Schöning, Michael Josef
T1  - Real-time in-situ electrical monitoring of the degradation of biopolymers using semiconductor field-effect devices
T2  - Biodegradable biopolymers. Vol. 1
Y1  - 2015
SN  - 978-1-63483-632-6
SP  - 135
EP  - 153
PB  - Nova Science Publ.
CY  - Hauppauge
ER  - 
TY  - JOUR
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor
JF  - Sensors and actuators B: Chemical
N2  - The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor with a field-effect structure to detect the variation of the Nernst potential at its sensor surface, the measured area on which is defined by illumination. Thanks to this light-addressability, the LAPS can be applied to chemical imaging sensor systems, which can visualize the two-dimensional distribution of a particular target ion on the sensor surface. Chemical imaging sensor systems are expected to be useful for analysis of reaction and diffusion in various electrochemical and biological samples. Recent developments of LAPS-based chemical imaging sensor systems, in terms of the spatial resolution, measurement speed, image quality, miniaturization and integration with microfluidic devices, are summarized and discussed.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.snb.2014.09.002
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 207, Part B
SP  - 926
EP  - 932
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, M.
A1  - Molin, D. G. M.
A1  - Akker, N. M. S. van den
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation
JF  - Procedia Engineering
N2  - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.815
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 948
EP  - 951
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Simulating beating cardiomyocytes with electromechanical coupling
T2  - II. International Conference on Biomedical Technology : 28-30 October 2015 Hannover, Germany / T. Lenarz, P. Wriggers (Eds.)
Y1  - 2015
SP  - 1
EP  - 2
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Pieper, Martin
T1  - Simulating the electromagnetic‐thermal treatment of thin aluminium layers for adhesion improvement
JF  - Physica status solidi (a)
N2  - A composite layer material used in packaging industry is made from joining layers of different materials using an adhesive. An important processing step in the production of aluminium-containing composites is the surface treatment and consequent coating of adhesive material on the aluminium surface. To increase adhesion strength between aluminium layer and the adhesive material, the foil is heat treated. For efficient heating, induction heating was considered as state-of-the-art treatment process. Due to the complexity of the heating process and the unpredictable nature of the heating source, the control of the process is not yet optimised. In this work, a finite element analysis of the process was established and various process parameters were studied. The process was simplified and modelled in 3D. The numerical model contains an air domain, an aluminium layer and a copper coil fitted with a magnetic field concentrating material. The effect of changing the speed of the aluminium foil (or rolling speed) was studied with the change of the coil current. Statistical analysis was used for generating a general control equation of coil current with changing rolling speed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431893
SN  - 1862-6319
VL  - Vol. 212
IS  - 6
SP  - 1234
EP  - 1241
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Kremers, Alexander
A1  - Pieper, Martin
T1  - Simulation and Verification of Bionic Heat Exchangers with COMSOL Multiphysics® Software
T2  - COMSOL Conference 2015 User Presentations ; COMSOL Conference 2015 Grenoble October 14 - 16, 2015 - World Trade Center, Grenoble, France
Y1  - 2015
PB  - COMSOL
CY  - Göttingen ; Berlin
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Goßmann, Matthias
A1  - Raatschen, Hans-Jürgen
A1  - Temiz Artmann, Aysegül
A1  - Staat, Manfred
T1  - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM
T2  - Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)
N2  - We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.
Y1  - 2015
SN  - 978-3-319-02534-6 ; 978-3-319-02535-3
SP  - 187
EP  - 212
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - CHAP
A1  - Behbahani, Mehdi
A1  - Rible, Sebastian
A1  - Moulinec, Charles
A1  - Fournier, Yvan
A1  - Nicolai, Mike
A1  - Crosetto, Paolo
T1  - Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing
T2  - World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering
Y1  - 2015
VL  - 9
IS  - 5
ER  -